Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients

Introduction The aim of this study was to investigate whether in-hospital mortality was associated with the administered fraction of oxygen in inspired air (FiO 2 ) and achieved arterial partial pressure of oxygen (PaO 2 ). Methods This was a retrospective, observational study on data from the first...

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Vydáno v:	Critical care (London, England) Ročník 12; číslo 6; s. R156
Hlavní autoři:	de Jonge, Evert, Peelen, Linda, Keijzers, Peter J, Joore, Hans, de Lange, Dylan, van der Voort, Peter HJ, Bosman, Robert J, de Waal, Ruud AL, Wesselink, Ronald, de Keizer, Nicolette F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 10.12.2008 BioMed Central Ltd National Library of Medicine - MEDLINE Abstracts
Témata:	Aged Arteries - physiopathology Artificial respiration Care and treatment Complications and side effects Critical Care Medicine Critically ill Emergency Medicine Female Health aspects Hospital Mortality Humans Intensive Intensive Care Units Logistic Models Lung diseases Male Medicine Medicine & Public Health Methods Middle Aged Netherlands - epidemiology Observation Oximetry Oxygen - administration & dosage Oxygen - blood Patient outcomes Pulmonary Gas Exchange - physiology Respiration, Artificial - mortality Retrospective Studies Risk factors Netherlands Intensive Care Unit Intensive Care Unit Stay Intensive Care Unit Admission Sequential Organ Failure Assessment Intensive Care Unit Patient
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
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Shrnutí:	Introduction The aim of this study was to investigate whether in-hospital mortality was associated with the administered fraction of oxygen in inspired air (FiO 2 ) and achieved arterial partial pressure of oxygen (PaO 2 ). Methods This was a retrospective, observational study on data from the first 24 h after admission from 36,307 consecutive patients admitted to 50 Dutch intensive care units (ICUs) and treated with mechanical ventilation. Oxygenation data from all admission days were analysed in a subset of 3,322 patients in 5 ICUs. Results Mean PaO 2 and FiO 2 in the first 24 h after ICU admission were 13.2 kPa (standard deviation (SD) 6.5) and 50% (SD 20%) respectively. Mean PaO 2 and FiO 2 from all admission days were 12.4 kPa (SD 5.5) and 53% (SD 18). Focusing on oxygenation in the first 24 h of admission, in-hospital mortality was shown to be linearly related to FiO 2 value and had a U-shaped relationship with PaO 2 (both lower and higher PaO 2 values were associated with a higher mortality), independent of each other and of Simplified Acute Physiology Score (SAPS) II, age, admission type, reduced Glasgow Coma Scale (GCS) score, and individual ICU. Focusing on the entire ICU stay, in-hospital mortality was independently associated with mean FiO 2 during ICU stay and with the lower two quintiles of mean PaO 2 value during ICU stay. Conclusions Actually achieved PaO 2 values in ICU patients in The Netherlands are higher than generally recommended in the literature. High FiO 2 , and both low PaO 2 and high PaO 2 in the first 24 h after admission are independently associated with in-hospital mortality in ICU patients. Future research should study whether this association is causal or merely a reflection of differences in severity of illness insufficiently corrected for in the multivariate analysis.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-2 content type line 23
ISSN:	1364-8535 1466-609X 1364-8535 1466-609X
DOI:	10.1186/cc7150