Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty
Osteoarthritis (OA) is a chronic condition marked by joint pain, inflammation and loss of articular cartilage, that can be treated with total joint arthroplasty (TJA) at end stages. TJA is marked by post-operative inflammation, which directly effects levels of cartilage degradation biomarkers, prote...
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| Vydáno v: | Clinical and applied thrombosis/hemostasis Ročník 27; s. 1076029621995569 |
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Los Angeles, CA
SAGE Publications
2021
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| ISSN: | 1076-0296, 1938-2723, 1938-2723 |
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| Abstract | Osteoarthritis (OA) is a chronic condition marked by joint pain, inflammation and loss of articular cartilage, that can be treated with total joint arthroplasty (TJA) at end stages. TJA is marked by post-operative inflammation, which directly effects levels of cartilage degradation biomarkers, proteoglycan-4 (PRG4) and matrix metalloproteinase-9 (MMP-9). PRG4 is a protective glycoprotein that is decreased in individuals with OA. MMP-9 is a matrix metalloproteinase that contributes to articular cartilage loss and is elevated in OA patients. It is upregulated by pro-inflammatory markers, such as IL-1, IL-6 and CRP. This study aims to elucidate the immediate post-operative changes in levels of PRG4, MMP-9, IL-6, CRP, and WBC in patients undergoing TJA to clarify the role of inflammation in recovery after surgery and in the overall pathogenesis of OA. Blood was collected at 3 time points (day 0, day 1 post-operatively, and days 5-7 post-operatively), from 63 patients undergoing TJA due to OA, and levels of these biomarkers were quantified. IL-6, CRP, WBC and MMP-9 were lowest at day 0, highest at day 1, and stabilized at an intermediate level at days 5-7. Meanwhile, PRG4 followed the opposite trend. These studies suggest that IL-6, CRP and WBC showed predictable fluctuations, with pro-inflammatory biomarkers upregulating MMP-9 and downregulating PRG4. Measuring these biomarkers may help expose the role of inflammation in the post-surgical recovery of TJA patients and in long-term pathogenesis of OA. These levels may help risk stratify patients pre-operatively and help develop individualized post-surgical plans. |
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| AbstractList | Osteoarthritis (OA) is a chronic condition marked by joint pain, inflammation and loss of articular cartilage, that can be treated with total joint arthroplasty (TJA) at end stages. TJA is marked by post-operative inflammation, which directly effects levels of cartilage degradation biomarkers, proteoglycan-4 (PRG4) and matrix metalloproteinase-9 (MMP-9). PRG4 is a protective glycoprotein that is decreased in individuals with OA. MMP-9 is a matrix metalloproteinase that contributes to articular cartilage loss and is elevated in OA patients. It is upregulated by pro-inflammatory markers, such as IL-1, IL-6 and CRP. This study aims to elucidate the immediate post-operative changes in levels of PRG4, MMP-9, IL-6, CRP, and WBC in patients undergoing TJA to clarify the role of inflammation in recovery after surgery and in the overall pathogenesis of OA. Blood was collected at 3 time points (day 0, day 1 post-operatively, and days 5-7 post-operatively), from 63 patients undergoing TJA due to OA, and levels of these biomarkers were quantified. IL-6, CRP, WBC and MMP-9 were lowest at day 0, highest at day 1, and stabilized at an intermediate level at days 5-7. Meanwhile, PRG4 followed the opposite trend. These studies suggest that IL-6, CRP and WBC showed predictable fluctuations, with pro-inflammatory biomarkers upregulating MMP-9 and downregulating PRG4. Measuring these biomarkers may help expose the role of inflammation in the post-surgical recovery of TJA patients and in long-term pathogenesis of OA. These levels may help risk stratify patients pre-operatively and help develop individualized post-surgical plans. Osteoarthritis (OA) is a chronic condition marked by joint pain, inflammation and loss of articular cartilage, that can be treated with total joint arthroplasty (TJA) at end stages. TJA is marked by post-operative inflammation, which directly effects levels of cartilage degradation biomarkers, proteoglycan-4 (PRG4) and matrix metalloproteinase-9 (MMP-9). PRG4 is a protective glycoprotein that is decreased in individuals with OA. MMP-9 is a matrix metalloproteinase that contributes to articular cartilage loss and is elevated in OA patients. It is upregulated by pro-inflammatory markers, such as IL-1, IL-6 and CRP. This study aims to elucidate the immediate post-operative changes in levels of PRG4, MMP-9, IL-6, CRP, and WBC in patients undergoing TJA to clarify the role of inflammation in recovery after surgery and in the overall pathogenesis of OA. Blood was collected at 3 time points (day 0, day 1 post-operatively, and days 5-7 post-operatively), from 63 patients undergoing TJA due to OA, and levels of