The role of mitochondria in insulin resistance and type 2 diabetes mellitus
This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensit...
Saved in:
| Published in: | Nature reviews. Endocrinology Vol. 8; no. 2; pp. 92 - 103 |
|---|---|
| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
01.02.2012
Nature Publishing Group |
| Subjects: | |
| ISSN: | 1759-5029, 1759-5037, 1759-5037 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity.
Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of mitochondrial oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and plasticity of mitochondria and/or lower mitochondrial content in skeletal muscle cells and potentially also in hepatocytes. Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial activity as the result of blunted mitochondrial plasticity. Hereditary insulin resistance is frequently associated with reduced mitochondrial activity at rest, probably due to diminished mitochondrial content. Lifestyle and pharmacological interventions can enhance the capacity for oxidative phosphorylation and mitochondrial content and improve insulin resistance in some (pre)diabetic cases. Various mitochondrial features can be abnormal but are not necessarily responsible for all forms of insulin resistance. Nevertheless, mitochondrial abnormalities might accelerate progression of insulin resistance and subsequent organ dysfunction via increased production of reactive oxygen species. This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity.
Key Points
Overt type 2 diabetes mellitus is associated with reduced oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and mitochondrial plasticity in insulin-responsive tissues
Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial plasticity that results in the inability of the organism to switch from fatty acid to glucose oxidation in skeletal muscle
Hereditary insulin resistance can be linked to reduced resting mitochondrial activity at least partly due to a decreased mitochondrial content
Lifestyle and pharmacological interventions can enhance oxidative phosphorylation capacity and mitochondrial content, and in most cases improve insulin resistance in (pre)diabetic states
Reduced oxidative phosphorylation capacity is unlikely to be the general cause of all forms of insulin resistance but might accelerate its progression and subsequent organ dysfunction via increased production of reactive oxygen species |
|---|---|
| AbstractList | Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of mitochondrial oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and plasticity of mitochondria and/or lower mitochondrial content in skeletal muscle cells and potentially also in hepatocytes. Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial activity as the result of blunted mitochondrial plasticity. Hereditary insulin resistance is frequently associated with reduced mitochondrial activity at rest, probably due to diminished mitochondrial content. Lifestyle and pharmacological interventions can enhance the capacity for oxidative phosphorylation and mitochondrial content and improve insulin resistance in some (pre)diabetic cases. Various mitochondrial features can be abnormal but are not necessarily responsible for all forms of insulin resistance. Nevertheless, mitochondrial abnormalities might accelerate progression of insulin resistance and subsequent organ dysfunction via increased production of reactive oxygen species. This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity. This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity. Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of mitochondrial oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and plasticity of mitochondria and/or lower mitochondrial content in skeletal muscle cells and potentially also in hepatocytes. Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial activity as the result of blunted mitochondrial plasticity. Hereditary insulin resistance is frequently associated with reduced mitochondrial activity at rest, probably due to diminished mitochondrial content. Lifestyle and pharmacological interventions can enhance the capacity for oxidative phosphorylation and mitochondrial content and improve insulin resistance in some (pre)diabetic cases. Various mitochondrial features can be abnormal but are not necessarily responsible for all forms of insulin resistance. Nevertheless, mitochondrial abnormalities might accelerate progression of insulin resistance and subsequent organ dysfunction via increased production of reactive oxygen species. This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity. Key Points Overt type 2 diabetes mellitus is associated with reduced oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and mitochondrial plasticity in insulin-responsive tissues Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial plasticity that results in the inability of the organism to switch from fatty acid to glucose oxidation in skeletal muscle Hereditary insulin resistance can be linked to reduced resting mitochondrial activity at least partly due to a decreased mitochondrial content Lifestyle and pharmacological interventions can enhance oxidative phosphorylation capacity and mitochondrial content, and in most cases improve insulin resistance in (pre)diabetic states Reduced oxidative phosphorylation capacity is unlikely to be the general cause of all forms of insulin resistance but might accelerate its progression and subsequent organ dysfunction via increased production of reactive oxygen species Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of mitochondrial oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and plasticity of mitochondria and/or lower mitochondrial content in skeletal muscle cells and potentially also in hepatocytes. Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial activity as the result of blunted mitochondrial plasticity. Hereditary insulin resistance is frequently associated with reduced mitochondrial activity at rest, probably due to diminished mitochondrial content. Lifestyle and pharmacological interventions can enhance the capacity for oxidative phosphorylation and mitochondrial content and improve insulin resistance in some (pre)diabetic cases. Various mitochondrial features can be abnormal but are not necessarily responsible for all forms of insulin resistance. Nevertheless, mitochondrial abnormalities might accelerate progression of insulin resistance and subsequent organ dysfunction via increased production of reactive oxygen species. This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity. Szendroedi, J. et al. Nat. Rev. Endocrinol. 8, 92-103 (2012); published online 13 September 2011; doi: 10.1038/nrendo.2011.138 Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of mitochondrial oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and plasticity of mitochondria and/or lower mitochondrial content in skeletal muscle cells and potentially also in hepatocytes. Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial activity as the result of blunted mitochondrial plasticity. Hereditary insulin resistance is frequently associated with reduced mitochondrial activity at rest, probably due to diminished mitochondrial content. Lifestyle and pharmacological interventions can enhance the capacity for oxidative phosphorylation and mitochondrial content and improve insulin resistance in some (pre)diabetic cases. Various mitochondrial features can be abnormal but are not necessarily responsible for all forms of insulin resistance. Nevertheless, mitochondrial abnormalities might accelerate progression of insulin resistance and subsequent organ dysfunction via increased production of reactive oxygen species. This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity.Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of mitochondrial oxidative phosphorylation capacity, submaximal ADP-stimulated oxidative phosphorylation and plasticity of mitochondria and/or lower mitochondrial content in skeletal muscle cells and potentially also in hepatocytes. Acquired insulin resistance is associated with reduced insulin-stimulated mitochondrial activity as the result of blunted mitochondrial plasticity. Hereditary insulin resistance is frequently associated with reduced mitochondrial activity at rest, probably due to diminished mitochondrial content. Lifestyle and pharmacological interventions can enhance the capacity for oxidative phosphorylation and mitochondrial content and improve insulin resistance in some (pre)diabetic cases. Various mitochondrial features can be abnormal but are not necessarily responsible for all forms of insulin resistance. Nevertheless, mitochondrial abnormalities might accelerate progression of insulin resistance and subsequent organ dysfunction via increased production of reactive oxygen species. This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with a main focus on studies in humans, and addresses the effects of therapeutic strategies that affect mitochondrial function and insulin sensitivity. |
| Audience | Academic |
| Author | Phielix, Esther Roden, Michael Szendroedi, Julia |
| Author_xml | – sequence: 1 givenname: Julia surname: Szendroedi fullname: Szendroedi, Julia organization: Institute for Clinical Diabetology, German Diabetes Center, Department of Metabolic Diseases, University Clinics Düsseldorf, Heinrich-Heine University – sequence: 2 givenname: Esther surname: Phielix fullname: Phielix, Esther organization: Institute for Clinical Diabetology, German Diabetes Center – sequence: 3 givenname: Michael surname: Roden fullname: Roden, Michael email: michael.roden@ddz.uni-duesseldorf.de organization: Institute for Clinical Diabetology, German Diabetes Center, Department of Metabolic Diseases, University Clinics Düsseldorf, Heinrich-Heine University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21912398$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kstrHSEUxiWk5L3urgiFdnVvfMyMugyhj9BAN-lanPGYa5jRW3UW-e_jcJM2CQkKivy-j-94zjHaDzEAQh8pWVPC5XlIEGxcM0LpmnK5h46oaNWqJVzs_7szdYiOc74jpOsa0RygQ0YVZVzJI_TrZgM4xRFwdHjyJQ6bGGzyBvtQd57HeibIPhcTBsAmWFzut4AZtt70UCDjCcbRlzmfog_OjBnOHs8T9Of7t5vLn6vr3z-uLi-uV0PLVFnxplkyEdOB7HgvCeHWOVVLAM5Fa4TpuWOttLSzXApibd-Zth-UcQ0TgvAT9HXnu03x7wy56MnnoYYwAeKctap1C9mprpKfX5F3cU6hhtNUSEG54kz-p27NCNoHF0syw-KpL5iQUtK2WbzWb1B1WZj8UNvifH1_IfjyTLABM5ZNjuNcfAz5JfjpMeXcT2D1NvnJpHv91KUKtDtgSDHnBE4PvpjFp0bwo6ZEL9Ogd9Ogl2nQdRqq7vyV7sn6fQXZKXIlwy2kZx_2juQBdHbEoA |
| CitedBy_id | crossref_primary_10_1513_AnnalsATS_201701_042AW crossref_primary_10_1016_j_ekir_2024_12_021 crossref_primary_10_1007_s00125_022_05851_x crossref_primary_10_1152_physiol_00004_2013 crossref_primary_10_3390_ijms25031425 crossref_primary_10_1016_j_dsx_2012_03_003 crossref_primary_10_4161_cc_28189 crossref_primary_10_1210_jc_2015_2892 crossref_primary_10_3390_ijms22105159 crossref_primary_10_1016_j_heliyon_2021_e07573 crossref_primary_10_1038_clpt_2014_174 crossref_primary_10_1039_C7RA02945D crossref_primary_10_1016_j_metabol_2018_01_018 crossref_primary_10_1016_j_mito_2018_04_004 crossref_primary_10_1152_japplphysiol_01067_2014 crossref_primary_10_1016_j_biocel_2014_02_014 crossref_primary_10_1289_EHP1404 crossref_primary_10_1513_AnnalsATS_201409_415OC crossref_primary_10_1038_s41598_017_00276_8 crossref_primary_10_1016_j_bbadis_2014_05_007 crossref_primary_10_3390_antiox12040782 crossref_primary_10_1016_j_mito_2016_08_004 crossref_primary_10_2337_dc18_0296 crossref_primary_10_1016_j_arr_2022_101702 crossref_primary_10_1002_mnfr_201300747 crossref_primary_10_1111_obr_12199 crossref_primary_10_2337_db13_0062 crossref_primary_10_1017_S0029665119001150 crossref_primary_10_1039_C8RA09482A crossref_primary_10_1016_j_apmr_2023_10_005 crossref_primary_10_1016_j_jmb_2019_09_011 crossref_primary_10_1038_srep22788 crossref_primary_10_1002_1878_0261_12531 crossref_primary_10_1155_2013_163062 crossref_primary_10_1007_s12035_021_02583_8 crossref_primary_10_1002_cbin_10598 crossref_primary_10_1007_s13105_019_00672_w crossref_primary_10_2337_dc13_0528 crossref_primary_10_1371_journal_pone_0100525 crossref_primary_10_1038_s41598_020_77621_x crossref_primary_10_1111_apha_12289 crossref_primary_10_1038_s41598_017_17086_7 crossref_primary_10_1016_j_bbrc_2017_06_129 crossref_primary_10_1016_j_phrs_2012_09_004 crossref_primary_10_1080_01913123_2021_1983099 crossref_primary_10_1210_er_2015_1116 crossref_primary_10_3390_antiox11112109 crossref_primary_10_2337_dc17_1318 crossref_primary_10_1038_nm_4245 crossref_primary_10_3390_antiox12030658 crossref_primary_10_1002_jcp_31317 crossref_primary_10_14336_AD_2015_0702 crossref_primary_10_1016_j_metabol_2015_09_002 crossref_primary_10_1177_0271678X15606719 crossref_primary_10_1038_s41467_022_31249_9 crossref_primary_10_3390_ijms21239204 crossref_primary_10_1016_j_jnutbio_2017_10_004 crossref_primary_10_3390_cells11132005 crossref_primary_10_1007_s11154_018_9446_3 crossref_primary_10_1038_s42003_022_04185_z crossref_primary_10_3390_molecules20058242 crossref_primary_10_1177_11779322241306290 crossref_primary_10_1016_j_scitotenv_2023_162920 crossref_primary_10_1007_s10863_013_9530_z crossref_primary_10_1016_j_jhazmat_2023_130791 crossref_primary_10_3390_ijms26157398 crossref_primary_10_1007_s40005_020_00481_0 crossref_primary_10_1177_0271678X17703887 crossref_primary_10_1038_srep13924 crossref_primary_10_1111_apm_12908 crossref_primary_10_1371_journal_pone_0226652 crossref_primary_10_1371_journal_pone_0228710 crossref_primary_10_1038_mi_2017_31 crossref_primary_10_1016_j_biopha_2025_118201 crossref_primary_10_1016_j_tem_2012_06_005 crossref_primary_10_1177_1535370214557218 crossref_primary_10_1038_cdd_2017_168 crossref_primary_10_1038_emm_2016_157 crossref_primary_10_1113_JP276386 crossref_primary_10_1210_clinem_dgab810 crossref_primary_10_4137_BCI_S36141 crossref_primary_10_1016_j_envint_2019_01_027 crossref_primary_10_1016_j_jdiacomp_2014_05_007 crossref_primary_10_3390_pharmaceutics14071406 crossref_primary_10_3390_ijms20225601 crossref_primary_10_1016_j_tjnut_2024_10_044 crossref_primary_10_1016_j_ajhg_2018_12_001 crossref_primary_10_2337_dc16_1898 crossref_primary_10_1073_pnas_1515733112 crossref_primary_10_1111_1440_1681_13172 crossref_primary_10_1111_bph_12413 crossref_primary_10_1155_2014_908539 crossref_primary_10_1101_gad_229724_113 crossref_primary_10_4239_wjd_v11_i5_165 crossref_primary_10_1111_cen_14396 crossref_primary_10_1007_s10735_023_10158_1 crossref_primary_10_1002_sscp_70012 crossref_primary_10_1002_mnfr_201500067 crossref_primary_10_3390_molecules27165109 crossref_primary_10_1016_j_tips_2015_04_010 crossref_primary_10_3390_foods13132137 crossref_primary_10_1128_MCB_00167_12 crossref_primary_10_1373_clinchem_2015_250761 crossref_primary_10_1016_j_arr_2021_101313 crossref_primary_10_1016_j_mito_2021_10_001 crossref_primary_10_1186_s43556_025_00284_5 crossref_primary_10_1093_eurheartj_ehv043 crossref_primary_10_1016_j_jff_2018_12_016 crossref_primary_10_3390_biom14111361 crossref_primary_10_1016_j_gene_2024_148216 crossref_primary_10_3389_fendo_2017_00271 crossref_primary_10_3945_ajcn_115_122937 crossref_primary_10_1016_j_bbadis_2024_167172 crossref_primary_10_1016_j_biopha_2024_116320 