RNA Interference Restricts Rift Valley Fever Virus in Multiple Insect Systems
Rift Valley fever virus (RVFV; Phlebovirus , Bunyaviridae ) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a b...
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| Vydané v: | mSphere Ročník 2; číslo 3; s. e00090 - 17 |
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| Médium: | Journal Article |
| Jazyk: | English |
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United States
American Society for Microbiology
01.05.2017
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| ISSN: | 2379-5042, 2379-5042 |
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| Abstract | Rift Valley fever virus (RVFV;
Phlebovirus
,
Bunyaviridae
) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect
Drosophila melanogaster
. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in
Culex quinquefasciatus
mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies.
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in
Drosophila melanogaster
cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult
Aedes
sp. and
Culex quinquefasciatus
mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in
Aedes
sp. but also in
C. quinquefasciatus
mosquitoes, indicating that antiviral RNA interference in
C. quinquefasciatus
mosquitoes is similar to the described activities of RNAi in
Aedes
sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes.
IMPORTANCE
Rift Valley fever virus (RVFV;
Phlebovirus
,
Bunyaviridae
) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect
Drosophila melanogaster
. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in
Culex quinquefasciatus
mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. |
|---|---|
| AbstractList | Rift Valley fever virus (RVFV;
Phlebovirus
,
Bunyaviridae
) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect
Drosophila melanogaster
. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in
Culex quinquefasciatus
mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies.
The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in
Drosophila melanogaster
cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult
Aedes
sp. and
Culex quinquefasciatus
mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in
Aedes
sp. but also in
C. quinquefasciatus
mosquitoes, indicating that antiviral RNA interference in
C. quinquefasciatus
mosquitoes is similar to the described activities of RNAi in
Aedes
sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes.
IMPORTANCE
Rift Valley fever virus (RVFV;
Phlebovirus
,
Bunyaviridae
) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect
Drosophila melanogaster
. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in
Culex quinquefasciatus
mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult sp. and mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in sp. but also in mosquitoes, indicating that antiviral RNA interference in mosquitoes is similar to the described activities of RNAi in sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes. Rift Valley fever virus (RVFV; , ) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect . We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect Drosophila melanogaster. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in Culex quinquefasciatus mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in Drosophila melanogaster cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult Aedes sp. and Culex quinquefasciatus mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in Aedes sp. but also in C. quinquefasciatus mosquitoes, indicating that antiviral RNA interference in C. quinquefasciatus mosquitoes is similar to the described activities of RNAi in Aedes sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes. IMPORTANCE Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect Drosophila melanogaster. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in Culex quinquefasciatus mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. ABSTRACT The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in Drosophila melanogaster cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult Aedes sp. and Culex quinquefasciatus mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in Aedes sp. but also in C. quinquefasciatus mosquitoes, indicating that antiviral RNA interference in C. quinquefasciatus mosquitoes is similar to the described activities of RNAi in Aedes sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes. IMPORTANCE Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect Drosophila melanogaster. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in Culex quinquefasciatus mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in Drosophila melanogaster cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult Aedes sp. and Culex quinquefasciatus mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in Aedes sp. but also in C. quinquefasciatus mosquitoes, indicating that antiviral RNA interference in C. quinquefasciatus mosquitoes is similar to the described activities of RNAi in Aedes sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes. IMPORTANCE Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect Drosophila melanogaster. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in Culex quinquefasciatus mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in Drosophila melanogaster cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult Aedes sp. and Culex quinquefasciatus mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in Aedes sp. but also in C. quinquefasciatus mosquitoes, indicating that antiviral RNA interference in C. quinquefasciatus mosquitoes is similar to the described activities of RNAi in Aedes sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes. IMPORTANCE Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect Drosophila melanogaster. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in Culex quinquefasciatus mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies.The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi) has been characterized as an important innate immune defense mechanism used by mosquitoes to limit replication of positive-sense RNA flaviviruses and togaviruses; however, little is known about its role against negative-strand RNA viruses such as RVFV. We show that virus-specific small RNAs are produced in infected mosquito cells, in Drosophila melanogaster cells, and, most importantly, also in RVFV vector mosquitoes. By addressing the production of small RNAs in adult Aedes sp. and Culex quinquefasciatus mosquitoes, we showed the presence of virus-derived Piwi-interacting RNAs (piRNAs) not only in Aedes sp. but also in C. quinquefasciatus mosquitoes, indicating that antiviral RNA interference in C. quinquefasciatus mosquitoes is similar to the described activities of RNAi in Aedes sp. mosquitoes. We also show that these have antiviral activity, since silencing of RNAi pathway effectors enhances viral replication. Moreover, our data suggest that RVFV does not encode a suppressor of RNAi. These findings point toward a significant role of RNAi in the control of RVFV in mosquitoes. IMPORTANCE Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health. Successful strategies of intervention in RVFV transmission by its mosquito vectors and the prevention of human and veterinary disease rely on a better understanding of the mechanisms that govern RVFV-vector interactions. Despite its medical importance, little is known about the factors that govern RVFV replication, dissemination, and transmission in the invertebrate host. Here we studied the role of the antiviral RNA interference immune pathways in the defense against RVFV in natural vector mosquitoes and mosquito cells and draw comparisons to the model insect Drosophila melanogaster. We found that RVFV infection induces both the exogenous small interfering RNA (siRNA) and piRNA pathways, which contribute to the control of viral replication in insects. Furthermore, we demonstrate the production of virus-derived piRNAs in Culex quinquefasciatus mosquitoes. Understanding these pathways and the targets within them offers the potential of the development of novel RVFV control measures in vector-based strategies. |
