Cell Cycle Deficits in Neurodegenerative Disorders: Uncovering Molecular Mechanisms to Drive Innovative Therapeutic Development

Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell cycle once differentiated and therefore the circumstances and mechanisms underlying aberrant cell cycle activation in...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Aging and disease Ročník 11; číslo 4; s. 946 - 966
Hlavní autoři: Joseph, Chitra, Mangani, Abubakar Siddiq, Gupta, Veer, Chitranshi, Nitin, Shen, Ting, Dheer, Yogita, KB, Devaraj, Mirzaei, Mehdi, You, Yuyi, Graham, Stuart L, Gupta, Vivek
Médium: Journal Article
Jazyk:angličtina
Vydáno: JKL International 01.08.2020
JKL International LLC
Témata:
Analysis
Cell cycle
Health aspects
Medical research
Neurodegenerative diseases
Neurons
Physiological aspects
Review
Tumor proteins
Australia
ISSN:2152-5250, 2152-5250
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell cycle once differentiated and therefore the circumstances and mechanisms underlying aberrant cell cycle activation in post-mitotic neurons in physiological and disease conditions remains an intriguing area of research. There is a strict requirement of concurrence to cell cycle regulation for neurons to ensure intracellular biochemical conformity as well as interrelationship with other cells within neural tissues. This review deliberates on various mechanisms underlying cell cycle regulation in neuronal cells and underscores potential implications of their non-compliance in neural pathology. Recent research suggests that successful duplication of genetic material without subsequent induction of mitosis induces inherent molecular flaws that eventually assert as apoptotic changes. The consequences of anomalous cell cycle activation and subsequent apoptosis are demonstrated by the increased presence of molecular stress response and apoptotic markers. This review delineates cell cycle events under normal physiological conditions and deficits amalgamated by alterations in protein levels and signalling pathways associated with cell-division are analysed. Cell cycle regulators essentially, cyclins, CDKs, cip/kip family of inhibitors, caspases, bax and p53 have been identified to be involved in impaired cell cycle regulation and associated with neural pathology. The pharmacological modulators of cell cycle that are shown to impart protection in various animal models of neurological deficits are summarised. Greater understanding of the molecular mechanisms that are indispensable to cell cycle regulation in neurons in health and disease conditions will facilitate targeted drug development for neuroprotection. Key words: Cell cycle, Apoptosis, Neuron, Neurodegeneration, CDK, Cyclin
AbstractList Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell cycle once differentiated and therefore the circumstances and mechanisms underlying aberrant cell cycle activation in post-mitotic neurons in physiological and disease conditions remains an intriguing area of research. There is a strict requirement of concurrence to cell cycle regulation for neurons to ensure intracellular biochemical conformity as well as interrelationship with other cells within neural tissues. This review deliberates on various mechanisms underlying cell cycle regulation in neuronal cells and underscores potential implications of their non-compliance in neural pathology. Recent research suggests that successful duplication of genetic material without subsequent induction of mitosis induces inherent molecular flaws that eventually assert as apoptotic changes. The consequences of anomalous cell cycle activation and subsequent apoptosis are demonstrated by the increased presence of molecular stress response and apoptotic markers. This review delineates cell cycle events under normal physiological conditions and deficits amalgamated by alterations in protein levels and signalling pathways associated with cell-division are analysed. Cell cycle regulators essentially, cyclins, CDKs, cip/kip family of inhibitors, caspases, bax and p53 have been identified to be involved in impaired cell cycle regulation and associated with neural pathology. The pharmacological modulators of cell cycle that are shown to impart protection in various animal models of neurological deficits are summarised. Greater understanding of the molecular mechanisms that are indispensable to cell cycle regulation in neurons in health and disease conditions will facilitate targeted drug development for neuroprotection. Key words: Cell cycle, Apoptosis, Neuron, Neurodegeneration, CDK, Cyclin
Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell cycle once differentiated and therefore the circumstances and mechanisms underlying aberrant cell cycle activation in post-mitotic neurons in physiological and disease conditions remains an intriguing area of research. There is a strict requirement of concurrence to cell cycle regulation for neurons to ensure intracellular biochemical conformity as well as interrelationship with other cells within neural tissues. This review deliberates on various mechanisms underlying cell cycle regulation in neuronal cells and underscores potential implications of their non-compliance in neural pathology. Recent research suggests that successful duplication of genetic material without subsequent induction of mitosis induces inherent molecular flaws that eventually assert as apoptotic changes. The consequences of anomalous cell cycle activation and subsequent apoptosis are demonstrated by the increased presence of molecular stress response and apoptotic markers. This review delineates cell cycle events under normal physiological conditions and deficits amalgamated by alterations in protein levels and signalling pathways associated with cell-division are analysed. Cell cycle regulators essentially, cyclins, CDKs, cip/kip family of inhibitors, caspases, bax and p53 have been identified to be involved in impaired cell cycle regulation and associated with neural pathology. The pharmacological modulators of cell cycle that are shown to impart protection in various animal models of neurological deficits are summarised. Greater understanding of the molecular mechanisms that are indispensable to cell cycle regulation in neurons in health and disease conditions will facilitate targeted drug development for neuroprotection.
Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell cycle once differentiated and therefore the circumstances and mechanisms underlying aberrant cell cycle activation in post-mitotic neurons in physiological and disease conditions remains an intriguing area of research. There is a strict requirement of concurrence to cell cycle regulation for neurons to ensure intracellular biochemical conformity as well as interrelationship with other cells within neural tissues. This review deliberates on various mechanisms underlying cell cycle regulation in neuronal cells and underscores potential implications of their non-compliance in neural pathology. Recent research suggests that successful duplication of genetic material without subsequent induction of mitosis induces inherent molecular flaws that eventually assert as apoptotic changes. The consequences of anomalous cell cycle activation and subsequent apoptosis are demonstrated by the increased presence of molecular stress response and apoptotic markers. This review delineates cell cycle events under normal physiological conditions and deficits amalgamated by alterations in protein levels and signalling pathways associated with cell-division are analysed. Cell cycle regulators essentially, cyclins, CDKs, cip/kip family of inhibitors, caspases, bax and p53 have been identified to be involved in impaired cell cycle regulation and associated with neural pathology. The pharmacological modulators of cell cycle that are shown to impart protection in various animal models of neurological deficits are summarised. Greater understanding of the molecular mechanisms that are indispensable to cell cycle regulation in neurons in health and disease conditions will facilitate targeted drug development for neuroprotection.Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative disorders. Specialised function obligates neuronal cells to subsist in a quiescent state of cell cycle once differentiated and therefore the circumstances and mechanisms underlying aberrant cell cycle activation in post-mitotic neurons in physiological and disease conditions remains an intriguing area of research. There is a strict requirement of concurrence to cell cycle regulation for neurons to ensure intracellular biochemical conformity as well as interrelationship with other cells within neural tissues. This review deliberates on various mechanisms underlying cell cycle regulation in neuronal cells and underscores potential implications of their non-compliance in neural pathology. Recent research suggests that successful duplication of genetic material without subsequent induction of mitosis induces inherent molecular flaws that eventually assert as apoptotic changes. The consequences of anomalous cell cycle activation and subsequent apoptosis are demonstrated by the increased presence of molecular stress response and apoptotic markers. This review delineates cell cycle events under normal physiological conditions and deficits amalgamated by alterations in protein levels and signalling pathways associated with cell-division are analysed. Cell cycle regulators essentially, cyclins, CDKs, cip/kip family of inhibitors, caspases, bax and p53 have been identified to be involved in impaired cell cycle regulation and associated with neural pathology. The pharmacological modulators of cell cycle that are shown to impart protection in various animal models of neurological deficits are summarised. Greater understanding of the molecular mechanisms that are indispensable to cell cycle regulation in neurons in health and disease conditions will facilitate targeted drug development for neuroprotection.
