Neuroimaging standards for research into small vessel disease—advances since 2013

Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living...

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Veröffentlicht in:Lancet neurology Jg. 22; H. 7; S. 602 - 618
Hauptverfasser: Duering, Marco, Biessels, Geert Jan, Brodtmann, Amy, Chen, Christopher, Cordonnier, Charlotte, de Leeuw, Frank-Erik, Debette, Stéphanie, Frayne, Richard, Jouvent, Eric, Rost, Natalia S, ter Telgte, Annemieke, Al-Shahi Salman, Rustam, Backes, Walter H, Bae, Hee-Joon, Brown, Rosalind, Chabriat, Hugues, De Luca, Alberto, deCarli, Charles, Dewenter, Anna, Doubal, Fergus N, Ewers, Michael, Field, Thalia S, Ganesh, Aravind, Greenberg, Steven, Helmer, Karl G, Hilal, Saima, Jochems, Angela C C, Jokinen, Hanna, Kuijf, Hugo, Lam, Bonnie Y K, Lebenberg, Jessica, MacIntosh, Bradley J, Maillard, Pauline, Mok, Vincent C T, Pantoni, Leonardo, Rudilosso, Salvatore, Satizabal, Claudia L, Schirmer, Markus D, Schmidt, Reinhold, Smith, Colin, Staals, Julie, Thrippleton, Michael J, van Veluw, Susanne J, Vemuri, Prashanthi, Wang, Yilong, Werring, David, Zedde, Marialuisa, Akinyemi, Rufus O, Del Brutto, Oscar H, Markus, Hugh S, Zhu, Yi-Cheng, Smith, Eric E, Dichgans, Martin, Wardlaw, Joanna M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.07.2023
Elsevier Limited
Elsevier
Schlagworte:
Activities of Daily Living
Aging
Brain - diagnostic imaging
Brain research
Cerebral Small Vessel Diseases - diagnostic imaging
Clinical trials
Cognitive ability
Cognitive Dysfunction
Humans
Ischemia
Life Sciences
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical imaging
Neurodegenerative Diseases
Neuroimaging
Pathology
Santé publique et épidémiologie
Terminology
Vascular diseases
ISSN:1474-4422, 1474-4465, 1474-4465
Online-Zugang:Volltext
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Zusammenfassung:Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living. Standards for Reporting Vascular Changes on Neuroimaging 1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI. Since then, new information on these established SVD markers and novel MRI sequences and imaging features have emerged. As the effect of combined SVD imaging features becomes clearer, a key role for quantitative imaging biomarkers to determine sub-visible tissue damage, subtle abnormalities visible at high-field strength MRI, and lesion-symptom patterns, is also apparent. Together with rapidly emerging machine learning methods, these metrics can more comprehensively capture the effect of SVD on the brain than the structural MRI features alone and serve as intermediary outcomes in clinical trials and future routine practice. Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.
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ISSN:1474-4422
1474-4465
1474-4465
DOI:10.1016/S1474-4422(23)00131-X