Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

Oncogenic transcription factors such as RUNX1/ETO, which is generated by the chromosomal translocation t(8;21), subvert normal blood cell development by impairing differentiation and driving malignant self-renewal. Here, we use digital footprinting and chromatin immunoprecipitation sequencing (ChIP-...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 8; H. 6; S. 1974 - 1988
Hauptverfasser:	Ptasinska, Anetta, Assi, Salam A., Martinez-Soria, Natalia, Imperato, Maria Rosaria, Piper, Jason, Cauchy, Pierre, Pickin, Anna, James, Sally R., Hoogenkamp, Maarten, Williamson, Dan, Wu, Mengchu, Tenen, Daniel G., Ott, Sascha, Westhead, David R., Cockerill, Peter N., Heidenreich, Olaf, Bonifer, Constanze
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 25.09.2014 Cell Press Elsevier
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-alpha - metabolism Cell Line, Tumor Chromatin Immunoprecipitation Chromosome Mapping Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 8 Core Binding Factor Alpha 2 Subunit - metabolism Gene Regulatory Networks Humans Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology LIM Domain Proteins - metabolism Protein Binding Proto-Oncogene Proteins - metabolism RNA Interference RNA, Messenger - metabolism RNA, Small Interfering Sequence Analysis, RNA Trans-Activators - metabolism Translocation, Genetic
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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