The role of mitochondria in insulin resistance and type 2 diabetes mellitus

This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensit...

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Bibliographic Details
Published in:	Nature reviews. Endocrinology Vol. 8; no. 2; pp. 92 - 103
Main Authors:	Szendroedi, Julia, Phielix, Esther, Roden, Michael
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.02.2012 Nature Publishing Group
Subjects:	631/443/319/333 631/80/86/2367 692/699/2743/137/773 Animals Development and progression Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Endocrinology Fatty acids Glucose Humans Hyperlipidemias - complications Hyperlipidemias - metabolism Hyperlipidemias - physiopathology Insulin resistance Insulin Resistance - physiology Medicine Medicine & Public Health Metabolism Metabolites Mitochondria Mitochondria, Muscle - physiology Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Musculoskeletal system Oxidation Oxidative Coupling Oxidative Phosphorylation Phosphorylation Physiological aspects review-article Terminology Type 2 diabetes Germany
ISSN:	1759-5029, 1759-5037, 1759-5037
Online Access:	Get full text
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