| Author | Failloux, Anna-Bella Brennan, Benjamin Huber, Katrin Dietrich, Isabelle Sall, Amadou A. Kohl, Alain Becker, Stefanie C. Ndiaye, El Hadji Elliott, Richard M. Diallo, Mawlouth Lorenzen, Stephan Rudolf, Martin Jansen, Stephanie Fall, Gamou Schicht, Sabine Schnettler, Esther Watson, Mick Heitmann, Anna Castelli, Ilaria |
| Author_xml | – sequence: 1 givenname: Isabelle surname: Dietrich fullname: Dietrich, Isabelle organization: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom – sequence: 2 givenname: Stephanie surname: Jansen fullname: Jansen, Stephanie organization: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany – sequence: 3 givenname: Gamou surname: Fall fullname: Fall, Gamou organization: Institut Pasteur de Dakar, Arbovirus and Viral Hemorrhagic Fever Unit, Dakar, Senegal – sequence: 4 givenname: Stephan surname: Lorenzen fullname: Lorenzen, Stephan organization: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany – sequence: 5 givenname: Martin surname: Rudolf fullname: Rudolf, Martin organization: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany – sequence: 6 givenname: Katrin surname: Huber fullname: Huber, Katrin organization: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany, German Mosquito Control Association (KABS/GFS), Waldsee, Germany – sequence: 7 givenname: Anna surname: Heitmann fullname: Heitmann, Anna organization: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany – sequence: 8 givenname: Sabine surname: Schicht fullname: Schicht, Sabine organization: Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany – sequence: 9 givenname: El Hadji surname: Ndiaye fullname: Ndiaye, El Hadji organization: Institut Pasteur de Dakar, Medical Entomology Unit, Dakar, Senegal – sequence: 10 givenname: Mick surname: Watson fullname: Watson, Mick organization: The Roslin Institute, Royal (Dick) School of Veterinary Studies, Division of Genetics and Genomics, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom – sequence: 11 givenname: Ilaria surname: Castelli fullname: Castelli, Ilaria organization: Department of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, France – sequence: 12 givenname: Benjamin orcidid: 0000-0003-4707-726X surname: Brennan fullname: Brennan, Benjamin organization: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom – sequence: 13 givenname: Richard M. surname: Elliott fullname: Elliott, Richard M. organization: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom – sequence: 14 givenname: Mawlouth surname: Diallo fullname: Diallo, Mawlouth organization: Institut Pasteur de Dakar, Medical Entomology Unit, Dakar, Senegal – sequence: 15 givenname: Amadou A. surname: Sall fullname: Sall, Amadou A. organization: Institut Pasteur de Dakar, Arbovirus and Viral Hemorrhagic Fever Unit, Dakar, Senegal – sequence: 16 givenname: Anna-Bella surname: Failloux fullname: Failloux, Anna-Bella organization: Department of Virology, Arboviruses and Insect Vectors, Institut Pasteur, Paris, France – sequence: 17 givenname: Esther surname: Schnettler fullname: Schnettler, Esther organization: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany – sequence: 18 givenname: Alain surname: Kohl fullname: Kohl, Alain organization: MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom – sequence: 19 givenname: Stefanie C. surname: Becker fullname: Becker, Stefanie C. organization: Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany, Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28497117$$D View this record in MEDLINE/PubMed https://pasteur.hal.science/pasteur-01573814$$DView record in HAL |
