Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at –420 on Plasma Resistin: Genotype and DNA Methylation

Methylation at RETN SNP–420 was inversely associated with plasma resistin dependent and independent of SNP–420 genotypes in the general Japanese population.AbstractContext:We previously reported that single nucleotide polymorphism (SNP)–420 C>G (rs1862513) in the promoter region of RETN was assoc...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism Jg. 102; H. 3; S. 884 - 892
Hauptverfasser:	Onuma, Hiroshi, Tabara, Yasuharu, Kawamura, Ryoichi, Ohashi, Jun, Nishida, Wataru, Takata, Yasunori, Ochi, Masaaki, Nishimiya, Tatsuya, Ohyagi, Yasumasa, Kawamoto, Ryuichi, Kohara, Katsuhiko, Miki, Tetsuro, Osawa, Haruhiko
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Washington, DC Endocrine Society 01.03.2017 Copyright Oxford University Press Oxford University Press
Schlagworte:	3' Untranslated regions Aged Asians - genetics Azacytidine Bisulfite Body Mass Index C-reactive protein C-Reactive Protein - metabolism Cell Line CpG Islands Cytosine Deoxyribonucleic acid Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics DNA DNA Methylation Epigenesis, Genetic - genetics Epigenetics Female Gene polymorphism Genotype Genotype & phenotype Genotypes Guanine Humans Japan Leukocytes Male Middle Aged Monocytes mRNA Nucleotide sequence Plasma Polymorphism Polymorphism, Single Nucleotide Resistin - blood Resistin - genetics RNA, Messenger - metabolism Single-nucleotide polymorphism Japan
ISSN:	0021-972X, 1945-7197
Online-Zugang:	Volltext
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