Exosome Processing and Characterization Approaches for Research and Technology Development
Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high‐quality exosomes; however,...
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| Vydáno v: | Advanced science Ročník 9; číslo 15; s. e2103222 - n/a |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Germany
John Wiley & Sons, Inc
01.05.2022
John Wiley and Sons Inc Wiley |
| Témata: | |
| ISSN: | 2198-3844, 2198-3844 |
| On-line přístup: | Získat plný text |
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| Abstract | Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high‐quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well‐characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on‐going clinical trials.
The capability to manufacture high quality exosomes is essential for fully realizing their potential as disease biomarkers as well as therapeutic agents. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. The figure shows relative yield, purity, and throughput of different exosome isolation techniques. |
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| AbstractList | Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high-quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well-characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on-going clinical trials. Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high‐quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well‐characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on‐going clinical trials. The capability to manufacture high quality exosomes is essential for fully realizing their potential as disease biomarkers as well as therapeutic agents. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. The figure shows relative yield, purity, and throughput of different exosome isolation techniques. Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high‐quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well‐characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on‐going clinical trials. The capability to manufacture high quality exosomes is essential for fully realizing their potential as disease biomarkers as well as therapeutic agents. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. The figure shows relative yield, purity, and throughput of different exosome isolation techniques. Abstract Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high‐quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well‐characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on‐going clinical trials. Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high-quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well-characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on-going clinical trials.Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents. Crucial to realizing this potential is the ability to manufacture high-quality exosomes; however, unlike biologics such as proteins, exosomes lack standardized Good Manufacturing Practices for their processing and characterization. Furthermore, there is a lack of well-characterized reference exosome materials to aid in selection of methods for exosome isolation, purification, and analysis. This review informs exosome research and technology development by comparing exosome processing and characterization methods and recommending exosome workflows. This review also provides a detailed introduction to exosomes, including their physical and chemical properties, roles in normal biological processes and in disease progression, and summarizes some of the on-going clinical trials. |
| Author | Korpany, Katalin V. Liang, Nai‐Wen Lunde, Ruby Chau, Zoe L. Lin, Li‐Han Lin, Yi‐Hsuan Liu, Joanne K. Chen, Sheng‐You Shen, Wei‐Ting Liu, Yu‐Chung Hill, John J. Lai, James J. |
| AuthorAffiliation | 1 Department of Bioengineering University of Washington Seattle WA 98195 USA 5 Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan 2 Department of Mechanical Engineering University of Washington Seattle WA 98195 USA 4 Department of Mechanical Engineering National Taiwan University Taipei City 10617 Taiwan 6 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu 30013 Taiwan 3 Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan |
| AuthorAffiliation_xml | – name: 5 Department of Engineering and System Science National Tsing Hua University Hsinchu 30013 Taiwan – name: 6 Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu 30013 Taiwan – name: 2 Department of Mechanical Engineering University of Washington Seattle WA 98195 USA – name: 1 Department of Bioengineering University of Washington Seattle WA 98195 USA – name: 3 Department of Materials Science and Engineering National Tsing Hua University Hsinchu 30013 Taiwan – name: 4 Department of Mechanical Engineering National Taiwan University Taipei City 10617 Taiwan |
| Author_xml | – sequence: 1 givenname: James J. orcidid: 0000-0003-3437-7810 surname: Lai fullname: Lai, James J. email: jilai@uw.edu organization: University of Washington – sequence: 2 givenname: Zoe L. surname: Chau fullname: Chau, Zoe L. organization: University of Washington – sequence: 3 givenname: Sheng‐You surname: Chen fullname: Chen, Sheng‐You organization: University of Washington – sequence: 4 givenname: John J. surname: Hill fullname: Hill, John J. organization: University of Washington – sequence: 5 givenname: Katalin V. orcidid: 0000-0002-9058-8500 surname: Korpany fullname: Korpany, Katalin V. organization: University of Washington – sequence: 6 givenname: Nai‐Wen surname: Liang fullname: Liang, Nai‐Wen organization: National Tsing Hua University – sequence: 7 givenname: Li‐Han surname: Lin fullname: Lin, Li‐Han organization: National Taiwan University – sequence: 8 givenname: Yi‐Hsuan surname: Lin fullname: Lin, Yi‐Hsuan organization: National Tsing Hua University – sequence: 9 givenname: Joanne K. surname: Liu fullname: Liu, Joanne K. organization: University of Washington – sequence: 10 givenname: Yu‐Chung surname: Liu fullname: Liu, Yu‐Chung organization: National Tsing Hua University – sequence: 11 givenname: Ruby surname: Lunde fullname: Lunde, Ruby organization: University of Washington – sequence: 12 givenname: Wei‐Ting surname: Shen fullname: Shen, Wei‐Ting organization: National Tsing Hua University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35332686$$D View this record in MEDLINE/PubMed |
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| PublicationYear | 2022 |
| Publisher | John Wiley & Sons, Inc John Wiley and Sons Inc Wiley |
| Publisher_xml | – name: John Wiley & Sons, Inc – name: John Wiley and Sons Inc – name: Wiley |
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| Title | Exosome Processing and Characterization Approaches for Research and Technology Development |
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