Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at –420 on Plasma Resistin: Genotype and DNA Methylation

Methylation at RETN SNP–420 was inversely associated with plasma resistin dependent and independent of SNP–420 genotypes in the general Japanese population.AbstractContext:We previously reported that single nucleotide polymorphism (SNP)–420 C>G (rs1862513) in the promoter region of RETN was assoc...

Full description

Saved in:

Bibliographic Details
Published in:	The journal of clinical endocrinology and metabolism Vol. 102; no. 3; pp. 884 - 892
Main Authors:	Onuma, Hiroshi, Tabara, Yasuharu, Kawamura, Ryoichi, Ohashi, Jun, Nishida, Wataru, Takata, Yasunori, Ochi, Masaaki, Nishimiya, Tatsuya, Ohyagi, Yasumasa, Kawamoto, Ryuichi, Kohara, Katsuhiko, Miki, Tetsuro, Osawa, Haruhiko
Format:	Journal Article
Language:	English
Published:	Washington, DC Endocrine Society 01.03.2017 Copyright Oxford University Press Oxford University Press
Subjects:	3' Untranslated regions Aged Asians - genetics Azacytidine Bisulfite Body Mass Index C-reactive protein C-Reactive Protein - metabolism Cell Line CpG Islands Cytosine Deoxyribonucleic acid Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics DNA DNA Methylation Epigenesis, Genetic - genetics Epigenetics Female Gene polymorphism Genotype Genotype & phenotype Genotypes Guanine Humans Japan Leukocytes Male Middle Aged Monocytes mRNA Nucleotide sequence Plasma Polymorphism Polymorphism, Single Nucleotide Resistin - blood Resistin - genetics RNA, Messenger - metabolism Single-nucleotide polymorphism Japan
ISSN:	0021-972X, 1945-7197
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Methylation at RETN SNP–420 was inversely associated with plasma resistin dependent and independent of SNP–420 genotypes in the general Japanese population.AbstractContext:We previously reported that single nucleotide polymorphism (SNP)–420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP–420 genotypes. SNP–420 is a CpG-SNP affecting the sequence of cytosine–phosphate–guanine dinucleotides.Objective:To examine whether methylation at SNP–420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP–420.Design and Methods:Genomic DNA was extracted from peripheral white blood cells in 2078 Japanese subjects. Quantification of the methylation was performed by pyrosequencing after DNA bisulfite conversion.Results:Methylation at SNP–420 was highest in the C/C genotype (36.9 ± 5.7%), followed by C/G (21.4 ± 3.5%) and G/G (2.9 ± 1.4%; P < 0.001). When assessed in each genotype, methylation at SNP–420 was inversely associated with plasma resistin in the C/C (β = –0.134, P < 0.001) or C/G (β = –0.227, P < 0.001) genotype. In THP-1 human monocytes intrinsically having the C/C genotype, a demethylating reagent, 5-aza-dC, decreased the methylation at SNP–420 and increased RETN messenger RNA. SNP+1263 (rs3745369), located in the 3′ untranslated region of RETN, was also associated with methylation at SNP–420. In addition, highly sensitive C-reactive protein was inversely associated with methylation at SNP–420 in the C/C genotype, whereas body mass index was positively associated.Conclusions:Plasma resistin was inversely associated with the extent of methylation at SNP–420 mainly dependent on the SNP–420 genotype. The association can also be explained partially independent of SNP–420 genotypes. SNP–420 could have dual, genetic and epigenetic effects on plasma resistin.
AbstractList	Context:We previously reported that single nucleotide polymorphism (SNP)–420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP–420 genotypes. SNP–420 is a CpG-SNP affecting the sequence of cytosine–phosphate–guanine dinucleotides.Objective:To examine whether methylation at SNP–420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP–420.Design and Methods:Genomic DNA was extracted from peripheral white blood cells in 2078 Japanese subjects. Quantification of the methylation was performed by pyrosequencing after DNA bisulfite conversion.Results:Methylation at SNP–420 was highest in the C/C genotype (36.9 ± 5.7%), followed by C/G (21.4 ± 3.5%) and G/G (2.9 ± 1.4%; P < 0.001). When assessed in each genotype, methylation at SNP–420 was inversely associated with plasma resistin in the C/C (β = –0.134, P < 0.001) or C/G (β = –0.227, P < 0.001) genotype. In THP-1 human monocytes intrinsically having the C/C genotype, a demethylating reagent, 5-aza-dC, decreased the methylation at SNP–420 and increased RETN messenger RNA. SNP+1263 (rs3745369), located in the 3′ untranslated region of RETN, was also associated with methylation at SNP–420. In addition, highly sensitive C-reactive protein was inversely associated with methylation at SNP–420 in the C/C genotype, whereas body mass index was positively associated.Conclusions:Plasma resistin was inversely associated with the extent of methylation at SNP–420 mainly dependent on the SNP–420 genotype. The association can also be explained partially independent of SNP–420 genotypes. SNP–420 could have dual, genetic and epigenetic effects on plasma resistin. CONTEXTWe previously reported that single nucleotide polymorphism (SNP)-420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP-420 genotypes. SNP-420 is a CpG-SNP affecting the sequence of cytosine-phosphate-guanine dinucleotides.OBJECTIVETo examine whether methylation at SNP-420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP-420.DESIGN AND METHODSGenomic DNA was extracted from peripheral white blood cells in 2078 Japanese subjects. Quantification of the methylation was performed by pyrosequencing after DNA bisulfite conversion.RESULTSMethylation at SNP-420 was highest in the C/C genotype (36.9 ± 5.7%), followed by C/G (21.4 ± 3.5%) and G/G (2.9 ± 1.4%; P < 0.001). When assessed in each genotype, methylation at SNP-420 was inversely associated with plasma resistin in the C/C (β = -0.134, P < 0.001) or C/G (β = -0.227, P < 0.001) genotype. In THP-1 human monocytes intrinsically having the C/C genotype, a demethylating reagent, 5-aza-dC, decreased the methylation at SNP-420 and increased RETN messenger RNA. SNP+1263 (rs3745369), located in the 3' untranslated region of RETN, was also associated with methylation at SNP-420. In addition, highly sensitive C-reactive protein was inversely associated with methylation at SNP-420 in the C/C genotype, whereas body mass index was positively associated.CONCLUSIONSPlasma resistin was inversely associated with the extent of methylation at SNP-420 mainly dependent on the SNP-420 genotype. The association can also be explained partially independent of SNP-420 genotypes. SNP-420 could have dual, genetic and epigenetic effects on plasma resistin. Methylation at RETN SNP–420 was inversely associated with plasma resistin dependent and independent of SNP–420 genotypes in the general Japanese population.AbstractContext:We previously reported that single nucleotide polymorphism (SNP)–420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP–420 genotypes. SNP–420 is a CpG-SNP affecting the sequence of cytosine–phosphate–guanine dinucleotides.Objective:To examine whether methylation at SNP–420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP–420.Design and Methods:Genomic DNA was extracted from peripheral white blood cells in 2078 Japanese subjects. Quantification of the methylation was performed by pyrosequencing after DNA bisulfite conversion.Results:Methylation at SNP–420 was highest in the C/C genotype (36.9 ± 5.7%), followed by C/G (21.4 ± 3.5%) and G/G (2.9 ± 1.4%; P < 0.001). When assessed in each genotype, methylation at SNP–420 was inversely associated with plasma resistin in the C/C (β = –0.134, P < 0.001) or C/G (β = –0.227, P < 0.001) genotype. In THP-1 human monocytes intrinsically having the C/C genotype, a demethylating reagent, 5-aza-dC, decreased the methylation at SNP–420 and increased RETN messenger RNA. SNP+1263 (rs3745369), located in the 3′ untranslated region of RETN, was also associated with methylation at SNP–420. In addition, highly sensitive C-reactive protein was inversely associated with methylation at SNP–420 in the C/C genotype, whereas body mass index was positively associated.Conclusions:Plasma resistin was inversely associated with the extent of methylation at SNP–420 mainly dependent on the SNP–420 genotype. The association can also be explained partially independent of SNP–420 genotypes. SNP–420 could have dual, genetic and epigenetic effects on plasma resistin. Methylation at RETN SNP-420 was inversely associated with plasma resistin dependent and independent of SNP-420 genotypes in the general Japanese population. Abstract We previously reported that single nucleotide polymorphism (SNP)-420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP-420 genotypes. SNP-420 is a CpG-SNP affecting the sequence of cytosine-phosphate-guanine dinucleotides. To examine whether methylation at SNP-420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP-420. Genomic DNA was extracted from peripheral white blood cells in 2078 Japanese subjects. Quantification of the methylation was performed by pyrosequencing after DNA bisulfite conversion. Methylation at SNP-420 was highest in the C/C genotype (36.9 ± 5.7%), followed by C/G (21.4 ± 3.5%) and G/G (2.9 ± 1.4%; P < 0.001). When assessed in each genotype, methylation at SNP-420 was inversely associated with plasma resistin in the C/C (β = -0.134, P < 0.001) or C/G (β = -0.227, P < 0.001) genotype. In THP-1 human monocytes intrinsically having the C/C genotype, a demethylating reagent, 5-aza-dC, decreased the methylation at SNP-420 and increased RETN messenger RNA. SNP+1263 (rs3745369), located in the 3' untranslated region of RETN, was also associated with methylation at SNP-420. In addition, highly sensitive C-reactive protein was inversely associated with methylation at SNP-420 in the C/C genotype, whereas body mass index was positively associated. Plasma resistin was inversely associated with the extent of methylation at SNP-420 mainly dependent on the SNP-420 genotype. The association can also be explained partially independent of SNP-420 genotypes. SNP-420 could have dual, genetic and epigenetic effects on plasma resistin. We previously reported that single nucleotide polymorphism (SNP)-420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP-420 genotypes. SNP-420 is a CpG-SNP affecting the sequence of cytosine-phosphate-guanine dinucleotides. To examine whether methylation at SNP-420 affects plasma resistin, we analyzed plasma resistin and methylation at RETN SNP-420. Genomic DNA was extracted from peripheral white blood cells in 2078 Japanese subjects. Quantification of the methylation was performed by pyrosequencing after DNA bisulfite conversion. Methylation at SNP-420 was highest in the C/C genotype (36.9 ± 5.7%), followed by C/G (21.4 ± 3.5%) and G/G (2.9 ± 1.4%; P < 0.001). When assessed in each genotype, methylation at SNP-420 was inversely associated with plasma resistin in the C/C (β = -0.134, P < 0.001) or C/G (β = -0.227, P < 0.001) genotype. In THP-1 human monocytes intrinsically having the C/C genotype, a demethylating reagent, 5-aza-dC, decreased the methylation at SNP-420 and increased RETN messenger RNA. SNP+1263 (rs3745369), located in the 3' untranslated region of RETN, was also associated with methylation at SNP-420. In addition, highly sensitive C-reactive protein was inversely associated with methylation at SNP-420 in the C/C genotype, whereas body mass index was positively associated. Plasma resistin was inversely associated with the extent of methylation at SNP-420 mainly dependent on the SNP-420 genotype. The association can also be explained partially independent of SNP-420 genotypes. SNP-420 could have dual, genetic and epigenetic effects on plasma resistin.
