Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

In addition to its central role in cellular stress signaling, the tumor suppressor p53 modulates mitochondrial respiration through its nuclear transcription factor activity and localizes to mitochondria, where it enhances apoptosis and suppresses mitochondrial DNA (mtDNA) mutagenesis. Here we demons...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1787; H. 5; S. 328 - 334
Hauptverfasser:	Lebedeva, Maria A., Eaton, Jana S., Shadel, Gerald S.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.05.2009
Schlagworte:	Animals Cancer DNA Primers DNA, Mitochondrial - genetics Fibroblasts - cytology Fibroblasts - physiology Gene Deletion Homeostasis Humans Membrane Potentials Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism Mitochondria - physiology Mitochondrial transcription factor A mtDNA depletion Oxidative Phosphorylation p53 p53R2 Polymerase Chain Reaction Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Messenger - genetics Transcription, Genetic Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Mitochondrial transcription factor A Reactive oxygen species mtDNA depletion p53R2 p53 Cancer
ISSN:	0005-2728, 0006-3002, 1879-2650
Online-Zugang:	Volltext
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