Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia

Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized by the new onset of maternal hypertension after 20 weeks of gestation, accompanied by proteinuria, maternal organ damage, and...

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Vydáno v:Frontiers in immunology Ročník 11; s. 1864
Hlavní autoři: Aneman, Ingrid, Pienaar, Dillan, Suvakov, Sonja, Simic, Tatjana P., Garovic, Vesna D., McClements, Lana
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 18.08.2020
Témata:
early-onset preeclampsia
Female
Gestational Age
Humans
immune cells
Immunity, Innate - immunology
Immunology
inflammation
late-onset preeclampsia
Pre-Eclampsia - immunology
preeclampsia
Pregnancy
Time Factors
late-onset preeclampsia
innate immunity
inflammation
early-onset preeclampsia
pregnancy
immune cells
preeclampsia
ISSN:1664-3224, 1664-3224
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Abstract Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized by the new onset of maternal hypertension after 20 weeks of gestation, accompanied by proteinuria, maternal organ damage, and/or uteroplacental dysfunction. Preeclampsia can be subdivided into early- and late-onset phenotypes (EOPE and LOPE), diagnosed before 34 weeks or from 34 weeks of gestation, respectively. Impaired placental development in early pregnancy and subsequent growth restriction is often associated with EOPE, while LOPE is associated with maternal endothelial dysfunction. The innate immune system plays an essential role in normal progression of physiological pregnancy and fetal development. However, inappropriate or excessive activation of this system can lead to placental dysfunction or poor maternal vascular adaptation and contribute to the development of preeclampsia. This review aims to comprehensively outline the mechanisms of key innate immune cells including macrophages, neutrophils, natural killer (NK) cells, and innate B1 cells, in normal physiological pregnancy, EOPE and LOPE. The roles of the complement system, syncytiotrophoblast extracellular vesicles and mesenchymal stem cells (MSCs) are also discussed in the context of innate immune system regulation and preeclampsia. The outlined molecular mechanisms, which represent potential therapeutic targets, and associated emerging treatments, are evaluated as treatments for preeclampsia. Therefore, by addressing the current understanding of innate immunity in the pathogenesis of EOPE and LOPE, this review will contribute to the body of research that could lead to the development of better diagnosis, prevention, and treatment strategies. Importantly, it will delineate the differences in the mechanisms of the innate immune system in two different types of preeclampsia, which is necessary for a more personalized approach to the monitoring and treatment of affected women.
AbstractList Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized by the new onset of maternal hypertension after 20 weeks of gestation, accompanied by proteinuria, maternal organ damage, and/or uteroplacental dysfunction. Preeclampsia can be subdivided into early- and late-onset phenotypes (EOPE and LOPE), diagnosed before 34 weeks or from 34 weeks of gestation, respectively. Impaired placental development in early pregnancy and subsequent growth restriction is often associated with EOPE, while LOPE is associated with maternal endothelial dysfunction. The innate immune system plays an essential role in normal progression of physiological pregnancy and fetal development. However, inappropriate or excessive activation of this system can lead to placental dysfunction or poor maternal vascular adaptation and contribute to the development of preeclampsia. This review aims to comprehensively outline the mechanisms of key innate immune cells including macrophages, neutrophils, natural killer (NK) cells, and innate B1 cells, in normal physiological pregnancy, EOPE and LOPE. The roles of the complement system, syncytiotrophoblast extracellular vesicles and mesenchymal stem cells (MSCs) are also discussed in the context of innate immune system regulation and preeclampsia. The outlined molecular mechanisms, which represent potential therapeutic targets, and associated emerging treatments, are evaluated as treatments for preeclampsia. Therefore, by addressing the current understanding of innate immunity in the pathogenesis of EOPE and LOPE, this review will contribute to the body of research that could lead to the development of better diagnosis, prevention, and treatment strategies. Importantly, it will delineate the differences in the mechanisms of the innate immune system in two different types of preeclampsia, which is necessary for a more personalized approach to the monitoring and treatment of affected women.Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized by the new onset of maternal hypertension after 20 weeks of gestation, accompanied by proteinuria, maternal organ damage, and/or uteroplacental dysfunction. Preeclampsia can be subdivided into early- and late-onset phenotypes (EOPE and LOPE), diagnosed before 34 weeks or from 34 weeks of gestation, respectively. Impaired placental development in early pregnancy and subsequent growth restriction is often associated with EOPE, while LOPE is associated with maternal endothelial dysfunction. The innate immune system plays an essential role in normal progression of physiological pregnancy and fetal development. However, inappropriate or excessive activation of this system can lead to placental dysfunction or poor maternal vascular adaptation and contribute to the development of preeclampsia. This review aims to comprehensively outline the mechanisms of key innate immune cells including macrophages, neutrophils, natural killer (NK) cells, and innate B1 cells, in normal physiological pregnancy, EOPE and LOPE. The roles of the complement system, syncytiotrophoblast extracellular vesicles and mesenchymal stem cells (MSCs) are also discussed in the context of innate immune system regulation and preeclampsia. The outlined molecular mechanisms, which represent potential therapeutic targets, and associated emerging treatments, are evaluated as treatments for preeclampsia. Therefore, by addressing the current understanding of innate immunity in the pathogenesis of EOPE and LOPE, this review will contribute to the body of research that could lead to the development of better diagnosis, prevention, and treatment strategies. Importantly, it will delineate the differences in the mechanisms of the innate immune system in two different types of preeclampsia, which is necessary for a more personalized approach to the monitoring and treatment of affected women.
Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying multifactorial pathogeneses; however, its etiology is not fully understood. It is characterized by the new onset of maternal hypertension after 20 weeks of gestation, accompanied by proteinuria, maternal organ damage, and/or uteroplacental dysfunction. Preeclampsia can be subdivided into early- and late-onset phenotypes (EOPE and LOPE), diagnosed before 34 weeks or from 34 weeks of gestation, respectively. Impaired placental development in early pregnancy and subsequent growth restriction is often associated with EOPE, while LOPE is associated with maternal endothelial dysfunction. The innate immune system plays an essential role in normal progression of physiological pregnancy and fetal development. However, inappropriate or excessive activation of this system can lead to placental dysfunction or poor maternal vascular adaptation and contribute to the development of preeclampsia. This review aims to comprehensively outline the mechanisms of key innate immune cells including macrophages, neutrophils, natural killer (NK) cells, and innate B1 cells, in normal physiological pregnancy, EOPE and LOPE. The roles of the complement system, syncytiotrophoblast extracellular vesicles and mesenchymal stem cells (MSCs) are also discussed in the context of innate immune system regulation and preeclampsia. The outlined molecular mechanisms, which represent potential therapeutic targets, and associated emerging treatments, are evaluated as treatments for preeclampsia. Therefore, by addressing the current understanding of innate immunity in the pathogenesis of EOPE and LOPE, this review will contribute to the body of research that could lead to the development of better diagnosis, prevention, and treatment strategies. Importantly, it will delineate the differences in the mechanisms of the innate immune system in two different types of preeclampsia, which is necessary for a more personalized approach to the monitoring and treatment of affected women.
Author Suvakov, Sonja
Simic, Tatjana P.
Aneman, Ingrid
Garovic, Vesna D.
Pienaar, Dillan
McClements, Lana
AuthorAffiliation 3 Faculty of Medicine, Institute of Medical and Clinical Biochemistry, University of Belgrade , Belgrade , Serbia
2 Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic , Rochester, MN , United States
1 Faculty of Science, School of Life Sciences, University of Technology Sydney , Sydney, NSW , Australia
4 Department of Medical Sciences, Serbian Academy of Sciences and Arts , Belgrade , Serbia
AuthorAffiliation_xml – name: 4 Department of Medical Sciences, Serbian Academy of Sciences and Arts , Belgrade , Serbia
– name: 2 Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic , Rochester, MN , United States
– name: 1 Faculty of Science, School of Life Sciences, University of Technology Sydney , Sydney, NSW , Australia
– name: 3 Faculty of Medicine, Institute of Medical and Clinical Biochemistry, University of Belgrade , Belgrade , Serbia
Author_xml – sequence: 1
  givenname: Ingrid
  surname: Aneman
  fullname: Aneman, Ingrid
– sequence: 2
  givenname: Dillan
  surname: Pienaar
  fullname: Pienaar, Dillan
– sequence: 3
  givenname: Sonja
  surname: Suvakov
  fullname: Suvakov, Sonja
– sequence: 4
  givenname: Tatjana P.
  surname: Simic
  fullname: Simic, Tatjana P.
– sequence: 5
  givenname: Vesna D.
  surname: Garovic
  fullname: Garovic, Vesna D.