crossref_primary_10_1007_s00018_022_04401_3 crossref_primary_10_1002_dmrr_2894 crossref_primary_10_1016_j_molmet_2014_04_004 crossref_primary_10_1016_j_metabol_2017_08_004 crossref_primary_10_1016_j_jep_2020_113289 crossref_primary_10_1074_jbc_M117_804005 crossref_primary_10_1038_s41598_019_41244_8 crossref_primary_10_4161_epi_24656 crossref_primary_10_3390_ijms20040874 crossref_primary_10_3390_ijms232112910 crossref_primary_10_2337_dc13_1359 crossref_primary_10_1142_S0192415X20500317 crossref_primary_10_1016_j_mito_2019_12_001 crossref_primary_10_1016_j_ijcard_2018_05_019 crossref_primary_10_1038_s41556_024_01586_6 crossref_primary_10_1016_j_mito_2021_02_007 crossref_primary_10_1016_j_cmet_2022_08_012 crossref_primary_10_2337_db13_1301 crossref_primary_10_3389_fnagi_2017_00345 crossref_primary_10_1155_2020_8297984 crossref_primary_10_1186_s12964_025_02308_7 crossref_primary_10_1039_D5SC03665H crossref_primary_10_1371_journal_pone_0092753 crossref_primary_10_1590_0001_3765202020191340 crossref_primary_10_1146_annurev_nutr_071715_050656 crossref_primary_10_1016_j_freeradbiomed_2016_01_021 crossref_primary_10_3389_fchem_2021_683220 crossref_primary_10_1038_s41467_020_20313_x crossref_primary_10_3168_jds_2018_14546 crossref_primary_10_4103_jisp_jisp_678_21 crossref_primary_10_1038_cddis_2012_206 crossref_primary_10_1002_agm2_12221 crossref_primary_10_1111_acel_12683 crossref_primary_10_3389_fendo_2020_558271 crossref_primary_10_1016_j_fertnstert_2013_03_003 crossref_primary_10_1371_journal_pone_0149033 crossref_primary_10_1016_j_jconrel_2015_03_036 crossref_primary_10_1016_j_phrs_2018_12_020 crossref_primary_10_1016_j_febslet_2014_05_011 crossref_primary_10_1080_08820538_2022_2100714 crossref_primary_10_1007_s11010_019_03590_z crossref_primary_10_1007_s00018_022_04490_0 crossref_primary_10_1093_abbs_gmu065 crossref_primary_10_1016_j_indcrop_2017_04_022 crossref_primary_10_1093_rheumatology_keu016 crossref_primary_10_1007_s12265_018_9803_3 crossref_primary_10_15252_embr_201846363 crossref_primary_10_1016_j_lfs_2025_123773 crossref_primary_10_1016_j_mce_2025_112466 crossref_primary_10_2337_dbi18_0030 crossref_primary_10_1007_s11892_017_0959_z crossref_primary_10_1016_j_nbd_2012_03_016 crossref_primary_10_1007_s00125_016_4038_9 crossref_primary_10_3390_metabo12111092 crossref_primary_10_3389_fphar_2019_00661 crossref_primary_10_1096_fj_202500415R crossref_primary_10_1002_oby_23705 crossref_primary_10_3390_biom13121789 crossref_primary_10_4093_dmj_2022_0092 crossref_primary_10_1038_s41422_018_0078_7 crossref_primary_10_1007_s12272_024_01490_5 crossref_primary_10_3390_antiox11112297 crossref_primary_10_1002_dmrr_2601 crossref_primary_10_1016_j_neuropharm_2020_108305 crossref_primary_10_1038_s41420_024_02227_5 crossref_primary_10_1074_jbc_M115_654129 crossref_primary_10_1016_j_tem_2016_02_003 crossref_primary_10_1038_s12276_018_0154_6 crossref_primary_10_4093_dmj_2019_0191 crossref_primary_10_1093_ageing_afy067 crossref_primary_10_1124_jpet_112_192104 crossref_primary_10_1016_j_ebiom_2023_104714 crossref_primary_10_1210_er_2013_1084 crossref_primary_10_1016_j_envint_2025_109287 crossref_primary_10_1093_ajcn_nqz191 crossref_primary_10_3390_genes9010010 crossref_primary_10_1016_j_cpcardiol_2019_03_006 crossref_primary_10_1038_s41598_023_43438_7 crossref_primary_10_1016_j_bbabio_2016_04_286 crossref_primary_10_1111_sms_12537 crossref_primary_10_2337_db13_1234 crossref_primary_10_3390_biomedicines13051053 crossref_primary_10_1097_MD_0000000000005921 crossref_primary_10_3389_fnut_2018_00077 crossref_primary_10_3390_ijms23062979 crossref_primary_10_3390_ijms22062862 crossref_primary_10_1111_jfbc_13125 crossref_primary_10_1172_JCI67615 crossref_primary_10_1016_j_cmet_2024_04_006 crossref_primary_10_1016_j_nbd_2013_05_015 crossref_primary_10_1096_fj_201802714R crossref_primary_10_1194_jlr_M023382 crossref_primary_10_1210_clinem_dgz267 crossref_primary_10_3390_ijms22094558 crossref_primary_10_3390_nu10040438 crossref_primary_10_1111_jdi_12064 crossref_primary_10_1016_j_mce_2013_06_017 crossref_primary_10_2147_DMSO_S286888 crossref_primary_10_3390_nu10030350 crossref_primary_10_1016_j_biopha_2024_116962 crossref_primary_10_1016_j_pharmthera_2016_06_019 crossref_primary_10_1007_s00125_023_06073_5 crossref_primary_10_1042_BST20210798 crossref_primary_10_1111_imr_13157 crossref_primary_10_14814_phy2_13723 crossref_primary_10_1016_j_jhepr_2025_101539 crossref_primary_10_14814_phy2_13600 crossref_primary_10_1016_j_nucmedbio_2025_109046 crossref_primary_10_1002_jimd_12231 crossref_primary_10_1210_jc_2018_02057 crossref_primary_10_1016_j_bbrc_2017_03_010 crossref_primary_10_1186_s12711_017_0346_x crossref_primary_10_1038_s42003_024_06955_3 crossref_primary_10_2174_0929867326666191125092111 crossref_primary_10_1016_j_jep_2023_116214 crossref_primary_10_1016_j_freeradbiomed_2021_10_014 crossref_primary_10_31965_infokes_Vol19_Iss2_534 crossref_primary_10_1016_j_mito_2015_10_003 crossref_primary_10_1210_endrev_bnae032 crossref_primary_10_3390_ijms22126642 crossref_primary_10_26508_lsa_202403038 crossref_primary_10_1002_hep_27618 crossref_primary_10_1007_s12035_020_01900_x crossref_primary_10_1002_1873_3468_14068 crossref_primary_10_1002_mrc_5341 crossref_primary_10_1007_s11684_013_0262_6 crossref_primary_10_1155_2021_3734252 crossref_primary_10_1016_j_bbrc_2013_03_104 crossref_primary_10_1016_j_cell_2019_05_008 crossref_primary_10_1080_17435889_2025_2510188 crossref_primary_10_1186_s40200_015_0218_2 crossref_primary_10_1038_s41598_018_34251_8 crossref_primary_10_3390_pharmaceutics13040526 crossref_primary_10_1016_S2213_8587_23_00329_7 crossref_primary_10_1111_jne_12433 crossref_primary_10_1016_j_cophys_2022_100487 crossref_primary_10_2337_db23_0353 crossref_primary_10_1007_s00125_014_3187_y crossref_primary_10_3390_nu14040774 crossref_primary_10_1080_14789450_2018_1528147 crossref_primary_10_1038_s41598_019_57276_z crossref_primary_10_1007_s11010_012_1276_0 crossref_primary_10_1088_1742_6596_983_1_012185 crossref_primary_10_1016_j_diabet_2020_08_006 crossref_primary_10_1002_nbm_4422 crossref_primary_10_1124_pr_115_011502 crossref_primary_10_1016_j_mito_2014_07_008 crossref_primary_10_3389_fphys_2014_00285 crossref_primary_10_1016_j_cell_2014_04_043 crossref_primary_10_1080_13813455_2020_1861028 crossref_primary_10_3389_fmicb_2022_1056499 crossref_primary_10_1089_ars_2012_4910 crossref_primary_10_7554_eLife_10575 crossref_primary_10_1016_j_tox_2017_07_015 crossref_primary_10_1007_s43657_022_00060_3 crossref_primary_10_3390_ijerph20021388 crossref_primary_10_1007_s12263_014_0451_1 crossref_primary_10_2147_DMSO_S399367 crossref_primary_10_3390_jcm12072740 crossref_primary_10_1002_mnfr_201500892 crossref_primary_10_1186_s13148_015_0093_1 crossref_primary_10_1111_jdi_13303 crossref_primary_10_1113_JP270386 crossref_primary_10_1096_fj_201701264R crossref_primary_10_1016_j_jnutbio_2014_10_003 crossref_primary_10_1016_j_metabol_2025_156151 crossref_primary_10_1038_s41556_018_0124_1 crossref_primary_10_1007_s11154_014_9297_5 crossref_primary_10_1089_jmf_2017_4059 crossref_primary_10_2337_dc15_2688 crossref_primary_10_2337_db16_0924 crossref_primary_10_1530_EJE_14_0006 crossref_primary_10_1016_j_metabol_2021_154803 crossref_primary_10_1007_s00125_015_3629_1 crossref_primary_10_3390_nu13124202 crossref_primary_10_1186_s40246_021_00335_2 crossref_primary_10_1016_j_cmet_2012_10_004 crossref_primary_10_1111_1753_0407_13524 crossref_primary_10_1007_s11154_013_9282_4 crossref_primary_10_1096_fj_201903233R crossref_primary_10_1136_bmjopen_2018_027004 crossref_primary_10_1042_BST20150019 crossref_primary_10_3390_nu14061158 crossref_primary_10_1155_2019_4951379 crossref_primary_10_1016_j_nut_2020_110752 crossref_primary_10_1002_jcla_70056 crossref_primary_10_1155_2018_7634362 crossref_primary_10_1159_000366079 crossref_primary_10_2337_db14_0892 crossref_primary_10_1016_j_ymgme_2015_06_004 crossref_primary_10_1096_fj_201901117RR crossref_primary_10_2337_db13_0303 crossref_primary_10_1016_j_bbrc_2020_04_062 crossref_primary_10_1016_j_intimp_2025_114572 crossref_primary_10_14814_phy2_13893 crossref_primary_10_1155_2016_8470394 crossref_primary_10_3945_an_113_004648 crossref_primary_10_1016_j_trsl_2012_10_006 crossref_primary_10_3389_fendo_2022_1032235 crossref_primary_10_3390_ijms21155374 crossref_primary_10_1111_eci_12461 crossref_primary_10_3892_ijmm_2017_3169 crossref_primary_10_1038_s41598_025_12910_x crossref_primary_10_1186_s13018_021_02210_1 crossref_primary_10_1038_nprot_2012_058 crossref_primary_10_1096_fj_202500707RR crossref_primary_10_1155_2016_1592731 crossref_primary_10_1371_journal_pone_0286756 crossref_primary_10_3389_fendo_2022_842575 crossref_primary_10_3389_fphar_2023_1138499 crossref_primary_10_1002_mds_28551 crossref_primary_10_2337_dc14_0316 crossref_primary_10_1111_cpr_13613 crossref_primary_10_1016_j_biocel_2013_06_013 crossref_primary_10_1016_j_omtn_2019_08_002 crossref_primary_10_1038_s41467_023_38410_y crossref_primary_10_1088_1612_202X_aa6b21 crossref_primary_10_1007_s11033_020_06019_9 crossref_primary_10_1097_COH_0000000000000607 crossref_primary_10_1002_dmrr_3177 crossref_primary_10_3390_app13042238 crossref_primary_10_1038_s41598_018_22806_8 crossref_primary_10_1038_ncomms10210 crossref_primary_10_1007_s10544_016_0066_y crossref_primary_10_1172_JCI162479 crossref_primary_10_1186_s12967_022_03693_0 crossref_primary_10_14814_phy2_14681 crossref_primary_10_1016_j_phrs_2024_107180 crossref_primary_10_2337_db12_1219 crossref_primary_10_1038_s12276_019_0214_6 crossref_primary_10_1038_s42255_021_00368_w crossref_primary_10_1016_j_exger_2023_112156 crossref_primary_10_3390_nu14204384 crossref_primary_10_1016_j_bbadis_2018_03_003 crossref_primary_10_3390_ijms22083903 crossref_primary_10_1016_j_biopha_2023_114872 crossref_primary_10_1016_j_febslet_2014_09_006 crossref_primary_10_1111_jdi_13629 crossref_primary_10_3390_antiox14060725 crossref_primary_10_1002_jcp_30878 crossref_primary_10_1016_j_drudis_2014_05_001 crossref_primary_10_3390_ijms24065999 crossref_primary_10_3390_ijms16035528 crossref_primary_10_1016_j_jacc_2017_05_043 crossref_primary_10_2337_db16_0754 crossref_primary_10_1016_j_metabol_2011_12_016 crossref_primary_10_1016_j_celbio_2025_100049 crossref_primary_10_1016_j_bbrc_2017_05_057 crossref_primary_10_1016_j_redox_2017_01_013 crossref_primary_10_1016_j_mce_2015_06_015 crossref_primary_10_1016_j_lfs_2015_07_001 crossref_primary_10_1111_eci_12146 crossref_primary_10_1002_cbf_3589 crossref_primary_10_1016_j_jid_2020_10_019 crossref_primary_10_3389_fphys_2019_00461 crossref_primary_10_3892_etm_2017_4152 crossref_primary_10_3389_fphar_2022_932116 crossref_primary_10_1016_j_phrs_2015_03_007 crossref_primary_10_3389_fendo_2020_522340 crossref_primary_10_1155_2018_1435934 crossref_primary_10_1111_febs_12096 crossref_primary_10_3390_ijms22010421 crossref_primary_10_1016_j_ypmed_2021_106552 crossref_primary_10_1371_journal_pone_0253926 crossref_primary_10_1007_s12015_022_10357_5 crossref_primary_10_1016_j_semcdb_2016_08_021 crossref_primary_10_1186_s12915_021_01082_5 crossref_primary_10_3109_09513590_2012_736556 crossref_primary_10_1007_s00125_012_2513_5 crossref_primary_10_1002_dmrr_3131 crossref_primary_10_3389_fendo_2024_1474232 crossref_primary_10_1016_j_freeradbiomed_2021_12_009 crossref_primary_10_3390_ijerph192114331 crossref_primary_10_1016_j_placenta_2014_06_368 crossref_primary_10_1016_j_addr_2018_11_007 crossref_primary_10_2337_db20_0096 crossref_primary_10_1016_j_freeradbiomed_2025_03_012 crossref_primary_10_1186_s40842_016_0027_7 crossref_primary_10_3389_fendo_2023_1346441 crossref_primary_10_1016_j_tibtech_2025_07_025 crossref_primary_10_1080_15376516_2020_1717704 crossref_primary_10_1038_s41387_024_00299_x crossref_primary_10_1016_j_freeradbiomed_2013_02_028 crossref_primary_10_3390_antiox10081257 crossref_primary_10_3390_biomedicines11030729 crossref_primary_10_2337_db11_1725 crossref_primary_10_2337_db12_1152 crossref_primary_10_1038_s41598_017_02029_z crossref_primary_10_1007_s11892_015_0671_9 crossref_primary_10_1016_j_bbadis_2013_03_018 crossref_primary_10_1093_eurheartj_ehu235 crossref_primary_10_1002_cbdv_202200784 crossref_primary_10_1002_mds_29333 crossref_primary_10_3389_fphys_2016_00178 crossref_primary_10_3390_cells11244020 |
| Cites_doi | 10.1172/JCI25151 10.1079/BJN2003000968 10.2337/db06-0062 10.2337/db07-0141 10.3945/ajcn.2008.26717B 10.2337/db09-1322 10.1073/pnas.82.24.8384 10.1097/00005768-200301000-00016 10.1210/endo-116-4-1529 10.2337/db08-0391 10.1007/s00125-009-1354-3 10.1073/pnas.1032913100 10.1210/jc.2009-1387 10.1111/j.1365-2796.2010.02298.x 10.1152/ajpendo.00692.2009 10.1038/ng1180 10.1002/hep.21983 10.1001/jama.282.17.1659 10.1073/pnas.0803901105 10.2337/db10-0174 10.1172/JCI40671 10.1161/01.CIR.0000026392.80723.DC 10.1186/1471-230X-8-40 10.1152/ajpheart.00782.2007 10.1007/s00125-008-1256-9 10.1016/j.cell.2006.11.013 10.1002/ana.1001 10.1073/pnas.78.11.6714 10.2337/dc10-1002 10.2337/diabetes.55.01.06.db05-1286 10.1016/j.ab.2010.04.040 10.2337/diabetes.51.10.2944 10.1152/ajpendo.00141.2004 10.1016/j.cmet.2007.10.013 10.1007/s00125-007-0594-3 10.1152/jappl.1997.83.1.166 10.2337/db05-0853 10.3945/ajcn.2008.26717C 10.2337/dc10-1076 10.1016/j.jacc.2009.04.074 10.1038/nm.2297 10.1371/journal.pmed.0020233 10.1210/jc.2007-0482 10.1016/S0168-8278(99)80033-6 10.1152/ajpendo.00797.2007 10.1002/nbm.1109 10.1016/j.biocel.2009.03.013 10.1002/nbm.1207 10.2337/db08-1240 10.1016/j.cmet.2009.02.002 10.1111/j.1365-2362.2006.01615.x 10.2337/diabetes.55.01.06.db05-0943 10.2337/diabetes.51.6.1913 10.1152/ajpendo.00639.2006 10.2337/db09-0591 10.1053/gast.2001.23256 10.1081/JCMR-120016387 10.1002/nbm.1095 10.2337/db09-1519 10.1056/NEJMoa060326 10.2337/db09-0214 10.1111/j.1572-0241.2003.07725.x 10.1148/radiol.10091351 10.1097/MCO.0b013e32833cc93d 10.1152/ajpcell.1997.272.2.C501 10.1074/jbc.M313478200 10.1073/pnas.74.12.5551 10.1056/NEJMoa031314 10.1089/ars.2009.2531 10.1007/s10545-009-1263-0 10.1038/nrm2275 10.1371/journal.pone.0003958 10.1023/B:REMD.0000021434.98627.dc 10.2105/AJPH.24.10.1045 10.2337/db07-1429 10.2337/dc06-2429 10.2337/db07-1556 10.1042/CS20080433 10.2337/diabetes.54.3.603 10.1002/hep.23093 10.1056/NEJM199907223410404 10.1073/pnas.1332551100 10.1016/j.jacc.2008.07.062 10.2337/db06-0981 10.1152/ajpcell.00146.2003 10.1042/BJ20080868 10.1096/fj.04-2263com 10.1073/pnas.120131997 10.1042/bj3470045 10.1074/jbc.M109.032888 10.1172/JCI5001 10.1016/j.bbadis.2005.04.001 10.1111/j.1469-7793.2000.t01-1-00203.x 10.1007/s00421-003-0926-z 10.1096/fasebj.13.14.2051 10.1007/s00125-004-1362-2 10.1301/nr.2007.jun.S39-S46 10.2337/db07-0093 10.1002/nbm.1519 10.1152/jappl.1992.73.4.1644 10.1007/s00125-006-0475-1 10.1161/01.CIR.0000072789.89096.10 10.1038/nature05483 10.1073/pnas.0802057105 10.1016/j.cell.2007.08.047 10.1038/jcbfm.2010.48 10.1016/j.metabol.2009.03.014 10.2337/diabetes.54.5.1392 10.1371/journal.pmed.0040154 10.2337/db10-0698 10.2337/dc08-2078 10.1210/jc.2010-0989 10.1007/s00125-010-1764-2 10.1074/jbc.M404421200 10.1002/nbm.1192 10.1097/00075197-200107000-00003 10.1016/j.arr.2009.11.004 10.1056/NEJMoa0907929 10.1016/S0960-8966(00)00108-5 10.1210/er.2009-0003 10.2337/diabetes.54.1.8 10.1016/j.jacc.2009.07.031 10.1016/S0735-1097(03)00625-9 10.1074/jbc.M408985200 10.1007/s00125-008-1153-2 10.1111/j.1530-0277.2006.00287.x 10.1172/JCI118742 10.1038/oby.2009.510 10.3945/jn.108.103754 10.1038/nm0410-400 10.2337/db06-0521 10.2337/diab.37.8.1020 10.1016/j.cmet.2007.01.002 10.1002/nbm.1940060504 10.1152/ajpendo.00317.2009 10.1016/j.cmet.2005.05.004 10.1038/nrendo.2010.64 10.1093/cvr/cvm029 10.1523/JNEUROSCI.0212-07.2007 10.1126/science.1082889 10.1210/jc.2010-0822 10.1016/0076-6879(88)57064-7 10.1161/CIRCULATIONAHA.106.645614 10.2337/diabetes.53.12.3048 10.1126/science.1104343 10.1053/meta.2002.50108 10.1016/j.ab.2009.09.029 10.1042/BST0330897 10.1152/ajpendo.00756.2009 10.1210/jc.2006-2210 10.1007/s00125-003-1265-7 10.1016/S0021-9258(18)70051-3 10.1016/S0021-9258(18)96046-1 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2011 COPYRIGHT 2012 Nature Publishing Group Copyright Nature Publishing Group Feb 2012 |