Audience Academic
Author Shen, Ting
KB, Devaraj
Mirzaei, Mehdi
Chitranshi, Nitin
You, Yuyi
Dheer, Yogita
Gupta, Veer
Mangani, Abubakar Siddiq
Gupta, Vivek
Joseph, Chitra
Graham, Stuart L
AuthorAffiliation 4 Save Sight Institute, Sydney University, Sydney, NSW 2109, Australia
2 School of Medicine, Deakin University, Melbourne, VIC, Australia
3 Department of Molecular Sciences, Macquarie University, North Ryde, NSW 2109, Australia
1 Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia
AuthorAffiliation_xml – name: 4 Save Sight Institute, Sydney University, Sydney, NSW 2109, Australia
– name: 2 School of Medicine, Deakin University, Melbourne, VIC, Australia
– name: 1 Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2109, Australia
– name: 3 Department of Molecular Sciences, Macquarie University, North Ryde, NSW 2109, Australia
Author_xml – sequence: 1
  givenname: Chitra
  surname: Joseph
  fullname: Joseph, Chitra
– sequence: 2
  givenname: Abubakar Siddiq
  surname: Mangani
  fullname: Mangani, Abubakar Siddiq
– sequence: 3
  givenname: Veer
  surname: Gupta
  fullname: Gupta, Veer
– sequence: 4
  givenname: Nitin
  surname: Chitranshi
  fullname: Chitranshi, Nitin
– sequence: 5
  givenname: Ting
  surname: Shen
  fullname: Shen, Ting
– sequence: 6
  givenname: Yogita
  surname: Dheer
  fullname: Dheer, Yogita
– sequence: 7
  givenname: Devaraj
  surname: KB
  fullname: KB, Devaraj
– sequence: 8
  givenname: Mehdi
  surname: Mirzaei
  fullname: Mirzaei, Mehdi
– sequence: 9
  givenname: Yuyi
  surname: You
  fullname: You, Yuyi
– sequence: 10
  givenname: Stuart L
  surname: Graham
  fullname: Graham, Stuart L
– sequence: 11
  givenname: Vivek
  surname: Gupta
  fullname: Gupta, Vivek
BookMark eNptkstr3DAQxkVJadI0x94NhZKLt7IefvRQWHb7CCTtJTkLRR6vVWRpK9mGnPqvd9xNIVsiHSQ0v-8bZjSvyYkPHgh5W9BVITgvP6y3K0aLZkUbxl-QM1ZIlksm6cmT-ym5SOknxcWRavgrcspZVcpGlmfk9wacyzYPxkG2hc4aO6bM-uw7TDG0sAMPUY92xqhNIbYQ08fszpswQ7R-l90EB2ZyOmY3YHrtbRpSNoZsGxfNlfdhPshvezTawzRag4lmcGE_gB_fkJeddgkuHs9zcvfl8-3mW3794-vVZn2dG8nqMa-orCsQwEAUQnDNO13cN23b1kIa3hW10bwSdVmLWgNozQ0W2pUcy6cC4_ycfDr47qf7AVqDqaN2ah_toOODCtqq44i3vdqFWVW8oZIzNLh8NIjh1wRpVINNBpunPYQpKSZ4UTPKK4rouwO60w6U9V1AR7Pgal1yKUTZ8Bqp1TMU7hYGa_CfO4vvR4L3TwQ9aDf2KTjsaPDpGOQH0MSQUoRO4a_qBcMM1qmCqr_To9ZbtUyPWqYHVfl_qn_NeZ7_A0hIxlE
CitedBy_id crossref_primary_10_1016_j_fbio_2023_102442
crossref_primary_10_1016_j_exer_2023_109668
crossref_primary_10_1016_j_ceca_2024_102856
crossref_primary_10_1016_j_fbio_2024_103673
crossref_primary_10_1038_s44319_023_00049_7
crossref_primary_10_1016_j_lfs_2021_120006
crossref_primary_10_1007_s12035_024_04130_7
crossref_primary_10_1016_j_bbamcr_2023_119430
crossref_primary_10_1111_gtc_12884
crossref_primary_10_1016_j_compbiomed_2021_104859
crossref_primary_10_1016_j_lfs_2023_121999
crossref_primary_10_1515_biol_2022_1051
crossref_primary_10_1016_j_hsr_2022_100071
crossref_primary_10_3389_fnins_2021_752153
crossref_primary_10_1016_j_cell_2024_10_045
crossref_primary_10_1111_ejn_15252
crossref_primary_10_3390_ijms23063223
crossref_primary_10_1016_j_cell_2024_02_014
crossref_primary_10_1016_j_pneurobio_2022_102386
crossref_primary_10_1038_s41598_024_57918_x
crossref_primary_10_1016_j_biopha_2021_111690
crossref_primary_10_3390_cells10081946
crossref_primary_10_1016_j_arr_2023_102174
crossref_primary_10_1016_j_cbi_2023_110561
crossref_primary_10_1186_s13024_025_00848_7
crossref_primary_10_1016_j_neulet_2021_135741
crossref_primary_10_1016_j_compbiomed_2025_109781
crossref_primary_10_1007_s12031_023_02124_z
crossref_primary_10_3389_fnins_2024_1385675
crossref_primary_10_3390_ph15121546
crossref_primary_10_1016_j_fct_2022_113011
crossref_primary_10_1016_j_neuro_2022_03_004
crossref_primary_10_1016_j_taap_2022_116255
crossref_primary_10_1093_hmg_ddac118
crossref_primary_10_1186_s40478_022_01500_x
crossref_primary_10_1242_dev_204421
crossref_primary_10_1002_ijc_34682
crossref_primary_10_4103_1673_5374_360165
crossref_primary_10_1016_j_bbamcr_2024_119848
crossref_primary_10_1016_j_isci_2022_104278
crossref_primary_10_1016_j_tins_2025_05_010
crossref_primary_10_3390_nu16234152
crossref_primary_10_1007_s12032_023_01963_5
crossref_primary_10_1016_j_coph_2021_11_009
crossref_primary_10_3389_fnagi_2022_866886
crossref_primary_10_3390_cells11060987
crossref_primary_10_3390_pharmaceutics17030365
crossref_primary_10_3390_ijms22084045
Cites_doi 10.1093/nar/gkl010
10.1016/j.bbrc.2014.09.104
10.1002/jnr.22665
10.1186/s12967-015-0683-x
10.1002/biot.200700059
10.1136/jnnp-2017-315995
10.1155/2010/190724
10.1016/j.stem.2013.04.003
10.1093/mutage/geh025
10.2174/1874375701004010011
10.1038/ncb1101-950
10.1007/s00018-013-1428-8
10.1007/s10571-009-9410-6
10.1186/1756-6606-4-3
10.1523/JNEUROSCI.3347-04.2004
10.1523/JNEUROSCI.07-11-03739.1987
10.1006/exnr.2000.7594
10.1097/IJG.0b013e31815c3a7f
10.1016/S0896-6273(04)00017-0
10.1038/mt.2011.213
