An IRAK1–PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy

Drug-based strategies to overcome tumour resistance to radiotherapy (R-RT) remain limited by the single-agent toxicity of traditional radiosensitizers (for example, platinums) and a lack of targeted alternatives. In a screen for compounds that restore radiosensitivity in p53 mutant zebrafish while t...

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Veröffentlicht in:	Nature cell biology Jg. 21; H. 2; S. 203 - 213
Hauptverfasser:	Liu, Peter H., Shah, Richa B., Li, Yuanyuan, Arora, Arshi, Ung, Peter Man-Un, Raman, Renuka, Gorbatenko, Andrej, Kozono, Shingo, Zhou, Xiao Zhen, Brechin, Vincent, Barbaro, John M., Thompson, Ruth, White, Richard M., Aguirre-Ghiso, Julio A., Heymach, John V., Lu, Kun Ping, Silva, Jose M., Panageas, Katherine S., Schlessinger, Avner, Maki, Robert G., Skinner, Heath D., de Stanchina, Elisa, Sidi, Samuel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.02.2019 Nature Publishing Group
Schlagworte:	13/106 13/2 13/89 14 14/1 14/19 42/41 59 631/67 631/67/1059/485 631/67/1059/602 631/80/86/2366 64 64/116 64/60 82 96 96/109 96/95 Animals Anthelmintic agents Antiparasitic agents Apoptosis Benzimidazoles Biomedical and Life Sciences Cancer Cancer Research Cancer treatment Caspase Caspase-2 Cell Biology Cell Line, Tumor Chemoradiotherapy Cytokine receptors Developmental Biology Genetic aspects HCT116 Cells Health aspects HEK293 Cells HeLa Cells Humans Immune response Immune system Inhibitors Interleukin 1 Interleukin 1 receptors Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Interleukins Ionizing radiation IRAK protein Life Sciences MCF-7 Cells Medical schools Methods Mice, Inbred NOD Mice, Knockout Mice, SCID Mutation MyD88 protein Neoplasms - genetics Neoplasms - metabolism Neoplasms - radiotherapy NIMA-Interacting Peptidylprolyl Isomerase - antagonists & inhibitors NIMA-Interacting Peptidylprolyl Isomerase - genetics NIMA-Interacting Peptidylprolyl Isomerase - metabolism Oxfendazole p53 Protein Pathogenic microorganisms Patient outcomes Peptidylprolyl isomerase Pin1 protein Proteins Radiation (Physics) Radiation therapy Radiation tolerance Radiation Tolerance - drug effects Radiation Tolerance - genetics Radiosensitivity Radiosensitizers Radiotherapy Signal Transduction Stem Cells Synergistic effect Toll-like receptors Toxicity TRAF6 protein Tumor proteins Tumor Suppressor Protein p53 - genetics Tumors Xenograft Model Antitumor Assays - methods Zebrafish
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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