| Copyright_xml | – notice: Springer Nature Limited 2011 – notice: COPYRIGHT 2012 Nature Publishing Group – notice: Copyright Nature Publishing Group Feb 2012 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 |
| DOI | 10.1038/nrendo.2011.138 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection ProQuest Health & Medical Collection Medical Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest Central Student MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1759-5037 |
| EndPage | 103 |
| ExternalDocumentID | 4046877691 A278881546 21912398 10_1038_nrendo_2011_138 |
| Genre | Journal Article Review |
| GeographicLocations | Germany |
| GeographicLocations_xml | – name: Germany |
| GroupedDBID | --- .XZ 0R~ 29M 39C 3V. 53G 5S5 70F 7X7 88E 8FE 8FH 8FI 8FJ AAEEF AARCD AASDW AAWTL AAWYQ AAYZH AAZLF ABAWZ ABJNI ABLJU ABUWG ACGFS ADBBV AENEX AFFVI AFKRA AFSHS AGAYW AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ARMCB AXYYD BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU DB5 EBS EE. EJD EXGXG F5P FQGFK FSGXE FYUFA HCIFZ HMCUK HZ~ IAO IGS IHR IHW INH INR ITC LK8 M1P M7P NNMJJ O9- ODYON OVD PQQKQ PROAC PSQYO RNR RNT RNTTT S70 SHXYY SIXXV SNYQT SOJ TAOOD TBHMF TDRGL TEORI TSG UKHRP AAYXX AFANA AFFHD ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7XB 8FK AZQEC DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO |
| ID | FETCH-LOGICAL-c529t-34450290a6e863b8003dff9011e3375a7ab3f258d16d3870ddb6a5bc9af427703 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 486 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000299493600008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1759-5029 1759-5037 |
| IngestDate | Thu Oct 02 18:21:05 EDT 2025 Sat Nov 29 14:33:56 EST 2025 Tue Nov 11 10:25:44 EST 2025 Tue Nov 04 17:57:13 EST 2025 Thu May 22 21:22:10 EDT 2025 Thu Apr 03 07:09:20 EDT 2025 Sat Nov 29 02:04:36 EST 2025 Tue Nov 18 20:58:52 EST 2025 Fri Feb 21 02:37:12 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | http://www.springer.com/tdm |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c529t-34450290a6e863b8003dff9011e3375a7ab3f258d16d3870ddb6a5bc9af427703 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| PMID | 21912398 |
| PQID | 1787139328 |
| PQPubID | 2041936 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_917578696 proquest_journals_1787139328 gale_infotracmisc_A278881546 gale_infotracacademiconefile_A278881546 gale_healthsolutions_A278881546 pubmed_primary_21912398 crossref_citationtrail_10_1038_nrendo_2011_138 crossref_primary_10_1038_nrendo_2011_138 springer_journals_10_1038_nrendo_2011_138 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-02-01 |
| PublicationDateYYYYMMDD | 2012-02-01 |
| PublicationDate_xml | – month: 02 year: 2012 text: 2012-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature reviews. Endocrinology |
| PublicationTitleAbbrev | Nat Rev Endocrinol |
| PublicationTitleAlternate | Nat Rev Endocrinol |
| PublicationYear | 2012 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Lodi (CR154) 2001; 49 Schmid (CR102) 2011; 34 Hansen (CR133) 2009; 52 Sivitz, Yorek (CR5) 2010; 12 Szendroedi, Roden (CR4) 2008; 51 Brehm (CR70) 2010; 299 Yadava, Nicholls (CR36) 2007; 27 Diamant (CR109) 2003; 42 Schmid (CR156) 2008; 21 Nair, V, Arnold, Diehl (CR150) 2003; 98 Roden (CR1) 2001; 4 Bartelt (CR126) 2011; 17 Newgard (CR83) 2009; 9 Morino (CR34) 2005; 115 Iossa (CR77) 2003; 90 Mihalik (CR82) 2010; 18 Mattson (CR123) 2010; 9 Szendroedi (CR17) 2009; 32 Paganini, Foley, Meyer (CR23) 1997; 272 Patti (CR35) 2003; 100 Roden (CR65) 1996; 97 Toledo (CR50) 2008; 57 Brand (CR28) 2005; 33 Ritov (CR47) 2010; 298 Ortenblad (CR89) 2005; 1741 Soeters (CR73) 2009; 116 Lagouge (CR145) 2006; 127 Kawahara, Fukura, Tsuchishima, Takase (CR96) 2007; 31 Metzler (CR110) 2002; 4 Rijzewijk (CR108) 2009; 54 Mantena (CR93) 2008; 417 Richardson (CR72) 2005; 280 Gnaiger (CR21) 2009; 41 Hancock (CR76) 2008; 105 Chance, Im, Nioka, Kushmerick (CR19) 2006; 19 Bujanda (CR144) 2008; 8 Petersen, Dufour, Befroy, Garcia, Shulman (CR55) 2004; 350 Lefort (CR60) 2010; 59 Chance, Conrad (CR27) 1959; 234 Noland (CR81) 2009; 284 Pospisilik (CR61) 2007; 131 Rosen, Spiegelman (CR121) 2006; 444 Anderson (CR114) 2009; 54 Schiff (CR12) 2009; 32 Høeg (CR69) 2011; 60 Turner (CR74) 2007; 56 CR57 Holloszy (CR11) 2009; 89 Messer, Jackman, Willis (CR30) 2004; 286 Lidell, Enerbäck (CR124) 2010; 6 Sreekumar, Nair (CR7) 2007; 125 Chance, Eleff, Leigh, Sokolow, Sapega (CR151) 1981; 78 Kelley, He, Menshikova, Ritov (CR41) 2002; 51 Heilbronn, Gan, Turner, Campbell, Chisholm (CR49) 2007; 92 Stump, Short, Bigelow, Schimke, Nair (CR45) 2003; 100 Chavez (CR71) 2010; 95 Schwartz, Figlewicz, Baskin, Woods, Porte (CR116) 1992; 13 Mootha (CR51) 2003; 34 Belfort (CR139) 2006; 355 Karlsson, Ahlsen, Zierath, Wallberg-Henriksson, Koistinen (CR52) 2006; 55 Parra (CR115) 2008; 77 Phielix, Meex, Moonen-Kornips, Hesselink, Schrauwen (CR134) 2010; 53 Chomentowski, Coen, Radiková, Goodpaster, Toledo (CR39) 2011; 96 Chance (CR15) 1985; 82 Bogacka, Xie, Bray, Smith (CR122) 2005; 54 Simoneau, Kelley (CR2) 1997; 83 Kotronen, Westerbacka, Bergholm, Pietiläinen, Yki-Järvinen (CR91) 2007; 92 Simoneau, Veerkamp, Turcotte, Kelley (CR129) 1999; 13 Szendroedi (CR46) 2007; 4 Brehm (CR85) 2006; 55 Toledo (CR130) 2007; 56 Kemp (CR9) 2008; 294 Samuel (CR68) 2004; 279 Sevastianova (CR97) 2010; 256 Szendroedi (CR56) 2008; 3 Koch (CR117) 2008; 118 Sreekumar, Halvatsiotis, Schimke, Nair (CR147) 2002; 51 Scheuermann-Freestone (CR111) 2003; 107 Detmer, Chan (CR148) 2007; 8 Kemp, Meyerspeer, Moser (CR22) 2007; 20 Eckel, Wirdeier, Herberg, Reinauer (CR103) 1985; 116 Rijzewijk (CR107) 2008; 52 Zou (CR141) 2004; 279 Brown, Ugurbil, Shulman (CR155) 1977; 74 Pagel-Langenickel (CR31) 2007; 293 Meex (CR131) 2010; 59 Conley, Jubrias, Esselman (CR149) 2000; 526 Cline (CR88) 1999; 341 Kukidome (CR142) 2006; 55 Mogensen (CR44) 2007; 56 Karakelides, Irving, Short, O'Brien, Nair (CR59) 2009; 59 Holloway, Gurd, Snook, Lally, Bonen (CR75) 2010; 59 Bandyopadhyay, Yu, Ofrecio, Olefsky (CR79) 2006; 55 Coletta (CR138) 2009; 52 Krssák, Roden (CR64) 2004; 5 Phielix (CR29) 2008; 57 Holloszy (CR127) 1967; 242 Erion, Shulman (CR13) 2010; 16 Miele (CR98) 2003; 98 Nielsen (CR146) 2010; 298 Holloway (CR78) 2007; 292 Cortez-Pinto (CR99) 1999; 282 Hwang (CR48) 2010; 59 Perseghin (CR113) 2008; 47 Lanza, Nair (CR8) 2010; 13 Ouellet (CR125) 2011; 96 Sanyal (CR140) 2010; 362 Lim, Hollingsworth, Thelwall, Taylor (CR86) 2010; 23 Sanyal (CR94) 2001; 120 Bischof (CR119) 2004; 47 Jucker (CR38) 2000; 97 Petersen, Dufour, Shulman (CR58) 2005; 2 Kacerovsky-Bielesz (CR16) 2009; 58 Prompers (CR20) 2006; 19 Holloway, Bonen, Spriet (CR80) 2009; 89 Lin, Handschin, Spiegelman (CR53) 2005; 1 Schmoller (CR118) 2010; 30 Caldwell (CR95) 1999; 31 Bruce, Kriketos, Cooney, Hawley (CR132) 2004; 47 Kraegen, Cooney, Turner (CR10) 2008; 105 Endo, Iino (CR26) 1988; 157 Perseghin (CR112) 2007; 30 Kacerovsky (CR87) 2011; 269 Holland (CR92) 2007; 5 Boushel (CR42) 2007; 50 Ukropcova (CR3) 2007; 56 Koves (CR37) 2008; 7 Holland (CR67) 2007; 65 Hoppeler, Fluck (CR32) 2003; 35 Petersen (CR135) 2005; 54 Vorgerd (CR153) 2000; 10 Krssák (CR90) 2004; 53 Kemp (CR18) 1993; 6 Foretz (CR33) 2010; 120 Rabøl (CR128) 2009; 58 Diepart (CR157) 2010; 396 Bischof (CR120) 2006; 36 Beeson, Beeson, Schnellmann (CR158) 2010; 404 Razeghi, Young, Cockrill, Frazier, Taegtmeyer (CR104) 2002; 106 Nair (CR62) 2008; 57 Adams (CR84) 2009; 139 Lowell, Shulman (CR6) 2005; 307 Cha (CR137) 2005; 289 Ritov (CR43) 2005; 54 Pagel-Langenickel, Bao, Pang, Sack (CR14) 2010; 31 Petersen (CR54) 2003; 300 Prikoszovich (CR100) 2011; 34 Binzoni, Ferretti, Schenker, Cerretelli (CR152) 1992; 73 Szendroedi (CR101) 2009; 50 Rossignol, Letellier, Malgat, Rocher, Mazat (CR25) 2000; 347 Dresner (CR66) 1999; 103 Sharma (CR105) 2004; 18 Tainter, Cutting, Stockton (CR136) 1934; 24 di Prampero (CR24) 2003; 90 Mathieu-Costello (CR143) 2003; 52 McGavock (CR106) 2007; 116 Schrauwen-Hinderling (CR40) 2007; 50 Reaven, Hollenbeck, Jeng, Wu, Chen (CR63) 1988; 37 G Perseghin (BFnrendo2011138_CR113) 2008; 47 M Roden (BFnrendo2011138_CR65) 1996; 97 A Brehm (BFnrendo2011138_CR85) 2006; 55 H Hoppeler (BFnrendo2011138_CR32) 2003; 35 J Eckel (BFnrendo2011138_CR103) 1985; 116 WI Sivitz (BFnrendo2011138_CR5) 2010; 12 M Krssák (BFnrendo2011138_CR90) 2004; 53 KE Conley (BFnrendo2011138_CR149) 2000; 526 GP Holloway (BFnrendo2011138_CR80) 2009; 89 H Hwang (BFnrendo2011138_CR48) 2010; 59 P Razeghi (BFnrendo2011138_CR104) 2002; 106 GJ Kemp (BFnrendo2011138_CR18) 1993; 6 BM Jucker (BFnrendo2011138_CR38) 2000; 97 PE di Prampero (BFnrendo2011138_CR24) 2003; 90 AJ Sanyal (BFnrendo2011138_CR94) 2001; 120 AI Schmid (BFnrendo2011138_CR102) 2011; 34 DK Coletta (BFnrendo2011138_CR138) 2009; 52 VT Samuel (BFnrendo2011138_CR68) 2004; 279 BS Cha (BFnrendo2011138_CR137) 2005; 289 H Kawahara (BFnrendo2011138_CR96) 2007; 31 JA Simoneau (BFnrendo2011138_CR2) 1997; 83 SH Adams (BFnrendo2011138_CR84) 2009; 139 AI Schmid (BFnrendo2011138_CR156) 2008; 21 DK Richardson (BFnrendo2011138_CR72) 2005; 280 GP Holloway (BFnrendo2011138_CR75) 2010; 59 H Karakelides (BFnrendo2011138_CR59) 2009; 59 M Scheuermann-Freestone (BFnrendo2011138_CR111) 2003; 107 MH Zou (BFnrendo2011138_CR141) 2004; 279 EW Kraegen (BFnrendo2011138_CR10) 2008; 105 CR Hancock (BFnrendo2011138_CR76) 2008; 105 O Mathieu-Costello (BFnrendo2011138_CR143) 2003; 52 R Lodi (BFnrendo2011138_CR154) 2001; 49 I Pagel-Langenickel (BFnrendo2011138_CR14) 2010; 31 LJ Rijzewijk (BFnrendo2011138_CR107) 2008; 52 S Iossa (BFnrendo2011138_CR77) 2003; 90 M Schiff (BFnrendo2011138_CR12) 2009; 32 B Chance (BFnrendo2011138_CR19) 2006; 19 R Boushel (BFnrendo2011138_CR42) 2007; 50 SA Detmer (BFnrendo2011138_CR148) 2007; 8 JJ Prompers (BFnrendo2011138_CR20) 2006; 19 ME Patti (BFnrendo2011138_CR35) 2003; 100 JO Holloszy (BFnrendo2011138_CR127) 1967; 242 I Bogacka (BFnrendo2011138_CR122) 2005; 54 B Chance (BFnrendo2011138_CR151) 1981; 78 TR Koves (BFnrendo2011138_CR37) 2008; 7 JM McGavock (BFnrendo2011138_CR106) 2007; 116 WL Holland (BFnrendo2011138_CR92) 2007; 5 GJ Kemp (BFnrendo2011138_CR22) 2007; 20 RC Meex (BFnrendo2011138_CR131) 2010; 59 KF Petersen (BFnrendo2011138_CR58) 2005; 2 MP Mattson (BFnrendo2011138_CR123) 2010; 9 M Vorgerd (BFnrendo2011138_CR153) 2000; 10 ML Tainter (BFnrendo2011138_CR136) 1934; 24 LD Høeg (BFnrendo2011138_CR69) 2011; 60 JO Holloszy (BFnrendo2011138_CR11) 2009; 89 R Rossignol (BFnrendo2011138_CR25) 2000; 347 BB Lowell (BFnrendo2011138_CR6) 2005; 307 AT Paganini (BFnrendo2011138_CR23) 1997; 272 SH Caldwell (BFnrendo2011138_CR95) 1999; 31 L Bujanda (BFnrendo2011138_CR144) 2008; 8 R Rabøl (BFnrendo2011138_CR128) 2009; 58 C Diepart (BFnrendo2011138_CR157) 2010; 396 AJ Sanyal (BFnrendo2011138_CR140) 2010; 362 S Nair (BFnrendo2011138_CR150) 2003; 98 S Sharma (BFnrendo2011138_CR105) 2004; 18 M Mogensen (BFnrendo2011138_CR44) 2007; 56 B Metzler (BFnrendo2011138_CR110) 2002; 4 E Phielix (BFnrendo2011138_CR29) 2008; 57 J Lin (BFnrendo2011138_CR53) 2005; 1 M Kacerovsky (BFnrendo2011138_CR87) 2011; 269 J Szendroedi (BFnrendo2011138_CR17) 2009; 32 JI Messer (BFnrendo2011138_CR30) 2004; 286 J Szendroedi (BFnrendo2011138_CR56) 2008; 3 N Yadava (BFnrendo2011138_CR36) 2007; 27 WL Holland (BFnrendo2011138_CR67) 2007; 65 R Belfort (BFnrendo2011138_CR139) 2006; 355 L Miele (BFnrendo2011138_CR98) 2003; 98 MR Soeters (BFnrendo2011138_CR73) 2009; 116 J Szendroedi (BFnrendo2011138_CR46) 2007; 4 H Cortez-Pinto (BFnrendo2011138_CR99) 1999; 282 K Sevastianova (BFnrendo2011138_CR97) 2010; 256 E Gnaiger (BFnrendo2011138_CR21) 2009; 41 M Endo (BFnrendo2011138_CR26) 1988; 157 J Szendroedi (BFnrendo2011138_CR4) 2008; 51 V Ouellet (BFnrendo2011138_CR125) 2011; 96 P Chomentowski (BFnrendo2011138_CR39) 2011; 96 B Chance (BFnrendo2011138_CR27) 1959; 234 MD Brand (BFnrendo2011138_CR28) 2005; 33 KS Nair (BFnrendo2011138_CR62) 2008; 57 J Nielsen (BFnrendo2011138_CR146) 2010; 298 CC Beeson (BFnrendo2011138_CR158) 2010; 404 G Perseghin (BFnrendo2011138_CR112) 2007; 30 T Prikoszovich (BFnrendo2011138_CR100) 2011; 34 SJ Mihalik (BFnrendo2011138_CR82) 2010; 18 GK Bandyopadhyay (BFnrendo2011138_CR79) 2006; 55 E Phielix (BFnrendo2011138_CR134) 2010; 53 DE Kelley (BFnrendo2011138_CR41) 2002; 51 HK Karlsson (BFnrendo2011138_CR52) 2006; 55 D Hansen (BFnrendo2011138_CR133) 2009; 52 M Diamant (BFnrendo2011138_CR109) 2003; 42 A Bartelt (BFnrendo2011138_CR126) 2011; 17 CS Stump (BFnrendo2011138_CR45) 2003; 100 N Lefort (BFnrendo2011138_CR60) 2010; 59 B Chance (BFnrendo2011138_CR15) 1985; 82 MG Bischof (BFnrendo2011138_CR120) 2006; 36 J Szendroedi (BFnrendo2011138_CR101) 2009; 50 EJ Anderson (BFnrendo2011138_CR114) 2009; 54 ED Rosen (BFnrendo2011138_CR121) 2006; 444 GP Holloway (BFnrendo2011138_CR78) 2007; 292 M Krssák (BFnrendo2011138_CR64) 2004; 5 A Dresner (BFnrendo2011138_CR66) 1999; 103 D Kukidome (BFnrendo2011138_CR142) 2006; 55 KF Petersen (BFnrendo2011138_CR54) 2003; 300 K Morino (BFnrendo2011138_CR34) 2005; 115 KF Petersen (BFnrendo2011138_CR135) 2005; 54 TR Brown (BFnrendo2011138_CR155) 1977; 74 JA Pospisilik (BFnrendo2011138_CR61) 2007; 131 JA Simoneau (BFnrendo2011138_CR129) 1999; 13 AO Chavez (BFnrendo2011138_CR71) 2010; 95 GJ Kemp (BFnrendo2011138_CR9) 2008; 294 KF Petersen (BFnrendo2011138_CR55) 2004; 350 N Ortenblad (BFnrendo2011138_CR89) 2005; 1741 A Schmoller (BFnrendo2011138_CR118) 2010; 30 A Brehm (BFnrendo2011138_CR70) 2010; 299 L Koch (BFnrendo2011138_CR117) 2008; 118 CR Bruce (BFnrendo2011138_CR132) 2004; 47 SK Mantena (BFnrendo2011138_CR93) 2008; 417 MW Schwartz (BFnrendo2011138_CR116) 1992; 13 M Roden (BFnrendo2011138_CR1) 2001; 4 N Turner (BFnrendo2011138_CR74) 2007; 56 A Kotronen (BFnrendo2011138_CR91) 2007; 92 M Lagouge (BFnrendo2011138_CR145) 2006; 127 VB Ritov (BFnrendo2011138_CR43) 2005; 54 M Foretz (BFnrendo2011138_CR33) 2010; 120 VB Schrauwen-Hinderling (BFnrendo2011138_CR40) 2007; 50 FG Toledo (BFnrendo2011138_CR130) 2007; 56 DM Erion (BFnrendo2011138_CR13) 2010; 16 G Kacerovsky-Bielesz (BFnrendo2011138_CR16) 2009; 58 V Parra (BFnrendo2011138_CR115) 2008; 77 VB Ritov (BFnrendo2011138_CR47) 2010; 298 VK Mootha (BFnrendo2011138_CR51) 2003; 34 R Sreekumar (BFnrendo2011138_CR7) 2007; 125 GW Cline (BFnrendo2011138_CR88) 1999; 341 FG Toledo (BFnrendo2011138_CR50) 2008; 57 B Ukropcova (BFnrendo2011138_CR3) 2007; 56 MG Bischof (BFnrendo2011138_CR119) 2004; 47 LK Heilbronn (BFnrendo2011138_CR49) 2007; 92 BFnrendo2011138_CR57 ME Lidell (BFnrendo2011138_CR124) 2010; 6 I Pagel-Langenickel (BFnrendo2011138_CR31) 2007; 293 RC Noland (BFnrendo2011138_CR81) 2009; 284 EL Lim (BFnrendo2011138_CR86) 2010; 23 GM Reaven (BFnrendo2011138_CR63) 1988; 37 CB Newgard (BFnrendo2011138_CR83) 2009; 9 R Sreekumar (BFnrendo2011138_CR147) 2002; 51 T Binzoni (BFnrendo2011138_CR152) 1992; 73 LJ Rijzewijk (BFnrendo2011138_CR108) 2009; 54 IR Lanza (BFnrendo2011138_CR8) 2010; 13 20442322 - Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E33-8 15166226 - J Biol Chem. 2004 Jul 30;279(31):32345-53 20682693 - Diabetes. 