Author	Kohara, Katsuhiko Nishida, Wataru Nishimiya, Tatsuya Kawamoto, Ryuichi Onuma, Hiroshi Ohashi, Jun Ochi, Masaaki Tabara, Yasuharu Takata, Yasunori Miki, Tetsuro Ohyagi, Yasumasa Osawa, Haruhiko Kawamura, Ryoichi
AuthorAffiliation	1Departments of Diabetes and Molecular Genetics, 2Geriatric Medicine, and 3Community Medicine, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan; 4Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; and 5Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-8654, Japan
AuthorAffiliation_xml	– name: 1Departments of Diabetes and Molecular Genetics, 2Geriatric Medicine, and 3Community Medicine, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan; 4Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; and 5Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-8654, Japan
Author_xml	– sequence: 1 givenname: Hiroshi surname: Onuma fullname: Onuma, Hiroshi email: harosawa@m.ehime-u.ac.jp organization: 1Departments of Diabetes and Molecular Genetics – sequence: 2 givenname: Yasuharu surname: Tabara fullname: Tabara, Yasuharu organization: 4Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; and – sequence: 3 givenname: Ryoichi surname: Kawamura fullname: Kawamura, Ryoichi organization: 1Departments of Diabetes and Molecular Genetics – sequence: 4 givenname: Jun surname: Ohashi fullname: Ohashi, Jun organization: 5Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-8654, Japan – sequence: 5 givenname: Wataru surname: Nishida fullname: Nishida, Wataru organization: 1Departments of Diabetes and Molecular Genetics – sequence: 6 givenname: Yasunori surname: Takata fullname: Takata, Yasunori organization: 1Departments of Diabetes and Molecular Genetics – sequence: 7 givenname: Masaaki surname: Ochi fullname: Ochi, Masaaki organization: 1Departments of Diabetes and Molecular Genetics – sequence: 8 givenname: Tatsuya surname: Nishimiya fullname: Nishimiya, Tatsuya organization: 1Departments of Diabetes and Molecular Genetics – sequence: 9 givenname: Yasumasa surname: Ohyagi fullname: Ohyagi, Yasumasa organization: 2Geriatric Medicine, and – sequence: 10 givenname: Ryuichi surname: Kawamoto fullname: Kawamoto, Ryuichi organization: 3Community Medicine, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan – sequence: 11 givenname: Katsuhiko surname: Kohara fullname: Kohara, Katsuhiko organization: 2Geriatric Medicine, and – sequence: 12 givenname: Tetsuro surname: Miki fullname: Miki, Tetsuro organization: 2Geriatric Medicine, and – sequence: 13 givenname: Haruhiko surname: Osawa fullname: Osawa, Haruhiko organization: 1Departments of Diabetes and Molecular Genetics
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27929711$$D View this record in MEDLINE/PubMed
BookMark	eNp9kkFvFCEYhompsdvqzbMh8WBNnAoMDOCtaddqUteNrYk3wg7gzsrAODA2e_M_-A_9Jc5020uTyoVAnufjy_dyAPZCDBaA5xgdY4LR2019TBCuCkIxfwRmWFJWcCz5HpghRHAhOfm2Dw5S2iCEKWXlE7BPuCSSYzwDv84G7eHcOVvnBKODGn6ZXy3gZRO-ewsXQ-1tzI2xcBn9to19t25SC48uF8vXUGf49_cfShCMAS69Tu1o29Sk3IR38NyGmLedhToYeLY4gZ9sXm-9zk0MT8Fjp32yz273Q_D1_fzq9ENx8fn84-nJRVEzInjBMJeYMWMMYyuJjag1qsxKS4NKgUhpiHTI0cpVRlDhkEVcYEdNjZnTuCzLQ3C0q9v18edgU1Ztk2rrvQ42DklhQbmQnKEJfXkP3cShD2N3qsQVLUeIov9RZGxICCLZVOvFLTWsWmtU1zet7rfqbu4jQHZA3ceUeutU3eSbyeReN15hpKZw1aZWU7hqCneU3tyT7uo-gNMdfh19tn364Ydr26u11T6vFRoXrbgoRoGjcjwV09WkvdppcegeeuDms5X_AEnlvQo
CitedBy_id	crossref_primary_10_1089_gtmb_2017_0212 crossref_primary_10_3390_ijms231911813 crossref_primary_10_1038_s41598_019_51592_0 crossref_primary_10_3390_nu14235092 crossref_primary_10_1007_s13167_019_00178_x crossref_primary_10_20960_nh_04206 crossref_primary_10_1097_MD_0000000000009485 crossref_primary_10_1038_s41598_024_84142_4 crossref_primary_10_1038_s41398_018_0205_8 crossref_primary_10_3390_nu14091789 crossref_primary_10_1016_j_ygeno_2018_06_005 crossref_primary_10_1002_jcp_29887 crossref_primary_10_1016_j_cca_2020_11_010
