Molecular basis of resistance to proteasome inhibitors in hematological malignancies

Over the past decade, the proteasome inhibitor bortezomib (Velcade) has not only gained a cornerstone position in the treatment of hematological malignancies, particularly multiple myeloma and mantle cell lymphoma, but also in experimental therapeutics of acute leukemia. However, the therapeutic eff...

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Bibliographic Details
Published in:	Drug resistance updates Vol. 18; pp. 18 - 35
Main Authors:	Niewerth, Denise, Jansen, Gerrit, Assaraf, Yehuda G., Zweegman, Sonja, Kaspers, Gertjan J.L., Cloos, Jacqueline
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01.01.2015
Subjects:	Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology Boronic Acids - adverse effects Boronic Acids - pharmacology Bortezomib Drug Resistance, Neoplasm Hematologic Neoplasms - drug therapy Hematologic Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Infectious Disease Leukemia Multiple myeloma Proteasome inhibitor Proteasome Inhibitors - pharmacology Pyrazines - adverse effects Pyrazines - pharmacology Resistance Resistance Bortezomib Proteasome inhibitor Leukemia Multiple myeloma
ISSN:	1368-7646, 1532-2084, 1532-2084
Online Access:	Get full text
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