10.1073/pnas.92.18.8493
10.12659/MSM.894006
10.1167/iovs.10-5280
10.1016/j.molcel.2005.03.027
10.1083/jcb.143.2.457
10.1016/j.molcel.2007.03.019
10.1016/S0197-4580(02)00196-3
10.1242/jcs.1125880
10.1523/JNEUROSCI.20-09-03104.2000
10.1038/351242a0
10.1016/j.biochi.2008.01.004
10.1038/s41598-017-10488-7
10.1007/s13311-011-0028-2
10.1097/WNO.0b013e318267fd5f
10.1146/annurev.cellbio.17.1.351
10.1038/ncomms9897
10.3389/fnmol.2017.00229
10.1073/pnas.88.3.961
10.1016/j.preteyeres.2004.05.001
10.1074/jbc.M809393200
10.1101/cshperspect.a009399
10.1172/JCI200318182
10.1016/S0002-9440(10)63879-5
10.1016/j.bbadis.2013.10.015
10.1016/j.jocn.2014.12.014
10.1371/journal.pone.0033389
10.1016/j.celrep.2018.12.025
10.1016/S0197-4580(97)00157-7
10.1371/journal.pone.0213673
10.1016/S0014-5793(02)02934-4
10.1038/cddis.2011.2
10.1074/jbc.M002466200
10.1016/j.bbrc.2014.10.087
10.1167/iovs.05-0996
10.1016/j.ajo.2012.07.023
10.1093/jnen/62.1.68
10.1038/cdd.2014.47
10.1074/jbc.274.27.19011
10.1016/j.devcel.2013.05.007
10.1523/JNEUROSCI.22-01-00156.2002
10.1007/s12035-018-1041-9
10.1155/2014/361020
10.1111/bph.12312
10.1152/physrev.00026.2013
10.1172/JCI2425
10.1073/pnas.0611671104
10.1523/JNEUROSCI.0186-07.2007
10.18632/aging.100045
10.1242/dmm.022558
10.3389/fpsyt.2014.00022
10.1016/j.molcel.2010.05.009
10.1038/s41598-018-23644-4
10.4161/cc.6.3.3752
10.1371/journal.pone.0018449
10.1186/s13041-015-0095-0
10.1523/JNEUROSCI.23-07-02557.2003
10.1093/hmg/ddy174
10.1073/pnas.91.16.7525
10.1136/bjo.2008.148064
10.1161/01.RES.88.4.443
10.1038/nature03094
10.1038/ng.824
10.1007/s12035-012-8262-0
10.1016/j.bbamcr.2013.02.028
10.1091/mbc.e06-12-1110
10.1038/ncb3600
10.1038/35037739
10.1089/ars.2010.3208
10.1016/j.neulet.2007.03.026
10.1016/j.nbd.2014.06.014
10.3390/ijms18051057
10.1016/j.dnarep.2018.12.005
10.1002/j.1460-2075.1996.tb01006.x
10.1126/science.7539157
10.1016/j.expneurol.2019.01.015
10.1038/mt.2013.281
10.1007/s12035-019-1479-4
10.1096/fasebj.13.15.2225
10.1016/S0896-6273(00)80938-1
10.2174/1389450053765824
10.1016/S0896-6273(01)00268-9
10.1007/s00401-015-1431-2
10.1586/17469899.2014.903157
10.1038/nrc.2016.138
10.1007/978-1-4939-0888-2_2
10.1093/hmg/ddx063
10.1016/S0002-9440(10)64837-7
10.1038/cdd.2009.221
10.1523/JNEUROSCI.17-04-01256.1997
10.1016/S0002-9440(10)65133-4
10.1523/JNEUROSCI.22-07-02590.2002
10.1128/MCB.05659-11
10.1007/s004410100396
10.1038/nature12634
10.1074/jbc.M207825200
10.1016/S1097-2765(02)00524-5
10.1111/j.1460-9568.1995.tb01057.x
10.3892/ijmm.13.5.629
10.1186/1750-1172-5-40
10.1016/j.bbadis.2016.09.010
10.1111/nan.12202
10.3892/mmr.2017.6838
10.3233/JAD-141083
10.1074/jbc.M511658200
10.7554/eLife.34202
10.1016/bs.mie.2017.03.012
10.1056/NEJMra022366
10.1128/MCB.02301-05
10.1371/journal.pone.0078842
10.1002/jnr.20999
10.1016/j.ymthe.2018.09.019
10.2353/ajpath.2010.090955
10.1038/cddis.2012.166
10.1002/jcp.20689
10.1016/j.cell.2007.09.036
10.1002/jnr.21739
10.1080/15384101.2015.1004937
10.1152/ajpendo.00199.2012
10.1038/s41598-018-21104-7
10.1038/45159
10.2174/1570159X16666171206144045
10.1167/iovs.10-5317
10.1021/cr3000994
10.1186/1750-1326-8-29
10.1074/jbc.M112.343152
10.1016/S0197-4580(00)00221-9
10.1523/JNEUROSCI.21-08-02661.2001
10.1074/jbc.M002413200
10.1073/pnas.0500989102
10.1371/journal.pone.0095561
10.1016/S0002-9440(10)64970-X
10.1016/j.neulet.2006.12.003
10.4306/pi.2016.13.1.127
10.1016/j.neuroscience.2017.09.028
10.1073/pnas.0906121107
10.1016/j.neuron.2011.09.012
10.1523/JNEUROSCI.0379-07.2007
10.1016/j.preteyeres.2011.02.004
10.1523/JNEUROSCI.17-23-08975.1997
10.1242/jcs.01486
10.4149/neo_2014_064
10.1038/ng1769
10.1002/jnr.22384
10.1038/nn.3356
10.1158/0008-5472.CAN-08-3745
10.1016/S1534-5807(01)00029-6
10.1111/j.1365-2133.2008.08931.x
10.1038/onc.2015.524
10.1038/nature01034
10.1172/JCI72723
10.1006/nbdi.2000.0314
10.1523/JNEUROSCI.23-06-02131.2003
10.14336/AD.2017.0717
10.1038/sj.emboj.7601017
10.1371/journal.pone.0115523
10.1093/hmg/ddx170
10.1093/jnen/61.8.678
10.1038/onc.2009.170
10.1038/jcbfm.2011.117
10.1007/s12035-015-9595-2
10.7554/eLife.08160
10.1038/embor.2010.142
10.1212/WNL.58.12.1809
10.1016/j.celrep.2016.04.071
10.1042/bj20021535
10.1016/j.disamonth.2010.06.001
10.1001/archopht.1997.01100160201010
10.1074/jbc.M603950200
10.1101/gad.9.11.1340
10.1101/gad.10.22.2849
10.1167/iovs.06-1282
10.1073/pnas.2232515100
10.1016/j.neuint.2008.10.013
10.1093/hmg/ddr026
10.1046/j.1471-4159.1997.69052064.x
10.1016/j.neuron.2014.06.034
10.1371/journal.pone.0119865
10.1101/cshperspect.a006189
10.1016/j.mrfmmm.2006.06.007
10.3390/ijms19103082
10.1523/JNEUROSCI.17-10-03588.1997
10.1016/j.neuroscience.2006.07.006
ContentType Journal Article
Copyright COPYRIGHT 2020 JKL International
Copyright: © 2020 Joseph et al.
Copyright: © 2020 Joseph et al. 2020
Copyright_xml – notice: COPYRIGHT 2020 JKL International
– notice: Copyright: © 2020 Joseph et al.
