The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in the PD-1 pathway exhibit impaired CD8+ T cell memory follo...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 31; H. 13; S. 107827
Hauptverfasser:	Pauken, Kristen E., Godec, Jernej, Odorizzi, Pamela M., Brown, Keturah E., Yates, Kathleen B., Ngiow, Shin Foong, Burke, Kelly P., Maleri, Seth, Grande, Shannon M., Francisco, Loise M., Ali, Mohammed-Alkhatim, Imam, Sabrina, Freeman, Gordon J., Haining, W. Nicholas, Wherry, E. John, Sharpe, Arlene H.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 30.06.2020 Elsevier
Schlagworte:	acute infection Administration, Intranasal Animals CD8+ T cell CD8-Positive T-Lymphocytes - immunology Cell Death - immunology Cell Differentiation - immunology Cell Proliferation checkpoint blockade effector Immunologic Memory influenza Influenza A Virus, H3N2 Subtype - physiology memory Mice, Inbred C57BL Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology PD-1 PD-L1 PD-L2 Programmed Cell Death 1 Receptor - metabolism Signal Transduction Species Specificity influenza checkpoint blockade memory acute infection PD-L1 PD-L2 effector PD-1 CD8+ T cell CD8(+) T cell
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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