The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair

The molecular mechanism by which foreign DNA integrates into the human genome is poorly understood yet critical to many disease processes, including retroviral infection and carcinogenesis, and to gene therapy. We hypothesized that the mechanism of genomic integration may be similar to transposition...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 50; p. 18075
Main Authors:	Lee, Suk-Hee, Oshige, Masahiko, Durant, Stephen T, Rasila, Kanwaldeep Kaur, Williamson, Elizabeth A, Ramsey, Heather, Kwan, Lori, Nickoloff, Jac A, Hromas, Robert
Format:	Journal Article
Language:	English
Published:	United States 13.12.2005
Subjects:	Amino Acid Sequence Cell Line DNA - metabolism DNA Methylation DNA Primers DNA Repair - genetics DNA Repair Enzymes - genetics Histone-Lysine N-Methyltransferase Histones - metabolism Humans Methyltransferases - classification Methyltransferases - genetics Molecular Sequence Data Protein Structure, Tertiary Sequence Analysis, DNA Virus Integration - genetics Virus Integration - physiology
ISSN:	0027-8424
Online Access:	Get more information
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