these biomarkers were quantified. IL-6, CRP, WBC and MMP-9 were lowest at day 0, highest at day 1, and stabilized at an intermediate level at days 5-7. Meanwhile, PRG4 followed the opposite trend. These studies suggest that IL-6, CRP and WBC showed predictable fluctuations, with pro-inflammatory biomarkers upregulating MMP-9 and downregulating PRG4. Measuring these biomarkers may help expose the role of inflammation in the post-surgical recovery of TJA patients and in long-term pathogenesis of OA. These levels may help risk stratify patients pre-operatively and help develop individualized post-surgical plans.Osteoarthritis (OA) is a chronic condition marked by joint pain, inflammation and loss of articular cartilage, that can be treated with total joint arthroplasty (TJA) at end stages. TJA is marked by post-operative inflammation, which directly effects levels of cartilage degradation biomarkers, proteoglycan-4 (PRG4) and matrix metalloproteinase-9 (MMP-9). PRG4 is a protective glycoprotein that is decreased in individuals with OA. MMP-9 is a matrix metalloproteinase that contributes to articular cartilage loss and is elevated in OA patients. It is upregulated by pro-inflammatory markers, such as IL-1, IL-6 and CRP. This study aims to elucidate the immediate post-operative changes in levels of PRG4, MMP-9, IL-6, CRP, and WBC in patients undergoing TJA to clarify the role of inflammation in recovery after surgery and in the overall pathogenesis of OA. Blood was collected at 3 time points (day 0, day 1 post-operatively, and days 5-7 post-operatively), from 63 patients undergoing TJA due to OA, and levels of these biomarkers were quantified. IL-6, CRP, WBC and MMP-9 were lowest at day 0, highest at day 1, and stabilized at an intermediate level at days 5-7. Meanwhile, PRG4 followed the opposite trend. These studies suggest that IL-6, CRP and WBC showed predictable fluctuations, with pro-inflammatory biomarkers upregulating MMP-9 and downregulating PRG4. Measuring these biomarkers may help expose the role of inflammation in the post-surgical recovery of TJA patients and in long-term pathogenesis of OA. These levels may help risk stratify patients pre-operatively and help develop individualized post-surgical plans. |
| Author | Jezovnik, Mateja Hopkinson, William Poredos, Pavel Fareed, Jawed Khanna, Rajan Hoppensteadt, Debra Slovacek, Hannah Poredos, Peter |
| AuthorAffiliation | 4 Department of Advanced Cardiopulmonary Therapies and Transplantation, 12340 University of Texas Health Science Center at Houston , TX, USA 5 Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute, 2456 Loyola University Chicago , Health Sciences Division, Maywood, IL, USA 1 Department of Pathology and Laboratory Medicine, 25815 Loyola University Medical Center , Maywood, IL, USA 6 Orthopaedic Surgery and Rehabilitation Department, 2456 Loyola University Chicago , Health Sciences Division, Maywood, IL, USA 2 Medical Clinic Division of Vascular Medicine, University Medical Centre Ljubljana, Slovenia 3 Department of Anesthesiology and Perioperative Intensive Care, University Medical Centre Ljubljana, Slovenia |
| AuthorAffiliation_xml | – name: 2 Medical Clinic Division of Vascular Medicine, University Medical Centre Ljubljana, Slovenia – name: 1 Department of Pathology and Laboratory Medicine, 25815 Loyola University Medical Center , Maywood, IL, USA – name: 4 Department of Advanced Cardiopulmonary Therapies and Transplantation, 12340 University of Texas Health Science Center at Houston , TX, USA – name: 3 Department of Anesthesiology and Perioperative Intensive Care, University Medical Centre Ljubljana, Slovenia – name: 6 Orthopaedic Surgery and Rehabilitation Department, 2456 Loyola University Chicago , Health Sciences Division, Maywood, IL, USA – name: 5 Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute, 2456 Loyola University Chicago , Health Sciences Division, Maywood, IL, USA |
| Author_xml | – sequence: 1 givenname: Hannah orcidid: 0000-0003-0678-9615 surname: Slovacek fullname: Slovacek, Hannah email: hslovacek@luc.edu – sequence: 2 givenname: Rajan orcidid: 0000-0003-2784-8856 surname: Khanna fullname: Khanna, Rajan – sequence: 3 givenname: Pavel orcidid: 0000-0002-9913-1419 surname: Poredos fullname: Poredos, Pavel – sequence: 4 givenname: Peter orcidid: 0000-0001-5258-443X surname: Poredos fullname: Poredos, Peter – sequence: 5 givenname: Mateja orcidid: 0000-0002-5317-0148 surname: Jezovnik fullname: Jezovnik, Mateja – sequence: 6 givenname: Debra orcidid: 0000-0001-9342-4213 surname: Hoppensteadt fullname: Hoppensteadt, Debra – sequence: 7 givenname: Jawed orcidid: 0000-0003-3465-2499 surname: Fareed fullname: Fareed, Jawed – sequence: 8 givenname: William surname: Hopkinson fullname: Hopkinson, William |
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| Keywords | cartilage degradation inflammation matrix metalloproteinase-9 osteoarthritis proteoglycan-4 |
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| Title | Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty |
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