Cites_doi	10.1111/j.1365-2796.2007.01787.x 10.1371/journal.pmed.0010045 10.1007/s00125-012-2815-7 10.1038/nature08514 10.2337/dc06-1936 10.1172/JCI30938 10.1186/gb-2011-12-1-r10 10.2337/dc08-1625 10.1111/j.1365-2265.2006.02710.x 10.1210/me.2012-1004 10.1111/j.1365-2265.2007.03154.x 10.1371/journal.pone.0009718 10.1016/j.ajhg.2010.02.005 10.2217/epi.12.45 10.1016/j.ajhg.2008.03.015 10.1086/424761 10.1016/j.bbrc.2005.07.122 10.1038/35053000 10.1007/s00125-010-1665-4 10.1111/j.1369-1600.2011.00323.x 10.1530/eje.1.02338 10.1093/bioinformatics/btl268 10.1038/nrg2341 10.1038/nrg3142 10.1016/S0140-6736(13)62674-4 10.2337/db11-1048 10.1016/S0006-291X(02)02841-3 10.1186/1741-7015-8-87 10.1016/j.jacc.2005.04.022 10.1038/ng.946 10.1371/journal.pone.0073480 10.2337/diacare.27.10.2450 10.1007/s00125-007-0916-5 10.1161/01.CIR.0000155620.10387.43 10.7326/0003-4819-149-5-200809020-00005 10.1016/j.jacc.2007.06.012 10.1038/nature05913 10.1101/gr.104695.109 10.1371/journal.pgen.1000952
ContentType	Journal Article
Copyright	Copyright © 2017 by the Endocrine Society 2017 Copyright © Oxford University Press 2015 Copyright © 2017 by the Endocrine Society Copyright © 2017 Endocrine Society
Copyright_xml	– notice: Copyright © 2017 by the Endocrine Society 2017 – notice: Copyright © Oxford University Press 2015 – notice: Copyright © 2017 by the Endocrine Society – notice: Copyright © 2017 Endocrine Society
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QP 7T5 7TM 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8
DOI	10.1210/jc.2016-2417
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Immunology Abstracts Nucleic Acids Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central ProQuest One Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	AIDS and Cancer Research Abstracts MEDLINE - Academic ProQuest One Academic Middle East (New) MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1945-7197
EndPage	892
ExternalDocumentID	27929711 10_1210_jc_2016_2417 00004678-201703000-00007 10.1210/jc.2016-2417
Genre	Journal Article
GeographicLocations	Japan
GeographicLocations_xml	– name: Japan
GroupedDBID	--- -~X .55 .GJ .XZ 08P 0R~ 18M 1TH 29K 2WC 34G 354 39C 3O- 3V. 4.4 48X 53G 5GY 5RS 5YH 7X7 88E 8F7 8FI 8FJ AABZA AACZT AAIMJ AAJQQ AAKAS AAPGJ AAPQZ AAPXW AAQQT AARHZ AAUAY AAUQX AAVAP AAWDT AAWTL AAYJJ ABBLC ABDFA ABDPE ABEJV ABGNP ABJNI ABLJU ABMNT ABNHQ ABOCM ABPMR ABPPZ ABPQP ABPTD ABQNK ABUWG ABVGC ABWST ABXVV ACFRR ACGFO ACGFS ACPRK ACUTJ ACYHN ACZBC ADBBV ADGKP ADGZP ADHKW ADQBN ADRTK ADVEK ADZCM AELWJ AEMDU AENEX AENZO AERZD AETBJ AEWNT AFCHL AFFNX AFFQV AFFZL AFGWE AFKRA AFOFC AFRAH AFXAL AFYAG AGINJ AGKRT AGMDO AGQXC AGUTN AHMBA AHMMS AI. AJEEA ALMA_UNASSIGNED_HOLDINGS APIBT APJGH AQDSO AQKUS ARIXL ASPBG ATGXG AVWKF AZFZN BAWUL BAYMD BCRHZ BENPR BEYMZ BPHCQ BSWAC BTRTY BVXVI C45 CCPQU CDBKE CS3 D-I DAKXR DIK E3Z EBS EIHJH EJD EMOBN ENERS F5P FECEO FEDTE FHSFR FLUFQ FOEOM FOTVD FQBLK FYUFA GAUVT GJXCC GX1 H13 HMCUK HVGLF HZ~ H~9 IAO IHR INH ITC J5H KBUDW KOP KQ8 KSI KSN L7B M1P M5~ MBLQV MHKGH MJL N4W N9A NLBLG NOMLY NOYVH NVLIB O9- OAUYM OBH OCB ODMLO OFXIZ OGEVE OHH OJZSN OK1 OPAEJ OVD OVIDX P2P P6G PQQKQ PROAC PSQYO REU ROX ROZ TEORI TJX TLC TMA TR2 TWZ UKHRP VH1 VVN W8F WHG WOQ X52 X7M YBU YFH YHG YOC YSK ZGI ZXP ZY1 ~02 ~H1 ABXZS ACVCV ADMTO ADNBA AEMQT AEOTA AGORE AHGBF AJBYB AJDVS ALXQX AVNTJ NU- OBFPC PHGZM PHGZT AAYXX AEHZK AFFHD CITATION PJZUB PPXIY CGR CUY CVF ECM EIF NPM 7QP 7T5 7TM 7XB 8FK H94 K9. PKEHL PQEST PQUKI PRINS 7X8
ID	FETCH-LOGICAL-c5287-5179155ddd55b91d8ca06dba9d038023d29f0f46f6d848f0e0781f4dc15fa1333
IEDL.DBID	7X7
ISICitedReferencesCount	13
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=00004678-201703000-00007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0021-972X
IngestDate	Sun Nov 09 14:11:06 EST 2025 Tue Oct 07 07:23:25 EDT 2025 Tue Oct 07 06:41:50 EDT 2025 Wed Feb 19 02:26:15 EST 2025 Sat Nov 29 02:29:11 EST 2025 Tue Nov 18 22:06:35 EST 2025 Fri May 16 03:42:55 EDT 2025 Fri Feb 07 10:35:36 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	3
Language	English
License	Copyright © 2017 by the Endocrine Society
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c5287-5179155ddd55b91d8ca06dba9d038023d29f0f46f6d848f0e0781f4dc15fa1333