– notice: Copyright: © 2020 Joseph et al. 2020
DBID AAYXX
CITATION
7X8
5PM
DOI 10.14336/AD.2019.0923
DatabaseName CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2152-5250
EndPage 966
ExternalDocumentID PMC7390532
A635446938
10_14336_AD_2019_0923
GeographicLocations Australia
GeographicLocations_xml – name: Australia
GroupedDBID 53G
5VS
AAYXX
ABDBF
ACUHS
ADBBV
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BCNDV
C1A
CITATION
DIK
EBD
ESX
GROUPED_DOAJ
HYE
IAO
IHR
IHW
ITC
KQ8
M~E
OK1
RPM
TUS
7X8
5PM
ID FETCH-LOGICAL-c528t-70587e4e2e41443a3fa1b9ddd845c3f18ca37486848aeeaa3c393f63250043f13
ISICitedReferencesCount 58
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000556664900020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2152-5250
IngestDate Thu Aug 21 13:54:06 EDT 2025
Thu Oct 02 10:41:00 EDT 2025
Tue Feb 18 23:12:59 EST 2025
Wed Feb 12 06:49:47 EST 2025
Thu May 22 21:16:55 EDT 2025
Sat Nov 29 06:32:55 EST 2025
Tue Nov 18 19:51:06 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c528t-70587e4e2e41443a3fa1b9ddd845c3f18ca37486848aeeaa3c393f63250043f13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink http://dx.doi.org/10.14336/AD.2019.0923
PMID 32765956
PQID 2431820370
PQPubID 23479
PageCount 21
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7390532
proquest_miscellaneous_2431820370
gale_infotracmisc_A635446938
gale_infotracacademiconefile_A635446938
gale_healthsolutions_A635446938
crossref_citationtrail_10_14336_AD_2019_0923
crossref_primary_10_14336_AD_2019_0923
PublicationCentury 2000
PublicationDate 2020-08-01
PublicationDateYYYYMMDD 2020-08-01
PublicationDate_xml – month: 08
  year: 2020
  text: 2020-08-01
  day: 01
PublicationDecade 2020
PublicationTitle Aging and disease
PublicationYear 2020
Publisher JKL International
JKL International LLC
Publisher_xml – name: JKL International
– name: JKL International LLC
References key-10.14336/AD.2019.0923-119
key-10.14336/AD.2019.0923-29
key-10.14336/AD.2019.0923-25
key-10.14336/AD.2019.0923-26
key-10.14336/AD.2019.0923-27
key-10.14336/AD.2019.0923-28
key-10.14336/AD.2019.0923-21
key-10.14336/AD.2019.0923-110
key-10.14336/AD.2019.0923-22
key-10.14336/AD.2019.0923-23
key-10.14336/AD.2019.0923-24
key-10.14336/AD.2019.0923-114
key-10.14336/AD.2019.0923-113
key-10.14336/AD.2019.0923-112
key-10.14336/AD.2019.0923-20
key-10.14336/AD.2019.0923-111
key-10.14336/AD.2019.0923-118
key-10.14336/AD.2019.0923-117
key-10.14336/AD.2019.0923-116
key-10.14336/AD.2019.0923-115
key-10.14336/AD.2019.0923-3
key-10.14336/AD.2019.0923-4
key-10.14336/AD.2019.0923-1
key-10.14336/AD.2019.0923-2
key-10.14336/AD.2019.0923-7
key-10.14336/AD.2019.0923-8
key-10.14336/AD.2019.0923-5
key-10.14336/AD.2019.0923-6
key-10.14336/AD.2019.0923-18
key-10.14336/AD.2019.0923-19
key-10.14336/AD.2019.0923-14
key-10.14336/AD.2019.0923-15
key-10.14336/AD.2019.0923-16
key-10.14336/AD.2019.0923-17
key-10.14336/AD.2019.0923-10
key-10.14336/AD.2019.0923-121
key-10.14336/AD.2019.0923-11
key-10.14336/AD.2019.0923-120
key-10.14336/AD.2019.0923-12
key-10.14336/AD.2019.0923-13
key-10.14336/AD.2019.0923-125
key-10.14336/AD.2019.0923-124
key-10.14336/AD.2019.0923-9
key-10.14336/AD.2019.0923-123
key-10.14336/AD.2019.0923-122
key-10.14336/AD.2019.0923-129
key-10.14336/AD.2019.0923-128
key-10.14336/AD.2019.0923-127
key-10.14336/AD.2019.0923-126
key-10.14336/AD.2019.0923-47
key-10.14336/AD.2019.0923-48
key-10.14336/AD.2019.0923-49
key-10.14336/AD.2019.0923-43
key-10.14336/AD.2019.0923-44
key-10.14336/AD.2019.0923-45
key-10.14336/AD.2019.0923-46
key-10.14336/AD.2019.0923-40
key-10.14336/AD.2019.0923-41
key-10.14336/AD.2019.0923-42
key-10.14336/AD.2019.0923-109
key-10.14336/AD.2019.0923-108
key-10.14336/AD.2019.0923-36
key-10.14336/AD.2019.0923-37
key-10.14336/AD.2019.0923-38
key-10.14336/AD.2019.0923-39
key-10.14336/AD.2019.0923-32
key-10.14336/AD.2019.0923-33
key-10.14336/AD.2019.0923-34
key-10.14336/AD.2019.0923-35
key-10.14336/AD.2019.0923-103
key-10.14336/AD.2019.0923-102
key-10.14336/AD.2019.0923-30
key-10.14336/AD.2019.0923-101
key-10.14336/AD.2019.0923-31
key-10.14336/AD.2019.0923-100
key-10.14336/AD.2019.0923-107
key-10.14336/AD.2019.0923-106
key-10.14336/AD.2019.0923-105
key-10.14336/AD.2019.0923-104
key-10.14336/AD.2019.0923-208
key-10.14336/AD.2019.0923-207
key-10.14336/AD.2019.0923-202
key-10.14336/AD.2019.0923-201
key-10.14336/AD.2019.0923-200
key-10.14336/AD.2019.0923-206
key-10.14336/AD.2019.0923-205
key-10.14336/AD.2019.0923-204
key-10.14336/AD.2019.0923-203
key-10.14336/AD.2019.0923-194
key-10.14336/AD.2019.0923-193
key-10.14336/AD.2019.0923-192
key-10.14336/AD.2019.0923-191
key-10.14336/AD.2019.0923-198
key-10.14336/AD.2019.0923-197
key-10.14336/AD.2019.0923-196
key-10.14336/AD.2019.0923-195
key-10.14336/AD.2019.0923-199
key-10.14336/AD.2019.0923-98
key-10.14336/AD.2019.0923-99
key-10.14336/AD.2019.0923-94
key-10.14336/AD.2019.0923-95
key-10.14336/AD.2019.0923-96
key-10.14336/AD.2019.0923-97
key-10.14336/AD.2019.0923-90
key-10.14336/AD.2019.0923-91
key-10.14336/AD.2019.0923-92
key-10.14336/AD.2019.0923-93
key-10.14336/AD.2019.0923-172
key-10.14336/AD.2019.0923-171
