The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks

DNA double strand breaks (DSBs) are the most cytotoxic DNA lesions and, if not repaired, lead to chromosomal rearrangement, genomic instability and cell death. Cells have evolved a complex network of DNA repair and signalling molecules which promptly detect and repair DSBs, commonly known as the DNA...

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Bibliographic Details

Published in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 372; no. 1731
Main Authors:	Torrecilla, Ignacio, Oehler, Judith, Ramadan, Kristijan
Format:	Journal Article
Language:	English
Published:	England 05.10.2017
Subjects:	Animals DNA Breaks, Double-Stranded DNA Repair Humans Ubiquitinated Proteins - metabolism Ubiquitination Valosin Containing Protein - metabolism genome stability CHROMAD chromatin dynamics p97 (vcp/cdc48) DNA double strand breaks DNA repair
ISSN:	1471-2970, 1471-2970
Online Access:	Get more information
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