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://academic.oup.com/jcem/article-pdf/102/3/884/10913269/jc.2016-2417.pdf
PMID	27929711
PQID	2023882953
PQPubID	2046206
PageCount	9
ParticipantIDs	proquest_miscellaneous_1847897503 proquest_journals_3164375040 proquest_journals_2023882953 pubmed_primary_27929711 crossref_citationtrail_10_1210_jc_2016_2417 crossref_primary_10_1210_jc_2016_2417 wolterskluwer_health_00004678-201703000-00007 oup_primary_10_1210_jc_2016-2417
PublicationCentury	2000
PublicationDate	2017-March
PublicationDateYYYYMMDD	2017-03-01
PublicationDate_xml	– month: 03 year: 2017 text: 2017-March
PublicationDecade	2010
PublicationPlace	Washington, DC
PublicationPlace_xml	– name: Washington, DC – name: United States – name: Washington
PublicationTitle	The journal of clinical endocrinology and metabolism
PublicationTitleAlternate	J Clin Endocrinol Metab
PublicationYear	2017
Publisher	Endocrine Society Copyright Oxford University Press Oxford University Press
Publisher_xml	– name: Endocrine Society – name: Copyright Oxford University Press – name: Oxford University Press
References	Suzuki (2019041122165989700_B17) 2008; 9 Ohmori (2019041122165989700_B12) 2005; 46 Yang (2019041122165989700_B21) 2012; 26 Osawa (2019041122165989700_B7) 2010; 53 Feil (2019041122165989700_B30) 2012; 13 Hage (2019041122165989700_B34) 2007; 50 Bird (2019041122165989700_B19) 2007; 447 Shetty (2019041122165989700_B38) 2004; 27 Taqi (2019041122165989700_B26) 2011; 16 Tsai (2019041122165989700_B28) 2012; 4 Bell (2019041122165989700_B31) 2011; 12 Gibbs (2019041122165989700_B32) 2010; 6 Chen (2019041122165989700_B14) 2009; 32 Osawa (2019041122165989700_B5) 2005; 335 Solé (2019041122165989700_B25) 2006; 22 Norata (2019041122165989700_B10) 2007; 262 Osawa (2019041122165989700_B11) 2008; 69 Dayeh (2019041122165989700_B24) 2013; 56 Sun (2019041122165989700_B36) 2013; 8 Ling (2019041122165989700_B20) 2008; 51 Schwartz (2019041122165989700_B13) 2011; 22 Ridker (2019041122165989700_B35) 2008; 82 Patel (2019041122165989700_B2) 2003; 300 Heidemann (2019041122165989700_B15) 2008; 149 Dick (2019041122165989700_B40) 2014; 383 Lehrke (2019041122165989700_B37) 2004; 1 Zhang (2019041122165989700_B33) 2010; 86 Onuma (2019041122165989700_B6) 2010; 5 Reilly (2019041122165989700_B8) 2005; 111 Wang (2019041122165989700_B39) 2010; 8 Zhao (2019041122165989700_B22) 2012; 61 Lienert (2019041122165989700_B29) 2011; 43 Osawa (2019041122165989700_B4) 2007; 30 Ling (2019041122165989700_B27) 2007; 117 Xu (2019041122165989700_B16) 2007; 66 Norata (2019041122165989700_B9) 2007; 156 Shoemaker (2019041122165989700_B23) 2010; 20 Lister (2019041122165989700_B18) 2009; 462 Steppan (2019041122165989700_B1) 2001; 409 Osawa (2019041122165989700_B3) 2004; 75
References_xml	– volume: 262 start-page: 104 issue: 1 year: 2007 ident: 2019041122165989700_B10 article-title: Effect of the –420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction publication-title: J Intern Med doi: 10.1111/j.1365-2796.2007.01787.x – volume: 1 start-page: e45 issue: 2 year: 2004 ident: 2019041122165989700_B37 article-title: An inflammatory cascade leading to hyperresistinemia in humans publication-title: PLoS Med doi: 10.1371/journal.pmed.0010045 – volume: 56 start-page: 1036 issue: 5 year: 2013 ident: 2019041122165989700_B24 article-title: Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets publication-title: Diabetologia doi: 10.1007/s00125-012-2815-7 – volume: 462 start-page: 315 issue: 7271 year: 2009 ident: 2019041122165989700_B18 article-title: Human DNA methylomes at base resolution show widespread epigenomic differences publication-title: Nature doi: 10.1038/nature08514 – volume: 30 start-page: 1501 issue: 6 year: 2007 ident: 2019041122165989700_B4 article-title: Plasma resistin, associated with single nucleotide polymorphism –420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population publication-title: Diabetes Care doi: 10.2337/dc06-1936 – volume: 117 start-page: 3427 issue: 11 year: 2007 ident: 2019041122165989700_B27 article-title: Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle publication-title: J Clin Invest doi: 