Truncal Distribution of Fat Mass, Metabolic Profile and Hypothalamic-Pituitary Adrenal Axis Activity in Prepubertal Obese Children
To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children. TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity a...
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| Vydáno v: | The Journal of pediatrics Ročník 150; číslo 5; s. 535 - 539.e1 |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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New York, NY
Mosby, Inc
2007
Elsevier |
| Témata: | |
| ISSN: | 0022-3476, 1097-6833, 1097-6833 |
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| Abstract | To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children.
TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys).
After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = −0.43, 95% CI [−0.71; −0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = −0.56, 95% CI [−0.85; −0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively.
Association exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile. |
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| AbstractList | To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children.
TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys).
After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = -0.43, 95% CI [-0.71; -0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = -0.56, 95% CI [-0.85; -0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively.
Association exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile. To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children. TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys). After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = −0.43, 95% CI [−0.71; −0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = −0.56, 95% CI [−0.85; −0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively. Association exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile. To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children.OBJECTIVETo investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children.TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys).STUDY DESIGNTDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys).After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = -0.43, 95% CI [-0.71; -0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = -0.56, 95% CI [-0.85; -0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively.RESULTSAfter adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = -0.43, 95% CI [-0.71; -0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = -0.56, 95% CI [-0.85; -0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively.Association exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile.CONCLUSIONSAssociation exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile. Objective To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity in prepubertal obese children. Study design TDFM, assessed with dual energy X-ray absorptiometry and a comprehensive set of measures of HPA axis activity and reactivity have been studied in 45 prepubertal obese children aged 6 to 11 years (girls) and 6 to 13 years (boys). Results After adjustment for whole body fat mass (%) (WBFM), TDFM correlated positively with insulin (r = 0.50, 95% CI [0.23; 0.70]) and homeostasis model assessment of insulin resistance (r = 0.52, 95% CI [0.25; 0.71]). When adjusted for WBFM, TDFM correlated positively with morning plasma cortisol (r = 0.38, 95% CI [0.15; 0.64]) in the total population. TDFM correlated negatively with the rise of salivary cortisol after a standard meal (r = −0.43, 95% CI [−0.71; −0.02]), obviously in girls. When adjusted for WBFM and TDFM, morning plasma cortisol correlated positively with total cholesterol (r = 0.41, 95% CI [0.11; 0.65]) and triglyceride (r = 0.44, 95% CI [0.14; 0.67]). The rise of salivary cortisol after a standard meal was negatively (r = −0.56, 95% CI [−0.85; −0.01]) and positively (r = 0.74, 95% CI [0.16; 0.94]) correlated with homeostasis model assessment of insulin resistance in boys and girls, respectively. Conclusions Association exists in prepubertal obese children between TDFM and markers of HPA axis activity. These data suggest that HPA axis could be involved early in life in obesity associated with pejorative metabolic profile. |
| Author | Mormede, Pierre Corcuff, Jean-Benoît Barthe, Nicole Gayard-Cros, Michelle Tauber, Maïthé Barat, Pascal Jouret, Béatrice Germain, Christine Perez, Paul Andrew, Ruth Duclos, Martine Walker, Brian R. |
| Author_xml | – sequence: 1 givenname: Pascal surname: Barat fullname: Barat, Pascal email: pascal.barat@chu-bordeaux.fr organization: From the Department of Pediatric Endocrinology, Centre Hospitalier Universitaire de Bordeaux, France – sequence: 2 givenname: Michelle surname: Gayard-Cros fullname: Gayard-Cros, Michelle organization: Department of Pediatric Endocrinology, Centre Hospitalier Universitaire de Toulouse, France – sequence: 3 givenname: Ruth surname: Andrew fullname: Andrew, Ruth organization: Endocrinology Unit, Centre of Cardiovascular Science, University of Edinburgh, United Kingdom – sequence: 4 givenname: Jean-Benoît surname: Corcuff fullname: Corcuff, Jean-Benoît organization: Department of Nuclear Medicine, Centre Hospitalier Universitaire de Bordeaux, France – sequence: 5 givenname: Béatrice surname: Jouret fullname: Jouret, Béatrice organization: Department of Pediatric Endocrinology, Centre Hospitalier Universitaire de Toulouse, France – sequence: 6 givenname: Nicole surname: Barthe fullname: Barthe, Nicole organization: Department of Nuclear Medicine, Centre Hospitalier Universitaire de Bordeaux, France – sequence: 7 givenname: Paul surname: Perez fullname: Perez, Paul organization: Clinical Epidemiology Unit, Centre Hospitalier Universitaire de Bordeaux, France – sequence: 8 givenname: Christine surname: Germain fullname: Germain, Christine organization: Clinical Epidemiology Unit, Centre Hospitalier Universitaire de Bordeaux, France – sequence: 9 givenname: Maïthé surname: Tauber fullname: Tauber, Maïthé organization: Department of Pediatric Endocrinology, Centre Hospitalier Universitaire de Toulouse, France – sequence: 10 givenname: Brian R. surname: Walker fullname: Walker, Brian R. organization: Endocrinology Unit, Centre of Cardiovascular Science, University of Edinburgh, United Kingdom – sequence: 11 givenname: Pierre surname: Mormede fullname: Mormede, Pierre organization: Laboratoire Neurogénétique et Stress, University of Bordeaux, France – sequence: 12 givenname: Martine surname: Duclos fullname: Duclos, Martine organization: Laboratoire Neurogénétique et Stress, University of Bordeaux, France |
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| Keywords | TDFM THE THF QUICKI DEXA ACTH DXM HPA CBG HOMA WBFM BMI Tetrahydrocortisone Dexamethasone Quantitative insulin sensitivity check index Corticosteroid binding globulin Body mass index Hypothalamic-pituitary-adrenocortical Truncal distribution of fat mass Tetrahydrocortisol Homeostasis model assessment of insulin resistance Adrenocorticotropin hormone Whole body fat mass Dual energy-X ray absorptiometry Human Obesity Pediatrics Trunk Adipose tissue Hypothalamohypophysoadrenal axis Nutrition disorder Metabolism Fat mass Biological activity Profile Prepuberty Distribution Child Nutritional status HYPOTHALAMIC-PITUITARY-ADRENAL AXIS CORTISOL |
| Language | English |
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| Snippet | To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis activity... Objective To investigate whether truncal distribution of fat mass (TDFM) is associated with variations of the hypothalamic-pituitary-adrenocortical (HPA) axis... |
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| SubjectTerms | Adolescent Biological and medical sciences Body Fat Distribution Child Female General aspects Human health and pathology Humans Hypothalamo-Hypophyseal System - physiopathology Life Sciences Male Medical sciences Metabolic diseases Obesity Obesity - metabolism Obesity - physiopathology Pediatrics Pituitary-Adrenal System - physiopathology |
| Title | Truncal Distribution of Fat Mass, Metabolic Profile and Hypothalamic-Pituitary Adrenal Axis Activity in Prepubertal Obese Children |
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