– sequence: 6
  givenname: Lana
  surname: McClements
  fullname: McClements, Lana
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33013837$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1111/j.1600-0897.2010.00852.x
10.1016/j.jri.2016.08.008
10.1016/j.placenta.2018.04.012
10.3791/54204
10.1161/HYPERTENSIONAHA.112.191817
10.1161/01.hyp.5.1.105
10.4049/jimmunol.1001374
10.1161/HYPERTENSIONAHA.109.140061
10.1111/sji.12651
10.1080/09513590.2018.1441401
10.1164/rccm.201701-0170OC
10.3389/fimmu.2018.03142
10.1016/j.jaci.2011.06.051
10.1007/s11906-020-1034-8
10.3389/fimmu.2014.00312
10.1016/j.ejogrb.2012.08.003
10.1093/rheumatology/ken168
10.1007/s10517-019-04383-6
10.1093/aje/kwr168
10.1111/bph.14466
10.1016/j.placenta.2004.12.012
10.1080/10641950801958067
10.1080/14767050500361703
10.1161/HYPERTENSIONAHA.117.10510
10.1080/10641955.2019.1640725
10.1016/j.ejogrb.2013.05.005
10.1002/eji.200737296
10.12659/MSM.915777
10.1016/j.preghy.2013.04.005
10.3390/ijms19061689
10.1016/s1471-4906(01)02154-8
10.3892/mmr.2017.6921
10.1016/j.preghy.2019.11.011
10.2174/1389201019666180427110547
10.4049/jimmunol.0900788
10.1161/HYPERTENSIONAHA.111.188276
10.1073/pnas.1611944114
10.1080/14767058.2020.1740675
10.5582/ddt.2019.01006
10.1155/2012/307189
10.1080/19336918.2016.1148866
10.1016/j.clim.2011.07.008
10.1016/j.ajog.2015.08.003
10.1177/1933719114557899
10.1007/s00125-018-4705-0
10.1016/j.tibtech.2020.01.003
10.1038/srep42397
10.3109/10641963.2013.863324
10.1007/s12016-016-8596-x
10.1186/1472-6882-14-89
10.1016/j.ijgo.2012.07.010
10.1182/bloodadvances.2018020644
10.1007/s11906-015-0595-4
10.1080/09513590.2019.1706085
10.1016/j.vph.2017.11.006
10.1161/HYPERTENSIONAHA.111.172114
10.3390/ijms20153695
10.1016/j.humpath.2003.08.027
10.1111/j.1600-0897.2012.01115.x
10.1002/ijgo.12701
10.4049/jimmunol.168.2.554
10.4049/jimmunol.173.7.4286
10.1007/s00011-016-0968-4
10.1111/j.1447-0756.2004.00209.x
10.1038/nm.1905
10.1080/13543776.2016.1185415
10.1016/j.genm.2012.03.001
10.1159/000009973
10.1111/cei.12001
10.1002/pds.4213
10.1002/0471142735.im1412s109
10.4103/0973-7847.79105
10.1111/dme.13523
10.2353/ajpath.2010.091247
10.1097/AOG.0000000000002980
10.1111/j.1600-0897.2007.00486.x
10.1016/j.placenta.2004.11.007
10.1111/aji.12477
10.1111/j.1600-0897.2006.00429.x
10.1111/j.1471-0528.2002.t01-1-01009.x
10.1007/s11906-017-0786-2
10.1111/aogs.13540
10.1007/s10620-011-1653-7
10.1016/j.it.2011.06.013
10.1016/j.phrs.2017.03.015
10.1016/j.preghy.2020.03.011.263-5
10.1371/journal.pone.0191040
10.1016/j.placenta.2017.03.001
10.1387/ijdb.140054ae
10.1034/j.1600-0897.2002.01133.x
10.3389/fphys.2013.00159
10.3389/fimmu.2019.00792
10.1016/j.fertnstert.2008.09.061
10.1016/j.cyto.2017.07.018
10.1007/s12015-013-9455-2
10.1152/ajpheart.00328.2013
10.3109/10641955.2014.944709
10.1155/2015/263109
10.1016/j.trim.2016.04.008
10.1016/j.preghy.2016.01.005
10.1186/s12906-016-1079-z
10.5603/GP.2016.0021
10.3389/fimmu.2019.03098
10.1081/PRG-120021060
10.1136/bmj.l2381
10.1038/srep13938
10.1016/j.intimp.2019.02.050
10.1016/j.placenta.2010.10.011
10.1053/plac.2001.0624
10.1016/0165-0378(94)00907-o
10.1016/j.placenta.2016.12.003
10.4049/jimmunol.136.12.4480
10.1161/HYPERTENSIONAHA.110.163329
10.1038/ajh.2009.185
10.1097/ANC.0000000000000218
10.1111/aji.12541
10.1016/j.ajog.2005.12.049
10.1111/j.1365-2249.2011.04330.x
10.1016/j.placenta.2017.06.004
10.1016/j.ajog.2017.11.561
10.12688/f1000research.17535.1
10.1016/S0049-3848(17)30067-1
10.1189/jlb.0406250
10.1177/1535370217697386
10.1210/clinem/dgaa403.
10.1530/REP-14-0614
10.1080/14767058.2017.1410701
10.1080/10641955.2016.1237644
10.1371/journal.pone.0020245
10.4103/1110-2098.192433
10.1152/ajpheart.00469.2019
10.1182/blood-2004-04-1559
10.1007/s00404-005-0093-z
10.1371/journal.pone.0147186
10.1111/j.1600-0897.2010.00836.x
10.4103/ijmr.IJMR_776_15
10.1093/humupd/6.1.28
10.1016/S0140-6736(15)00070-7
10.1016/S1472-6483(10)60430-0
10.3390/vaccines5040034
10.3109/14767058.2011.648233
10.1093/oxfordjournals.humrep.a137430
10.1007/s00005-019-00552-7
10.1111/aji.12647
10.1155/2018/3057624
10.1093/cid/ciu709
10.1530/REP-09-0007
10.1016/j.ajpath.2015.12.021
10.1371/journal.pone.0026313
10.1111/aji.12079
10.1634/stemcells.2004-0359
10.3389/fimmu.2017.00809
10.4274/tjod.galenos.2019.93708
10.1371/journal.pone.0226969
10.1161/HYPERTENSIONAHA.117.10803
10.1016/j.placenta.2013.12.008
10.1002/14651858.CD003106.pub3
10.1093/cvr/cvy304
10.1016/j.ajpath.2010.10.011
10.1042/CS20171008
10.3389/fimmu.2014.00298
10.1007/s10875-010-9396-3
10.1038/s41598-017-06178-z
10.1111/aji.12000
10.1136/bmj.39335.385301.BE
10.1016/j.febslet.2010.06.006
10.1186/s12967-019-1999-8
10.4049/jimmunol.175.12.8096
10.4049/jimmunol.1101498
10.1093/humrep/dev067
10.1095/biolreprod.113.113266
10.1016/j.immuni.2019.03.020
10.1080/01443615.2019.1706160
10.1016/j.jri.2009.10.003
10.1093/jn/133.5.1668S
10.1126/science.1092385
10.1152/ajpregu.00514.2016
10.1371/journal.pone.0041884
10.1002/jcb.22453
10.1016/j.jri.2012.01.008
10.1016/j.ogc.2016.07.004
10.1016/j.molimm.2010.01.021
10.3389/fphys.2019.01236
10.1152/ajpregu.00712.2009
10.1371/journal.pone.0132063
10.1016/j.biopha.2017.08.077
10.1016/j.jep.2014.09.049
10.1111/j.1600-0897.2004.00156.x
10.1016/j.jri.2019.07.004
10.1016/j.jep.2011.08.026
10.1042/CS20150555
10.1016/j.arcmed.2011.08.003
10.1186/s13293-019-0
10.3389/fphys.2017.00508
10.1046/j.1365-2567.2002.01491.x
10.1189/jlb.1112603
10.1146/annurev.immunol.21.120601.141126
10.1080/14767050802034545
10.1155/2019/7918631
10.1161/HYPERTENSIONAHA.110.167569
10.1161/HYPERTENSIONAHA.119.12707
10.1053/j.semperi.2009.02.010
10.1016/j.jri.2011.04.006
10.3389/fimmu.2012.00362
10.3233/SHTI190372
10.1152/ajpheart.00132.2019
10.1016/j.tjog.2014.03.006
10.1016/j.imlet.2017.05.006
10.1093/eurheartj/ehv142
10.2215/CJN.12081115
10.1071/RD15143
10.1007/s11906-016-0678-x
10.1371/journal.pone.0089006
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Keywords late-onset preeclampsia
innate immunity
inflammation
early-onset preeclampsia
pregnancy
immune cells
preeclampsia
Language English
License Copyright © 2020 Aneman, Pienaar, Suvakov, Simic, Garovic and McClements.