2010 Oct;59(10):2444-52 20623795 - NMR Biomed. 2010 Oct;23(8):952-7 19887598 - Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E49-58 14960743 - N Engl J Med. 2004 Feb 12;350(7):664-71 17334651 - Diabetologia. 2007 Apr;50(4):790-6 19056574 - Am J Clin Nutr. 2009 Jan;89(1):463S-6S 14667188 - Br J Nutr. 2003 Nov;90(5):953-60 10899450 - Neuromuscul Disord. 2000 Aug;10(6):430-5 20422397 - Diabetologia. 2010 Aug;53(8):1714-21 17384336 - Diabetes Care. 2007 Jun;30(6):1520-6 8268062 - NMR Biomed. 1993 Sep-Oct;6(5):302-10 4290225 - J Biol Chem. 1967 May 10;242(9):2278-82 17093944 - Diabetologia. 2007 Jan;50(1):113-20 17327442 - Diabetes. 2007 Mar;56(3):720-7 16054085 - Cell Metab. 2005 Jun;1(6):361-70 12549236 - J Cardiovasc Magn Reson. 2002;4(4):493-502 17536063 - Diabetes. 2007 Aug;56(8):2142-7 19370339 - Diabetologia. 2009 Sep;52(9):1789-97 17112576 - Cell. 2006 Dec 15;127(6):1109-22 14572600 - Am J Gastroenterol. 2003 Oct;98 (10 ):2335-6 19467914 - Int J Biochem Cell Biol. 2009 Oct;41(10):1837-45 19369366 - J Nutr. 2009 Jun;139(6):1073-81 12031981 - Diabetes. 2002 Jun;51(6):1913-20 15616005 - Diabetes. 2005 Jan;54(1):8-14 19821144 - J Inherit Metab Dis. 2009 Dec;32(6):684-98 18451994 - J Clin Invest. 2008 Jun;118(6):2132-47 17698735 - Circulation. 2007 Sep 4;116(10):1170-5 10488700 - J Hepatol. 1999 Sep;31(3):430-4 18252894 - Diabetes. 2008 Apr;57(4):987-94 20616711 - Curr Opin Clin Nutr Metab Care. 2010 Sep;13(5):511-7 20978097 - Diabetes Care. 2011 Feb;34(2):430-6 10544188 - FASEB J. 1999 Nov;13(14 ):2051-60 20376053 - Nat Med. 2010 Apr;16(4):400-2 13654418 - J Biol Chem. 1959 Jun;234(6):1568-70 12832613 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71 21258337 - Nat Med. 2011 Feb;17(2):200-5 11458018 - Curr Opin Clin Nutr Metab Care. 2001 Jul;4(4):261-6 20028967 - Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E706-13 16089501 - PLoS Med. 2005 Sep;2(9):e233 18509063 - Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7815-20 15298341 - Diabetologia. 2004 Apr;47(4):648-51 16284649 - J Clin Invest. 2005 Dec;115(12):3587-93 19169664 - Diabetologia. 2009 Apr;52(4):723-32 15522914 - FASEB J. 2004 Nov;18(14):1692-700 16380486 - Diabetes. 2006 Jan;55(1):136-40 20386559 - Nat Rev Endocrinol. 2010 Jun;6(6):319-25 19356713 - Cell Metab. 2009 Apr;9(4):311-26 19022158 - J Am Coll Cardiol. 2008 Nov 25;52(22):1793-9 19131470 - Diabetes Care. 2009 Apr;32(4):677-9 9916137 - J Clin Invest. 1999 Jan;103(2):253-9 1447115 - J Appl Physiol (1985). 1992 Oct;73(4):1644-9 17981116 - Cell. 2007 Nov 2;131(3):476-91 12135937 - Circulation. 2002 Jul 23;106(4):407-11 1425482 - Endocr Rev. 1992 Aug;13(3):387-414 18177724 - Cell Metab. 2008 Jan;7(1):45-56 16873691 - Diabetes. 2006 Aug;55(8):2277-85 12808457 - Nat Genet. 2003 Jul;34(3):267-73 3231088 - Methods Enzymol. 1988;157:12-26 17595248 - J Clin Endocrinol Metab. 2007 Sep;92 (9):3490-7 17075956 - NMR Biomed. 2006 Nov;19(7):927-53 17351150 - Diabetes. 2007 Jun;56(6):1592-9 17311893 - Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1782-9 146199 - Proc Natl Acad Sci U S A. 1977 Dec;74(12):5551-3 14602577 - Am J Physiol Cell Physiol. 2004 Mar;286(3):C565-72 17611283 - J Neurosci. 2007 Jul 4;27(27):7310-7 12759881 - Metabolism. 2003 May;52(5):540-6 17928812 - Nat Rev Mol Cell Biol. 2007 Nov;8(11):870-9 20111019 - Obesity (Silver Spring). 2010 Sep;18(9):1695-700 20956497 - Diabetes. 2011 Jan;60(1):64-73 19969105 - Ageing Res Rev. 2010 Jan;9(1):69-76 17331167 - Alcohol Clin Exp Res. 2007 Jan;31(1 Suppl):S54-60 20389303 - J Cereb Blood Flow Metab. 2010 Jul;30(7):1403-10 21106709 - J Clin Endocrinol Metab. 2011 Feb;96(2):494-503 15662004 - Science. 2005 Jan 21;307(5708):384-7 18014064 - Am J Public Health Nations Health. 1934 Oct;24(10):1045-53 19833885 - Diabetes. 2010 Jan;59(1):89-97 9124293 - Am J Physiol. 1997 Feb;272(2 Pt 1):C501-10 19056573 - Am J Clin Nutr. 2009 Jan;89(1):455S-62S 16380484 - Diabetes. 2006 Jan;55(1):120-7 19833877 - Diabetes. 2010 Jan;59(1):33-42 19553674 - J Biol Chem. 2009 Aug 21;284(34):22840-52 17135584 - N Engl J Med. 2006 Nov 30;355(22):2297-307 19864449 - J Clin Endocrinol Metab. 2010 Jan;95(1):422-9 18945215 - Clin Sci (Lond). 2009 Apr;116(7):585-92 12544642 - Med Sci Sports Exerc. 2003 Jan;35(1):95-104 20656836 - Radiology. 2010 Aug;256(2):466-73 20465991 - Anal Biochem. 2010 Sep 1;404(1):75-81 16506960 - Eur J Clin Invest. 2006 Mar;36(3):164-9 18782455 - BMC Gastroenterol. 2008 Sep 09;8:40 19892241 - J Am Coll Cardiol. 2009 Nov 10;54(20):1891-8 17955548 - Hepatology. 2008 Jan;47(1):51-8 12750520 - Science. 2003 May 16;300(5622):1140-2 11357949 - Ann Neurol. 2001 May;49(5):590-6 15598661 - J Biol Chem. 2005 Mar 18;280(11):10290-7 18006463 - Cardiovasc Res. 2008 Jan 15;77(2):387-97 12810608 - Circulation. 2003 Jun 24;107(24):3040-6 19861693 - Endocr Rev. 2010 Feb;31(1):25-51 12808136 - Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7996-8001 17910026 - NMR Biomed. 2008 Jun;21(5):437-43 15265871 - J Biol Chem. 2004 Oct 15;279(42):43940-51 10727400 - Biochem J. 2000 Apr 1;347 Pt 1:45-53 19637187 - Hepatology. 2009 Oct;50(4):1079-86 17167472 - Nature. 2006 Dec 14;444(7121):847-53 17890427 - Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2659-66 15727952 - Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E151-9 15734833 - Diabetes. 2005 Mar;54(3):603-8 17075955 - NMR Biomed. 2006 Nov;19(7):904-26 9216960 - J Appl Physiol (1985). 1997 Jul;83(1):166-71 10823916 - Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6880-4 21216854 - Diabetes Care. 2011 Feb;34(2):448-53 17496364 - Indian J Med Res. 2007 Mar;125(3):399-410 20943785 - J Clin Endocrinol Metab. 2011 Jan;96(1):192-9 20427778 - N Engl J Med. 2010 May 6;362(18):1675-85 10413736 - N Engl J Med. 1999 Jul 22;341(4):240-6 19815124 - J Am Coll Cardiol. 2009 Oct 13;54(16):1524-32 19265027 - Diabetes. 2009 Jun;58(6):1333-41 6947247 - Proc Natl Acad Sci U S A. 1981 Nov;78(11):6714-8 17519422 - Diabetes. 2007 Aug;56(8):2085-92 15561933 - Diabetes. 2004 Dec;53(12):3048-56 19454354 - Metabolism. 2009 Aug;58(8):1145-52 20577053 - J Clin Invest. 2010 Jul;120(7):2355-69 21205021 - J Intern Med. 2011 Feb;269(2):189-99 18752470 - Biochem J. 2009 Jan 1;417(1):183-93 17339025 - Cell Metab. 2007 Mar;5(3):167-79 17605313 - Nutr Rev. 2007 Jun;65(6 Pt 2):S39-46 20028948 - Diabetes. 2010 Mar;59(3):572-9 18678616 - Diabetes. 2008 Nov;57(11):2943-9 12875772 - J Am Coll Cardiol. 2003 Jul 16;42(2):328-35 21842500 - Magn Reson Med. 2012 Apr;67(4):898-905 8675698 - J Clin Invest. 1996 Jun 15;97(12):2859-65 11266382 - Gastroenterology. 2001 Apr;120(5):1183-92 15855325 - Diabetes. 2005 May;54(5):1392-9 18509057 - Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7627-8 14673522 - Diabetologia. 2004 Jan;47(1):23-30 17244782 - J Clin Endocrinol Metab. 2007 Apr;92(4):1467-73 19766582 - Anal Biochem. 2010 Jan 15;396(2):250-6 19650713 - Antioxid Redox Signal. 2010 Apr;12(4):537-77 10878112 - J Physiol. 2000 Jul 1;526 Pt 1:203-10 3882413 - Endocrinology. 1985 Apr;116(4):1529-34 3866229 - Proc Natl Acad Sci U S A. 1985 Dec;82(24):8384-8 18802678 - Diabetologia. 2008 Dec;51(12):2155-67 16246006 - Biochem Soc Trans. 2005 Nov;33(Pt 5):897-904 10553793 - JAMA. 1999 Nov 3;282(17):1659-64 16644684 - Diabetes. 2006 May;55(5):1283-8 3292322 - Diabetes. 1988 Aug;37(8):1020-4 19093000 - PLoS One. 2008;3(12):e3958 12910345 - Eur J Appl Physiol. 2003 Oct;90(3-4):420-9 20103701 - Diabetes. 2010 Apr;59(4):819-28 17628042 - NMR Biomed. 2007 Oct;20(6):555-65 12591070 - Am J Gastroenterol. 2003 Feb;98(2):466-70 15041788 - Rev Endocr Metab Disord. 2004 May;5(2):127-34 18285554 - Diabetes. 2008 May;57(5):1166-75 17472434 - PLoS Med. 2007 May;4(5):e154 15894466 - Biochim Biophys Acta. 2005 Jun 30;1741(1-2):206-14 18325881 - Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E640-2; author reply E643-4 12351431 - Diabetes. 2002 Oct;51(10):2944-50 |
| References_xml | – volume: 115 start-page: 3587 year: 2005 end-page: 3593 ident: CR34 article-title: Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents publication-title: J. Clin. Invest. doi: 10.1172/JCI25151 – volume: 90 start-page: 953 year: 2003 end-page: 960 ident: CR77 article-title: Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats publication-title: Br. J. Nutr. doi: 10.1079/BJN2003000968 – volume: 55 start-page: 2277 year: 2006 end-page: 2285 ident: CR79 article-title: Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects publication-title: Diabetes doi: 10.2337/db06-0062 – volume: 56 start-page: 2142 year: 2007 end-page: 2147 ident: CR130 article-title: Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes publication-title: Diabetes doi: 10.2337/db07-0141 – volume: 89 start-page: 455S year: 2009 end-page: 462S ident: CR80 article-title: Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.2008.26717B – volume: 59 start-page: 572 year: 2010 end-page: 579 ident: CR131 article-title: Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity publication-title: Diabetes doi: 10.2337/db09-1322 – volume: 82 start-page: 8384 year: 1985 end-page: 8388 ident: CR15 article-title: Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.82.24.8384 – volume: 35 start-page: 95 year: 2003 end-page: 104 ident: CR32 article-title: Plasticity of skeletal muscle mitochondria: structure and function publication-title: Med. Sci. Sports Exerc. doi: 10.1097/00005768-200301000-00016 – volume: 116 start-page: 1529 year: 1985 end-page: 1534 ident: CR103 article-title: Insulin resistance in the heart: studies on isolated cardiocytes of genetically obese Zucker rats publication-title: Endocrinology doi: 10.1210/endo-116-4-1529 – volume: 57 start-page: 2943 year: 2008 end-page: 2949 ident: CR29 article-title: Lower intrinsic ADP-stimulated mitochondrial respiration underlies mitochondrial dysfunction in muscle of male type 2 diabetic patients publication-title: Diabetes doi: 10.2337/db08-0391 – volume: 52 start-page: 1789 year: 2009 end-page: 1797 ident: CR133 article-title: Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA in obese type 2 diabetes patients publication-title: Diabetologia doi: 10.1007/s00125-009-1354-3 – volume: 100 start-page: 8466 year: 2003 end-page: 8471 ident: CR35 article-title: Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1032913100 – volume: 95 start-page: 422 year: 2010 end-page: 429 ident: CR71 article-title: Effect of short-term free fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2009-1387 – volume: 269 start-page: 189 year: 2011 end-page: 199 ident: CR87 article-title: Impaired insulin stimulation of muscular ATP production in patients with type 1 diabetes publication-title: J. Intern. Med. doi: 10.1111/j.1365-2796.2010.02298.x – volume: 298 start-page: E706 year: 2010 end-page: E713 ident: CR146 article-title: Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00692.2009 – volume: 34 start-page: 267 year: 2003 end-page: 273 ident: CR51 article-title: PGC 1α responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes publication-title: Nat. Genet. doi: 10.1038/ng1180 – volume: 47 start-page: 51 year: 2008 end-page: 58 ident: CR113 article-title: Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver publication-title: Hepatology doi: 10.1002/hep.21983 – volume: 13 start-page: 387 year: 1992 end-page: 414 ident: CR116 article-title: Insulin in the brain: a hormonal regulator of energy balance publication-title: Endocr. Rev. – volume: 282 start-page: 1659 year: 1999 end-page: 1664 ident: CR99 article-title: Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study publication-title: JAMA doi: 10.1001/jama.282.17.1659 – volume: 105 start-page: 7627 year: 2008 end-page: 7628 ident: CR10 article-title: Muscle insulin resistance: a case of fat overconsumption, not mitochondrial dysfunction publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0803901105 – volume: 59 start-page: 2444 year: 2010 end-page: 2452 ident: CR60 article-title: Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle publication-title: Diabetes doi: 10.2337/db10-0174 – volume: 120 start-page: 2355 year: 2010 end-page: 2369 ident: CR33 article-title: Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state publication-title: J. Clin. Invest. doi: 10.1172/JCI40671 – volume: 106 start-page: 407 year: 2002 end-page: 411 ident: CR104 article-title: Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure publication-title: Circulation doi: 10.1161/01.CIR.0000026392.80723.DC – volume: 8 start-page: 40 year: 2008 ident: CR144 article-title: Resveratrol inhibits nonalcoholic fatty liver disease in rats publication-title: BMC Gastroenterol. doi: 10.1186/1471-230X-8-40 – volume: 293 start-page: H2659 year: 2007 end-page: H2666 ident: CR31 article-title: A discordance in rosiglitazone mediated insulin sensitization and skeletal muscle mitochondrial content/activity in type 2 diabetes mellitus publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00782.2007 – volume: 52 start-page: 723 year: 2009 end-page: 732 ident: CR138 article-title: Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle : a randomised trial publication-title: Diabetologia doi: 10.1007/s00125-008-1256-9 – volume: 127 start-page: 1109 year: 2006 end-page: 1122 ident: CR145 article-title: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α publication-title: Cell doi: 10.1016/j.cell.2006.11.013 – volume: 49 start-page: 590 year: 2001 end-page: 596 ident: CR154 article-title: Antioxidant treatment improves in vivo cardiac and skeletal muscle bioenergetics in patients with Friedreich's ataxia publication-title: Ann. Neurol. doi: 10.1002/ana.1001 – volume: 78 start-page: 6714 year: 1981 end-page: 6718 ident: CR151 article-title: Mitochondrial regulation of phosphocreatine/inorganic phosphate ratios in exercising human muscle: a gated P NMR study publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.78.11.6714 – volume: 34 start-page: 430 year: 2011 end-page: 436 ident: CR100 article-title: Body and liver fat mass rather than muscle mitochondrial function determine glucose metabolism in women with a history of gestational diabetes mellitus publication-title: Diabetes Care doi: 10.2337/dc10-1002 – volume: 55 start-page: 136 year: 2006 end-page: 140 ident: CR85 article-title: Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle publication-title: Diabetes doi: 10.2337/diabetes.55.01.06.db05-1286 – volume: 404 start-page: 75 year: 2010 end-page: 81 ident: CR158 article-title: A high-throughput respirometric assay for mitochondrial biogenesis and toxicity publication-title: Anal. Biochem. doi: 10.1016/j.ab.2010.04.040 – volume: 51 start-page: 2944 year: 2002 end-page: 2950 ident: