ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier

Podocytes, highly specialized epithelial cells, build the outer part of the kidney filtration barrier and withstand high mechanical forces through a complex network of cellular protrusions. Here, we show that Arp2/3-dependent actin polymerization controls actomyosin contractility and focal adhesion...

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Veröffentlicht in:	Developmental cell Jg. 47; H. 6; S. 741
Hauptverfasser:	Schell, Christoph, Sabass, Benedikt, Helmstaedter, Martin, Geist, Felix, Abed, Ahmed, Yasuda-Yamahara, Mako, Sigle, August, Maier, Jasmin I, Grahammer, Florian, Siegerist, Florian, Artelt, Nadine, Endlich, Nicole, Kerjaschki, Dontscho, Arnold, Hans-Henning, Dengjel, Jörn, Rogg, Manuel, Huber, Tobias B
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.12.2018
Schlagworte:	Actin Cytoskeleton - metabolism Actin-Related Protein 3 - metabolism Actin-Related Protein 3 - physiology Actins - metabolism Actomyosin - metabolism Animals Cell Adhesion Focal Adhesions - metabolism Glomerular Filtration Barrier - metabolism Glomerular Filtration Barrier - physiology Humans Kidney - metabolism Kidney - physiology Mice Mice, Knockout Podocytes - metabolism Podocytes - physiology Signal Transduction Wiskott-Aldrich Syndrome Protein, Neuronal - metabolism focal adhesion Arp2/3 cell process generation podocytes actomyosin kidney filtration barrier glomerular epithelial cells actin networks N-WASP
ISSN:	1878-1551, 1878-1551
Online-Zugang:	Weitere Angaben
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