10.1172/JCI30938 – volume: 12 start-page: R10 issue: 1 year: 2011 ident: 2019041122165989700_B31 article-title: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines publication-title: Genome Biol doi: 10.1186/gb-2011-12-1-r10 – volume: 32 start-page: 329 issue: 2 year: 2009 ident: 2019041122165989700_B14 article-title: Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts publication-title: Diabetes Care doi: 10.2337/dc08-1625 – volume: 66 start-page: 211 issue: 2 year: 2007 ident: 2019041122165989700_B16 article-title: Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2006.02710.x – volume: 26 start-page: 1203 issue: 7 year: 2012 ident: 2019041122165989700_B21 article-title: Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes publication-title: Mol Endocrinol doi: 10.1210/me.2012-1004 – volume: 69 start-page: 74 issue: 1 year: 2008 ident: 2019041122165989700_B11 article-title: Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2007.03154.x – volume: 5 start-page: e9718 issue: 3 year: 2010 ident: 2019041122165989700_B6 article-title: A at single nucleotide polymorphism-358 is required for G at –420 to confer the highest plasma resistin in the general Japanese population publication-title: PLoS One doi: 10.1371/journal.pone.0009718 – volume: 86 start-page: 411 issue: 3 year: 2010 ident: 2019041122165989700_B33 article-title: Genetic control of individual differences in gene-specific methylation in human brain publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2010.02.005 – volume: 4 start-page: 511 issue: 5 year: 2012 ident: 2019041122165989700_B28 article-title: Using epigenome-wide association scans of DNA methylation in age-related complex human traits publication-title: Epigenomics doi: 10.2217/epi.12.45 – volume: 82 start-page: 1185 issue: 5 year: 2008 ident: 2019041122165989700_B35 article-title: Loci related to metabolic-syndrome pathways including LEPR, HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women’s Genome Health Study publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2008.03.015 – volume: 75 start-page: 678 issue: 4 year: 2004 ident: 2019041122165989700_B3 article-title: The G/G genotype of a resistin single-nucleotide polymorphism at –420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3 publication-title: Am J Hum Genet doi: 10.1086/424761 – volume: 335 start-page: 596 issue: 2 year: 2005 ident: 2019041122165989700_B5 article-title: Resistin SNP–420 determines its monocyte mRNA and serum levels inducing type 2 diabetes publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2005.07.122 – volume: 409 start-page: 307 issue: 6818 year: 2001 ident: 2019041122165989700_B1 article-title: The hormone resistin links obesity to diabetes publication-title: Nature doi: 10.1038/35053000 – volume: 53 start-page: 795 issue: 4 year: 2010 ident: 2019041122165989700_B7 article-title: Is rs34861192 or rs1862513 a more promising variant for determining plasma resistin in an aged Japanese population? publication-title: Diabetologia doi: 10.1007/s00125-010-1665-4 – volume: 16 start-page: 499 issue: 3 year: 2011 ident: 2019041122165989700_B26 article-title: Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics publication-title: Addict Biol doi: 10.1111/j.1369-1600.2011.00323.x – volume: 156 start-page: 279 issue: 2 year: 2007 ident: 2019041122165989700_B9 article-title: Plasma resistin levels correlate with determinants of the metabolic syndrome publication-title: Eur J Endocrinol doi: 10.1530/eje.1.02338 – volume: 22 start-page: 1928 issue: 15 year: 2006 ident: 2019041122165989700_B25 article-title: SNPStats: a web tool for the analysis of association studies publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl268 – volume: 9 start-page: 465 issue: 6 year: 2008 ident: 2019041122165989700_B17 article-title: DNA methylation landscapes: provocative insights from epigenomics publication-title: Nat Rev Genet doi: 10.1038/nrg2341 – volume: 13 start-page: 97 issue: 2 year: 2012 ident: 2019041122165989700_B30 article-title: Epigenetics and the environment: emerging patterns and implications