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Reviewed by: Sandy Davidge, University of Alberta, Canada; Piyali Chatterjee, Central Texas Veterans Health Care System, United States
Edited by: Sherry Fleming, Kansas State University, United States
This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
These authors have contributed equally to this work
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References Zhang (B56) 2017; 77
Chatterjee (B123) 2011; 58
Aggarwal (B175) 2005; 105
Hashemi (B50) 2017; 95
Pedersen (B176) 1983; 5
Tronnes (B211) 2017; 26
Saito (B131) 2010; 63
Gogoi (B6) 2019; 144
Jena (B80) 2019; 67
Lampe (B88) 2017; 36
Lamarca (B133) 2012; 9
Liu (B200) 2018; 61
Orgul (B26) 2019; 16
Zarember (B111) 2002; 168
Du (B108) 2020
B206
Németh (B179) 2009; 15
Pelzer (B187) 2017; 54
Roth (B193) 2018; 2
Young (B213) 2017; 242
Jin (B178) 2019; 17
Talukdar (B143) 2018; 102
Bavishi (B184) 2015; 36
Pareek (B207) 2011; 5
Von Dadelszen (B21) 2003; 22
Serin (B96) 2016; 6
Ann-Charlotte (B115) 2013; 3
Lash (B103) 2006; 80
Roberge (B19) 2018; 218
He (B151) 2016; 76
Han (B68) 2019; 10
Kennedy (B181) 2016; 16
Flint (B160) 2019; 98
Bulmer (B100) 1991; 6
Holmlund (B110) 2002; 107
Pelekanos (B165) 2016; 112
Nguyen (B59) 2013; 171
Abrahams (B38) 2004; 51
Huppertz (B23) 2018; 19
Brinkmann (B92) 2004; 303
Patra (B194) 2016; 26
Smith (B195) 2011; 56
Bürk (B79) 2001; 22
Suvakov (B167) 2019; 10
Abumaree (B177) 2013; 9
Morrison (B210) 2017; 196
Huang (B164) 2010; 109
Bhat (B129) 1995; 28
Wang (B128) 2015; 149
Cadden (B83) 2008; 27
Suvakov (B70) 2020; 22
Lokki (B147) 2014; 5
Siddiqui (B137) 2010; 55
Lopez-Campos (B32) 2019; 264
Bonney (B34) 2016; 43
Jia (B150) 2019; 25
Owen (B36) 2013; 4
Göhner (B67) 2017; 60
Abrahams (B113) 2005; 175
Beckers (B188) 2020; 318
Lanier (B101) 1986; 136
Mannaerts (B95) 2017; 313
Sotiropoulou (B172) 2006; 24
Abalos (B11) 2013; 170
Laskarin (B102) 2002; 48
Zuurbier (B209) 2019; 115
Vacca (B52) 2011; 32
Yao (B82) 2019; 10
Gezer (B5) 2016; 87
Lan (B203) 2015; 161
Bachmayer (B107) 2006; 56
Gill (B183) 2019; 73
Nadkarni (B48) 2016; 113
Huang (B55) 2010; 177
Sharma (B75) 2007; 58
Abais-Battad (B199) 2017; 120
Stock (B180) 2019; 8
Robinson (B134) 2006; 195
Fuchisawa (B90) 2004; 30
Mor (B33) 2010; 63
Bellamy (B30) 2007; 335
Brown (B1) 2018; 72
O'Mahony (B46) 2011; 128
Alqudah (B20) 2018; 35
Williams (B106) 2009; 138
Ayenehdeh (B166) 2017; 188
Del Rio (B43) 2012; 188
Lim (B146) 2012; 165
Suvakov (B31) 2020; 20
Faas (B40) 2018; 69
Chatterjee (B144) 2017; 131
Nakashima (B169) 2012; 67
He (B127) 2018; 71
Derzsy (B63) 2010; 47
Vishnyakova (B182) 2019; 20
Michelo (B173) 2016; 37
Cant (B196) 2017; 8
Ernst (B208) 2002; 109
Banadakoppa (B149) 2015; 2015
Sun (B51) 2016; 11
Li (B78) 2016; 186
Chaiworapongsa (B119) 2005; 18
Pineda (B125) 2011; 42
Wang (B57) 2014; 7
Denny (B62) 2013; 69
Gupta (B3) 2006; 273
Goswami (B154) 2006; 27
Gao (B214) 2017; 8
Tskhay (B18) 2019; 36
O'Brien (B161) 2017; 7
Giaglis (B94) 2016; 10
Oylumlu (B4) 2014; 36
Eledel (B130) 2016; 29
Gupta (B93) 2010; 584
Panwar (B97) 2019; 13
Faas (B37) 2017; 56
Gardiner (B157) 2011; 6
Nizyaeva (B121) 2019; 166
Faas (B41) 2014; 5
Takeda (B117) 2015; 109
Dragovic (B156) 2013; 89
Woidacki (B44) 2015; 5
Kumazaki (B112) 2004; 35
Panda (B126) 2012; 94
Romero (B118) 2003; 133
Laule (B140) 2019; 317
Phipps (B29) 2016; 11
Fan (B142) 2011; 141
Yonekura Collier (B159) 2019; 38
Harris (B174) 2002; 23
Della Bella (B54) 2011; 164
Myatt (B215) 2015; 17
Tannetta (B66) 2017; 119
Gibson (B104) 2015; 30
Schonkeren (B42) 2011; 178
Familari (B65) 2017; 29
Wang (B163) 2018; 2018
Croxatto (B170) 2014; 9
Nancy (B98) 2014; 58
Burwick (B148) 2018; 132
Churchill (B14) 2018; 10
Li (B76) 2018; 9
Kucur (B81) 2014; 33
Alijotas-Reig (B85) 2017; 53
Binder (B139) 2010; 30
Fu (B171) 2017; 16
Beijar (B122) 2006; 27
Brantsaeter (B186) 2011; 174
Szewczyk (B45) 2012; 2012
Konecna (B91) 2018; 87
Al-khafaji (B35) 2017
Chu (B205) 2014; 14
Wang (B136) 2012; 60
Mannaerts (B16) 2019; 32
Dunlop (B185) 2015; 15
Burton (B2) 2019; 366
LaMarca (B138) 2011; 57
Mol (B9) 2016; 387
Bouter (B22) 2020; 19
Milosevic-Stevanovic (B77) 2016; 144
McNally (B7) 2017; 19
Caputi (B198) 2018; 19
Chatterjee (B124) 2012; 7
Lai (B190) 2011; 57
Lurie (B86) 1998; 45
Hahn (B89) 2012; 3
Kusuma (B71) 2017; 7
Sheffield (B212) 2014; 59
Regal (B87) 2015; 10
Chatterjee (B162) 2016; 130
Wang (B105) 2009; 18
Pierik (B8) 2019; 10
Moldenhauer (B53) 2010; 185
Shukla (B84) 2015; 22
King (B99) 2000; 6
Wu (B145) 2016; 65
Xie (B204) 2019; 2019
Schindler (B13) 2018; 34
McCarthy (B116) 2014; 306
Staff (B24) 2019; 5
Muzzio (B58) 2013; 69
Wang (B73) 2019; 70
Duley (B12) 2009; 33
Gardiner (B25) 2017; 151
Zhong (B132) 2007; 37
Cemgil Arikan (B47) 2012; 25
Dimitrov (B168) 2010; 93
Heil (B15) 2019; 14
Todd (B28) 2020
Sato (B17) 2020
Jensen (B60) 2012; 59
Southcombe (B64) 2011; 6
Cornelius (B61) 2019; 176
Chen (B153) 2012; 119
Mihu (B10) 2015; 54
Takeda (B109) 2003; 21
Redman (B158) 2015; 213
Guller (B152) 2011; 32
Abrahams (B114) 2004; 173
Tinsley (B120) 2009; 22
Thaxton (B201) 2009; 183
Miller (B216) 2020; 38
Tinsley (B191) 2010; 298
Ning (B39) 2016; 75
Kaminska (B69) 2018; 101
Fukui (B49) 2011; 90
Erez (B135) 2008; 21
Kuzmich (B202) 2017; 5
Sun (B197) 2011; 137
Wheeler (B72) 2018; 13
Fox (B141) 2010; 84
Ostensen (B192) 2008; 47
Gilani (B155) 2016; 18
Laresgoiti-Servitje (B74) 2013; 94
Redman (B27) 2014; 35
Ouyang (B189) 2019; 50
References_xml – volume: 63
  start-page: 601
  year: 2010
  ident: B131
  article-title: Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/j.1600-0897.2010.00852.x
– volume: 119
  start-page: 98
  year: 2017
  ident: B66
  article-title: Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia
  publication-title: J Reprod Immunol.
  doi: 10.1016/j.jri.2016.08.008
– volume: 69
  start-page: 125
  year: 2018
  ident: B40
  article-title: Innate immune cells in the placental bed in healthy pregnancy and preeclampsia
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2018.04.012
– volume: 112
  start-page: e54204
  year: 2016
  ident: B165
  article-title: Isolation and expansion of mesenchymal stem/stromal cells derived from human placenta tissue
  publication-title: JoVE.
  doi: 10.3791/54204
– volume: 60
  start-page: 712
  year: 2012
  ident: B136
  article-title: Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.112.191817
– volume: 5
  start-page: 105
  year: 1983
  ident: B176
  article-title: Preeclampsia – a state of prostaglandin deficiency? Urinary prostaglandin excretion, the renin-aldosterone system, and circulating catecholamines in preeclampsia
  publication-title: Hypertension.
  doi: 10.1161/01.hyp.5.1.105
– volume: 185
  start-page: 7085
  year: 2010
  ident: B53
  article-title: GM-CSF is an essential regulator of T cell activation competence in uterine dendritic cells during early pregnancy in mice
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.1001374
– volume: 55
  start-page: 386
  year: 2010
  ident: B137
  article-title: Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.109.140061
– volume: 87
  start-page: e12651
  year: 2018
  ident: B91
  article-title: Immune activation by nucleic acids: a role in pregnancy complications
  publication-title: Scand J Immunol.
  doi: 10.1111/sji.12651
– volume: 34
  start-page: 636
  year: 2018
  ident: B13
  article-title: New data about preeclampsia: some possibilities of prevention
  publication-title: Gynecol Endocrinol.
