Chorionic and amniotic membrane-derived stem cells have distinct, and gestational diabetes mellitus independent, proliferative, differentiation, and immunomodulatory capacities

Placental membrane-derived mesenchymal stem cells (MSCs), with the advantages of being non-invasive and having fewer ethical issues, are a promising source for cell therapy. Gestational diabetes (GDM) alters the uterine environment and may affect the therapeutic potential of MSCs derived from placen...

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Bibliographic Details
Published in:	Stem cell research Vol. 40; p. 101537
Main Authors:	Chen, Liyun, Merkhan, Marwan M., Forsyth, Nicholas R., Wu, Pensee
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01.10.2019 Elsevier
Subjects:	Adipogenesis Adipogenesis - drug effects Adiponectin - genetics Adiponectin - metabolism Adult Amnion - cytology Amniotic MSC Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Chorionic MSC Coculture Techniques Culture Media, Conditioned - pharmacology Diabetes, Gestational - pathology Female Gestational diabetes mellitus (GDM) Humans Immunomodulation Immunomodulation - drug effects Infant, Newborn Male Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Placenta - cytology Placental membrane PPAR gamma - genetics PPAR gamma - metabolism Pregnancy THP-1 Cells Amniotic MSC Immunomodulation CXCL-8 PMA ADIPOQ Gestational diabetes mellitus (GDM) PHA CMSCs AMSCs CCL-17 GDM Chorionic MSC OD Placental membrane MRC1 PPARG MSC GAPDH Adipogenesis
ISSN:	1873-5061, 1876-7753, 1876-7753
Online Access:	Get full text
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