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| Cites_doi | 10.1051/vetres/2010033 10.1371/journal.pone.0030861 10.1186/1471-2180-11-45 10.1371/journal.pntd.0001565 10.1093/nar/gku528 10.1016/S0092-8674(03)00984-X 10.1128/JVI.02774-12 10.1016/j.cell.2007.01.043 10.1038/nrm3089 10.1016/j.mib.2008.05.007 10.1101/gad.1210204 10.1038/emi.2014.71 10.1086/345671 10.1099/vir.0.82122-0 10.1128/JVI.02778-06 10.1016/j.cellsig.2005.07.006 10.1073/pnas.1607952113 10.1093/nar/gkv590 10.1371/journal.ppat.1002470 10.1371/journal.ppat.1003922 10.1007/978-1-61779-037-9_23 10.1371/journal.pntd.0004452 10.1128/JVI.00595-10 10.1099/vir.0.83293-0 10.1099/vir.0.053850-0 10.1093/jmedent/8.5.610 10.1002/path.1700340418 10.2174/1874357901004020008 10.1101/gad.1482006 10.1261/rna.101606 10.3389/fpubh.2014.00169 10.1093/bioinformatics/btp324 10.1371/journal.pone.0055458 10.1099/vir.0.007567-0 10.3390/v7020820 10.1128/JVI.02641-06 10.1086/378747 10.1038/nmeth0709-474 10.1126/science.1140494 10.1128/JVI.01104-12 10.1101/gad.1454806 10.4269/ajtmh.13-0405 10.1016/j.antiviral.2012.06.001 10.4269/ajtmh.1991.44.278 10.1073/pnas.0406983101 10.1128/JVI.79.11.6940-6946.2005 10.1371/journal.pntd.0005272 10.1128/JVI.02440-08 10.1007/978-1-61779-037-9_12 10.1128/JVI.05322-11 10.1128/JVI.03360-12 10.4269/ajtmh.1988.39.597 10.1371/journal.pntd.0002994 10.1016/j.virol.2006.03.018 10.1371/journal.ppat.1002872 10.1016/j.cell.2009.03.040 10.1371/journal.ppat.1000299 10.1371/journal.pntd.0000856 10.1128/JVI.02795-12 10.1016/0264-410X(90)90096-5 10.20506/rst.23.2.1500 10.1128/JVI.77.2.1329-1336.2003 10.1371/journal.pntd.0001265 10.1186/1471-2164-9-425 10.1038/nri3763 10.1099/vir.0.036749-0 |
| ContentType | Journal Article |
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| Keywords | Rift Valley fever virus RNA interference antiviral immunity Drosophila melanogaster mosquito |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC5415632 Citation Dietrich I, Jansen S, Fall G, Lorenzen S, Rudolf M, Huber K, Heitmann A, Schicht S, Ndiaye EH, Watson M, Castelli I, Brennan B, Elliott RM, Diallo M, Sall AA, Failloux A-B, Schnettler E, Kohl A, Becker SC. 2017. RNA interference restricts Rift Valley fever virus in multiple insect systems. mSphere 2:e00090-17. https://doi.org/10.1128/mSphere.00090-17. Present address: Isabelle Dietrich, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom. I.D., S.J., and G.F. should be regarded as joint first authors. |
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| References | e_1_3_2_26_2 e_1_3_2_49_2 e_1_3_2_28_2 e_1_3_2_41_2 e_1_3_2_20_2 e_1_3_2_43_2 e_1_3_2_62_2 Smithburn KC (e_1_3_2_4_2) 1949; 30 e_1_3_2_22_2 e_1_3_2_45_2 e_1_3_2_68_2 e_1_3_2_24_2 e_1_3_2_47_2 e_1_3_2_66_2 e_1_3_2_60_2 e_1_3_2_9_2 e_1_3_2_16_2 e_1_3_2_37_2 e_1_3_2_7_2 e_1_3_2_18_2 e_1_3_2_39_2 e_1_3_2_54_2 e_1_3_2_10_2 e_1_3_2_31_2 e_1_3_2_52_2 e_1_3_2_5_2 e_1_3_2_12_2 e_1_3_2_33_2 e_1_3_2_58_2 e_1_3_2_3_2 e_1_3_2_14_2 e_1_3_2_35_2 e_1_3_2_56_2 e_1_3_2_50_2 e_1_3_2_27_2 e_1_3_2_48_2 Team RC (e_1_3_2_64_2) 2014 e_1_3_2_29_2 e_1_3_2_40_2 e_1_3_2_65_2 e_1_3_2_21_2 e_1_3_2_42_2 e_1_3_2_63_2 e_1_3_2_23_2 e_1_3_2_44_2 e_1_3_2_69_2 e_1_3_2_25_2 e_1_3_2_46_2 e_1_3_2_67_2 e_1_3_2_61_2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_17_2 e_1_3_2_59_2 e_1_3_2_6_2 e_1_3_2_19_2 e_1_3_2_30_2 e_1_3_2_53_2 e_1_3_2_32_2 e_1_3_2_51_2 e_1_3_2_11_2 e_1_3_2_34_2 e_1_3_2_57_2 e_1_3_2_13_2 e_1_3_2_36_2 e_1_3_2_55_2 e_1_3_2_2_2 |
