Mechanisms of HBV-induced hepatocellular carcinoma

Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early steps of clonal tumor expansion and induces both genomic instability and direct insertional mutagenesis of diverse cancer...

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Vydané v:	Journal of hepatology Ročník 64; číslo 1; s. S84 - S101
Hlavní autori:	Levrero, Massimo, Zucman-Rossi, Jessica
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.04.2016
Predmet:	Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Transformation, Neoplastic - genetics DNA, Neoplasm - genetics DNA, Viral - genetics Epigenetics Gastroenterology and Hepatology HBx protein Hepatitis B - complications Hepatitis B - pathology Hepatitis B - virology Hepatitis B virus (HBV) Hepatitis B virus - genetics Hepatocellular carcinoma (HCC) Hepatocytes - pathology Hepatocytes - virology Humans Liver Neoplasms - etiology Liver Neoplasms - metabolism Liver Neoplasms - pathology miRNAs Mutation preS mutants Epigenetics miRNAs Hepatitis B virus (HBV) preS mutants HBx protein Hepatocellular carcinoma (HCC)
ISSN:	0168-8278, 1600-0641, 1600-0641
On-line prístup:	Získať plný text
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