publication-title: Nat Rev Genet doi: 10.1038/nrg3142 – volume: 383 start-page: 1990 issue: 9933 year: 2014 ident: 2019041122165989700_B40 article-title: DNA methylation and body-mass index: a genome-wide analysis publication-title: Lancet doi: 10.1016/S0140-6736(13)62674-4 – volume: 61 start-page: 542 issue: 2 year: 2012 ident: 2019041122165989700_B22 article-title: Global DNA methylation is associated with insulin resistance: a monozygotic twin study publication-title: Diabetes doi: 10.2337/db11-1048 – volume: 300 start-page: 472 issue: 2 year: 2003 ident: 2019041122165989700_B2 article-title: Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(02)02841-3 – volume: 8 start-page: 87 year: 2010 ident: 2019041122165989700_B39 article-title: Obesity related methylation changes in DNA of peripheral blood leukocytes publication-title: BMC Med doi: 10.1186/1741-7015-8-87 – volume: 46 start-page: 379 issue: 2 year: 2005 ident: 2019041122165989700_B12 article-title: Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2005.04.022 – volume: 43 start-page: 1091 issue: 11 year: 2011 ident: 2019041122165989700_B29 article-title: Identification of genetic elements that autonomously determine DNA methylation states publication-title: Nat Genet doi: 10.1038/ng.946 – volume: 8 start-page: e73480 issue: 8 year: 2013 ident: 2019041122165989700_B36 article-title: Gene-specific DNA methylation association with serum levels of C-reactive protein in African Americans publication-title: PLoS One doi: 10.1371/journal.pone.0073480 – volume: 27 start-page: 2450 issue: 10 year: 2004 ident: 2019041122165989700_B38 article-title: Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes publication-title: Diabetes Care doi: 10.2337/diacare.27.10.2450 – volume: 51 start-page: 615 issue: 4 year: 2008 ident: 2019041122165989700_B20 article-title: Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion publication-title: Diabetologia doi: 10.1007/s00125-007-0916-5 – volume: 111 start-page: 932 issue: 7 year: 2005 ident: 2019041122165989700_B8 article-title: Resistin is an inflammatory marker of atherosclerosis in humans publication-title: Circulation doi: 10.1161/01.CIR.0000155620.10387.43 – volume: 149 start-page: 307 issue: 5 year: 2008 ident: 2019041122165989700_B15 article-title: Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women publication-title: Ann Intern Med doi: 10.7326/0003-4819-149-5-200809020-00005 – volume: 50 start-page: 1115 issue: 12 year: 2007 ident: 2019041122165989700_B34 article-title: C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2007.06.012 – volume: 447 start-page: 396 issue: 7143 year: 2007 ident: 2019041122165989700_B19 article-title: Perceptions of epigenetics publication-title: Nature doi: 10.1038/nature05913 – volume: 20 start-page: 883 issue: 7 year: 2010 ident: 2019041122165989700_B23 article-title: Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome publication-title: Genome Res doi: 10.1101/gr.104695.109 – volume: 22 start-page: 259 issue: 7 year: 2011 ident: 2019041122165989700_B13 article-title: Human resistin: found in translation from mouse to man publication-title: Trends Endocrinol Metab – volume: 6 start-page: e1000952 issue: 5 year: 2010 ident: 2019041122165989700_B32 article-title: Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000952
SSID	ssj0014453
Score	2.2953718
Snippet	Methylation at RETN SNP–420 was inversely associated with plasma resistin dependent and independent of SNP–420 genotypes in the general Japanese... We previously reported that single nucleotide polymorphism (SNP)-420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma... Methylation at RETN SNP-420 was inversely associated with plasma resistin dependent and independent of SNP-420 genotypes in the general Japanese population.... Context:We previously reported that single nucleotide polymorphism (SNP)–420 C>G (rs1862513) in the promoter region of RETN was associated with type 2... CONTEXTWe previously reported that single nucleotide polymorphism (SNP)-420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes....