CR41 article-title: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes publication-title: Diabetes doi: 10.2337/diabetes.51.10.2944 – ident: CR57 – volume: 289 start-page: E151 year: 2005 end-page: E159 ident: CR137 article-title: Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARγ agonists publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00141.2004 – volume: 7 start-page: 45 year: 2008 end-page: 56 ident: CR37 article-title: Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.10.013 – volume: 118 start-page: 2132 year: 2008 end-page: 2147 ident: CR117 article-title: Central insulin action regulates peripheral glucose and fat metabolism in mice publication-title: J. Clin. Invest. – volume: 50 start-page: 790 year: 2007 end-page: 796 ident: CR42 article-title: Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle publication-title: Diabetologia doi: 10.1007/s00125-007-0594-3 – volume: 83 start-page: 166 year: 1997 end-page: 171 ident: CR2 article-title: Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1997.83.1.166 – volume: 55 start-page: 1283 year: 2006 end-page: 1288 ident: CR52 article-title: Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients publication-title: Diabetes doi: 10.2337/db05-0853 – volume: 89 start-page: 463S year: 2009 end-page: 466S ident: CR11 article-title: Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.2008.26717C – volume: 34 start-page: 448 year: 2011 end-page: 453 ident: CR102 article-title: Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes mellitus publication-title: Diabetes Care doi: 10.2337/dc10-1076 – volume: 54 start-page: 1524 year: 2009 end-page: 1532 ident: CR108 article-title: Altered myocardial substrate metabolism and decreased diastolic function in nonischemic human diabetic cardiomyopathy: studies with cardiac positron emission tomography and magnetic resonance imaging publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2009.04.074 – volume: 17 start-page: 200 year: 2011 end-page: 205 ident: CR126 article-title: Brown adipose tissue activity controls triglyceride clearance publication-title: Nat. Med. doi: 10.1038/nm.2297 – volume: 2 start-page: e233 year: 2005 ident: CR58 article-title: Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents publication-title: PLoS Med. doi: 10.1371/journal.pmed.0020233 – volume: 92 start-page: 3490 year: 2007 end-page: 3497 ident: CR91 article-title: Liver fat in the metabolic syndrome publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2007-0482 – volume: 31 start-page: 430 year: 1999 end-page: 434 ident: CR95 article-title: Mitochondrial abnormalities in non-alcoholic steatohepatitis publication-title: J. Hepatol. doi: 10.1016/S0168-8278(99)80033-6 – volume: 294 start-page: E640 year: 2008 end-page: E642 ident: CR9 article-title: The interpretation of abnormal P magnetic resonance saturation transfer measurements of Pi/ATP exchange in insulin-resistant skeletal muscle publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00797.2007 – volume: 19 start-page: 904 year: 2006 end-page: 926 ident: CR19 article-title: Skeletal muscle energetics with PNMR: personal views and historic perspectives publication-title: NMR Biomed. doi: 10.1002/nbm.1109 – volume: 41 start-page: 1837 year: 2009 end-page: 1845 ident: CR21 article-title: Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2009.03.013 – volume: 21 start-page: 437 year: 2008 end-page: 443 ident: CR156 article-title: Quantitative ATP synthesis in human liver measured by localized P spectroscopy using the magnetization transfer experiment publication-title: NMR Biomed. doi: 10.1002/nbm.1207 – volume: 58 start-page: 1333 year: 2009 end-page: 1341 ident: CR16 article-title: Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes publication-title: Diabetes doi: 10.2337/db08-1240 – volume: 9 start-page: 311 year: 2009 end-page: 326 ident: CR83 article-title: A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance publication-title: Cell Metab. doi: 10.1016/j.cmet.2009.02.002 – volume: 98 start-page: 466 year: 2003 end-page: 470 ident: CR150 article-title: Hepatic ATP reserve and efficiency of replenishing: comparison between obese and nonobese normal individuals publication-title: Am. J. Gastroenterol. – volume: 36 start-page: 164 year: 2006 end-page: 169 ident: CR120 article-title: Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans publication-title: Eur. J. Clin. Invest. doi: 10.1111/j.1365-2362.2006.01615.x – volume: 55 start-page: 120 year: 2006 end-page: 127 ident: CR142 article-title: Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells publication-title: Diabetes doi: 10.2337/diabetes.55.01.06.db05-0943 – volume: 51 start-page: 1913 year: 2002 end-page: 1920 ident: CR147 article-title: Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment publication-title: Diabetes doi: 10.2337/diabetes.51.6.1913 – volume: 292 start-page: E1782 year: 2007 end-page: E1789 ident: CR78 article-title: Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00639.2006 – volume: 59 start-page: 89 year: 2009 end-page: 97 ident: CR59 article-title: Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function publication-title: Diabetes doi: 10.2337/db09-0591 – volume: 120 start-page: 1183 year: 2001 end-page: 1192 ident: CR94 article-title: Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities publication-title: Gastroenterology doi: 10.1053/gast.2001.23256 – volume: 4 start-page: 493 year: 2002 end-page: 502 ident: CR110 article-title: Decreased high-energy phosphate ratios in the myocardium of men with diabetes mellitus type I publication-title: J. Cardiovasc. Magn. Reson. doi: 10.1081/JCMR-120016387 – volume: 19 start-page: 927 year: 2006 end-page: 953 ident: CR20 article-title: Dynamic MRS and MRI of skeletal muscle function and biomechanics publication-title: NMR Biomed. doi: 10.1002/nbm.1095 – volume: 59 start-page: 819 year: 2010 end-page: 828 ident: CR75 article-title: Compensatory increases in nuclear PGC1α protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats publication-title: Diabetes doi: 10.2337/db09-1519 – volume: 355 start-page: 2297 year: 2006 end-page: 2307 ident: CR139 article-title: A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa060326 – volume: 59 start-page: 33 year: 2010 end-page: 42 ident: CR48 article-title: Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes publication-title: Diabetes doi: 10.2337/db09-0214 – volume: 98 start-page: 2335 year: 2003 end-page: 2336 ident: CR98 article-title: Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath test publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.2003.07725.x – volume: 256 start-page: 466 year: 2010 end-page: 473 ident: CR97 article-title: Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with 3.0-T P MR spectroscopy with proton decoupling publication-title: Radiology doi: 10.1148/radiol.10091351 – volume: 13 start-page: 511 year: 2010 end-page: 517 ident: CR8 article-title: Mitochondrial metabolic function assessed in vivo and in vitro publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/MCO.0b013e32833cc93d – volume: 125 start-page: 399 year: 2007 end-page: 410 ident: CR7 article-title: Skeletal muscle mitochondrial dysfunction & diabetes publication-title: Indian J. Med. Res. – volume: 272 start-page: C501 year: 1997 end-page: C510 ident: CR23 article-title: Linear dependence of muscle phosphocreatine kinetics on oxidative capacity publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1997.272.2.C501 – volume: 279 start-page: 32345 year: 2004 end-page: 32353 ident: CR68 article-title: Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease publication-title: J. Biol. Chem. doi: 10.1074/jbc.M313478200 – volume: 74 start-page: 5551 year: 1977 end-page: 5553 ident: CR155 article-title: P nuclear magnetic resonance measurements of ATPase kinetics in aerobic cells publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.74.12.5551 – volume: 350 start-page: 664 year: 2004 end-page: 671 ident: CR55 article-title: Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa031314 – volume: 12 start-page: 537 year: 2010 end-page: 577 ident: CR5 article-title: Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities publication-title: Antioxid. Redox. Signal doi: 10.1089/ars.2009.2531 – volume: 32 start-page: 684 year: 2009 end-page: 698 ident: CR12 article-title: Mitochondria and diabetes mellitus: untangling a conflictive relationship? publication-title: J. Inherit. Metab. Dis. doi: 10.1007/s10545-009-1263-0 – volume: 8 start-page: 870 year: 2007 end-page: 879 ident: CR148 article-title: Functions and dysfunctions of mitochondrial dynamics publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2275 – volume: 3 start-page: e3958 year: 2008 ident: CR56 article-title: Reduced basal ATP synthetic flux of skeletal muscle in patients with previous acromegaly publication-title: PLoS ONE doi: 10.1371/journal.pone.0003958 – volume: 5 start-page: 127 year: 2004 end-page: 134 ident: CR64 article-title: The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans publication-title: Rev. Endocr. Metab. Disord. doi: 10.1023/B:REMD.0000021434.98627.dc – volume: 24 start-page: 1045 year: 1934 end-page: 1053 ident: CR136 article-title: Use of dinitrophenol in nutritional disorders: a critical survey of clinical results publication-title: Am. J. Public Health Nations Health doi: 10.2105/AJPH.24.10.1045 – volume: 57 start-page: 987 year: 2008 end-page: 994 ident: CR50 article-title: Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content publication-title: Diabetes doi: 10.2337/db07-1429 – volume: 30 start-page: 1520 year: 2007 end-page: 1526 ident: CR112 article-title: Abnormal left ventricular energy metabolism in obese men with preserved systolic and diastolic functions is associated with insulin resistance publication-title: Diabetes Care doi: 10.2337/dc06-2429 – volume: 57 start-page: 1166 year: 2008 end-page: 1175 ident: CR62 article-title: Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance publication-title: Diabetes doi: 10.2337/db07-1556 – volume: 116 start-page: 585 year: 2009 end-page: 592 ident: CR73 article-title: Muscle acylcarnitines during short-term fasting in lean healthy men publication-title: Clin. Sci. (Lond.) doi: 10.1042/CS20080433 – volume: 54 start-page: 603 year: 2005 end-page: 608 ident: CR135 article-title: Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes publication-title: Diabetes doi: 10.2337/diabetes.54.3.603 – volume: 50 start-page: 1079 year: 2009 end-page: 1086 ident: CR101 article-title: Abnormal hepatic energy homeostasis in type 2 diabetes publication-title: Hepatology doi: 10.1002/hep.23093 – volume: 341 start-page: 240 year: 1999 end-page: 246 ident: CR88 article-title: Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199907223410404 – volume: 100 start-page: 7996 year: 2003 end-page: 8001 ident: CR45 article-title: Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1332551100 – volume: 52 start-page: 1793 year: 2008 end-page: 1799 ident: CR107 article-title: Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2008.07.062 – volume: 56 start-page: 1592 year: 2007 end-page: 1599 ident: CR44 article-title: Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes publication-title: Diabetes doi: 10.2337/db06-0981 – volume: 286 start-page: C565 year: 2004 end-page: C572 ident: CR30 article-title: Pyruvate and citric acid cycle carbon requirements in isolated skeletal muscle mitochondria publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00146.2003 – volume: 417 start-page: 183 year: 2008 end-page: 193 ident: CR93 article-title: High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function publication-title: Biochem. J. doi: 10.1042/BJ20080868 – volume: 18 start-page: 1692 year: 2004 end-page: 1700 ident: CR105 article-title: Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart publication-title: FASEB J. doi: 10.1096/fj.04-2263com – volume: 97 start-page: 6880 year: 2000 end-page: 6884 ident: CR38 article-title: Assessment of mitochondrial energy coupling in vivo by C/ P NMR publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.120131997 – volume: 347 start-page: 45 issue: Pt 1 year: 2000 end-page: 53 ident: CR25 article-title: Tissue variation in the control of oxidative phosphorylation: implication for mitochondrial diseases publication-title: Biochem. J. doi: 10.1042/bj3470045 – volume: 284 start-page: 22840 year: 2009 end-page: 22852 ident: CR81 article-title: Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.032888 – volume: 103 start-page: 253 year: 1999 end-page: 259 ident: CR66 article-title: Effects of free fatty acids on glucose transport and IRS 1 associated phosphatidylinositol 3-kinase activity publication-title: J. Clin. Invest. doi: 10.1172/JCI5001 – volume: 1741 start-page: 206 year: 2005 end-page: 214 ident: CR89 article-title: Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2005.04.001 – volume: 526 start-page: 203 issue: Pt 1 year: 2000 end-page: 210 ident: CR149 article-title: Oxidative capacity and ageing in human muscle publication-title: J. Physiol. doi: 10.1111/j.1469-7793.2000.t01-1-00203.x – volume: 90 start-page: 420 year: 2003 end-page: 429 ident: CR24 article-title: Factors limiting maximal performance in humans publication-title: Eur. J. Appl. Physiol. doi: 10.1007/s00421-003-0926-z – volume: 13 start-page: 2051 year: 1999 end-page: 2060 ident: CR129 article-title: Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss publication-title: FASEB J. doi: 10.1096/fasebj.13.14.2051 – volume: 47 start-page: 648 year: 2004 end-page: 651 ident: CR119 article-title: Brain energy metabolism during hypoglycaemia in healthy and type 1 diabetic subjects publication-title: Diabetologia doi: 10.1007/s00125-004-1362-2 – volume: 65 start-page: S39 year: 2007 end-page: 46 ident: CR67 article-title: Lipid mediators of insulin resistance publication-title: Nutr. Rev. doi: 10.1301/nr.2007.jun.S39-S46 – volume: 56 start-page: 2085 year: 2007 end-page: 2092 ident: CR74 article-title: Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents publication-title: Diabetes doi: 10.2337/db07-0093 – volume: 23 start-page: 952 year: 2010 end-page: 957 ident: CR86 article-title: Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy publication-title: NMR Biomed. doi: 10.1002/nbm.1519 – volume: 73 start-page: 1644 year: 1992 end-page: 1649 ident: CR152 article-title: Phosphocreatine hydrolysis by P-NMR at the onset of constant-load exercise in humans publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1992.73.4.1644 – volume: 50 start-page: 113 year: 2007 end-page: 120 ident: CR40 article-title: Impaired mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects publication-title: Diabetologia doi: 10.1007/s00125-006-0475-1 – volume: 107 start-page: 3040 year: 2003 end-page: 3046 ident: CR111 article-title: Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes publication-title: Circulation doi: 10.1161/01.CIR.0000072789.89096.10 – volume: 444 start-page: 847 year: 2006 end-page: 853 ident: CR121 article-title: Adipocytes as regulators of energy balance and glucose homeostasis publication-title: Nature doi: 10.1038/nature05483 – volume: 105 