Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer

Here, we report that functional heterogeneity of macrophages in cancer could be determined by the nature of their precursors: monocytes (Mons) and monocytic myeloid-derived suppressor cells (M-MDSCs). Macrophages that are differentiated from M-MDSCs, but not from Mons, are immune suppressive, with a...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 33; H. 13; S. 108571
Hauptverfasser:	Kwak, Taekyoung, Wang, Fang, Deng, Hui, Condamine, Thomas, Kumar, Vinit, Perego, Michela, Kossenkov, Andrew, Montaner, Luis J., Xu, Xiaowei, Xu, Wei, Zheng, Cathy, Schuchter, Lynn M., Amaravadi, Ravi K., Mitchell, Tara C., Karakousis, Giorgos C., Mulligan, Charles, Nam, Brian, Masters, Gregory, Hockstein, Neil, Bennett, Joseph, Nefedova, Yulia, Gabrilovich, Dmitry I.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 29.12.2020
Schlagworte:	immune suppression myeloid-derived suppressor cells S100A9 tumor associated macrophages tumor immunology tumor associated macrophages tumor immunology immune suppression S100A9 myeloid-derived suppressor cells
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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