Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

Clinical neuropathologic studies suggest that the selective vulnerability of hippocampal CA1 pyramidal projection neurons plays a key role in the onset of cognitive impairment during the early phases of Alzheimer's disease (AD). Disruption of this neuronal population likely affects hippocampal...

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Bibliographic Details
Published in:	Neuropharmacology Vol. 79; pp. 172 - 179
Main Authors:	Counts, Scott E., Alldred, Melissa J., Che, Shaoli, Ginsberg, Stephen D., Mufson, Elliott J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.2014
Subjects:	Aged, 80 and over Alzheimer Disease - metabolism Alzheimer's disease CA1 Region, Hippocampal - metabolism Cognitive Dysfunction - metabolism Female Gene Expression Gene regulation Hippocampus Humans Male Microarray Mild cognitive impairment Polymerase Chain Reaction Pyramidal Cells - metabolism Severity of Illness Index Synaptic Tissue Array Analysis Synaptic Microarray Mild cognitive impairment Alzheimer's disease Gene regulation Hippocampus
ISSN:	0028-3908, 1873-7064, 1873-7064
Online Access:	Get full text
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