RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer, and this amplification is associated with increased expression of both FXR1 mRNA and protein. FXR1 expression directly associates with the survival and proliferation of cancer cells. Surface sensing of trans...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 37; no. 5; p. 109934
Main Authors:	George, Jasmine, Li, Yongsheng, Kadamberi, Ishaque P., Parashar, Deepak, Tsaih, Shirng-Wern, Gupta, Prachi, Geethadevi, Anjali, Chen, Changliang, Ghosh, Chandrima, Sun, Yunguang, Mittal, Sonam, Ramchandran, Ramani, Rui, Hallgeir, Lopez-Berestein, Gabriel, Rodriguez-Aguayo, Cristian, Leone, Gustavo, Rader, Janet S., Sood, Anil K., Dey, Madhusudan, Pradeep, Sunila, Chaluvally-Raghavan, Pradeep
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 02.11.2021 Elsevier
Subjects:	3' Untranslated Regions Animals ARE AU Rich Elements Cell Line, Tumor Cell Proliferation Cell Survival cMYC CNV EIF4F eIFs Eukaryotic Initiation Factor-4F - genetics Eukaryotic Initiation Factor-4F - metabolism Female FXR1 Gene Expression Regulation, Neoplastic Humans Mice Mice, Nude mRNA circularization ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Peptide Chain Initiation, Translational Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction SUnSET translation Tumor Burden FXR1 ARE mRNA circularization ovarian cancer SUnSET translation cMYC CNV EIF4F eIFs
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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