start-page: 7815 year: 2008 end-page: 7820 ident: CR76 article-title: High-fat diets cause insulin resistance despite an increase in muscle mitochondria publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0802057105 – volume: 131 start-page: 476 year: 2007 end-page: 491 ident: CR61 article-title: Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes publication-title: Cell doi: 10.1016/j.cell.2007.08.047 – volume: 30 start-page: 1403 year: 2010 end-page: 1410 ident: CR118 article-title: Evidence for a relationship between body mass and energy metabolism in the human brain publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2010.48 – volume: 58 start-page: 1145 year: 2009 end-page: 1152 ident: CR128 article-title: Reduced skeletal muscle mitochondrial respiration and improved glucose metabolism in nondiabetic obese women during a very low calorie dietary intervention leading to rapid weight loss publication-title: Metabolism doi: 10.1016/j.metabol.2009.03.014 – volume: 54 start-page: 1392 year: 2005 end-page: 1399 ident: CR122 article-title: Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue publication-title: Diabetes doi: 10.2337/diabetes.54.5.1392 – volume: 4 start-page: e154 year: 2007 ident: CR46 article-title: Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes publication-title: PLoS Med. doi: 10.1371/journal.pmed.0040154 – volume: 60 start-page: 64 year: 2011 end-page: 73 ident: CR69 article-title: Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling publication-title: Diabetes doi: 10.2337/db10-0698 – volume: 32 start-page: 677 year: 2009 end-page: 679 ident: CR17 article-title: Impaired mitochondrial function and insulin resistance of skeletal muscle in mitochondrial diabetes publication-title: Diabetes Care doi: 10.2337/dc08-2078 – volume: 96 start-page: 192 year: 2011 end-page: 199 ident: CR125 article-title: Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of F FDG detected BAT in humans publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-0989 – volume: 53 start-page: 1714 year: 2010 end-page: 1721 ident: CR134 article-title: Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals publication-title: Diabetologia doi: 10.1007/s00125-010-1764-2 – volume: 279 start-page: 43940 year: 2004 end-page: 43951 ident: CR141 article-title: Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species publication-title: J. Biol. Chem. doi: 10.1074/jbc.M404421200 – volume: 20 start-page: 555 year: 2007 end-page: 565 ident: CR22 article-title: Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by P MRS: a quantitative review publication-title: NMR Biomed. doi: 10.1002/nbm.1192 – volume: 4 start-page: 261 year: 2001 end-page: 266 ident: CR1 article-title: Non-invasive studies of glycogen metabolism in human skeletal muscle using nuclear magnetic resonance spectroscopy publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/00075197-200107000-00003 – volume: 9 start-page: 69 year: 2010 end-page: 76 ident: CR123 article-title: Perspective: Does brown fat protect against diseases of aging? publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2009.11.004 – volume: 362 start-page: 1675 year: 2010 end-page: 1685 ident: CR140 article-title: Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0907929 – volume: 10 start-page: 430 year: 2000 end-page: 435 ident: CR153 article-title: Mitochondrial impairment of human muscle in Friedreich ataxia publication-title: Neuromuscul. Disord. doi: 10.1016/S0960-8966(00)00108-5 – volume: 31 start-page: 25 year: 2010 end-page: 51 ident: CR14 article-title: The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance publication-title: Endocr. Rev. doi: 10.1210/er.2009-0003 – volume: 54 start-page: 8 year: 2005 end-page: 14 ident: CR43 article-title: Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes publication-title: Diabetes doi: 10.2337/diabetes.54.1.8 – volume: 54 start-page: 1891 year: 2009 end-page: 1898 ident: CR114 article-title: Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2009.07.031 – volume: 42 start-page: 328 year: 2003 end-page: 335 ident: CR109 article-title: Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(03)00625-9 – volume: 280 start-page: 10290 year: 2005 end-page: 10297 ident: CR72 article-title: Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle publication-title: J. Biol. Chem. doi: 10.1074/jbc.M408985200 – volume: 51 start-page: 2155 year: 2008 end-page: 2167 ident: CR4 article-title: Mitochondrial fitness and insulin sensitivity in humans publication-title: Diabetologia doi: 10.1007/s00125-008-1153-2 – volume: 31 start-page: S54 year: 2007 end-page: S60 ident: CR96 article-title: Mutation of mitochondrial DNA in livers from patients with alcoholic hepatitis and nonalcoholic steatohepatitis publication-title: Alcohol Clin. Exp. Res. doi: 10.1111/j.1530-0277.2006.00287.x – volume: 97 start-page: 2859 year: 1996 end-page: 2865 ident: CR65 article-title: Mechanism of free fatty acid-induced insulin resistance in humans publication-title: J. Clin. Invest. doi: 10.1172/JCI118742 – volume: 18 start-page: 1695 year: 2010 end-page: 1700 ident: CR82 article-title: Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity publication-title: Obesity (Silver Spring doi: 10.1038/oby.2009.510 – volume: 139 start-page: 1073 year: 2009 end-page: 1081 ident: CR84 article-title: Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women publication-title: J. Nutr. doi: 10.3945/jn.108.103754 – volume: 16 start-page: 400 year: 2010 end-page: 402 ident: CR13 article-title: Diacylglycerol-mediated insulin resistance publication-title: Nat. Med. doi: 10.1038/nm0410-400 – volume: 242 start-page: 2278 year: 1967 end-page: 2282 ident: CR127 article-title: Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle publication-title: J. Biol. Chem. – volume: 56 start-page: 720 year: 2007 end-page: 727 ident: CR3 article-title: Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle publication-title: Diabetes doi: 10.2337/db06-0521 – volume: 37 start-page: 1020 year: 1988 end-page: 1024 ident: CR63 article-title: Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM publication-title: Diabetes doi: 10.2337/diab.37.8.1020 – volume: 5 start-page: 167 year: 2007 end-page: 179 ident: CR92 article-title: Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated fat, and obesity-induced insulin resistance publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.01.002 – volume: 6 start-page: 302 year: 1993 end-page: 310 ident: CR18 article-title: Quantitative analysis by P magnetic resonance spectroscopy of abnormal mitochondrial oxidation in skeletal muscle during recovery from exercise publication-title: NMR Biomed. doi: 10.1002/nbm.1940060504 – volume: 234 start-page: 1568 year: 1959 end-page: 1570 ident: CR27 article-title: Acid-linked functions of intermediates in oxidative phosphorylation. II. Experimental studies of the effect of pH upon respiratory, phosphorylative and transfer activities of liver and heart mitochondria publication-title: J. Biol. Chem. – volume: 298 start-page: E49 year: 2010 end-page: E58 ident: CR47 article-title: Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00317.2009 – volume: 1 start-page: 361 year: 2005 end-page: 370 ident: CR53 article-title: Metabolic control through the PGC-1 family of transcription coactivators publication-title: Cell Metab. doi: 10.1016/j.cmet.2005.05.004 – volume: 6 start-page: 319 year: 2010 end-page: 325 ident: CR124 article-title: Brown adipose tissue—a new role in humans? publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2010.64 – volume: 77 start-page: 387 year: 2008 end-page: 397 ident: CR115 article-title: Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvm029 – volume: 27 start-page: 7310 year: 2007 end-page: 7317 ident: CR36 article-title: Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0212-07.2007 – volume: 300 start-page: 1140 year: 2003 end-page: 1142 ident: CR54 article-title: Mitochondrial dysfunction in the elderly: possible role in insulin resistance publication-title: Science doi: 10.1126/science.1082889 – volume: 96 start-page: 494 year: 2011 end-page: 503 ident: CR39 article-title: Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-0822 – volume: 157 start-page: 12 year: 1988 end-page: 26 ident: CR26 article-title: Measurement of Ca2+ release in skinned fibers from skeletal muscle publication-title: Methods Enzymol. doi: 10.1016/0076-6879(88)57064-7 – volume: 116 start-page: 1170 year: 2007 end-page: 1175 ident: CR106 article-title: Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.645614 – volume: 53 start-page: 3048 year: 2004 end-page: 3056 ident: CR90 article-title: Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes publication-title: Diabetes doi: 10.2337/diabetes.53.12.3048 – volume: 307 start-page: 384 year: 2005 end-page: 387 ident: CR6 article-title: Mitochondrial dysfunction and type 2 diabetes publication-title: Science doi: 10.1126/science.1104343 – volume: 52 start-page: 540 year: 2003 end-page: 546 ident: CR143 article-title: Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: relationship to glucose disposal publication-title: Metabolism doi: 10.1053/meta.2002.50108 – volume: 396 start-page: 250 year: 2010 end-page: 256 ident: CR157 article-title: Comparison of methods for measuring oxygen consumption in tumor cells in vitro publication-title: Anal. Biochem. doi: 10.1016/j.ab.2009.09.029 – volume: 33 start-page: 897 year: 2005 end-page: 904 ident: CR28 article-title: The efficiency and plasticity of mitochondrial energy transduction publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0330897 – volume: 299 start-page: E33 year: 2010 end-page: E38 ident: CR70 article-title: Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00756.2009 – volume: 92 start-page: 1467 year: 2007 end-page: 1473 ident: CR49 article-title: Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2006-2210 – volume: 47 start-page: 23 year: 2004 end-page: 30 ident: CR132 article-title: Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with type 2 diabetes publication-title: Diabetologia doi: 10.1007/s00125-003-1265-7 – volume: 4 start-page: 493 year: 2002 ident: BFnrendo2011138_CR110 publication-title: J. Cardiovasc. Magn. Reson. doi: 10.1081/JCMR-120016387 – volume: 116 start-page: 1170 year: 2007 ident: BFnrendo2011138_CR106 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.645614 – volume: 51 start-page: 2155 year: 2008 ident: BFnrendo2011138_CR4 publication-title: Diabetologia doi: 10.1007/s00125-008-1153-2 – volume: 50 start-page: 790 year: 2007 ident: BFnrendo2011138_CR42 publication-title: Diabetologia doi: 10.1007/s00125-007-0594-3 – volume: 100 start-page: 7996 year: 2003 ident: BFnrendo2011138_CR45 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1332551100 – volume: 30 start-page: 1520 year: 2007 ident: BFnrendo2011138_CR112 publication-title: Diabetes Care doi: 10.2337/dc06-2429 – volume: 341 start-page: 240 year: 1999 ident: BFnrendo2011138_CR88 publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199907223410404 – volume: 307 start-page: 384 year: 2005 ident: BFnrendo2011138_CR6 publication-title: Science doi: 10.1126/science.1104343 – volume: 96 start-page: 494 year: 2011 ident: BFnrendo2011138_CR39 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-0822 – volume: 52 start-page: 1789 year: 2009 ident: BFnrendo2011138_CR133 publication-title: Diabetologia doi: 10.1007/s00125-009-1354-3 – volume: 120 start-page: 1183 year: 2001 ident: BFnrendo2011138_CR94 publication-title: Gastroenterology doi: 10.1053/gast.2001.23256 – volume: 97 start-page: 2859 year: 1996 ident: BFnrendo2011138_CR65 publication-title: J. Clin. Invest. doi: 10.1172/JCI118742 – volume: 103 start-page: 253 year: 1999 ident: BFnrendo2011138_CR66 publication-title: J. Clin. Invest. doi: 10.1172/JCI5001 – volume: 92 start-page: 3490 year: 2007 ident: BFnrendo2011138_CR91 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2007-0482 – volume: 58 start-page: 1145 year: 2009 ident: BFnrendo2011138_CR128 publication-title: Metabolism doi: 10.1016/j.metabol.2009.03.014 – volume: 58 start-page: 1333 year: 2009 ident: BFnrendo2011138_CR16 publication-title: Diabetes doi: 10.2337/db08-1240 – volume: 6 start-page: 302 year: 1993 ident: BFnrendo2011138_CR18 publication-title: NMR Biomed. doi: 10.1002/nbm.1940060504 – volume: 269 start-page: 189 year: 2011 ident: BFnrendo2011138_CR87 publication-title: J. Intern. Med. doi: 10.1111/j.1365-2796.2010.02298.x – volume: 33 start-page: 897 year: 2005 ident: BFnrendo2011138_CR28 publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0330897 – ident: BFnrendo2011138_CR57 – volume: 30 start-page: 1403 year: 2010 ident: BFnrendo2011138_CR118 publication-title: J. Cereb. Blood Flow Metab. doi: 10.1038/jcbfm.2010.48 – volume: 404 start-page: 75 year: 2010 ident: BFnrendo2011138_CR158 publication-title: Anal. Biochem. doi: 10.1016/j.ab.2010.04.040 – volume: 54 start-page: 1392 year: 2005 ident: BFnrendo2011138_CR122 publication-title: Diabetes doi: 10.2337/diabetes.54.5.1392 – volume: 24 start-page: 1045 year: 1934 ident: BFnrendo2011138_CR136 publication-title: Am. J. Public Health Nations Health doi: 10.2105/AJPH.24.10.1045 – volume: 89 start-page: 463S year: 2009 ident: BFnrendo2011138_CR11 publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.2008.26717C – volume: 52 start-page: 540 year: 2003 ident: BFnrendo2011138_CR143 publication-title: Metabolism doi: 10.1053/meta.2002.50108 – volume: 89 start-page: 455S year: 2009 ident: BFnrendo2011138_CR80 publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.2008.26717B – volume: 51 start-page: 2944 year: 2002 ident: BFnrendo2011138_CR41 publication-title: Diabetes doi: 10.2337/diabetes.51.10.2944 – volume: 157 start-page: 12 year: 1988 ident: BFnrendo2011138_CR26 publication-title: Methods Enzymol. doi: 10.1016/0076-6879(88)57064-7 – volume: 47 start-page: 51 year: 2008 ident: BFnrendo2011138_CR113 publication-title: Hepatology doi: 10.1002/hep.21983 – volume: 47 start-page: 648 year: 2004 ident: BFnrendo2011138_CR119 publication-title: Diabetologia doi: 10.1007/s00125-004-1362-2 – volume: 42 start-page: 328 year: 2003 ident: BFnrendo2011138_CR109 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/S0735-1097(03)00625-9 – volume: 526 start-page: 203 issue: Pt 1 year: 2000 ident: BFnrendo2011138_CR149 publication-title: J. Physiol. doi: 10.1111/j.1469-7793.2000.t01-1-00203.x – volume: 35 start-page: 95 year: 2003 ident: BFnrendo2011138_CR32 publication-title: Med. Sci. Sports Exerc. doi: 10.1097/00005768-200301000-00016 – volume: 347 start-page: 45 issue: Pt 1 year: 2000 ident: BFnrendo2011138_CR25 publication-title: Biochem. J. doi: 10.1042/bj3470045 – volume: 55 start-page: 136 year: 2006 ident: BFnrendo2011138_CR85 publication-title: Diabetes doi: 10.2337/diabetes.55.01.06.db05-1286 – volume: 272 start-page: C501 year: 1997 ident: BFnrendo2011138_CR23 publication-title: Am. J. Physiol. doi: 10.1152/ajpcell.1997.272.2.C501 – volume: 107 start-page: 3040 year: 2003 ident: BFnrendo2011138_CR111 publication-title: Circulation doi: 10.1161/01.CIR.0000072789.89096.10 – volume: 60 start-page: 64 year: 2011 ident: BFnrendo2011138_CR69 