South African and International Reference Values for Lung Function and its Relationship with Blood Pressure in Africans

In South Africa respiratory diseases are highly prevalent, with cardiovascular disease being a manifestation. However, international reference values for lung function are commonly used, which may not be appropriate to correctly identify reduced lung function. An inverse relationship exists between...

Full description

Saved in:
Bibliographic Details
Published in:Heart, lung & circulation Vol. 24; no. 6; pp. 573 - 582
Main Authors: van Rooyen, Yolandi, Huisman, Hugo W., Schutte, Aletta E., Eloff, Fritz C., Du Plessis, Johan L., Kruger, Annamarie, Van Rooyen, Johannes M.
Format: Journal Article
Language:English
Published: Australia Elsevier B.V 01.06.2015
Subjects:
Adult
Black or African American
Black People - statistics & numerical data
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - physiopathology
Cross-Sectional Studies
Ethnicity
Europe
Female
Forced Expiratory Volume - physiology
Humans
Hypertension
Hypertension - ethnology
Hypertension - physiopathology
Internationality
Lung function
Male
Middle Aged
Predictive Value of Tests
Reference Values
Respiratory diseases
Respiratory Function Tests
Respiratory Tract Diseases - epidemiology
Respiratory Tract Diseases - physiopathology
South Africa
Spirometry
United States
Vital Capacity - physiology
White People - statistics & numerical data
United States
South Africa
Europe
Hypertension
Cardiovascular disease
Ethnicity
Lung function
Respiratory diseases
ISSN:1443-9506, 1444-2892, 1444-2892
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In South Africa respiratory diseases are highly prevalent, with cardiovascular disease being a manifestation. However, international reference values for lung function are commonly used, which may not be appropriate to correctly identify reduced lung function. An inverse relationship exists between lung function and blood pressure (BP) but is not investigated extensively in black South Africans. We included 2010 Africans from the PURE (Prospective Urban Rural Epidemiology) study (aged > 35 years) in the North West Province. Spirometry was performed and predicted values for forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were calculated from South African, European and United States prediction equations. With the exception of the European predicted values, all other predicted mean FEV1 and FVC were above 80%. South African reference values displayed the highest percentages of the predicted values for FEV1 and FVC (87.9 and 99.7%, respectively.) BP increased from quintiles five to one for both FEV1 and FVC, (p for trend <0.001). After adjustment the differences remained (p<0.05). South African reference values yielded higher percentages of predicted FEV1 and FVC values than European and US equations suggesting that South African prediction equations may be more useful when investigating lung function in black South Africans. Elevated BP is related to reduced lung function, highlighting the importance in managing both respiratory- and cardiovascular disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1443-9506
1444-2892
1444-2892
DOI:10.1016/j.hlc.2014.12.005