  doi: 10.1080/09513590.2018.1441401
– volume: 196
  start-page: 1275
  year: 2017
  ident: B210
  article-title: Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer
  publication-title: Am J Respir Crit Care Med.
  doi: 10.1164/rccm.201701-0170OC
– volume: 9
  start-page: 3142
  year: 2018
  ident: B76
  article-title: Galectin-9 alleviates LPS-induced preeclampsia-like impairment in rats via switching decidual macrophage polarization to M2 subtype
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2018.03142
– volume: 128
  start-page: 1153
  year: 2011
  ident: B46
  article-title: Regulation of the immune response and inflammation by histamine and histamine receptors
  publication-title: J Allergy Clin Immunol.
  doi: 10.1016/j.jaci.2011.06.051
– volume: 22
  start-page: 37
  year: 2020
  ident: B70
  article-title: Emerging therapeutic potential of mesenchymal stem/stromal cells in preeclampsia
  publication-title: Curr Hypertens Rep.
  doi: 10.1007/s11906-020-1034-8
– volume: 5
  start-page: 312
  year: 2014
  ident: B147
  article-title: Complement activation and regulation in preeclamptic placenta
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2014.00312
– volume: 165
  start-page: 194
  year: 2012
  ident: B146
  article-title: Decreased expression of complement 3a receptor (C3aR) in human placentas from severe preeclamptic pregnancies
  publication-title: Eur J Obstetr Gynecol Reprod Biol.
  doi: 10.1016/j.ejogrb.2012.08.003
– volume: 47
  start-page: iii28
  year: 2008
  ident: B192
  article-title: Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs
  publication-title: Rheumatology.
  doi: 10.1093/rheumatology/ken168
– volume: 166
  start-page: 507
  year: 2019
  ident: B121
  article-title: Peculiarities of the expression of TLR4 and inhibitor of TLR-cascade tollip in the placenta in early and late-onset preeclampsia
  publication-title: Bull Exp Biol Med.
  doi: 10.1007/s10517-019-04383-6
– volume: 174
  start-page: 807
  year: 2011
  ident: B186
  article-title: Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian Mother and Child Cohort Study
  publication-title: Am J Epidemiol.
  doi: 10.1093/aje/kwr168
– volume: 176
  start-page: 1914
  year: 2019
  ident: B61
  article-title: Inflammatory mediators: a causal link to hypertension during preeclampsia
  publication-title: Br J Pharmacol.
  doi: 10.1111/bph.14466
– volume: 27
  start-page: 322
  year: 2006
  ident: B122
  article-title: Expression and subcellular localization of TLR-4 in term and first trimester human placenta
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2004.12.012
– volume: 27
  start-page: 396
  year: 2008
  ident: B83
  article-title: Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia
  publication-title: Hypertens Pregnancy.
  doi: 10.1080/10641950801958067
– volume: 18
  start-page: 405
  year: 2005
  ident: B119
  article-title: Macrophage migration inhibitory factor in patients with preterm parturition and microbial invasion of the amniotic cavity
  publication-title: J Matern Fetal Neonatal Med.
  doi: 10.1080/14767050500361703
– volume: 71
  start-page: 671
  year: 2018
  ident: B127
  article-title: TLR9 (Toll-Like Receptor 9) agonist suppresses angiogenesis by differentially regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in preeclampsia
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.117.10510
– volume: 38
  start-page: 193
  year: 2019
  ident: B159
  article-title: Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia
  publication-title: Hypertens Pregnancy.
  doi: 10.1080/10641955.2019.1640725
– volume: 170
  start-page: 1
  year: 2013
  ident: B11
  article-title: Global and regional estimates of preeclampsia and eclampsia: a systematic review
  publication-title: Eur J Obstet Gynecol Reprod Biol.
  doi: 10.1016/j.ejogrb.2013.05.005
– volume: 37
  start-page: 2400
  year: 2007
  ident: B132
  article-title: Reciprocal generation of Th1/Th17 and Treg cells by B1 and B2 B cells
  publication-title: Eur J Immunol.
  doi: 10.1002/eji.200737296
– volume: 25
  start-page: 7087
  year: 2019
  ident: B150
  article-title: Serum levels of complement factors C1q, Bb, and H in normal pregnancy and severe pre-eclampsia
  publication-title: Med Sci Monit.
  doi: 10.12659/MSM.915777
– volume: 3
  start-page: 58
  year: 2013
  ident: B115
  article-title: Inflammatory mechanisms in preeclampsia
  publication-title: Pregnancy Hypertens.
  doi: 10.1016/j.preghy.2013.04.005
– volume: 19
  start-page: 1689
  year: 2018
  ident: B198
  article-title: Microbiome-gut-brain axis and toll-like receptors in Parkinson's Disease
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms19061689
– volume: 23
  start-page: 144
  year: 2002
  ident: B174
  article-title: Prostaglandins as modulators of immunity
  publication-title: Trends Immunol.
  doi: 10.1016/s1471-4906(01)02154-8
– volume: 16
  start-page: 2791
  year: 2017
  ident: B171
  article-title: Human decidua mesenchymal stem cells regulate decidual natural killer cell function via interactions between collagen and leukocyte associated immunoglobulin like receptor 1
  publication-title: Mol Med Rep.
  doi: 10.3892/mmr.2017.6921
– start-page: p. 020012
  volume-title: AIP Conference Proceedings
  year: 2017
  ident: B35
  article-title: Localization and counting of CD68-labelled macrophages in placentas of normal and preeclamptic women
– volume: 19
  start-page: 206
  year: 2020
  ident: B22
  article-title: Evaluation of the clinical impact of the revised ISSHP and ACOG definitions on preeclampsia
  publication-title: Pregnancy Hypertens.
  doi: 10.1016/j.preghy.2019.11.011
– volume: 19
  start-page: 771
  year: 2018
  ident: B23
  article-title: The critical role of abnormal trophoblast development in the etiology of preeclampsia
  publication-title: Curr Pharm Biotechnol.
  doi: 10.2174/1389201019666180427110547
– volume: 183
  start-page: 1144
  year: 2009
  ident: B201
  article-title: TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.0900788
– volume: 59
  start-page: 861
  year: 2012
  ident: B60
  article-title: CD19+ CD5+ cells as indicators of preeclampsia
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.111.188276
– volume: 113
  start-page: E8415
  year: 2016
  ident: B48
  article-title: Neutrophilsinduce proangiogenic T cells with aregulatory phenotype in pregnancy
  publication-title: Proc Natl Acad Sci USA.
  doi: 10.1073/pnas.1611944114
– start-page: 1
  year: 2020
  ident: B108
  article-title: Natural killer cells in the pathogenesis of preeclampsia: a double-edged sword
  publication-title: J Matern Fetal Neonatal Med.
  doi: 10.1080/14767058.2020.1740675
– volume: 13
  start-page: 34
  year: 2019
  ident: B97
  article-title: Raised neutrophil lymphocyte ratio and serum beta hCG level in early second trimester of pregnancy as predictors for development and severity of preeclampsia
  publication-title: Drug Discov Ther.
  doi: 10.5582/ddt.2019.01006
– volume: 2012
  start-page: 307189
  year: 2012
  ident: B45
  article-title: Mast cells and histamine: do they influence placental vascular network and development in preeclampsia?
  publication-title: Mediators Inflamm.
  doi: 10.1155/2012/307189
– volume: 10
  start-page: 208
  year: 2016
  ident: B94
  article-title: Neutrophil migration into the placenta: good, bad or deadly?
  publication-title: Cell Adh Migr.
  doi: 10.1080/19336918.2016.1148866
– volume: 141
  start-page: 284
  year: 2011
  ident: B142
  article-title: The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancy
  publication-title: Clin Immunol.
  doi: 10.1016/j.clim.2011.07.008
– volume: 213
  start-page: S9 e1
  year: 2015
  ident: B158
  article-title: Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity
  publication-title: Am J Obstet Gynecol.
  doi: 10.1016/j.ajog.2015.08.003
– volume: 22
  start-page: 300
  year: 2015
  ident: B84
  article-title: Neutrophil release of myeloperoxidase in systemic vasculature of obese women may put them at risk for preeclampsia
  publication-title: Reprod Sci.
  doi: 10.1177/1933719114557899
– volume: 61
  start-page: 2333
  year: 2018
  ident: B200
  article-title: Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes
  publication-title: Diabetologia.
  doi: 10.1007/s00125-018-4705-0
– volume: 38
  start-page: 857
  year: 2020
  ident: B216
  article-title: Engineering microphysiological immune system responses on chips
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2020.01.003
– volume: 7
  start-page: 42397
  year: 2017
  ident: B71
  article-title: Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists
  publication-title: Sci Rep.
  doi: 10.1038/srep42397
– volume: 36
  start-page: 503
  year: 2014
  ident: B4
  article-title: New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio
  publication-title: Clin Exp Hypertens.
  doi: 10.3109/10641963.2013.863324
– volume: 53
  start-page: 40
  year: 2017
  ident: B85
  article-title: Tumor necrosis factor-alpha and pregnancy: focus on biologics. An updated and comprehensive review
  publication-title: Clin Rev Allergy Immunol.