SourceID	proquest pubmed crossref wolterskluwer oup
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	884
SubjectTerms	3' Untranslated regions Aged Asians - genetics Azacytidine Bisulfite Body Mass Index C-reactive protein C-Reactive Protein - metabolism Cell Line CpG Islands Cytosine Deoxyribonucleic acid Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics DNA DNA Methylation Epigenesis, Genetic - genetics Epigenetics Female Gene polymorphism Genotype Genotype & phenotype Genotypes Guanine Humans Japan Leukocytes Male Middle Aged Monocytes mRNA Nucleotide sequence Plasma Polymorphism Polymorphism, Single Nucleotide Resistin - blood Resistin - genetics RNA, Messenger - metabolism Single-nucleotide polymorphism
Title	Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at –420 on Plasma Resistin: Genotype and DNA Methylation
URI	https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-201703000-00007 https://www.ncbi.nlm.nih.gov/pubmed/27929711 https://www.proquest.com/docview/2023882953 https://www.proquest.com/docview/3164375040 https://www.proquest.com/docview/1847897503
Volume	102
WOSCitedRecordID	wos00004678-201703000-00007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1945-7197 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0014453 issn: 0021-972X databaseCode: 7X7 dateStart: 20170101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1945-7197 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0014453 issn: 0021-972X databaseCode: BENPR dateStart: 20170101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwELZgQwg08RtWGJORQGJClpLGieO9oME6eFkUbUPqm-XajtTRxmNJmfjvuUvcskqMF176Ykdydefz9_nO3xHyNuXaJI6D80pTMS64YXIiEpYZmwF3E0JK3TWbEEWRj8eyDBduTSirXMbELlBbb_COHEl6AmhQpsnHix8Mu0ZhdjW00LhNNrFtNmrni_GKcAFXCCqUWIYghuNQ-I6vVs5RvjDOGBxgYu1IWnvmdg1t3idbVx4T2M33rn792il09PB_1_-IPAj4kx70DvOY3HL1E3L3OGTYn5L2cAHDvaZxQ31FNT0ZnRX0FI64maMFyh_7dmodLf3s19yDmabNnL4_Lco9qlvK-DCivqYloPI5fOsaDCL1Pv3iao_3vVTXlh4WB_TYgY_0lXjPyLej0dnnryx0ZmAmBYrFUNcLgIi1Nk0nMra50VFmJ1raKEFFOTuUVVTxrMpszvMqcigpVHFr4rTSwIqT52Sj9rXbJtQAPpsAaAav0Nyha_AcSFuKSnsAPeMB-bA0jjJBthy7Z8wU0hcwpTo3Ck2p0JQD8m41-6KX67hhHgU73zSF9VN2loZUYV836o8V_zqcxJgHTSEwDsib1TBsWMzC6Nr5RaOAUotcYvp4QF70vrVaB6o5ShHDn2Zrzqb6R7GqY3QALyC2xRiqe1WASLz891pfkXv4QV86t0M22suFe03umJ_ttLnc7fZM95vvks1Po6I8-Q01RhiU
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3bbtNAEB2VgrgIcb8ECiwSlajQSnZ8WS8SQhVpadXGimgq5W3r7K6llMQutUPVn-IbmfElNBLlrQ8879pa22dn5nhmzwC8C_xEe9ZH8Eqdcl_4msux8HioTYjcTQgpk6rZhIjjaDSSgxX41Z6FobLK1iZWhtrkmv6RE0n3MBqUgff55AenrlGUXW1baNSw2LPnZ0jZik-7Pfy-693u9tbwyw5vugpwHSA94KRJhU7UGBMEY-maSCdOaMaJNI5HamimK1Mn9cM0NJEfpY4lOZzUN9oN0gQZnYf3vQbX0Y4LKiETowXBQ27SqF5S2YPojppCezolc0xyiW7I0WGKJRe4dKzuQnR7B-6e5ZQwL75X9fIXvN72_f_tfT2Ae018zTbrDfEQVmz2CG72mwqCx1D25jhcazYXLE9Zwr5tDWN2gC58allM8s55OTGWDfLp-SxHGE6KGXt_EA82WFIy7ncdlmdsgKxjhtfagoxk9pF9tVlO_7NZkhnWizdZ3-IeqCsNn8DhlTzzU1jN8sw-B6Yx_hwjKUDUJ74l6PsRktKAlAQxtHY78KEFg9KNLDt1B5kqomcIHXWsFUFHEXQ6sL6YfVLLkVwyjyGuLpvC6ylrLXBUY7cK9Qc1fx32XMrzBmj4O_B2MYwGibJMSWbzeaFcjHciSenxDjyrsbxYB6lVSuHiQ_MlcKv60K-qGCuGT2i7XXJFteqBI178e61v4NbOsL-v9nfjvZdwmy6uywTXYLU8ndtXcEP_LCfF6etqvzI4umrA_wa_NXF5
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dual+Effects+of+a+RETN+Single+Nucleotide+Polymorphism+%28SNP%29+at+-420+on+Plasma+Resistin%3A+Genotype+and+DNA+Methylation&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Onuma%2C+Hiroshi&rft.au=Tabara%2C+Yasuharu&rft.au=Kawamura%2C+Ryoichi&rft.au=Ohashi%2C+Jun&rft.date=2017-03-01&rft.eissn=1945-7197&rft.volume=102&rft.issue=3&rft.spage=884&rft.epage=892&rft_id=info:doi/10.1210%2Fjc.2016-2417&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon