Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity. However, the physiological demands or aberrations in folding may result in an imbalance which can le...

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Bibliographic Details

Published in:	Frontiers in molecular biosciences Vol. 6; p. 11
Main Authors:	Adams, Christopher J., Kopp, Megan C., Larburu, Natacha, Nowak, Piotr R., Ali, Maruf M. U.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 12.03.2019
Subjects:	BiP crystal structures ER stress Hsp70 IRE1 inositol-requiring enzyme 1 Molecular Biosciences unfolded protein response (UPR) BiP ER stress Hsp70 IRE1 inositol-requiring enzyme 1 crystal structures unfolded protein response (UPR)
ISSN:	2296-889X, 2296-889X
Online Access:	Get full text
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