Translocator protein ligand, YL-IPA08, attenuates lipopolysaccharide-induced depression-like behavior by promoting neural regeneration

Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice wer...

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Vydané v:Neural regeneration research Ročník 13; číslo 11; s. 1937 - 1944
Hlavní autori: Zhang, Xiao-Ying, Zhang, Li-Ming, Mi, Wei-Dong, Li, Yun-Feng
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: India Medknow Publications and Media Pvt. Ltd 01.11.2018
Medknow Publications & Media Pvt. Ltd
Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China%Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China%State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China
Medknow Publications & Media Pvt Ltd
Predmet:
Analysis
Behavior
Brain
Depression, Mental
Inflammation
Laboratory animals
Ligands
Ligands (Biochemistry)
Lipopolysaccharides
Medical research
Mental depression
Mice
Nervous system
Neurogenesis
Regeneration
Beijing China
United States > US
China
dentate gyrus
neural regeneration
translocator protein
hippocampus
neuroinflammation
nerve regeneration
depression
lipopolysaccharide
YL-IPA08
ISSN:1673-5374, 1876-7958
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Shrnutí:Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. Mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16-24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.
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Author contributions: XYZ conceived the study, carried out the study execution and data analysis and contributed to the manuscript draft. LMZ participated in the study design, the construction of recombinant lentiviruses and the draft of manuscript. WDM and YFL contributed to the study design, data analysis and manuscript revision. All authors approved the final version of this paper.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.239442