  doi: 10.1007/s12016-016-8596-x
– volume: 14
  start-page: 89
  year: 2014
  ident: B205
  article-title: Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor
  publication-title: BMC Complement Altern Med.
  doi: 10.1186/1472-6882-14-89
– volume: 119
  start-page: 234
  year: 2012
  ident: B153
  article-title: Syncytiotrophoblast-derived microparticle shedding in early-onset and late-onset severe pre-eclampsia
  publication-title: Int J Gynaecol Obstet.
  doi: 10.1016/j.ijgo.2012.07.010
– volume: 2
  start-page: 2176
  year: 2018
  ident: B193
  article-title: Ravulizumab (ALXN1210) in patients with paroxysmal nocturnal hemoglobinuria: results of 2 phase 1b/2 studies
  publication-title: Blood Adv.
  doi: 10.1182/bloodadvances.2018020644
– volume: 17
  start-page: 83
  year: 2015
  ident: B215
  article-title: Preeclampsia: syndrome or disease?
  publication-title: Curr Hypertens Rep.
  doi: 10.1007/s11906-015-0595-4
– volume: 36
  start-page: 698
  year: 2019
  ident: B18
  article-title: The role of progestogen supplementation (dydrogesterone) in the prevention of preeclampsia
  publication-title: Gynecol Endocrinol.
  doi: 10.1080/09513590.2019.1706085
– volume: 101
  start-page: 21
  year: 2018
  ident: B69
  article-title: Lactadherin: an unappreciated haemostasis regulator and potential therapeutic agent
  publication-title: Vasc Pharmacol.
  doi: 10.1016/j.vph.2017.11.006
– volume: 58
  start-page: 489
  year: 2011
  ident: B123
  article-title: Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.111.172114
– volume: 20
  start-page: 3695
  year: 2019
  ident: B182
  article-title: Role of the monocyte-macrophage system in normal pregnancy and preeclampsia
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms20153695
– volume: 35
  start-page: 47
  year: 2004
  ident: B112
  article-title: Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis
  publication-title: Hum Pathol.
  doi: 10.1016/j.humpath.2003.08.027
– volume: 67
  start-page: 304
  year: 2012
  ident: B169
  article-title: The balance of the immune system between T cells and NK cells in miscarriage
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/j.1600-0897.2012.01115.x
– volume: 144
  start-page: 16
  year: 2019
  ident: B6
  article-title: Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia
  publication-title: Int J Gynaecol Obstet.
  doi: 10.1002/ijgo.12701
– volume: 168
  start-page: 554
  year: 2002
  ident: B111
  article-title: Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.168.2.554
– volume: 173
  start-page: 4286
  year: 2004
  ident: B114
  article-title: Divergent trophoblast responses to bacterial products mediated by TLRs
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.173.7.4286
– volume: 65
  start-page: 837
  year: 2016
  ident: B145
  article-title: Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China
  publication-title: Inflamm Res.
  doi: 10.1007/s00011-016-0968-4
– volume: 30
  start-page: 342
  year: 2004
  ident: B90
  article-title: Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
  publication-title: J Obstet Gynaecol Res.
  doi: 10.1111/j.1447-0756.2004.00209.x
– volume: 15
  start-page: 42
  year: 2009
  ident: B179
  article-title: Bone marrow stromal cells attenuate sepsis via prostaglandin E 2–dependent reprogramming of host macrophages to increase their interleukin-10 production
  publication-title: Nat Med.
  doi: 10.1038/nm.1905
– volume: 26
  start-page: 719
  year: 2016
  ident: B194
  article-title: Recent progress in the development of Toll-like receptor (TLR) antagonists
  publication-title: Expert Opin Ther Pat.
  doi: 10.1080/13543776.2016.1185415
– volume: 9
  start-page: 139
  year: 2012
  ident: B133
  article-title: Agonistic autoantibodies to the angiotensin II type i receptor cause pathophysiologic characteristics of preeclampsia
  publication-title: Gender Med.
  doi: 10.1016/j.genm.2012.03.001
– volume: 45
  start-page: 229
  year: 1998
  ident: B86
  article-title: Comparison of the differential distribution of leukocytes in preeclampsia versus uncomplicated pregnancy
  publication-title: Gynecol Obstet Invest.
  doi: 10.1159/000009973
– volume: 171
  start-page: 124
  year: 2013
  ident: B59
  article-title: To B or not to B cells-mediate a healthy start to life
  publication-title: Clin Exp Immunol.
  doi: 10.1111/cei.12001
– volume: 26
  start-page: 802
  year: 2017
  ident: B211
  article-title: Safety profile of medication used during pregnancy: results of a multinational European study
  publication-title: Pharmacoepidemiol Drug Saf.
  doi: 10.1002/pds.4213
– volume: 109
  start-page: 14 12 11-14 12 10
  year: 2015
  ident: B117
  article-title: Toll-like receptors
  publication-title: Curr Protoc Immunol.
  doi: 10.1002/0471142735.im1412s109
– volume: 5
  start-page: 103
  year: 2011
  ident: B207
  article-title: Feverfew (Tanacetum parthenium L
  publication-title: Pharmacogn Rev.
  doi: 10.4103/0973-7847.79105
– volume: 35
  start-page: 160
  year: 2018
  ident: B20
  article-title: Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis
  publication-title: Diabet Med.
  doi: 10.1111/dme.13523
– volume: 177
  start-page: 2472
  year: 2010
  ident: B55
  article-title: The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia
  publication-title: Am J Pathol.
  doi: 10.2353/ajpath.2010.091247
– volume: 132
  start-page: 1477
  year: 2018
  ident: B148
  article-title: Terminal complement activation in preeclampsia
  publication-title: Obstet Gynecol.
  doi: 10.1097/AOG.0000000000002980
– volume: 58
  start-page: 21
  year: 2007
  ident: B75
  article-title: Leptin, IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/j.1600-0897.2007.00486.x
– volume: 27
  start-page: 56
  year: 2006
  ident: B154
  article-title: Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2004.11.007
– volume: 75
  start-page: 298
  year: 2016
  ident: B39
  article-title: The role of decidual macrophages during normal and pathological pregnancy
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/aji.12477
– volume: 56
  start-page: 292
  year: 2006
  ident: B107
  article-title: Aberrant uterine natural killer (NK)-cell expression and altered placental and serum levels of the NK-cell promoting cytokine interleukin-12 in pre-eclampsia
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/j.1600-0897.2006.00429.x
– volume: 109
  start-page: 227
  year: 2002
  ident: B208
  article-title: Herbal medicinal products during pregnancy: are they safe?
  publication-title: BJOG.
  doi: 10.1111/j.1471-0528.2002.t01-1-01009.x
– volume: 19
  start-page: 93
  year: 2017
  ident: B7
  article-title: Elucidating the pathogenesis of pre-eclampsia using in vitro models of spiral uterine artery remodelling
  publication-title: Curr Hypertens Rep.
  doi: 10.1007/s11906-017-0786-2
– volume: 98
  start-page: 700
  year: 2019
  ident: B160
  article-title: The role of angiogenic factors in the management of preeclampsia
  publication-title: Acta Obstet Gynecol Scand.
  doi: 10.1111/aogs.13540
– volume: 56
  start-page: 2088
  year: 2011
  ident: B195
  article-title: Therapy with the opioid antagonist naltrexone promotes mucosal healing in active Crohn's disease: a randomized placebo-controlled trial
  publication-title: Dig Dis Sci.
  doi: 10.1007/s10620-011-1653-7
– volume: 32
  start-page: 517
  year: 2011
  ident: B52
  article-title: Origin, phenotype and function of human natural killer cells in pregnancy
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2011.06.013
– volume: 120
  start-page: 109
  year: 2017
  ident: B199
  article-title: Novel adaptive and innate immunity targets in hypertension
  publication-title: Pharmacol Res.
  doi: 10.1016/j.phrs.2017.03.015
– volume: 20
  start-page: 131
  year: 2020
  ident: B31
  article-title: Overlapping pathogenic signallingpathways and biomarkers in preeclampsia and cardiovascular disease
  publication-title: Pregnancy Hypertens.
  doi: 10.1016/j.preghy.2020.03.011.263-5
– volume: 13
  start-page: e0191040
  year: 2018
  ident: B72
  article-title: VEGF may contribute to macrophage recruitment and M2 polarization in the decidua
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0191040
– volume: 56
  start-page: 44
  year: 2017
  ident: B37
  article-title: Uterine NK cells and macrophages in pregnancy
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2017.03.001
– volume: 58
  start-page: 189
  year: 2014
  ident: B98
  article-title: T cell behavior at the maternal-fetal interface
  publication-title: Int J Dev Biol
  doi: 10.1387/ijdb.140054ae
– volume: 48
  start-page: 201
  year: 2002
  ident: B102
  article-title: Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity
  publication-title: Am J Reprod Immunol.
  doi: 10.1034/j.1600-0897.2002.01133.x
– volume: 4
  start-page: 159
  year: 2013
  ident: B36
  article-title: Macrophages and chemokines as mediators of angiogenesis
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2013.00159
– volume: 10
  start-page: 792
  year: 2019
  ident: B82
  article-title: Macrophage polarization in physiological and pathological pregnancy
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2019.00792
– volume: 93
  start-page: 210
  year: 2010
  ident: B168
  article-title: First-trimester human decidua contains a population of mesenchymal stem cells
  publication-title: Fertil Steril.