publication-title: Diabetes doi: 10.2337/db10-0698 – volume: 50 start-page: 113 year: 2007 ident: BFnrendo2011138_CR40 publication-title: Diabetologia doi: 10.1007/s00125-006-0475-1 – volume: 280 start-page: 10290 year: 2005 ident: BFnrendo2011138_CR72 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M408985200 – volume: 120 start-page: 2355 year: 2010 ident: BFnrendo2011138_CR33 publication-title: J. Clin. Invest. doi: 10.1172/JCI40671 – volume: 19 start-page: 927 year: 2006 ident: BFnrendo2011138_CR20 publication-title: NMR Biomed. doi: 10.1002/nbm.1095 – volume: 90 start-page: 420 year: 2003 ident: BFnrendo2011138_CR24 publication-title: Eur. J. Appl. Physiol. doi: 10.1007/s00421-003-0926-z – volume: 396 start-page: 250 year: 2010 ident: BFnrendo2011138_CR157 publication-title: Anal. Biochem. doi: 10.1016/j.ab.2009.09.029 – volume: 4 start-page: e154 year: 2007 ident: BFnrendo2011138_CR46 publication-title: PLoS Med. doi: 10.1371/journal.pmed.0040154 – volume: 294 start-page: E640 year: 2008 ident: BFnrendo2011138_CR9 publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00797.2007 – volume: 32 start-page: 677 year: 2009 ident: BFnrendo2011138_CR17 publication-title: Diabetes Care doi: 10.2337/dc08-2078 – volume: 115 start-page: 3587 year: 2005 ident: BFnrendo2011138_CR34 publication-title: J. Clin. Invest. doi: 10.1172/JCI25151 – volume: 20 start-page: 555 year: 2007 ident: BFnrendo2011138_CR22 publication-title: NMR Biomed. doi: 10.1002/nbm.1192 – volume: 98 start-page: 2335 year: 2003 ident: BFnrendo2011138_CR98 publication-title: Am. J. Gastroenterol. doi: 10.1111/j.1572-0241.2003.07725.x – volume: 57 start-page: 987 year: 2008 ident: BFnrendo2011138_CR50 publication-title: Diabetes doi: 10.2337/db07-1429 – volume: 292 start-page: E1782 year: 2007 ident: BFnrendo2011138_CR78 publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00639.2006 – volume: 47 start-page: 23 year: 2004 ident: BFnrendo2011138_CR132 publication-title: Diabetologia doi: 10.1007/s00125-003-1265-7 – volume: 59 start-page: 572 year: 2010 ident: BFnrendo2011138_CR131 publication-title: Diabetes doi: 10.2337/db09-1322 – volume: 73 start-page: 1644 year: 1992 ident: BFnrendo2011138_CR152 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1992.73.4.1644 – volume: 234 start-page: 1568 year: 1959 ident: BFnrendo2011138_CR27 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)70051-3 – volume: 56 start-page: 720 year: 2007 ident: BFnrendo2011138_CR3 publication-title: Diabetes doi: 10.2337/db06-0521 – volume: 52 start-page: 723 year: 2009 ident: BFnrendo2011138_CR138 publication-title: Diabetologia doi: 10.1007/s00125-008-1256-9 – volume: 12 start-page: 537 year: 2010 ident: BFnrendo2011138_CR5 publication-title: Antioxid. Redox. Signal doi: 10.1089/ars.2009.2531 – volume: 293 start-page: H2659 year: 2007 ident: BFnrendo2011138_CR31 publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00782.2007 – volume: 279 start-page: 43940 year: 2004 ident: BFnrendo2011138_CR141 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M404421200 – volume: 13 start-page: 2051 year: 1999 ident: BFnrendo2011138_CR129 publication-title: FASEB J. doi: 10.1096/fasebj.13.14.2051 – volume: 2 start-page: e233 year: 2005 ident: BFnrendo2011138_CR58 publication-title: PLoS Med. doi: 10.1371/journal.pmed.0020233 – volume: 13 start-page: 511 year: 2010 ident: BFnrendo2011138_CR8 publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/MCO.0b013e32833cc93d – volume: 289 start-page: E151 year: 2005 ident: BFnrendo2011138_CR137 publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00141.2004 – volume: 21 start-page: 437 year: 2008 ident: BFnrendo2011138_CR156 publication-title: NMR Biomed. doi: 10.1002/nbm.1207 – volume: 90 start-page: 953 year: 2003 ident: BFnrendo2011138_CR77 publication-title: Br. J. Nutr. doi: 10.1079/BJN2003000968 – volume: 31 start-page: 430 year: 1999 ident: BFnrendo2011138_CR95 publication-title: J. Hepatol. doi: 10.1016/S0168-8278(99)80033-6 – volume: 59 start-page: 2444 year: 2010 ident: BFnrendo2011138_CR60 publication-title: Diabetes doi: 10.2337/db10-0174 – volume: 65 start-page: S39 year: 2007 ident: BFnrendo2011138_CR67 publication-title: Nutr. Rev. doi: 10.1301/nr.2007.jun.S39-S46 – volume: 18 start-page: 1695 year: 2010 ident: BFnrendo2011138_CR82 publication-title: Obesity (Silver Spring doi: 10.1038/oby.2009.510 – volume: 116 start-page: 585 year: 2009 ident: BFnrendo2011138_CR73 publication-title: Clin. Sci. (Lond.) doi: 10.1042/CS20080433 – volume: 31 start-page: 25 year: 2010 ident: BFnrendo2011138_CR14 publication-title: Endocr. Rev. doi: 10.1210/er.2009-0003 – volume: 31 start-page: S54 year: 2007 ident: BFnrendo2011138_CR96 publication-title: Alcohol Clin. Exp. Res. doi: 10.1111/j.1530-0277.2006.00287.x – volume: 59 start-page: 33 year: 2010 ident: BFnrendo2011138_CR48 publication-title: Diabetes doi: 10.2337/db09-0214 – volume: 100 start-page: 8466 year: 2003 ident: BFnrendo2011138_CR35 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1032913100 – volume: 54 start-page: 8 year: 2005 ident: BFnrendo2011138_CR43 publication-title: Diabetes doi: 10.2337/diabetes.54.1.8 – volume: 106 start-page: 407 year: 2002 ident: BFnrendo2011138_CR104 publication-title: Circulation doi: 10.1161/01.CIR.0000026392.80723.DC – volume: 284 start-page: 22840 year: 2009 ident: BFnrendo2011138_CR81 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.032888 – volume: 54 start-page: 1891 year: 2009 ident: BFnrendo2011138_CR114 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2009.07.031 – volume: 286 start-page: C565 year: 2004 ident: BFnrendo2011138_CR30 publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00146.2003 – volume: 57 start-page: 1166 year: 2008 ident: BFnrendo2011138_CR62 publication-title: Diabetes doi: 10.2337/db07-1556 – volume: 1 start-page: 361 year: 2005 ident: BFnrendo2011138_CR53 publication-title: Cell Metab. doi: 10.1016/j.cmet.2005.05.004 – volume: 56 start-page: 2142 year: 2007 ident: BFnrendo2011138_CR130 publication-title: Diabetes doi: 10.2337/db07-0141 – volume: 13 start-page: 387 year: 1992 ident: BFnrendo2011138_CR116 publication-title: Endocr. Rev. – volume: 96 start-page: 192 year: 2011 ident: BFnrendo2011138_CR125 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2010-0989 – volume: 18 start-page: 1692 year: 2004 ident: BFnrendo2011138_CR105 publication-title: FASEB J. doi: 10.1096/fj.04-2263com – volume: 417 start-page: 183 year: 2008 ident: BFnrendo2011138_CR93 publication-title: Biochem. J. doi: 10.1042/BJ20080868 – volume: 53 start-page: 3048 year: 2004 ident: BFnrendo2011138_CR90 publication-title: Diabetes doi: 10.2337/diabetes.53.12.3048 – volume: 7 start-page: 45 year: 2008 ident: BFnrendo2011138_CR37 publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.10.013 – volume: 97 start-page: 6880 year: 2000 ident: BFnrendo2011138_CR38 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.120131997 – volume: 56 start-page: 2085 year: 2007 ident: BFnrendo2011138_CR74 publication-title: Diabetes doi: 10.2337/db07-0093 – volume: 298 start-page: E706 year: 2010 ident: BFnrendo2011138_CR146 publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00692.2009 – volume: 98 start-page: 466 year: 2003 ident: BFnrendo2011138_CR150 publication-title: Am. J. Gastroenterol. – volume: 118 start-page: 2132 year: 2008 ident: BFnrendo2011138_CR117 publication-title: J. Clin. Invest. – volume: 77 start-page: 387 year: 2008 ident: BFnrendo2011138_CR115 publication-title: Cardiovasc. Res. doi: 10.1093/cvr/cvm029 – volume: 53 start-page: 1714 year: 2010 ident: BFnrendo2011138_CR134 publication-title: Diabetologia doi: 10.1007/s00125-010-1764-2 – volume: 125 start-page: 399 year: 2007 ident: BFnrendo2011138_CR7 publication-title: Indian J. Med. Res. – volume: 298 start-page: E49 year: 2010 ident: BFnrendo2011138_CR47 publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00317.2009 – volume: 55 start-page: 120 year: 2006 ident: BFnrendo2011138_CR142 publication-title: Diabetes doi: 10.2337/diabetes.55.01.06.db05-0943 – volume: 78 start-page: 6714 year: 1981 ident: BFnrendo2011138_CR151 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.78.11.6714 – volume: 9 start-page: 69 year: 2010 ident: BFnrendo2011138_CR123 publication-title: Ageing Res. Rev. doi: 10.1016/j.arr.2009.11.004 – volume: 23 start-page: 952 year: 2010 ident: BFnrendo2011138_CR86 publication-title: NMR Biomed. doi: 10.1002/nbm.1519 – volume: 52 start-page: 1793 year: 2008 ident: BFnrendo2011138_CR107 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2008.07.062 – volume: 50 start-page: 1079 year: 2009 ident: BFnrendo2011138_CR101 publication-title: Hepatology doi: 10.1002/hep.23093 – volume: 8 start-page: 40 year: 2008 ident: BFnrendo2011138_CR144 publication-title: BMC Gastroenterol. doi: 10.1186/1471-230X-8-40 – volume: 82 start-page: 8384 year: 1985 ident: BFnrendo2011138_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.82.24.8384 – volume: 41 start-page: 1837 year: 2009 ident: BFnrendo2011138_CR21 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/j.biocel.2009.03.013 – volume: 4 start-page: 261 year: 2001 ident: BFnrendo2011138_CR1 publication-title: Curr. Opin. Clin. Nutr. Metab. Care doi: 10.1097/00075197-200107000-00003 – volume: 55 start-page: 2277 year: 2006 ident: BFnrendo2011138_CR79 publication-title: Diabetes doi: 10.2337/db06-0062 – volume: 57 start-page: 2943 year: 2008 ident: BFnrendo2011138_CR29 publication-title: Diabetes doi: 10.2337/db08-0391 – volume: 6 start-page: 319 year: 2010 ident: BFnrendo2011138_CR124 publication-title: Nat. Rev. Endocrinol. doi: 10.1038/nrendo.2010.64 – volume: 5 start-page: 127 year: 2004 ident: BFnrendo2011138_CR64 publication-title: Rev. Endocr. Metab. Disord. doi: 10.1023/B:REMD.0000021434.98627.dc – volume: 256 start-page: 466 year: 2010 ident: BFnrendo2011138_CR97 publication-title: Radiology doi: 10.1148/radiol.10091351 – volume: 299 start-page: E33 year: 2010 ident: BFnrendo2011138_CR70 publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00756.2009 – volume: 350 start-page: 664 year: 2004 ident: BFnrendo2011138_CR55 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa031314 – volume: 16 start-page: 400 year: 2010 ident: BFnrendo2011138_CR13 publication-title: Nat. Med. doi: 10.1038/nm0410-400 – volume: 279 start-page: 32345 year: 2004 ident: BFnrendo2011138_CR68 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M313478200 – volume: 1741 start-page: 206 year: 2005 ident: BFnrendo2011138_CR89 publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2005.04.001 – volume: 34 start-page: 430 year: 2011 ident: BFnrendo2011138_CR100 publication-title: Diabetes Care doi: 10.2337/dc10-1002 – volume: 37 start-page: 1020 year: 1988 ident: BFnrendo2011138_CR63 publication-title: Diabetes doi: 10.2337/diab.37.8.1020 – volume: 362 start-page: 1675 year: 2010 ident: BFnrendo2011138_CR140 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0907929 – volume: 74 start-page: 5551 year: 1977 ident: BFnrendo2011138_CR155 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.74.12.5551 – volume: 55 start-page: 1283 year: 2006 ident: BFnrendo2011138_CR52 publication-title: Diabetes doi: 10.2337/db05-0853 – volume: 8 start-page: 870 year: 2007 ident: BFnrendo2011138_CR148 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2275 – volume: 95 start-page: 422 year: 2010 ident: BFnrendo2011138_CR71 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2009-1387 – volume: 242 start-page: 2278 year: 1967 ident: BFnrendo2011138_CR127 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)96046-1 – volume: 131 start-page: 476 year: 2007 ident: BFnrendo2011138_CR61 publication-title: Cell doi: 10.1016/j.cell.2007.08.047 – volume: 282 start-page: 1659 year: 1999 ident: BFnrendo2011138_CR99 publication-title: JAMA doi: 10.1001/jama.282.17.1659 – volume: 49 start-page: 590 year: 2001 ident: BFnrendo2011138_CR154 publication-title: Ann. Neurol. doi: 10.1002/ana.1001 – volume: 105 start-page: 7815 year: 2008 ident: BFnrendo2011138_CR76 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0802057105 – volume: 127 start-page: 1109 year: 2006 ident: BFnrendo2011138_CR145 publication-title: Cell doi: 10.1016/j.cell.2006.11.013 – volume: 116 start-page: 1529 year: 1985 ident: BFnrendo2011138_CR103 publication-title: Endocrinology doi: 10.1210/endo-116-4-1529 – volume: 59 start-page: 89 year: 2009 ident: BFnrendo2011138_CR59 publication-title: Diabetes doi: 10.2337/db09-0591 – volume: 56 start-page: 1592 year: 2007 ident: BFnrendo2011138_CR44 publication-title: Diabetes doi: 10.2337/db06-0981 – volume: 3 start-page: e3958 year: 2008 ident: BFnrendo2011138_CR56 publication-title: PLoS ONE doi: 10.1371/journal.pone.0003958 – volume: 139 start-page: 1073 year: 2009 ident: BFnrendo2011138_CR84 publication-title: J. Nutr. doi: 10.3945/jn.108.103754 – volume: 54 start-page: 603 year: 2005 ident: BFnrendo2011138_CR135 publication-title: Diabetes doi: 10.2337/diabetes.54.3.603 – volume: 36 start-page: 164 year: 2006 ident: BFnrendo2011138_CR120 publication-title: Eur. J. Clin. Invest. doi: 10.1111/j.1365-2362.2006.01615.x – volume: 10 start-page: 430 year: 2000 ident: BFnrendo2011138_CR153 publication-title: Neuromuscul. Disord. doi: 10.1016/S0960-8966(00)00108-5 – volume: 5 start-page: 167 year: 2007 ident: BFnrendo2011138_CR92 publication-title: Cell Metab. doi: 10.1016/j.cmet.2007.01.002 – volume: 92 start-page: 1467 year: 2007 ident: BFnrendo2011138_CR49 publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2006-2210 – volume: 59 start-page: 819 year: 2010 ident: BFnrendo2011138_CR75 publication-title: Diabetes doi: 10.2337/db09-1519 – volume: 9 start-page: 311 year: 2009 ident: BFnrendo2011138_CR83 publication-title: Cell Metab. doi: 10.1016/j.cmet.2009.02.002 – volume: 32 start-page: 684 year: 2009 ident: BFnrendo2011138_CR12 publication-title: J. Inherit. Metab. Dis. doi: 10.1007/s10545-009-1263-0 – volume: 54 start-page: 1524 year: 2009 ident: BFnrendo2011138_CR108 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2009.04.074 – volume: 34 start-page: 448 year: 2011 ident: BFnrendo2011138_CR102 publication-title: Diabetes Care doi: 10.2337/dc10-1076 – volume: 105 start-page: 7627 year: 2008 ident: BFnrendo2011138_CR10 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0803901105 – volume: 83 start-page: 166 year: 1997 ident: BFnrendo2011138_CR2 publication-title: J. Appl. Physiol. doi: 10.1152/jappl.1997.83.1.166 – volume: 17 start-page: 200 year: 2011 ident: BFnrendo2011138_CR126 publication-title: Nat. Med. doi: 10.1038/nm.2297 – volume: 34 start-page: 267 year: 2003 ident: BFnrendo2011138_CR51 publication-title: Nat. Genet. doi: 10.1038/ng1180 – volume: 51 start-page: 1913 year: 2002 ident: BFnrendo2011138_CR147 publication-title: Diabetes doi: 10.2337/diabetes.51.6.1913 – volume: 444 start-page: 847 year: 2006 ident: BFnrendo2011138_CR121 publication-title: Nature doi: 10.1038/nature05483 – volume: 355 start-page: 2297 year: 2006 ident: BFnrendo2011138_CR139 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa060326 – volume: 27 start-page: 7310 year: 2007 ident: BFnrendo2011138_CR36 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0212-07.2007 – volume: 19 start-page: 904 year: 2006 ident: BFnrendo2011138_CR19 publication-title: NMR Biomed. doi: 10.1002/nbm.1109 – volume: 300 start-page: 1140 year: 2003 ident: BFnrendo2011138_CR54 publication-title: Science doi: 10.1126/science.1082889 – reference: 20376053 - Nat Med. 2010 Apr;16(4):400-2 – reference: 16644684 - Diabetes. 