Prostate cancer heterogeneity: Discovering novel molecular targets for therapy

•Prostate cancer (PCa) shows a broad spectrum of biological and clinical behavior, which represents the epiphenomenon of an extreme genetic heterogeneity.•The AR and PI3K/Akt/mTOR signaling pathways are the two most frequently altered, representing therefore interestingly targets for therapy.•Germli...

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Bibliographic Details
Published in:	Cancer treatment reviews Vol. 54; pp. 68 - 73
Main Authors:	Ciccarese, Chiara, Massari, Francesco, Iacovelli, Roberto, Fiorentino, Michelangelo, Montironi, Rodolfo, Di Nunno, Vincenzo, Giunchi, Francesca, Brunelli, Matteo, Tortora, Giampaolo
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.03.2017
Subjects:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism BRCA CRPC DNA Repair - drug effects DNA Repair - genetics DRG Hematology, Oncology and Palliative Medicine Heterogeneity Humans Male Molecular Targeted Therapy - methods PARPi Phosphatidylinositol 3-Kinases - metabolism Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN PTEN Phosphohydrolase - genetics Receptors, Androgen - metabolism Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism Heterogeneity BRCA DRG PTEN PARPi Prostate cancer CRPC
ISSN:	0305-7372, 1532-1967, 1532-1967
Online Access:	Get full text
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