key-10.14336/AD.2019.0923-170
key-10.14336/AD.2019.0923-176
key-10.14336/AD.2019.0923-175
key-10.14336/AD.2019.0923-174
key-10.14336/AD.2019.0923-173
key-10.14336/AD.2019.0923-179
key-10.14336/AD.2019.0923-178
key-10.14336/AD.2019.0923-177
key-10.14336/AD.2019.0923-190
key-10.14336/AD.2019.0923-183
key-10.14336/AD.2019.0923-182
key-10.14336/AD.2019.0923-181
key-10.14336/AD.2019.0923-180
key-10.14336/AD.2019.0923-187
key-10.14336/AD.2019.0923-186
key-10.14336/AD.2019.0923-185
key-10.14336/AD.2019.0923-184
key-10.14336/AD.2019.0923-189
key-10.14336/AD.2019.0923-188
key-10.14336/AD.2019.0923-69
key-10.14336/AD.2019.0923-150
key-10.14336/AD.2019.0923-65
key-10.14336/AD.2019.0923-154
key-10.14336/AD.2019.0923-66
key-10.14336/AD.2019.0923-153
key-10.14336/AD.2019.0923-67
key-10.14336/AD.2019.0923-152
key-10.14336/AD.2019.0923-68
key-10.14336/AD.2019.0923-151
key-10.14336/AD.2019.0923-61
key-10.14336/AD.2019.0923-158
key-10.14336/AD.2019.0923-62
key-10.14336/AD.2019.0923-157
key-10.14336/AD.2019.0923-63
key-10.14336/AD.2019.0923-156
key-10.14336/AD.2019.0923-64
key-10.14336/AD.2019.0923-155
key-10.14336/AD.2019.0923-60
key-10.14336/AD.2019.0923-159
key-10.14336/AD.2019.0923-58
key-10.14336/AD.2019.0923-161
key-10.14336/AD.2019.0923-59
key-10.14336/AD.2019.0923-160
key-10.14336/AD.2019.0923-54
key-10.14336/AD.2019.0923-165
key-10.14336/AD.2019.0923-55
key-10.14336/AD.2019.0923-164
key-10.14336/AD.2019.0923-56
key-10.14336/AD.2019.0923-163
key-10.14336/AD.2019.0923-57
key-10.14336/AD.2019.0923-162
key-10.14336/AD.2019.0923-50
key-10.14336/AD.2019.0923-169
key-10.14336/AD.2019.0923-51
key-10.14336/AD.2019.0923-168
key-10.14336/AD.2019.0923-52
key-10.14336/AD.2019.0923-167
key-10.14336/AD.2019.0923-53
key-10.14336/AD.2019.0923-166
key-10.14336/AD.2019.0923-87
key-10.14336/AD.2019.0923-132
key-10.14336/AD.2019.0923-88
key-10.14336/AD.2019.0923-131
key-10.14336/AD.2019.0923-89
key-10.14336/AD.2019.0923-130
key-10.14336/AD.2019.0923-83
key-10.14336/AD.2019.0923-136
key-10.14336/AD.2019.0923-84
key-10.14336/AD.2019.0923-135
key-10.14336/AD.2019.0923-85
key-10.14336/AD.2019.0923-134
key-10.14336/AD.2019.0923-86
key-10.14336/AD.2019.0923-133
key-10.14336/AD.2019.0923-80
key-10.14336/AD.2019.0923-139
key-10.14336/AD.2019.0923-81
key-10.14336/AD.2019.0923-138
key-10.14336/AD.2019.0923-82
key-10.14336/AD.2019.0923-137
key-10.14336/AD.2019.0923-76
key-10.14336/AD.2019.0923-143
key-10.14336/AD.2019.0923-77
key-10.14336/AD.2019.0923-142
key-10.14336/AD.2019.0923-78
key-10.14336/AD.2019.0923-141
key-10.14336/AD.2019.0923-79
key-10.14336/AD.2019.0923-140
key-10.14336/AD.2019.0923-72
key-10.14336/AD.2019.0923-147
key-10.14336/AD.2019.0923-73
key-10.14336/AD.2019.0923-146
key-10.14336/AD.2019.0923-74
key-10.14336/AD.2019.0923-145
key-10.14336/AD.2019.0923-75
key-10.14336/AD.2019.0923-144
key-10.14336/AD.2019.0923-70
key-10.14336/AD.2019.0923-149
key-10.14336/AD.2019.0923-71
key-10.14336/AD.2019.0923-148
References_xml – ident: key-10.14336/AD.2019.0923-71
  doi: 10.1093/nar/gkl010
– ident: key-10.14336/AD.2019.0923-53
  doi: 10.1016/j.bbrc.2014.09.104
– ident: key-10.14336/AD.2019.0923-87
  doi: 10.1002/jnr.22665
– ident: key-10.14336/AD.2019.0923-129
  doi: 10.1186/s12967-015-0683-x
– ident: key-10.14336/AD.2019.0923-110
  doi: 10.1002/biot.200700059
– ident: key-10.14336/AD.2019.0923-175
  doi: 10.1136/jnnp-2017-315995
– ident: key-10.14336/AD.2019.0923-169
  doi: 10.1155/2010/190724
– ident: key-10.14336/AD.2019.0923-192
  doi: 10.1016/j.stem.2013.04.003
– ident: key-10.14336/AD.2019.0923-62
  doi: 10.1093/mutage/geh025
– ident: key-10.14336/AD.2019.0923-134
  doi: 10.2174/1874375701004010011
– ident: key-10.14336/AD.2019.0923-97
  doi: 10.1038/ncb1101-950
– ident: key-10.14336/AD.2019.0923-84
  doi: 10.1007/s00018-013-1428-8
– ident: key-10.14336/AD.2019.0923-188
  doi: 10.1007/s10571-009-9410-6
– ident: key-10.14336/AD.2019.0923-45
  doi: 10.1186/1756-6606-4-3
– ident: key-10.14336/AD.2019.0923-199
  doi: 10.1523/JNEUROSCI.3347-04.2004
– ident: key-10.14336/AD.2019.0923-23
  doi: 10.1523/JNEUROSCI.07-11-03739.1987
– ident: key-10.14336/AD.2019.0923-40
  doi: 10.1006/exnr.2000.7594
– ident: key-10.14336/AD.2019.0923-89
  doi: 10.1097/IJG.0b013e31815c3a7f
– ident: key-10.14336/AD.2019.0923-31
  doi: 10.1016/S0896-6273(04)00017-0
– ident: key-10.14336/AD.2019.0923-203
  doi: 10.1038/mt.2011.213
– ident: key-10.14336/AD.2019.0923-4
  doi: 10.1073/pnas.92.18.8493
– ident: key-10.14336/AD.2019.0923-83
  doi: 10.12659/MSM.894006
– ident: key-10.14336/AD.2019.0923-126
  doi: 10.1167/iovs.10-5280
– ident: key-10.14336/AD.2019.0923-82
  doi: 10.1016/j.molcel.2005.03.027
– ident: key-10.14336/AD.2019.0923-16
  doi: 10.1083/jcb.143.2.457
– ident: key-10.14336/AD.2019.0923-54
  doi: 10.1016/j.molcel.2007.03.019
– ident: key-10.14336/AD.2019.0923-181
  doi: 10.1016/S0197-4580(02)00196-3
– ident: key-10.14336/AD.2019.0923-41
  doi: 10.1242/jcs.1125880
– ident: key-10.14336/AD.2019.0923-18
  doi: 10.1523/JNEUROSCI.20-09-03104.2000
– ident: key-10.14336/AD.2019.0923-6
  doi: 10.1038/351242a0
– ident: key-10.14336/AD.2019.0923-34