  doi: 10.1016/j.fertnstert.2008.09.061
– volume: 102
  start-page: 117
  year: 2018
  ident: B143
  article-title: Peripheral Gamma Delta T cells secrete inflammatory cytokines in women with idiopathic recurrent pregnancy loss
  publication-title: Cytokine.
  doi: 10.1016/j.cyto.2017.07.018
– volume: 9
  start-page: 620
  year: 2013
  ident: B177
  article-title: Human placental mesenchymal stem cells (pMSCs) play a role as immune suppressive cells by shifting macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages
  publication-title: Stem Cell Rev Rep.
  doi: 10.1007/s12015-013-9455-2
– volume: 306
  start-page: H184
  year: 2014
  ident: B116
  article-title: Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension
  publication-title: Am J Physiol Heart Circ Physiol.
  doi: 10.1152/ajpheart.00328.2013
– volume: 33
  start-page: 467
  year: 2014
  ident: B81
  article-title: Maternal serum apelin and YKL-40 levels in early and late-onset pre-eclampsia
  publication-title: Hypertens Pregnancy.
  doi: 10.3109/10641955.2014.944709
– volume: 2015
  year: 2015
  ident: B149
  article-title: Complement split products in amniotic fluid in pregnancies subsequently developing early-onset preeclampsia
  publication-title: Dis Markers.
  doi: 10.1155/2015/263109
– volume: 37
  start-page: 1
  year: 2016
  ident: B173
  article-title: Added effects of dexamethasone and mesenchymal stem cells on early Natural Killer cell activation
  publication-title: Transpl Immunol.
  doi: 10.1016/j.trim.2016.04.008
– volume: 6
  start-page: 22
  year: 2016
  ident: B96
  article-title: Is neutrophil/lymphocyte ratio a useful marker to predict the severity of pre-eclampsia?
  publication-title: Pregnancy Hypertens.
  doi: 10.1016/j.preghy.2016.01.005
– volume: 16
  start-page: 102
  year: 2016
  ident: B181
  article-title: Safety classification of herbal medicines used in pregnancy in a multinational study
  publication-title: BMC Complement Altern Med.
  doi: 10.1186/s12906-016-1079-z
– volume: 87
  start-page: 431
  year: 2016
  ident: B5
  article-title: High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia
  publication-title: Ginekol Pol.
  doi: 10.5603/GP.2016.0021
– volume: 10
  start-page: 3098
  year: 2019
  ident: B8
  article-title: Dysregulation of complement activation and placental dysfunction: a potential target to treat preeclampsia?
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2019.03098
– volume: 22
  start-page: 143
  year: 2003
  ident: B21
  article-title: Subclassification of preeclampsia
  publication-title: Hypertens Pregnancy.
  doi: 10.1081/PRG-120021060
– volume: 366
  start-page: l2381
  year: 2019
  ident: B2
  article-title: Pre-eclampsia: pathophysiology and clinical implications
  publication-title: BMJ.
  doi: 10.1136/bmj.l2381
– volume: 5
  start-page: 1
  year: 2015
  ident: B44
  article-title: Transfer of regulatory T cells into abortion-prone mice promotes the expansion of uterine mast cells and normalizes early pregnancy angiogenesis
  publication-title: Sci Rep.
  doi: 10.1038/srep13938
– volume: 70
  start-page: 459
  year: 2019
  ident: B73
  article-title: M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds
  publication-title: Int Immunopharmacol.
  doi: 10.1016/j.intimp.2019.02.050
– volume: 32
  start-page: 63
  year: 2011
  ident: B152
  article-title: Protein composition of microparticles shed from human placenta during placental perfusion: Potential role in angiogenesis and fibrinolysis in preeclampsia
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2010.10.011
– volume: 22
  start-page: 309
  year: 2001
  ident: B79
  article-title: Severely reduced presence of tissue macrophages in the basal plate of pre-eclamptic placentae
  publication-title: Placenta.
  doi: 10.1053/plac.2001.0624
– volume: 28
  start-page: 53
  year: 1995
  ident: B129
  article-title: Human CD5+ B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy
  publication-title: J Reprod Immunol.
  doi: 10.1016/0165-0378(94)00907-o
– volume: 54
  start-page: 30
  year: 2017
  ident: B187
  article-title: Review: maternal health and the placental microbiome
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2016.12.003
– volume: 136
  start-page: 4480
  year: 1986
  ident: B101
  article-title: The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.136.12.4480
– volume: 57
  start-page: 505
  year: 2011
  ident: B190
  article-title: A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.110.163329
– volume: 22
  start-page: 1314
  year: 2009
  ident: B120
  article-title: Toll-like receptor 3 activation during pregnancy elicits preeclampsia-like symptoms in rats
  publication-title: Am J Hypertens.
  doi: 10.1038/ajh.2009.185
– volume: 15
  start-page: 377
  year: 2015
  ident: B185
  article-title: Maternal microbiome and pregnancy outcomes that impact infant health: a review
  publication-title: Adv Neonatal Care.
  doi: 10.1097/ANC.0000000000000218
– volume: 76
  start-page: 205
  year: 2016
  ident: B151
  article-title: Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/aji.12541
– volume: 195
  start-page: 255
  year: 2006
  ident: B134
  article-title: Evaluation of placenta growth factor and soluble Fms-like tyrosine kinase 1 receptor levels in mild and severe preeclampsia
  publication-title: Am J Obstet Gynecol.
  doi: 10.1016/j.ajog.2005.12.049
– volume: 164
  start-page: 180
  year: 2011
  ident: B54
  article-title: Incomplete activation of peripheral blood dendritic cells during healthy human pregnancy
  publication-title: Clin Exp Immunol.
  doi: 10.1111/j.1365-2249.2011.04330.x
– volume: 60
  start-page: S41
  year: 2017
  ident: B67
  article-title: Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2017.06.004
– volume: 7
  start-page: 5303
  year: 2014
  ident: B57
  article-title: Dendritic cells derived from preeclampsia patients influence Th1/Th17 cell differentiation in vitro
  publication-title: Int J Clin Exp Med.
– volume: 218
  start-page: 287
  year: 2018
  ident: B19
  article-title: Aspirin for the prevention of preterm and term preeclampsia: systematic review and meta-analysis
  publication-title: Am J Obstet Gynecol.
  doi: 10.1016/j.ajog.2017.11.561
– volume: 8
  start-page: 911
  year: 2019
  ident: B180
  article-title: Medicines in pregnancy
  publication-title: F1000Res.
  doi: 10.12688/f1000research.17535.1
– volume: 151
  start-page: S48
  year: 2017
  ident: B25
  article-title: Impact of haemostatic mechanisms on pathophysiology of preeclampsia
  publication-title: Thromb Res.
  doi: 10.1016/S0049-3848(17)30067-1
– volume: 80
  start-page: 572
  year: 2006
  ident: B103
  article-title: Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy
  publication-title: J Leukoc Biol.
  doi: 10.1189/jlb.0406250
– volume: 242
  start-page: 1690
  year: 2017
  ident: B213
  article-title: Microphysiologic systems in female reproductive biology
  publication-title: Exp Biol Med.
  doi: 10.1177/1535370217697386
– year: 2020
  ident: B28
  article-title: Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment
  publication-title: JCEM.
  doi: 10.1210/clinem/dgaa403.
– volume: 149
  start-page: 84
  year: 2015
  ident: B128
  article-title: Anakinra and etanercept prevent embryo loss in pregnant nonobese diabetic mice
  publication-title: Reproduction.
  doi: 10.1530/REP-14-0614
– volume: 32
  start-page: 1412
  year: 2019
  ident: B16
  article-title: Are neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia?
  publication-title: J Matern Fetal Neonatal Med.
  doi: 10.1080/14767058.2017.1410701
– volume: 36
  start-page: 59
  year: 2017
  ident: B88
  article-title: The effect of healthy pregnant plasma and preeclamptic plasma on the phagocytosis index of neutrophil granulocytes and monocytes of nonpregnant women
  publication-title: Hypertens Pregnancy.
  doi: 10.1080/10641955.2016.1237644
– volume: 6
  start-page: e20245
  year: 2011
  ident: B64
  article-title: The immunomodulatory role of syncytiotrophoblast microvesicles
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0020245
– volume: 29
  start-page: 319
  year: 2016
  ident: B130
  article-title: CD19+ CD5+ B-cell expansion and risk of pre-eclampsia
  publication-title: Menoufia Med J.
  doi: 10.4103/1110-2098.192433
– volume: 318
  start-page: H1
  year: 2020
  ident: B188
  article-title: Maternal microbiome and the hypertensive disorder of pregnancy, preeclampsia
  publication-title: Am J Physiol Heart Circ Physiol.
  doi: 10.1152/ajpheart.00469.2019
– volume: 105
  start-page: 1815
  year: 2005
  ident: B175
  article-title: Human mesenchymal stem cells modulate allogeneic immune cell responses
  publication-title: Blood
  doi: 10.1182/blood-2004-04-1559
– volume: 273
  start-page: 239
  year: 2006
  ident: B3
  article-title: Analysis of plasma elastase levels in early and late onset preeclampsia
  publication-title: Arch Gynecol Obstet.
