Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)

Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a family of fifteen mammalian serine proteases. While the physiological roles of several KLKs have been at least partially elucidated, their activation and regulation remain largely unclear. This obscurity may...

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Veröffentlicht in:	Biochimie Jg. 92; H. 11; S. 1546 - 1567
Hauptverfasser:	Goettig, Peter, Magdolen, Viktor, Brandstetter, Hans
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	France Elsevier B.V 01.11.2010 Editions Scientifiques Elsevier
Schlagworte:	Amino Acid Sequence Animals Biological Products - chemical synthesis Biological Products - chemistry Biological Products - pharmacology Drug Discovery Humans Inhibitory compound Kallikreins - antagonists & inhibitors Kallikreins - chemistry Molecular Sequence Data Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Review Rule of five Specificity pockets Tissue kallikrein Zinc Tissue kallikrein Inhibitory compound Rule of five Specificity pockets Zinc
ISSN:	0300-9084, 1638-6183, 1638-6183
Online-Zugang:	Volltext
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