  doi: 10.1016/j.biochi.2008.01.004
– ident: key-10.14336/AD.2019.0923-201
  doi: 10.1038/s41598-017-10488-7
– ident: key-10.14336/AD.2019.0923-185
  doi: 10.1007/s13311-011-0028-2
– ident: key-10.14336/AD.2019.0923-162
  doi: 10.1097/WNO.0b013e318267fd5f
– ident: key-10.14336/AD.2019.0923-96
  doi: 10.1146/annurev.cellbio.17.1.351
– ident: key-10.14336/AD.2019.0923-70
  doi: 10.1038/ncomms9897
– ident: key-10.14336/AD.2019.0923-149
  doi: 10.3389/fnmol.2017.00229
– ident: key-10.14336/AD.2019.0923-107
  doi: 10.1073/pnas.88.3.961
– ident: key-10.14336/AD.2019.0923-163
– ident: key-10.14336/AD.2019.0923-91
  doi: 10.1016/j.preteyeres.2004.05.001
– ident: key-10.14336/AD.2019.0923-125
  doi: 10.1074/jbc.M809393200
– ident: key-10.14336/AD.2019.0923-38
  doi: 10.1101/cshperspect.a009399
– ident: key-10.14336/AD.2019.0923-111
  doi: 10.1172/JCI200318182
– ident: key-10.14336/AD.2019.0923-133
  doi: 10.1016/S0002-9440(10)63879-5
– ident: key-10.14336/AD.2019.0923-92
  doi: 10.1016/j.bbadis.2013.10.015
– ident: key-10.14336/AD.2019.0923-184
  doi: 10.1016/j.jocn.2014.12.014
– ident: key-10.14336/AD.2019.0923-167
  doi: 10.1371/journal.pone.0033389
– ident: key-10.14336/AD.2019.0923-47
  doi: 10.1016/j.celrep.2018.12.025
– ident: key-10.14336/AD.2019.0923-158
  doi: 10.1016/S0197-4580(97)00157-7
– ident: key-10.14336/AD.2019.0923-186
  doi: 10.1371/journal.pone.0213673
– ident: key-10.14336/AD.2019.0923-115
  doi: 10.1016/S0014-5793(02)02934-4
– ident: key-10.14336/AD.2019.0923-190
  doi: 10.1038/cddis.2011.2
– ident: key-10.14336/AD.2019.0923-193
  doi: 10.1074/jbc.M002466200
– ident: key-10.14336/AD.2019.0923-95
  doi: 10.1016/j.bbrc.2014.10.087
– ident: key-10.14336/AD.2019.0923-121
  doi: 10.1167/iovs.05-0996
– ident: key-10.14336/AD.2019.0923-166
  doi: 10.1016/j.ajo.2012.07.023
– ident: key-10.14336/AD.2019.0923-138
  doi: 10.1093/jnen/62.1.68
– ident: key-10.14336/AD.2019.0923-24
  doi: 10.1038/cdd.2014.47
– ident: key-10.14336/AD.2019.0923-26
  doi: 10.1074/jbc.274.27.19011
– ident: key-10.14336/AD.2019.0923-43
  doi: 10.1016/j.devcel.2013.05.007
– ident: key-10.14336/AD.2019.0923-98
  doi: 10.1523/JNEUROSCI.22-01-00156.2002
– ident: key-10.14336/AD.2019.0923-196
  doi: 10.1007/s12035-018-1041-9
– ident: key-10.14336/AD.2019.0923-13
  doi: 10.1155/2014/361020
– ident: key-10.14336/AD.2019.0923-173
  doi: 10.1111/bph.12312
– ident: key-10.14336/AD.2019.0923-80
  doi: 10.1152/physrev.00026.2013
– ident: key-10.14336/AD.2019.0923-172
  doi: 10.1172/JCI2425
– ident: key-10.14336/AD.2019.0923-139
  doi: 10.1073/pnas.0611671104
– ident: key-10.14336/AD.2019.0923-117
  doi: 10.1523/JNEUROSCI.0186-07.2007
– ident: key-10.14336/AD.2019.0923-146
  doi: 10.18632/aging.100045
– ident: key-10.14336/AD.2019.0923-154
  doi: 10.1242/dmm.022558
– ident: key-10.14336/AD.2019.0923-161
  doi: 10.3389/fpsyt.2014.00022
– ident: key-10.14336/AD.2019.0923-48
  doi: 10.1016/j.molcel.2010.05.009
– ident: key-10.14336/AD.2019.0923-67
  doi: 10.1038/s41598-018-23644-4
– ident: key-10.14336/AD.2019.0923-63
  doi: 10.4161/cc.6.3.3752
– ident: key-10.14336/AD.2019.0923-52
  doi: 10.1371/journal.pone.0018449
– ident: key-10.14336/AD.2019.0923-178
  doi: 10.1186/s13041-015-0095-0
– ident: key-10.14336/AD.2019.0923-108
  doi: 10.1523/JNEUROSCI.23-07-02557.2003
– ident: key-10.14336/AD.2019.0923-35
  doi: 10.1093/hmg/ddy174
– ident: key-10.14336/AD.2019.0923-29
  doi: 10.1073/pnas.91.16.7525
– ident: key-10.14336/AD.2019.0923-159
  doi: 10.1136/bjo.2008.148064
– ident: key-10.14336/AD.2019.0923-10
  doi: 10.1161/01.RES.88.4.443
– ident: key-10.14336/AD.2019.0923-3
  doi: 10.1038/nature03094
– ident: key-10.14336/AD.2019.0923-123
  doi: 10.1038/ng.824
– ident: key-10.14336/AD.2019.0923-155
  doi: 10.1007/s12035-012-8262-0
– ident: key-10.14336/AD.2019.0923-55
  doi: 10.1016/j.bbamcr.2013.02.028
– ident: key-10.14336/AD.2019.0923-21
  doi: 10.1091/mbc.e06-12-1110
– ident: key-10.14336/AD.2019.0923-42
  doi: 10.1038/ncb3600
– ident: key-10.14336/AD.2019.0923-50
  doi: 10.1038/35037739
– ident: key-10.14336/AD.2019.0923-81
  doi: 10.1089/ars.2010.3208
– ident: key-10.14336/AD.2019.0923-119
  doi: 10.1016/j.neulet.2007.03.026
– ident: key-10.14336/AD.2019.0923-73
  doi: 10.1016/j.nbd.2014.06.014
– ident: key-10.14336/AD.2019.0923-59
  doi: 10.3390/ijms18051057
– ident: key-10.14336/AD.2019.0923-176
  doi: 10.1016/j.dnarep.2018.12.005
– ident: key-10.14336/AD.2019.0923-30
  doi: 10.1002/j.1460-2075.1996.tb01006.x
– ident: key-10.14336/AD.2019.0923-8
  doi: 10.1126/science.7539157
– ident: key-10.14336/AD.2019.0923-195
  doi: 10.1016/j.expneurol.2019.01.015
– ident: key-10.14336/AD.2019.0923-202
  doi: 10.1038/mt.2013.281
– ident: key-10.14336/AD.2019.0923-33
  doi: 10.1007/s12035-019-1479-4
– ident: key-10.14336/AD.2019.0923-147
  doi: 10.1096/fasebj.13.15.2225
– ident: key-10.14336/AD.2019.0923-101
  doi: 10.1016/S0896-6273(00)80938-1
– ident: key-10.14336/AD.2019.0923-198
  doi: 10.2174/1389450053765824
– ident: key-10.14336/AD.2019.0923-136
  doi: 10.1016/S0896-6273(01)00268-9
– ident: key-10.14336/AD.2019.0923-177
  doi: 10.1007/s00401-015-1431-2
