Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae. The pathogenesis of recurrent bleeding in CCM is incompletely understood. Here, we show that central nervous system hemorrhage in CCMs is as...

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Veröffentlicht in:	Blood Jg. 133; H. 3; S. 193
Hauptverfasser:	Lopez-Ramirez, Miguel Alejandro, Pham, Angela, Girard, Romuald, Wyseure, Tine, Hale, Preston, Yamashita, Atsuki, Koskimäki, Janne, Polster, Sean, Saadat, Laleh, Romero, Ignacio A, Esmon, Charles T, Lagarrigue, Frederic, Awad, Issam A, Mosnier, Laurent O, Ginsberg, Mark H
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.01.2019
Schlagworte:	Adult Animals Anticoagulants - metabolism Apoptosis Regulatory Proteins - physiology Blood Coagulation Case-Control Studies Cerebral Hemorrhage - blood Cerebral Hemorrhage - diagnosis Cerebral Hemorrhage - etiology Endothelial Protein C Receptor - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Hemangioma, Cavernous, Central Nervous System - complications Hemangioma, Cavernous, Central Nervous System - metabolism Hemangioma, Cavernous, Central Nervous System - physiopathology Humans KRIT1 Protein - physiology Membrane Proteins - physiology Mice Mice, Knockout Protein C - metabolism Proto-Oncogene Proteins - physiology Signal Transduction Thrombomodulin - blood Young Adult
ISSN:	1528-0020, 1528-0020
Online-Zugang:	Weitere Angaben
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