CXL-1020, a Novel Nitroxyl (HNO) Prodrug, Is More Effective than Milrinone in Models of Diastolic Dysfunction—A Cardiovascular Therapeutic: An Efficacy and Safety Study in the Rat

The nitroxyl (HNO) prodrug, CXL-1020, induces vasorelaxation and improves cardiac function in canine models and patients with systolic heart failure (HF). HNO's unique mechanism of action may be applicable to a broader subset of cardiac patients. This study investigated the load-independent saf...

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Bibliographic Details

Published in:	Frontiers in physiology Vol. 8; p. 894
Main Authors:	Roof, Steve R., Ueyama, Yukie, Mazhari, Reza, Hamlin, Robert L., Hartman, J. Craig, Ziolo, Mark T., Reardon, John E., del Rio, Carlos L.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 10.11.2017
Subjects:	cardiac diastolic dysfunction cardiovascular therapeutic CXL-1020 nitroxyl Physiology cardiac diastolic dysfunction cardiovascular therapeutic nitroxyl CXL-1020
ISSN:	1664-042X, 1664-042X
Online Access:	Get full text
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