– ident: key-10.14336/AD.2019.0923-104
  doi: 10.1586/17469899.2014.903157
– ident: key-10.14336/AD.2019.0923-204
  doi: 10.1038/nrc.2016.138
– ident: key-10.14336/AD.2019.0923-1
  doi: 10.1007/978-1-4939-0888-2_2
– ident: key-10.14336/AD.2019.0923-127
  doi: 10.1093/hmg/ddx063
– ident: key-10.14336/AD.2019.0923-116
  doi: 10.1016/S0002-9440(10)64837-7
– ident: key-10.14336/AD.2019.0923-15
  doi: 10.1038/cdd.2009.221
– ident: key-10.14336/AD.2019.0923-25
  doi: 10.1523/JNEUROSCI.17-04-01256.1997
– ident: key-10.14336/AD.2019.0923-27
  doi: 10.1016/S0002-9440(10)65133-4
– ident: key-10.14336/AD.2019.0923-189
  doi: 10.1523/JNEUROSCI.22-07-02590.2002
– ident: key-10.14336/AD.2019.0923-206
  doi: 10.1128/MCB.05659-11
– ident: key-10.14336/AD.2019.0923-61
  doi: 10.1007/s004410100396
– ident: key-10.14336/AD.2019.0923-11
  doi: 10.1038/nature12634
– ident: key-10.14336/AD.2019.0923-179
  doi: 10.1074/jbc.M207825200
– ident: key-10.14336/AD.2019.0923-28
  doi: 10.1016/S1097-2765(02)00524-5
– ident: key-10.14336/AD.2019.0923-106
  doi: 10.1111/j.1460-9568.1995.tb01057.x
– ident: key-10.14336/AD.2019.0923-205
  doi: 10.3892/ijmm.13.5.629
– ident: key-10.14336/AD.2019.0923-36
  doi: 10.1186/1750-1172-5-40
– ident: key-10.14336/AD.2019.0923-75
  doi: 10.1016/j.bbadis.2016.09.010
– ident: key-10.14336/AD.2019.0923-66
  doi: 10.1111/nan.12202
– ident: key-10.14336/AD.2019.0923-124
  doi: 10.3892/mmr.2017.6838
– ident: key-10.14336/AD.2019.0923-153
  doi: 10.3233/JAD-141083
– ident: key-10.14336/AD.2019.0923-56
  doi: 10.1074/jbc.M511658200
– ident: key-10.14336/AD.2019.0923-200
  doi: 10.7554/eLife.34202
– ident: key-10.14336/AD.2019.0923-68
  doi: 10.1016/bs.mie.2017.03.012
– ident: key-10.14336/AD.2019.0923-51
  doi: 10.1056/NEJMra022366
– ident: key-10.14336/AD.2019.0923-57
  doi: 10.1128/MCB.02301-05
– ident: key-10.14336/AD.2019.0923-150
  doi: 10.1371/journal.pone.0078842
– ident: key-10.14336/AD.2019.0923-191
  doi: 10.1002/jnr.20999
– ident: key-10.14336/AD.2019.0923-208
  doi: 10.1016/j.ymthe.2018.09.019
– ident: key-10.14336/AD.2019.0923-44
  doi: 10.2353/ajpath.2010.090955
– ident: key-10.14336/AD.2019.0923-58
  doi: 10.1038/cddis.2012.166
– ident: key-10.14336/AD.2019.0923-5
  doi: 10.1002/jcp.20689
– ident: key-10.14336/AD.2019.0923-19
  doi: 10.1016/j.cell.2007.09.036
– ident: key-10.14336/AD.2019.0923-86
  doi: 10.1002/jnr.21739
– ident: key-10.14336/AD.2019.0923-14
  doi: 10.1080/15384101.2015.1004937
– ident: key-10.14336/AD.2019.0923-170
  doi: 10.1152/ajpendo.00199.2012
– ident: key-10.14336/AD.2019.0923-128
  doi: 10.1038/s41598-018-21104-7
– ident: key-10.14336/AD.2019.0923-151
  doi: 10.1038/45159
– ident: key-10.14336/AD.2019.0923-160
  doi: 10.2174/1570159X16666171206144045
– ident: key-10.14336/AD.2019.0923-165
  doi: 10.1167/iovs.10-5317
– ident: key-10.14336/AD.2019.0923-118
  doi: 10.1021/cr3000994
– ident: key-10.14336/AD.2019.0923-143
  doi: 10.1186/1750-1326-8-29
– ident: key-10.14336/AD.2019.0923-109
  doi: 10.1074/jbc.M112.343152
– ident: key-10.14336/AD.2019.0923-60
  doi: 10.1016/S0197-4580(00)00221-9
– ident: key-10.14336/AD.2019.0923-157
  doi: 10.1523/JNEUROSCI.21-08-02661.2001
– ident: key-10.14336/AD.2019.0923-180
  doi: 10.1074/jbc.M002413200
– ident: key-10.14336/AD.2019.0923-114
  doi: 10.1073/pnas.0500989102
– ident: key-10.14336/AD.2019.0923-132
  doi: 10.1371/journal.pone.0095561
– ident: key-10.14336/AD.2019.0923-130
  doi: 10.1016/S0002-9440(10)64970-X
– ident: key-10.14336/AD.2019.0923-141
  doi: 10.1016/j.neulet.2006.12.003
– ident: key-10.14336/AD.2019.0923-113
  doi: 10.4306/pi.2016.13.1.127
– ident: key-10.14336/AD.2019.0923-93
  doi: 10.1016/j.neuroscience.2017.09.028
– ident: key-10.14336/AD.2019.0923-22
  doi: 10.1073/pnas.0906121107
– ident: key-10.14336/AD.2019.0923-32
  doi: 10.1016/j.neuron.2011.09.012
– ident: key-10.14336/AD.2019.0923-156
  doi: 10.1523/JNEUROSCI.0379-07.2007
– ident: key-10.14336/AD.2019.0923-168
  doi: 10.1016/j.preteyeres.2011.02.004
– ident: key-10.14336/AD.2019.0923-17
  doi: 10.1523/JNEUROSCI.17-23-08975.1997
– ident: key-10.14336/AD.2019.0923-9
  doi: 10.1242/jcs.01486
– ident: key-10.14336/AD.2019.0923-103
  doi: 10.4149/neo_2014_064
– ident: key-10.14336/AD.2019.0923-72
  doi: 10.1038/ng1769
– ident: key-10.14336/AD.2019.0923-102
  doi: 10.1002/jnr.22384
– ident: key-10.14336/AD.2019.0923-120
– ident: key-10.14336/AD.2019.0923-69
  doi: 10.1038/nn.3356
– ident: key-10.14336/AD.2019.0923-79
  doi: 10.1158/0008-5472.CAN-08-3745
– ident: key-10.14336/AD.2019.0923-99
  doi: 10.1016/S1534-5807(01)00029-6
– ident: key-10.14336/AD.2019.0923-194
  doi: 10.1111/j.1365-2133.2008.08931.x
– ident: key-10.14336/AD.2019.0923-90
– ident: key-10.14336/AD.2019.0923-49
  doi: 10.1038/onc.2015.524
– ident: key-10.14336/AD.2019.0923-85
  doi: 10.1038/nature01034
– ident: key-10.14336/AD.2019.0923-77
  doi: 10.1172/JCI72723
– ident: key-10.14336/AD.2019.0923-135
  doi: 10.1006/nbdi.2000.0314
– ident: key-10.14336/AD.2019.0923-137
  doi: 10.1523/JNEUROSCI.23-06-02131.2003
– ident: key-10.14336/AD.2019.0923-94
  doi: 10.14336/AD.2017.0717