2006 May;55(5):1283-8 – reference: 16873691 - Diabetes. 2006 Aug;55(8):2277-85 – reference: 8675698 - J Clin Invest. 1996 Jun 15;97(12):2859-65 – reference: 1447115 - J Appl Physiol (1985). 1992 Oct;73(4):1644-9 – reference: 12875772 - J Am Coll Cardiol. 2003 Jul 16;42(2):328-35 – reference: 16284649 - J Clin Invest. 2005 Dec;115(12):3587-93 – reference: 17384336 - Diabetes Care. 2007 Jun;30(6):1520-6 – reference: 17519422 - Diabetes. 2007 Aug;56(8):2085-92 – reference: 20943785 - J Clin Endocrinol Metab. 2011 Jan;96(1):192-9 – reference: 19056574 - Am J Clin Nutr. 2009 Jan;89(1):463S-6S – reference: 8268062 - NMR Biomed. 1993 Sep-Oct;6(5):302-10 – reference: 12549236 - J Cardiovasc Magn Reson. 2002;4(4):493-502 – reference: 17112576 - Cell. 2006 Dec 15;127(6):1109-22 – reference: 19369366 - J Nutr. 2009 Jun;139(6):1073-81 – reference: 19370339 - Diabetologia. 2009 Sep;52(9):1789-97 – reference: 18509063 - Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7815-20 – reference: 21258337 - Nat Med. 2011 Feb;17(2):200-5 – reference: 20111019 - Obesity (Silver Spring). 2010 Sep;18(9):1695-700 – reference: 17311893 - Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1782-9 – reference: 12808136 - Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7996-8001 – reference: 17327442 - Diabetes. 2007 Mar;56(3):720-7 – reference: 19892241 - J Am Coll Cardiol. 2009 Nov 10;54(20):1891-8 – reference: 19131470 - Diabetes Care. 2009 Apr;32(4):677-9 – reference: 17698735 - Circulation. 2007 Sep 4;116(10):1170-5 – reference: 19169664 - Diabetologia. 2009 Apr;52(4):723-32 – reference: 10488700 - J Hepatol. 1999 Sep;31(3):430-4 – reference: 14602577 - Am J Physiol Cell Physiol. 2004 Mar;286(3):C565-72 – reference: 3882413 - Endocrinology. 1985 Apr;116(4):1529-34 – reference: 20422397 - Diabetologia. 2010 Aug;53(8):1714-21 – reference: 15734833 - Diabetes. 2005 Mar;54(3):603-8 – reference: 12135937 - Circulation. 2002 Jul 23;106(4):407-11 – reference: 12910345 - Eur J Appl Physiol. 2003 Oct;90(3-4):420-9 – reference: 15662004 - Science. 2005 Jan 21;307(5708):384-7 – reference: 15894466 - Biochim Biophys Acta. 2005 Jun 30;1741(1-2):206-14 – reference: 17331167 - Alcohol Clin Exp Res. 2007 Jan;31(1 Suppl):S54-60 – reference: 16246006 - Biochem Soc Trans. 2005 Nov;33(Pt 5):897-904 – reference: 20616711 - Curr Opin Clin Nutr Metab Care. 2010 Sep;13(5):511-7 – reference: 17075956 - NMR Biomed. 2006 Nov;19(7):927-53 – reference: 19093000 - PLoS One. 2008;3(12):e3958 – reference: 17244782 - J Clin Endocrinol Metab. 2007 Apr;92(4):1467-73 – reference: 17472434 - PLoS Med. 2007 May;4(5):e154 – reference: 14960743 - N Engl J Med. 2004 Feb 12;350(7):664-71 – reference: 1425482 - Endocr Rev. 1992 Aug;13(3):387-414 – reference: 10544188 - FASEB J. 1999 Nov;13(14 ):2051-60 – reference: 15598661 - J Biol Chem. 2005 Mar 18;280(11):10290-7 – reference: 12810608 - Circulation. 2003 Jun 24;107(24):3040-6 – reference: 17135584 - N Engl J Med. 2006 Nov 30;355(22):2297-307 – reference: 15561933 - Diabetes. 2004 Dec;53(12):3048-56 – reference: 9124293 - Am J Physiol. 1997 Feb;272(2 Pt 1):C501-10 – reference: 18014064 - Am J Public Health Nations Health. 1934 Oct;24(10):1045-53 – reference: 17611283 - J Neurosci. 2007 Jul 4;27(27):7310-7 – reference: 14667188 - Br J Nutr. 2003 Nov;90(5):953-60 – reference: 18325881 - Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E640-2; author reply E643-4 – reference: 19833877 - Diabetes. 2010 Jan;59(1):33-42 – reference: 10878112 - J Physiol. 2000 Jul 1;526 Pt 1:203-10 – reference: 17351150 - Diabetes. 2007 Jun;56(6):1592-9 – reference: 15265871 - J Biol Chem. 2004 Oct 15;279(42):43940-51 – reference: 19833885 - Diabetes. 2010 Jan;59(1):89-97 – reference: 19969105 - Ageing Res Rev. 2010 Jan;9(1):69-76 – reference: 19265027 - Diabetes. 2009 Jun;58(6):1333-41 – reference: 17595248 - J Clin Endocrinol Metab. 2007 Sep;92 (9):3490-7 – reference: 17496364 - Indian J Med Res. 2007 Mar;125(3):399-410 – reference: 18945215 - Clin Sci (Lond). 2009 Apr;116(7):585-92 – reference: 12544642 - Med Sci Sports Exerc. 2003 Jan;35(1):95-104 – reference: 10727400 - Biochem J. 2000 Apr 1;347 Pt 1:45-53 – reference: 21205021 - J Intern Med. 2011 Feb;269(2):189-99 – reference: 16380486 - Diabetes. 2006 Jan;55(1):136-40 – reference: 18752470 - Biochem J. 2009 Jan 1;417(1):183-93 – reference: 20465991 - Anal Biochem. 2010 Sep 1;404(1):75-81 – reference: 18802678 - Diabetologia. 2008 Dec;51(12):2155-67 – reference: 19454354 - Metabolism. 2009 Aug;58(8):1145-52 – reference: 17075955 - NMR Biomed. 2006 Nov;19(7):904-26 – reference: 17628042 - NMR Biomed. 2007 Oct;20(6):555-65 – reference: 18006463 - Cardiovasc Res. 2008 Jan 15;77(2):387-97 – reference: 13654418 - J Biol Chem. 1959 Jun;234(6):1568-70 – reference: 20442322 - Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E33-8 – reference: 19022158 - J Am Coll Cardiol. 2008 Nov 25;52(22):1793-9 – reference: 15727952 - Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E151-9 – reference: 21106709 - J Clin Endocrinol Metab. 2011 Feb;96(2):494-503 – reference: 18177724 - Cell Metab. 2008 Jan;7(1):45-56 – reference: 12351431 - Diabetes. 2002 Oct;51(10):2944-50 – reference: 17536063 - Diabetes. 2007 Aug;56(8):2142-7 – reference: 19356713 - Cell Metab. 2009 Apr;9(4):311-26 – reference: 10553793 - JAMA. 1999 Nov 3;282(17):1659-64 – reference: 20682693 - Diabetes. 2010 Oct;59(10):2444-52 – reference: 15616005 - Diabetes. 2005 Jan;54(1):8-14 – reference: 3866229 - Proc Natl Acad Sci U S A. 1985 Dec;82(24):8384-8 – reference: 11458018 - Curr Opin Clin Nutr Metab Care. 2001 Jul;4(4):261-6 – reference: 15166226 - J Biol Chem. 2004 Jul 30;279(31):32345-53 – reference: 19766582 - Anal Biochem. 2010 Jan 15;396(2):250-6 – reference: 15522914 - FASEB J. 2004 Nov;18(14):1692-700 – reference: 11357949 - Ann Neurol. 2001 May;49(5):590-6 – reference: 19815124 - J Am Coll Cardiol. 2009 Oct 13;54(16):1524-32 – reference: 10823916 - Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6880-4 – reference: 17093944 - Diabetologia. 2007 Jan;50(1):113-20 – reference: 19887598 - Am J Physiol Endocrinol Metab. 2010 Jan;298(1):E49-58 – reference: 18252894 - Diabetes. 2008 Apr;57(4):987-94 – reference: 18678616 - Diabetes. 2008 Nov;57(11):2943-9 – reference: 20577053 - J Clin Invest. 2010 Jul;120(7):2355-69 – reference: 17955548 - Hepatology. 2008 Jan;47(1):51-8 – reference: 20386559 - Nat Rev Endocrinol. 2010 Jun;6(6):319-25 – reference: 17928812 - Nat Rev Mol Cell Biol. 2007 Nov;8(11):870-9 – reference: 17167472 - Nature. 2006 Dec 14;444(7121):847-53 – reference: 20028948 - Diabetes. 2010 Mar;59(3):572-9 – reference: 20103701 - Diabetes. 2010 Apr;59(4):819-28 – reference: 9216960 - J Appl Physiol (1985). 1997 Jul;83(1):166-71 – reference: 18782455 - BMC Gastroenterol. 2008 Sep 09;8:40 – reference: 16380484 - Diabetes. 2006 Jan;55(1):120-7 – reference: 19861693 - Endocr Rev. 2010 Feb;31(1):25-51 – reference: 12759881 - Metabolism. 2003 May;52(5):540-6 – reference: 19637187 - Hepatology. 2009 Oct;50(4):1079-86 – reference: 19553674 - J Biol Chem. 2009 Aug 21;284(34):22840-52 – reference: 17981116 - Cell. 2007 Nov 2;131(3):476-91 – reference: 17605313 - Nutr Rev. 2007 Jun;65(6 Pt 2):S39-46 – reference: 20389303 - J Cereb Blood Flow Metab. 2010 Jul;30(7):1403-10 – reference: 12832613 - Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71 – reference: 19650713 - Antioxid Redox Signal. 2010 Apr;12(4):537-77 – reference: 10413736 - N Engl J Med. 1999 Jul 22;341(4):240-6 – reference: 12750520 - Science. 2003 May 16;300(5622):1140-2 – reference: 12591070 - Am J Gastroenterol. 2003 Feb;98(2):466-70 – reference: 20623795 - NMR Biomed. 2010 Oct;23(8):952-7 – reference: 20656836 - Radiology. 2010 Aug;256(2):466-73 – reference: 18509057 - Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7627-8 – reference: 17910026 - NMR Biomed. 2008 Jun;21(5):437-43 – reference: 16089501 - PLoS Med. 2005 Sep;2(9):e233 – reference: 21842500 - Magn Reson Med. 2012 Apr;67(4):898-905 – reference: 17334651 - Diabetologia. 2007 Apr;50(4):790-6 – reference: 14673522 - Diabetologia. 2004 Jan;47(1):23-30 – reference: 17339025 - Cell Metab. 2007 Mar;5(3):167-79 – reference: 146199 - Proc Natl Acad Sci U S A. 1977 Dec;74(12):5551-3 – reference: 14572600 - Am J Gastroenterol. 2003 Oct;98 (10 ):2335-6 – reference: 12808457 - Nat Genet. 2003 Jul;34(3):267-73 – reference: 11266382 - Gastroenterology. 2001 Apr;120(5):1183-92 – reference: 17890427 - Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2659-66 – reference: 4290225 - J Biol Chem. 1967 May 10;242(9):2278-82 – reference: 12031981 - Diabetes. 2002 Jun;51(6):1913-20 – reference: 6947247 - Proc Natl Acad Sci U S A. 1981 Nov;78(11):6714-8 – reference: 18285554 - Diabetes. 2008 May;57(5):1166-75 – reference: 20956497 - Diabetes. 2011 Jan;60(1):64-73 – reference: 21216854 - Diabetes Care. 2011 Feb;34(2):448-53 – reference: 9916137 - J Clin Invest. 1999 Jan;103(2):253-9 – reference: 15041788 - Rev Endocr Metab Disord. 2004 May;5(2):127-34 – reference: 16054085 - Cell Metab. 2005 Jun;1(6):361-70 – reference: 19056573 - Am J Clin Nutr. 2009 Jan;89(1):455S-62S – reference: 10899450 - Neuromuscul Disord. 2000 Aug;10(6):430-5 – reference: 15855325 - Diabetes. 2005 May;54(5):1392-9 – reference: 15298341 - Diabetologia. 2004 Apr;47(4):648-51 – reference: 16506960 - Eur J Clin Invest. 2006 Mar;36(3):164-9 – reference: 20427778 - N Engl J Med. 2010 May 6;362(18):1675-85 – reference: 18451994 - J Clin Invest. 2008 Jun;118(6):2132-47 – reference: 20028967 - Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E706-13 – reference: 3292322 - Diabetes. 1988 Aug;37(8):1020-4 – reference: 19821144 - J Inherit Metab Dis. 2009 Dec;32(6):684-98 – reference: 19864449 - J Clin Endocrinol Metab. 2010 Jan;95(1):422-9 – reference: 3231088 - Methods Enzymol. 1988;157:12-26 – reference: 19467914 - Int J Biochem Cell Biol. 2009 Oct;41(10):1837-45 – reference: 20978097 - Diabetes Care. 2011 Feb;34(2):430-6 |
| SSID | ssj0066474 |
| Score | 2.5354483 |
| SecondaryResourceType | review_article |
| Snippet | This Review discusses the association between mitochondrial function and insulin sensitivity in various tissues, such as skeletal muscle, liver and heart, with... Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or... |
| SourceID | proquest gale pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 92 |
| SubjectTerms | 631/443/319/333 631/80/86/2367 692/699/2743/137/773 Animals Development and progression Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Endocrinology Fatty acids Glucose Humans Hyperlipidemias - complications Hyperlipidemias - metabolism Hyperlipidemias - physiopathology Insulin resistance Insulin Resistance - physiology Medicine Medicine & Public Health Metabolism Metabolites Mitochondria Mitochondria, Muscle - physiology Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Musculoskeletal system Oxidation Oxidative Coupling Oxidative Phosphorylation Phosphorylation Physiological aspects review-article Terminology Type 2 diabetes |
| Title | The role of mitochondria in insulin resistance and type 2 diabetes mellitus |
| URI | https://link.springer.com/article/10.1038/nrendo.2011.138 https://www.ncbi.nlm.nih.gov/pubmed/21912398 https://www.proquest.com/docview/1787139328 https://www.proquest.com/docview/917578696 |
| Volume | 8 |
| WOSCitedRecordID | wos000299493600008&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1759-5037 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0066474 issn: 1759-5029 databaseCode: M7P dateStart: 20051101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1759-5037 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0066474 issn: 1759-5029 databaseCode: 7X7 dateStart: 20090401 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1759-5037 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0066474 issn: 1759-5029 databaseCode: BENPR dateStart: 20090401 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RlgMXWiiP0LL4gHgcQhM7cZwTWlArJKTVCoG0NyuJHakS65RmF4l_z4zjbHcr4MJlL5lkncx7PP4G4KWoramkSGOF4hJnwuSxkkLEdavqpE0FBuXDsIliNlOLRTkPBbc-tFWONtEbatM1VCM_S1GyMFoRXL2_-hHT1CjaXQ0jNPbggFASuG_dm4-WWMrMozCjhyzjPOHlCO0j1JmjjtNugPBM6XDKlle6bZu3nNOt3VLvhC4O_3f5R3A_hJ9sOsjLA7hj3UM4njpMvZe_2CvmG0J9pf0YPqMIMeo-ZF3Llqj5aCmdQYFll46FHnaG2TpFoCg6rHKGUUWXcTZWdNmS8D5X6_4RfLs4__rxUxxmL8RNzstVLLKMvlhSSYu8qzGsFKZt6ZyqFaLIq6KqRctzZVJpBOq8MbWs8ropqzbjBZqRx7DvOmefAlNFbSxPMJNUJcGzKcuL2pY2yYywGJBE8G789roJwOQ0H-O79hvkQumBWZqYpZFZEbzZ3HA1YHL8nfQFMVMPh0o32qynnFJ_DB9lBK89Bekz_mtThWMJuHZCxtqhPN2hRD1sdi-PnNfBDvT6hu0RsM1lupN625zt1r3GhBnNpizxCU8GOdu8FbqTlAAaI3g7Ct7Ws__8ys_-vY4TuIeUfGg8P4X91fXaPoe7zc_VZX89gb1iUfhfNYGDD-ez-ZeJ16nfnu4jgw |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgkQvFCiP0EJ94HkITew8nEOFVkDVasuKQ5H25jqxI1XqJmWTBfVP8RuZyau7FXDrgXNsx06-edie-QbgpUit0ZHwXYlwcQNhQldGQrhpLlMv9wU65W2xiXgykdNp8nUNfvW5MBRW2evERlGbMqMz8j0fkYXeiuDyw8V3l6pG0e1qX0KjhcXYXv7ELVu1f_QJ_-8rzg8-n3w8dLuqAm4W8qR2RRCEHk88HVmcVYoOkzB5ThmYVog41LFORc5DafzICESzMWmkwzRLdB7wGAUEx70Ft1GPx7TZi6fDBi-Kgob1GS1y4tI7eiohIfcKinAtW8pQn5JhlqzgdVuwZAyv3c42Ru9g83_7XPfhXudes1ErDw9gzRYPYWtU6LqcXbLXrAl4bW4StmCMIsIoupKVOZuhZkNLUBgUSHZWsC5Gn81tRR42igbThWF0Ys0460-s2Yz4TOtF9Qi-3ciyHsN6URb2KTAZp8ZyD3fKMiH6OWl5nNrEeoERFh0uB973_1plHfE61f84V00AgJCqBYcicCgEhwNvhw4XLefI35vuEnhUmzQ7aCs14nS0ge5x5MCbpgXpK3xrpru0C5w7MX-ttNxZaYl6Jlt93CNNdXquUlcwc4ANj6knxe4VtlxUKvGpZkKU4AhPWlwPq0Jz6RMBpQPveqAvjf3nJT_79zx24e7hyZdjdXw0GW_DBvbibZD9DqzX84V9DneyH_VZNX_RyC6D05tG_2_lXXrk |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLUK98CqPQKE-8DyYTew8nANCC-2KatFqhUDqzU1iR6rUTcomC-pf49cxk8eyWwG3HjjHduz4m0fsb2YAnsnUmiSUHlcIF-5LE3AVSsnTXKVu7kl0yttiE9F0qo6P49kW_OxjYYhW2evERlGbMqMz8qGHyEJvRQo1zDtaxOxg_O78G6cKUnTT2pfTaCEysRc_8Petent0gHv9XIjx4ZcPH3lXYYBngYhrLn0_cEXsJqHFGaboPEmT5xSNaaWMgiRKUpmLQBkvNBKRbUwaJkGaxUnuiwiFBce9BtsROhn-ALbfH05nn3s7EIZ-kwMa7XPM6S19YiGphgXxXcs2gahHoTFrNvGyZVgzjZfuahsTOL71P3-823Czc7zZqJWUO7Bli7uwOyqSupxfsBesocI2dwy7MEHhYcS7ZGXO5qjz0EYUBkWVnRasY--zha3I90ahYUlhGJ1lM8H6s2w2p0yn9bK6B1-vZFn3YVCUhX0ITEWpscLFf2gVU2I6ZUWU2ti6vpEWXTEH3vT7rrMuJTtVBjnTDTVAKt0CRRNQNALFgVerDudtNpK_N90nIOk2nHalx_RI0KEHOs6hAy-bFqTJ8K1Z0gVk4NwpJ9hGy72NlqiBss3HPep0pwEr_RtyDrDVY-pJrL7ClstKxx5VUwhjHOFBi_HVqtCQepSa0oHXPejXxv7zkh_9ex77cANBrz8dTSePYQc7iZZ9vweDerG0T-B69r0-rRZPO0FmcHLV8P8FASCFBA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+role+of+mitochondria+in+insulin+resistance+and+type+2+diabetes+mellitus&rft.jtitle=Nature+reviews.+Endocrinology&rft.au=Roden%2C+Michael&rft.au=Szendroedi%2C+Julia&rft.au=Phielix%2C+Esther&rft.date=2012-02-01&rft.pub=Nature+Publishing+Group&rft.issn=1759-5029&rft.volume=8&rft.issue=2&rft.spage=92&rft_id=info:doi/10.1038%2Fnrendo.2011.138&rft.externalDBID=n%2Fa&rft.externalDocID=A278881546 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1759-5029&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1759-5029&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1759-5029&client=summon |