Comparison of efficacy of immune checkpoint inhibitors (ICIs) between younger and older patients: A systematic review and meta-analysis

•This meta-analysis compared the efficacy of ICIs between younger and older patients.•ICIs significantly improved OS in both younger (HR, 0.75) and older (HR, 0.73) groups.•An improvement in PFS was observed in younger (HR, 0.58) and older (HR, 0.77) patients.•In the PD-1 inhibitor subgroup, a signi...

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Bibliographic Details
Published in:	Cancer treatment reviews Vol. 45; pp. 30 - 37
Main Authors:	Nishijima, Tomohiro F., Muss, Hyman B., Shachar, Shlomit S., Moschos, Stergios J.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.04.2016
Subjects:	Age Age Factors Aging - immunology Antibodies, Monoclonal - classification Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antineoplastic Agents - classification Antineoplastic Agents - immunology Antineoplastic Agents - pharmacology Disease-Free Survival Hematology, Oncology and Palliative Medicine Humans Immune checkpoint inhibitor Immunosenescence Meta-analysis Neoplasms - drug therapy Neoplasms - immunology Overall survival Progression-free survival Randomized Controlled Trials as Topic Systematic review Treatment Outcome Immune checkpoint inhibitor Immunosenescence Systematic review Overall survival Progression-free survival Age Meta-analysis
ISSN:	0305-7372, 1532-1967, 1532-1967
Online Access:	Get full text
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