Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1

Birthdate-dependent neuronal layering is fundamental to neocortical functions. The extracellular protein Reelin is essential for the establishment of the eventual neuronal alignments. Although this Reelin-dependent neuronal layering is mainly established by the final neuronal migration step called &...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 76; H. 2; S. 353
Hauptverfasser:	Sekine, Katsutoshi, Kawauchi, Takeshi, Kubo, Ken-Ichiro, Honda, Takao, Herz, Joachim, Hattori, Mitsuharu, Kinashi, Tatsuo, Nakajima, Kazunori
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.10.2012
Schlagworte:	Adaptor Proteins, Signal Transducing Analysis of Variance Animals Cell Adhesion - drug effects Cell Adhesion - genetics Cell Adhesion - physiology Cell Adhesion Molecules, Neuronal - drug effects Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cell Line, Transformed Cell Movement - drug effects Cell Movement - genetics Cell Movement - physiology Electroporation Embryo, Mammalian Extracellular Matrix Proteins - drug effects Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Expression Regulation - physiology Green Fluorescent Proteins - genetics Humans Integrin alpha5beta1 - genetics Integrin alpha5beta1 - metabolism Mice Mice, Inbred ICR Mice, Neurologic Mutants Mice, Transgenic Mutation - genetics Nerve Tissue Proteins - drug effects Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - physiology Nuclear Proteins Pregnancy Proto-Oncogene Proteins c-crk - metabolism rap1 GTP-Binding Proteins - metabolism Serine Endopeptidases - drug effects Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction - genetics Signal Transduction - physiology Somatosensory Cortex - cytology
ISSN:	1097-4199, 1097-4199
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