TET2 Drives 5hmc Marking of GATA6 and Epigenetically Defines Pancreatic Ductal Adenocarcinoma Transcriptional Subtypes

Pancreatic ductal adenocarcinoma (PDAC) is characterized by advanced disease stage at presentation, aggressive disease biology, and resistance to therapy, resulting in an extremely poor 5-year survival rate of <10%. PDAC is classified into transcriptional subtypes with distinct survival character...

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Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 161; no. 2; p. 653
Main Authors:	Eyres, Michael, Lanfredini, Simone, Xu, Haonan, Burns, Adam, Blake, Andrew, Willenbrock, Frances, Goldin, Robert, Hughes, Daniel, Hughes, Sophie, Thapa, Asmita, Vavoulis, Dimitris, Hubert, Aline, D'Costa, Zenobia, Sabbagh, Ahmad, Abraham, Aswin G, Blancher, Christine, Jones, Stephanie, Verrill, Clare, Silva, Michael, Soonawalla, Zahir, Maughan, Timothy, Schuh, Anna, Mukherjee, Somnath, O'Neill, Eric
Format:	Journal Article
Language:	English
Published:	United States 01.08.2021
Subjects:	5-Methylcytosine - analogs & derivatives 5-Methylcytosine - metabolism Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Ascorbic Acid - pharmacology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - enzymology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell Differentiation Cell Line, Tumor Dioxygenases - genetics Dioxygenases - metabolism DNA Methylation - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic - drug effects Epigenome Epigenomics GATA6 Transcription Factor - genetics GATA6 Transcription Factor - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Metformin - pharmacology Mice Mice, Nude Mice, Transgenic Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Retrospective Studies Smad4 Protein - genetics Smad4 Protein - metabolism Transcription, Genetic - drug effects Transcriptome Wnt Signaling Pathway - genetics Xenograft Model Antitumor Assays Epigenetics GATA6 TET2 SMAD4 Pancreatic Cancer
ISSN:	1528-0012, 1528-0012
Online Access:	Get more information
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