Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role of p53 in regulating the anti-tumor immune response is still poorly understood. Here, we show that loss of p53 in cancer cells modulates the...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 30; no. 2; pp. 481 - 496.e6
Main Authors:	Blagih, Julianna, Zani, Fabio, Chakravarty, Probir, Hennequart, Marc, Pilley, Steven, Hobor, Sebastijan, Hock, Andreas K., Walton, Josephine B., Morton, Jennifer P., Gronroos, Eva, Mason, Susan, Yang, Ming, McNeish, Iain, Swanton, Charles, Blyth, Karen, Vousden, Karen H.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 14.01.2020 Cell Press Elsevier
Subjects:	Animals Humans Kras Mice myeloid cells Myeloid Cells - metabolism p53 T cell response T-Lymphocytes, Regulatory - metabolism tumor Tumor Suppressor Protein p53 - metabolism Kras myeloid cells tumor T cell response p53
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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