Mechanisms of HBV-induced hepatocellular carcinoma

Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early steps of clonal tumor expansion and induces both genomic instability and direct insertional mutagenesis of diverse cancer...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 64; no. 1; pp. S84 - S101
Main Authors:	Levrero, Massimo, Zucman-Rossi, Jessica
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2016
Subjects:	Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Transformation, Neoplastic - genetics DNA, Neoplasm - genetics DNA, Viral - genetics Epigenetics Gastroenterology and Hepatology HBx protein Hepatitis B - complications Hepatitis B - pathology Hepatitis B - virology Hepatitis B virus (HBV) Hepatitis B virus - genetics Hepatocellular carcinoma (HCC) Hepatocytes - pathology Hepatocytes - virology Humans Liver Neoplasms - etiology Liver Neoplasms - metabolism Liver Neoplasms - pathology miRNAs Mutation preS mutants Epigenetics miRNAs Hepatitis B virus (HBV) preS mutants HBx protein Hepatocellular carcinoma (HCC)
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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