  doi: 10.1007/s00404-005-0093-z
– volume: 11
  start-page: e0147186
  year: 2016
  ident: B51
  article-title: Tim-3 is upregulated in NK cells during early pregnancy and inhibits NK cytotoxicity toward trophoblast in galectin-9 dependent pathway
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0147186
– volume: 63
  start-page: 425
  year: 2010
  ident: B33
  article-title: The immune system in pregnancy: a unique complexity
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/j.1600-0897.2010.00836.x
– volume: 144
  start-page: 823
  year: 2016
  ident: B77
  article-title: Number of decidual natural killer cells & macrophages in pre-eclampsia
  publication-title: Indian J Med Res.
  doi: 10.4103/ijmr.IJMR_776_15
– volume: 6
  start-page: 28
  year: 2000
  ident: B99
  article-title: Uterine leukocytes and decidualization
  publication-title: Hum Reprod Update.
  doi: 10.1093/humupd/6.1.28
– volume: 387
  start-page: 999
  year: 2016
  ident: B9
  article-title: Pre-eclampsia
  publication-title: Lancet.
  doi: 10.1016/S0140-6736(15)00070-7
– volume: 18
  start-page: 95
  year: 2009
  ident: B105
  article-title: Improvement of fertility with adoptive CD25+ natural killer cell transfer in subfertile non-obese diabetic mice
  publication-title: Reprod Biomed Online.
  doi: 10.1016/S1472-6483(10)60430-0
– volume: 5
  start-page: 34
  year: 2017
  ident: B202
  article-title: TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis
  publication-title: Vaccines.
  doi: 10.3390/vaccines5040034
– volume: 25
  start-page: 1569
  year: 2012
  ident: B47
  article-title: Plasma IL-4, IL-8, IL-12, interferon-γ and CRP levels in pregnant women with preeclampsia, and their relation with severity of disease and fetal birth weight
  publication-title: J Matern Fetal Neonat Med.
  doi: 10.3109/14767058.2011.648233
– volume: 6
  start-page: 791
  year: 1991
  ident: B100
  article-title: Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies
  publication-title: Hum Reprod.
  doi: 10.1093/oxfordjournals.humrep.a137430
– volume: 67
  start-page: 295
  year: 2019
  ident: B80
  article-title: Role of macrophages in pregnancy and related complications
  publication-title: Arch Immunol Ther Exp.
  doi: 10.1007/s00005-019-00552-7
– volume: 77
  start-page: e12647
  year: 2017
  ident: B56
  article-title: Lnc-DC mediates the over-maturation of decidual dendritic cells and induces the increase in Th1 cells in preeclampsia
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/aji.12647
– volume: 2018
  start-page: 3057624
  year: 2018
  ident: B163
  article-title: Mesenchymal stem cell-based immunomodulation: properties and clinical application
  publication-title: Stem Cells Int.
  doi: 10.1155/2018/3057624
– volume: 59
  start-page: S437
  year: 2014
  ident: B212
  article-title: Designing drug trials: considerations for pregnant women
  publication-title: Clin Infect Dis.
  doi: 10.1093/cid/ciu709
– volume: 138
  start-page: 177
  year: 2009
  ident: B106
  article-title: Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy
  publication-title: Reproduction.
  doi: 10.1530/REP-09-0007
– volume: 186
  start-page: 1258
  year: 2016
  ident: B78
  article-title: Modulation of decidual macrophage polarization by macrophage colony-stimulating factor derived from first-trimester decidual cells: implication in preeclampsia
  publication-title: Am J Pathol.
  doi: 10.1016/j.ajpath.2015.12.021
– volume: 6
  start-page: e26313
  year: 2011
  ident: B157
  article-title: Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0026313
– volume: 69
  start-page: 408
  year: 2013
  ident: B58
  article-title: The role of B cells in pregnancy: the good and the bad
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/aji.12079
– volume: 24
  start-page: 74
  year: 2006
  ident: B172
  article-title: Interactions between human mesenchymal stem cells and natural killer cells
  publication-title: Stem Cells.
  doi: 10.1634/stemcells.2004-0359
– volume: 8
  start-page: 809
  year: 2017
  ident: B196
  article-title: Naltrexone inhibits IL-6 and TNFalpha production in human immune cell subsets following stimulation with ligands for intracellular toll-like receptors
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.00809
– volume: 16
  start-page: 112
  year: 2019
  ident: B26
  article-title: First trimester complete blood cell indices in early and late onset preeclampsia
  publication-title: Turk J Obstet Gynecol.
  doi: 10.4274/tjod.galenos.2019.93708
– volume: 14
  start-page: e0226969
  year: 2019
  ident: B15
  article-title: Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0226969
– volume: 72
  start-page: 24
  year: 2018
  ident: B1
  article-title: Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.117.10803
– volume: 35
  start-page: S20
  year: 2014
  ident: B27
  article-title: IFPA Senior Award Lecture: making sense of pre-eclampsia - two placental causes of preeclampsia?
  publication-title: Placenta.
  doi: 10.1016/j.placenta.2013.12.008
– ident: B206
– volume: 10
  start-page: CD003106
  year: 2018
  ident: B14
  article-title: Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation
  publication-title: Cochrane Database Syst Rev.
  doi: 10.1002/14651858.CD003106.pub3
– volume: 115
  start-page: 1131
  year: 2019
  ident: B209
  article-title: Innate immunity as a target for acute cardioprotection
  publication-title: Cardiovasc Res.
  doi: 10.1093/cvr/cvy304
– volume: 178
  start-page: 709
  year: 2011
  ident: B42
  article-title: Differential distribution and phenotype of decidual macrophages in preeclamptic versus control pregnancies
  publication-title: Am J Pathol.
  doi: 10.1016/j.ajpath.2010.10.011
– volume: 131
  start-page: 2047
  year: 2017
  ident: B144
  article-title: Depletion of MHC class II invariant chain peptide or γ-δ T-cells ameliorates experimental preeclampsia
  publication-title: Clin Sci.
  doi: 10.1042/CS20171008
– volume: 5
  start-page: 298
  year: 2014
  ident: B41
  article-title: Monocytes and macrophages in pregnancy and pre-eclampsia
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2014.00298
– volume: 30
  start-page: 56
  year: 2010
  ident: B139
  article-title: Natural IgM antibodies against oxidation-specific epitopes
  publication-title: J Clin Immunol
  doi: 10.1007/s10875-010-9396-3
– volume: 7
  start-page: 5887
  year: 2017
  ident: B161
  article-title: Endothelial dysfunction in severe preeclampsia is mediated by soluble factors, rather than extracellular vesicles
  publication-title: Sci Rep.
  doi: 10.1038/s41598-017-06178-z
– volume: 69
  start-page: 3
  year: 2013
  ident: B62
  article-title: Complement in pregnancy: a delicate balance
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/aji.12000
– volume: 335
  start-page: 974
  year: 2007
  ident: B30
  article-title: Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis
  publication-title: BMJ.
  doi: 10.1136/bmj.39335.385301.BE
– volume: 584
  start-page: 3193
  year: 2010
  ident: B93
  article-title: Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2010.06.006
– volume: 17
  start-page: 251
  year: 2019
  ident: B178
  article-title: Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy
  publication-title: J Transl Med.
  doi: 10.1186/s12967-019-1999-8
– volume: 175
  start-page: 8096
  year: 2005
  ident: B113
  article-title: A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.175.12.8096
– volume: 188
  start-page: 541
  year: 2012
  ident: B43
  article-title: Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system
  publication-title: J Immunol.
  doi: 10.4049/jimmunol.1101498
– volume: 30
  start-page: 1290
  year: 2015
  ident: B104
  article-title: Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2
  publication-title: Hum Reprod.
  doi: 10.1093/humrep/dev067
– volume: 89
  start-page: 151
  year: 2013
  ident: B156
  article-title: Multicolor flow cytometry and nanoparticle tracking analysis of extracellular vesicles in the plasma of normal pregnant and pre-eclamptic women
  publication-title: Biol Reprod.
  doi: 10.1095/biolreprod.113.113266
– volume: 50
  start-page: 871
  year: 2019
  ident: B189
  article-title: IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation
  publication-title: Immunity.
  doi: 10.1016/j.immuni.2019.03.020
– start-page: 1
  year: 2020
  ident: B17
  article-title: Factors contributing to favourable neonatal outcomes in early-onset severe preeclampsia
  publication-title: J Obstet Gynaecol.
  doi: 10.1080/01443615.2019.1706160
– volume: 84
  start-page: 52
  year: 2010
  ident: B141
  article-title: γδTCR+ cells of the pregnant ovine uterus express variable T cell receptors and contain granulysin
  publication-title: J Reprod Immunol.
  doi: 10.1016/j.jri.2009.10.003
– volume: 133
  start-page: 1668S
  year: 2003
  ident: B118
  article-title: Micronutrients and intrauterine infection, preterm birth and the fetal inflammatory response syndrome
  publication-title: J Nutr.
  doi: 10.1093/jn/133.5.1668S
– volume: 303
  start-page: 1532
  year: 2004
  ident: B92
  article-title: Neutrophil extracellular traps kill bacteria
  publication-title: Science.
