Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux

Thioredoxin-interacting protein (TXNIP) expression is ubiquitous and is induced by a variety of cellular stresses, including high intracellular glucose. TXNIP is associated with activation of oxidative stress and tubulointerstitial fibrosis in diabetic nephropathy. Autophagy is a major pathway that...

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Veröffentlicht in:	Laboratory investigation Jg. 94; H. 3; S. 309 - 320
Hauptverfasser:	Huang, Chunling, Lin, Mike Z, Cheng, Delfine, Braet, Filip, Pollock, Carol A, Chen, Xin-Ming
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Elsevier Inc 01.03.2014 Nature Publishing Group US Nature Publishing Group
Schlagworte:	631/80/39 692/420 692/699/1585/2759/1419 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals autophagy Autophagy - physiology autophagy flux Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - physiology Cell Line Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology Diabetic Nephropathies - genetics Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology diabetic nephropathy Gene Knockdown Techniques Humans Kidney Tubules, Proximal - pathology Kidney Tubules, Proximal - physiopathology Laboratory Medicine Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Microtubule-Associated Proteins - metabolism original-article Oxidative Stress Pathology Phagosomes - metabolism Phagosomes - pathology renal proximal tubular cells RNA, Messenger - genetics RNA, Messenger - metabolism Sequestosome-1 Protein thioredoxin-interacting protein Thioredoxins - genetics Thioredoxins - physiology Transcription Factor TFIIH Transcription Factors - genetics Transcription Factors - metabolism thioredoxin-interacting protein autophagy renal proximal tubular cells autophagy flux diabetic nephropathy
ISSN:	0023-6837, 1530-0307, 1530-0307
Online-Zugang:	Volltext
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