Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia

Philadelphia chromosome (Ph)-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3-kinase (PI3K) signaling and poor clinical outcomes. PI3K pathway signaling inhibitors have been minimally investigated in Ph-...

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Veröffentlicht in:	Blood Jg. 129; H. 2; S. 177 - 187
Hauptverfasser:	Tasian, Sarah K, Teachey, David T, Li, Yong, Shen, Feng, Harvey, Richard C, Chen, I-Ming, Ryan, Theresa, Vincent, Tiffaney L, Willman, Cheryl L, Perl, Alexander E, Hunger, Stephen P, Loh, Mignon L, Carroll, Martin, Grupp, Stephan A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 12.01.2017
Schlagworte:	Animals Antineoplastic Agents - pharmacology Cell Proliferation - drug effects Humans Janus Kinases - antagonists & inhibitors Mice Phosphoinositide-3 Kinase Inhibitors Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-abl - antagonists & inhibitors Random Allocation Signal Transduction - drug effects TOR Serine-Threonine Kinases - antagonists & inhibitors Xenograft Model Antitumor Assays
ISSN:	1528-0020
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