Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity. However, the physiological demands or aberrations in folding may result in an imbalance which can le...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Frontiers in molecular biosciences Jg. 6; S. 11
Hauptverfasser:	Adams, Christopher J., Kopp, Megan C., Larburu, Natacha, Nowak, Piotr R., Ali, Maruf M. U.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 12.03.2019
Schlagworte:	BiP crystal structures ER stress Hsp70 IRE1 inositol-requiring enzyme 1 Molecular Biosciences unfolded protein response (UPR) BiP ER stress Hsp70 IRE1 inositol-requiring enzyme 1 crystal structures unfolded protein response (UPR)
ISSN:	2296-889X, 2296-889X
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!