Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

Background Exercise is postulated to be a promising non-pharmacological intervention for the improvement of neurodegenerative disease pathology. However, the mechanism of beneficial effects of exercise on the brain remains to be further explored. In this study, we investigated the effect of an exerc...

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Bibliographic Details
Published in:	Immunity & ageing Vol. 20; no. 1; pp. 1 - 17
Main Authors:	Han, Hao, Zhao, Yawei, Du, Junda, Wang, Sushan, Yang, Xuehan, Li, Weijie, Song, Jiayi, Zhang, Siwei, Zhang, Ziyi, Tan, Yongfei, Hatch, Grant M., Zhang, Ming, Chen, Li
Format:	Journal Article
Language:	English
Published:	London BioMed Central 17.11.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Aging Aluminum chloride Alzheimer's disease Alzheimers disease Antibodies Biomedical and Life Sciences Biomedicine Clinical Nutrition Cognitive ability Cytokines Dementia Disease Exercise Fitness training programs Genes Genotype & phenotype Geriatrics/Gerontology Histone H3 Histones Immunology Inflammation Lactate Lactates Lactic acid Lactylation Memory Metabolites Microglia Morphology Nervous system diseases Neurodegeneration Neurodegenerative diseases Neuroimmunology and Ageing Neuroinflammation Non-pharmacological intervention Phenotypes Physical training Physiology Public Health Running Sodium lactate China Neuroinflammation Exercise Lactate Alzheimers disease Lactylation Microglia
ISSN:	1742-4933, 1742-4933
Online Access:	Get full text
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