– ident: key-10.14336/AD.2019.0923-105
  doi: 10.1038/sj.emboj.7601017
– ident: key-10.14336/AD.2019.0923-174
  doi: 10.1371/journal.pone.0115523
– ident: key-10.14336/AD.2019.0923-78
  doi: 10.1093/hmg/ddx170
– ident: key-10.14336/AD.2019.0923-112
  doi: 10.1093/jnen/61.8.678
– ident: key-10.14336/AD.2019.0923-2
  doi: 10.1038/onc.2009.170
– ident: key-10.14336/AD.2019.0923-12
– ident: key-10.14336/AD.2019.0923-187
  doi: 10.1038/jcbfm.2011.117
– ident: key-10.14336/AD.2019.0923-183
  doi: 10.1007/s12035-015-9595-2
– ident: key-10.14336/AD.2019.0923-46
  doi: 10.7554/eLife.08160
– ident: key-10.14336/AD.2019.0923-207
  doi: 10.1038/embor.2010.142
– ident: key-10.14336/AD.2019.0923-88
  doi: 10.1212/WNL.58.12.1809
– ident: key-10.14336/AD.2019.0923-74
  doi: 10.1016/j.celrep.2016.04.071
– ident: key-10.14336/AD.2019.0923-131
– ident: key-10.14336/AD.2019.0923-197
  doi: 10.1042/bj20021535
– ident: key-10.14336/AD.2019.0923-144
  doi: 10.1016/j.disamonth.2010.06.001
– ident: key-10.14336/AD.2019.0923-164
  doi: 10.1001/archopht.1997.01100160201010
– ident: key-10.14336/AD.2019.0923-142
  doi: 10.1074/jbc.M603950200
– ident: key-10.14336/AD.2019.0923-20
  doi: 10.1101/gad.9.11.1340
– ident: key-10.14336/AD.2019.0923-100
  doi: 10.1101/gad.10.22.2849
– ident: key-10.14336/AD.2019.0923-122
  doi: 10.1167/iovs.06-1282
– ident: key-10.14336/AD.2019.0923-140
  doi: 10.1073/pnas.2232515100
– ident: key-10.14336/AD.2019.0923-145
  doi: 10.1016/j.neuint.2008.10.013
– ident: key-10.14336/AD.2019.0923-182
  doi: 10.1093/hmg/ddr026
– ident: key-10.14336/AD.2019.0923-76
  doi: 10.1046/j.1471-4159.1997.69052064.x
– ident: key-10.14336/AD.2019.0923-39
  doi: 10.1016/j.neuron.2014.06.034
– ident: key-10.14336/AD.2019.0923-152
  doi: 10.1371/journal.pone.0119865
– ident: key-10.14336/AD.2019.0923-171
  doi: 10.1093/hmg/ddx063
– ident: key-10.14336/AD.2019.0923-37
  doi: 10.1101/cshperspect.a006189
– ident: key-10.14336/AD.2019.0923-65
  doi: 10.1016/j.mrfmmm.2006.06.007
– ident: key-10.14336/AD.2019.0923-7
  doi: 10.3390/ijms19103082
– ident: key-10.14336/AD.2019.0923-148
  doi: 10.1523/JNEUROSCI.17-10-03588.1997
– ident: key-10.14336/AD.2019.0923-64
  doi: 10.1016/j.neuroscience.2006.07.006
SSID ssj0000392393
Score 2.4557009
SecondaryResourceType review_article
Snippet Cell cycle dysregulation has been implicated in the pathogenesis of neurodegenerative disorders. Specialised function obligates neuronal cells to subsist in a...
SourceID pubmedcentral
proquest
gale
crossref
SourceType Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 946
SubjectTerms Analysis
Cell cycle
Health aspects
Medical research
Neurodegenerative diseases
Neurons
Physiological aspects
Review
Tumor proteins
Title Cell Cycle Deficits in Neurodegenerative Disorders: Uncovering Molecular Mechanisms to Drive Innovative Therapeutic Development
URI https://www.proquest.com/docview/2431820370
https://pubmed.ncbi.nlm.nih.gov/PMC7390532
Volume 11
WOSCitedRecordID wos000556664900020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2152-5250
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000392393
  issn: 2152-5250
  databaseCode: DOA
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2152-5250
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000392393
  issn: 2152-5250
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3fb9MwELa6gdBeEDAQhVGMhMbDKCRxGse8RS0IxDpNokN7ixzHHRFrWtp02l7gD-Sf4s753QkJkHiJotiJo9yX8_l89x0hz6eu7Vs-rE6U8GCBMtCqD9OC6MsI8CQdmDAjkyh8yI-O_NNTcdzp_CxzYS7OeZr6l5di8V9FDddA2Jg6-xfirh4KF-AchA5HEDsc_0jwQ_TGDa_gKigT5IfITMirYeGI9Zmhmc7jhQriTRMUd5IqDOZEx8G4rJh7MNaYF5ysZoYGYrTEuz4UZVThdFLnbjWDj5r2bnBWJkFu7ATlOw_5hn-SLavJYSzToszUQRCtI_kVXuNTEsfJtypSaL3ILd7Puo4szh-CoWc5vEtC8cKf4dTRdMVc8_FwwxlaVk_WRitiHd4-7sW2VLjdgKrb0Mei8G_mU7vIC7xcmzVcZuraBCMM9ROvLJGnQDfAspgZtDCHI__iBne3sQaOx0POBNbZ2CI3HD4QqGLH32uHnwWWKBOs4HnFIV83B9wht8qnt0ykTUNhM3i3YQ1N7pDbxTKGBjn87pKOTu-R3QC-5nx2RfepCSw2Oza75AcikhpE0hKRNEnpNUTSCpFvaI1HWuGR1nik2ZwaPNIaj7SBR9rA431y8u7tZPi-X9T96KuB42d9bg18rl3taBeW-0yyqbQjEcex7w4Um9q-kkia5PmuL7WWkin4rlOPASgsF9rZA7KdzlP9kFDLi6a24jb3dIyuCsmtOIqUdpWNTJJul7wsP3WoClJ8rM1yHuLiGIUUBqMQhRSikLpkv-q-yNlgftfxKcotzJOZK7USBmDfu64nmN8lL0wPBBiMqGSRDgPvjYxsrZ57rZ6g_1Wr-VmJjRCbMGgy1fP1KnRgcQAGPuNWl_AWaKqXR3L5dkuafDEk8wWYH_3znY_JTv1775HtbLnWT8hNdZElq2WPbPFTv2c8YD3zn_wCIrD9Dw
linkProvider ISSN International Centre
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cell+Cycle+Deficits+in+Neurodegenerative+Disorders%3A+Uncovering+Molecular+Mechanisms+to+Drive+Innovative+Therapeutic+Development&rft.jtitle=Aging+and+disease&rft.au=Joseph%2C+Chitra&rft.au=Mangani%2C+Abubakar+Siddiq&rft.au=Gupta%2C+Veer&rft.au=Chitranshi%2C+Nitin&rft.date=2020-08-01&rft.pub=JKL+International+LLC&rft.eissn=2152-5250&rft.volume=11&rft.issue=4&rft.spage=946&rft.epage=966&rft_id=info:doi/10.14336%2FAD.2019.0923&rft_id=info%3Apmid%2F32765956&rft.externalDocID=PMC7390532
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2152-5250&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2152-5250&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2152-5250&client=summon