Drug radiotherapy combinations: Review of previous failures and reasons for future optimism

•Combined chemo-radiotherapy typically improves clinical outcomes but increases side-effects.•Trials with targeted radiosensitising and hypoxia modifying drugs have been disappointing.•The reasons for this include a lack of biomarkers to identify those patients likely to benefit.•New drug strategies...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer treatment reviews Vol. 41; no. 2; pp. 105 - 113
Main Authors:	Higgins, Geoff S., O’Cathail, Sean M., Muschel, Ruth J., McKenna, W. Gillies
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.02.2015
Subjects:	Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cell Hypoxia - drug effects Chemo-radiotherapy Chemoradiotherapy - adverse effects Chemoradiotherapy - methods Chemoradiotherapy, Adjuvant - adverse effects Clinical Trials as Topic Combined Modality Therapy - methods DNA Repair - drug effects Drug-radiotherapy combinations Hematology, Oncology and Palliative Medicine Humans Immunotherapy Molecular Targeted Therapy - methods Neoplasms - genetics Neoplasms - metabolism Neoplasms - physiopathology Neoplasms - therapy Radiation-Sensitizing Agents - administration & dosage Radiation-Sensitizing Agents - adverse effects Radiosensitisation Signal Transduction - drug effects Treatment Failure Tumour hypoxia Drug-radiotherapy combinations Chemo-radiotherapy Radiosensitisation Tumour hypoxia
ISSN:	0305-7372, 1532-1967, 1532-1967
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!