| References_xml | – ident: e_1_3_2_8_2 doi: 10.1051/vetres/2010033 – ident: e_1_3_2_31_2 doi: 10.1371/journal.pone.0030861 – ident: e_1_3_2_36_2 doi: 10.1186/1471-2180-11-45 – volume-title: R:A language and environment for statistical computing year: 2014 ident: e_1_3_2_64_2 – ident: e_1_3_2_24_2 doi: 10.1371/journal.pntd.0001565 – ident: e_1_3_2_26_2 doi: 10.1093/nar/gku528 – ident: e_1_3_2_27_2 doi: 10.1016/S0092-8674(03)00984-X – ident: e_1_3_2_28_2 doi: 10.1128/JVI.02774-12 – ident: e_1_3_2_29_2 doi: 10.1016/j.cell.2007.01.043 – ident: e_1_3_2_34_2 doi: 10.1038/nrm3089 – ident: e_1_3_2_46_2 doi: 10.1016/j.mib.2008.05.007 – ident: e_1_3_2_61_2 doi: 10.1101/gad.1210204 – ident: e_1_3_2_9_2 doi: 10.1038/emi.2014.71 – ident: e_1_3_2_5_2 doi: 10.1086/345671 – ident: e_1_3_2_65_2 doi: 10.1099/vir.0.82122-0 – ident: e_1_3_2_43_2 doi: 10.1128/JVI.02778-06 – ident: e_1_3_2_67_2 doi: 10.1016/j.cellsig.2005.07.006 – ident: e_1_3_2_50_2 doi: 10.1073/pnas.1607952113 – ident: e_1_3_2_37_2 doi: 10.1093/nar/gkv590 – ident: e_1_3_2_30_2 doi: 10.1371/journal.ppat.1002470 – ident: e_1_3_2_51_2 doi: 10.1371/journal.ppat.1003922 – ident: e_1_3_2_48_2 doi: 10.1007/978-1-61779-037-9_23 – ident: e_1_3_2_38_2 doi: 10.1371/journal.pntd.0004452 – ident: e_1_3_2_20_2 doi: 10.1128/JVI.00595-10 – ident: e_1_3_2_66_2 doi: 10.1099/vir.0.83293-0 – ident: e_1_3_2_23_2 doi: 10.1099/vir.0.053850-0 – ident: e_1_3_2_57_2 doi: 10.1093/jmedent/8.5.610 – ident: e_1_3_2_2_2 doi: 10.1002/path.1700340418 – ident: e_1_3_2_10_2 doi: 10.2174/1874357901004020008 – ident: e_1_3_2_13_2 doi: 10.1101/gad.1482006 – ident: e_1_3_2_12_2 doi: 10.1261/rna.101606 – ident: e_1_3_2_40_2 doi: 10.3389/fpubh.2014.00169 – ident: e_1_3_2_63_2 doi: 10.1093/bioinformatics/btp324 – ident: e_1_3_2_39_2 doi: 10.1371/journal.pone.0055458 – ident: e_1_3_2_54_2 doi: 10.1099/vir.0.007567-0 – ident: e_1_3_2_15_2 doi: 10.3390/v7020820 – ident: e_1_3_2_42_2 doi: 10.1128/JVI.02641-06 – ident: e_1_3_2_7_2 doi: 10.1086/378747 – ident: e_1_3_2_45_2 doi: 10.1038/nmeth0709-474 – ident: e_1_3_2_33_2 doi: 10.1126/science.1140494 – ident: e_1_3_2_62_2 doi: 10.1128/JVI.01104-12 – ident: e_1_3_2_32_2 doi: 10.1101/gad.1454806 – ident: e_1_3_2_58_2 doi: 10.4269/ajtmh.13-0405 – ident: e_1_3_2_11_2 doi: 10.1016/j.antiviral.2012.06.001 – ident: e_1_3_2_60_2 doi: 10.4269/ajtmh.1991.44.278 – ident: e_1_3_2_17_2 doi: 10.1073/pnas.0406983101 – ident: e_1_3_2_55_2 doi: 10.1128/JVI.79.11.6940-6946.2005 – volume: 30 start-page: 1 year: 1949 ident: e_1_3_2_4_2 article-title: Rift Valley fever; the neurotropic adaptation of the virus and the experimental use of this modified virus as a vaccine publication-title: Br J Exp Pathol – ident: e_1_3_2_19_2 doi: 10.1371/journal.pntd.0005272 – ident: e_1_3_2_16_2 doi: 10.1128/JVI.02440-08 – ident: e_1_3_2_68_2 doi: 10.1007/978-1-61779-037-9_12 – ident: e_1_3_2_44_2 doi: 10.1128/JVI.05322-11 – ident: e_1_3_2_53_2 doi: 10.1128/JVI.03360-12 – ident: e_1_3_2_56_2 doi: 10.4269/ajtmh.1988.39.597 – ident: e_1_3_2_21_2 doi: 10.1371/journal.pntd.0002994 – ident: e_1_3_2_41_2 doi: 10.1016/j.virol.2006.03.018 – ident: e_1_3_2_69_2 doi: 10.1371/journal.ppat.1002872 – ident: e_1_3_2_35_2 doi: 10.1016/j.cell.2009.03.040 – ident: e_1_3_2_22_2 doi: 10.1371/journal.ppat.1000299 – ident: e_1_3_2_49_2 doi: 10.1371/journal.pntd.0000856 – ident: e_1_3_2_18_2 doi: 10.1128/JVI.02795-12 – ident: e_1_3_2_59_2 doi: 10.1016/0264-410X(90)90096-5 – ident: e_1_3_2_3_2 doi: 10.20506/rst.23.2.1500 – ident: e_1_3_2_25_2 doi: 10.1128/JVI.77.2.1329-1336.2003 – ident: e_1_3_2_6_2 doi: 10.1371/journal.pntd.0001265 – ident: e_1_3_2_14_2 doi: 10.1186/1471-2164-9-425 – ident: e_1_3_2_47_2 doi: 10.1038/nri3763 – ident: e_1_3_2_52_2 doi: 10.1099/vir.0.036749-0 |
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| Snippet | Rift Valley fever virus (RVFV;
Phlebovirus
,
Bunyaviridae
) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health.... The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference (RNAi)... ABSTRACT The emerging bunyavirus Rift Valley fever virus (RVFV) is transmitted to humans and livestock by a large number of mosquito species. RNA interference... Rift Valley fever virus (RVFV; Phlebovirus, Bunyaviridae) is an emerging zoonotic mosquito-borne pathogen of high relevance for human and animal health.... |
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