  doi: 10.1126/science.1092385
– volume: 313
  start-page: R518
  year: 2017
  ident: B95
  article-title: Flow-mediated dilation and peripheral arterial tonometry are disturbed in preeclampsia and reflect different aspects of endothelial function
  publication-title: Am J Physiol Regul Integr Comp Physiol.
  doi: 10.1152/ajpregu.00514.2016
– volume: 7
  start-page: e41884
  year: 2012
  ident: B124
  article-title: Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and mice
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0041884
– volume: 109
  start-page: 747
  year: 2010
  ident: B164
  article-title: Differentiation of human umbilical cord Wharton's jelly-derived mesenchymal stem cells into germ-like cells in vitro
  publication-title: J Cell Biochem.
  doi: 10.1002/jcb.22453
– volume: 94
  start-page: 210
  year: 2012
  ident: B126
  article-title: Dendritic cells in the circulation of women with preeclampsia demonstrate a pro-inflammatory bias secondary to dysregulation of TLR receptors
  publication-title: J Reprod Immunol.
  doi: 10.1016/j.jri.2012.01.008
– volume: 43
  start-page: 679
  year: 2016
  ident: B34
  article-title: Immune regulation in pregnancy: a matter of perspective?
  publication-title: Obstetr Gynecol Clin.
  doi: 10.1016/j.ogc.2016.07.004
– volume: 47
  start-page: 1500
  year: 2010
  ident: B63
  article-title: Activation of the complement system in normal pregnancy and preeclampsia
  publication-title: Mol Immunol.
  doi: 10.1016/j.molimm.2010.01.021
– volume: 10
  start-page: 1236
  year: 2019
  ident: B68
  article-title: Syncytiotrophoblast-derived extracellular vesicles in pathophysiology of preeclampsia
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2019.01236
– volume: 298
  start-page: R713
  year: 2010
  ident: B191
  article-title: Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats
  publication-title: Am J Physiol Regul Integr Comp Physiol.
  doi: 10.1152/ajpregu.00712.2009
– volume: 10
  start-page: e0132063
  year: 2015
  ident: B87
  article-title: Neutrophil depletion attenuates placental ischemia-induced hypertension in the rat
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0132063
– volume: 95
  start-page: 412
  year: 2017
  ident: B50
  article-title: Natural killer T cells in Preeclampsia: an updated review
  publication-title: Biomed Pharmacother.
  doi: 10.1016/j.biopha.2017.08.077
– volume: 161
  start-page: 69
  year: 2015
  ident: B203
  article-title: Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension
  publication-title: J Ethnopharmacol.
  doi: 10.1016/j.jep.2014.09.049
– volume: 51
  start-page: 275
  year: 2004
  ident: B38
  article-title: Macrophages and apoptotic cell clearance during pregnancy
  publication-title: Am J Reprod Immunol.
  doi: 10.1111/j.1600-0897.2004.00156.x
– volume: 5
  start-page: 1
  year: 2019
  ident: B24
  article-title: The two-stage placental model of preeclampsia: an update
  publication-title: J Reprod Immunol.
  doi: 10.1016/j.jri.2019.07.004
– volume: 137
  start-page: 1498
  year: 2011
  ident: B197
  article-title: Reproductive toxicity of Rhizoma Sparganii (Sparganium stoloniferum Buch
  publication-title: J Ethnopharmacol.
  doi: 10.1016/j.jep.2011.08.026
– volume: 130
  start-page: 513
  year: 2016
  ident: B162
  article-title: Human placenta-derived stromal cells decrease inflammation, placental injury and blood pressure in hypertensive pregnant mice
  publication-title: Clin Sci.
  doi: 10.1042/CS20150555
– volume: 42
  start-page: 382
  year: 2011
  ident: B125
  article-title: Expression of toll-like receptor TLR-2, TLR-3, TLR-4 and TLR-9 is increased in placentas from patients with preeclampsia
  publication-title: Arch Med Res.
  doi: 10.1016/j.arcmed.2011.08.003
– volume: 10
  start-page: 49
  year: 2019
  ident: B167
  article-title: Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia
  publication-title: Biol Sex Differ.
  doi: 10.1186/s13293-019-0
– volume: 8
  start-page: 508
  year: 2017
  ident: B214
  article-title: Inhibition of toll-like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2017.00508
– volume: 107
  start-page: 145
  year: 2002
  ident: B110
  article-title: Expression and regulation of the pattern recognition receptors Toll-like receptor-2 and Toll-like receptor-4 in the human placenta
  publication-title: Immunology.
  doi: 10.1046/j.1365-2567.2002.01491.x
– volume: 94
  start-page: 247
  year: 2013
  ident: B74
  article-title: A leading role for the immune system in the pathophysiology of preeclampsia
  publication-title: J Leukoc Biol.
  doi: 10.1189/jlb.1112603
– volume: 21
  start-page: 335
  year: 2003
  ident: B109
  article-title: Toll-like receptors
  publication-title: Annu Rev Immunol.
  doi: 10.1146/annurev.immunol.21.120601.141126
– volume: 21
  start-page: 279
  year: 2008
  ident: B135
  article-title: The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
  publication-title: J Matern Fetal Neonatal Med.
  doi: 10.1080/14767050802034545
– volume: 2019
  start-page: 7918631
  year: 2019
  ident: B204
  article-title: The effect of berberine on reproduction and metabolism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized control trials
  publication-title: Evid Based Complement Alternat Med.
  doi: 10.1155/2019/7918631
– volume: 57
  start-page: 865
  year: 2011
  ident: B138
  article-title: Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.110.167569
– volume: 73
  start-page: 1112
  year: 2019
  ident: B183
  article-title: Placental syncytiotrophoblast-derived extracellular vesicles carry active NEP (Neprilysin) and are increased in preeclampsia
  publication-title: Hypertension.
  doi: 10.1161/HYPERTENSIONAHA.119.12707
– volume: 33
  start-page: 130
  year: 2009
  ident: B12
  article-title: The global impact of pre-eclampsia and eclampsia
  publication-title: Semin Perinatol.
  doi: 10.1053/j.semperi.2009.02.010
– volume: 90
  start-page: 105
  year: 2011
  ident: B49
  article-title: Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia
  publication-title: J Reprod Immunol.
  doi: 10.1016/j.jri.2011.04.006
– volume: 3
  start-page: 362
  year: 2012
  ident: B89
  article-title: Neutrophil NETs in reproduction: from infertility to preeclampsia and the possibility of fetal loss
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2012.00362
– volume: 264
  start-page: 988
  year: 2019
  ident: B32
  article-title: An integrative biomedical informatics approach to elucidate the similarities between pre-eclampsia and hypertension
  publication-title: Stud Health Technol Inform
  doi: 10.3233/SHTI190372
– volume: 317
  start-page: H732
  year: 2019
  ident: B140
  article-title: Role of B1 and B2 lymphocytes in placental ischemia-induced hypertension
  publication-title: Am J Physiol Heart Circ Physiol.
  doi: 10.1152/ajpheart.00132.2019
– volume: 54
  start-page: 160
  year: 2015
  ident: B10
  article-title: Evaluation of maternal systemic inflammatory response in preeclampsia
  publication-title: Taiwan J Obstet Gynecol.
  doi: 10.1016/j.tjog.2014.03.006
– volume: 188
  start-page: 21
  year: 2017
  ident: B166
  article-title: Immunomodulatory and protective effects of adipose tissue-derived mesenchymal stem cells in an allograft islet composite transplantation for experimental autoimmune type 1 diabetes
  publication-title: Immunol Lett.
  doi: 10.1016/j.imlet.2017.05.006
– volume: 36
  start-page: 1967
  year: 2015
  ident: B184
  article-title: Role of neprilysin inhibitor combinations in hypertension: insights from hypertension and heart failure trials
  publication-title: Eur Heart J.
  doi: 10.1093/eurheartj/ehv142
– volume: 11
  start-page: 1102
  year: 2016
  ident: B29
  article-title: Preeclampsia: updates in pathogenesis, definitions, and guidelines
  publication-title: Clin J Am Soc Nephrol.
  doi: 10.2215/CJN.12081115
– volume: 29
  start-page: 433
  year: 2017
  ident: B65
  article-title: Placenta-derived extracellular vesicles: their cargo and possible functions
  publication-title: Reprod Fertil Dev.
  doi: 10.1071/RD15143
– volume: 18
  start-page: 68
  year: 2016
  ident: B155
  article-title: Preeclampsia and extracellular vesicles
  publication-title: Curr Hypertens Rep.
  doi: 10.1007/s11906-016-0678-x
– volume: 9
  start-page: e89006
  year: 2014
  ident: B170
  article-title: Stromal cells from human decidua exert a strong inhibitory effect on NK cell function and dendritic cell differentiation
  publication-title: PLoS ONE.
  doi: 10.1371/journal.pone.0089006
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Snippet Preeclampsia is a complex cardiovascular disorder of pregnancy with underlying multifactorial pathogeneses; however, its etiology is not fully understood. It...
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SubjectTerms early-onset preeclampsia
Female
Gestational Age
Humans
immune cells
Immunity, Innate - immunology
Immunology
inflammation
late-onset preeclampsia
Pre-Eclampsia - immunology
preeclampsia
Pregnancy
Time Factors
Title Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia
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