Long-term Progression and Risk Factors of Fundus Tessellation in the Beijing Eye Study

To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus te...

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Published in:Scientific reports Vol. 8; no. 1; pp. 10625 - 9
Main Authors: Yan, Yan Ni, Wang, Ya Xing, Yang, Yan, Xu, Liang, Xu, Jie, Wang, Qian, Yang, Xuan, Yang, Jing Yan, Zhou, Wen Jia, Wei, Wen Bin, Jonas, Jost B.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 13.07.2018
Nature Publishing Group
Subjects:
692/617/375/132
692/699/3161/1626
9/10
Acuity
Beta
Cognitive ability
Correlation coefficient
Humanities and Social Sciences
multidisciplinary
Multivariate analysis
Population studies
Risk factors
Science
Science (multidisciplinary)
Smoking
Beijing China
China
ISSN:2045-2322, 2045-2322
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Abstract To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 ( P  < 0.001; standardized regression coefficient beta: −0.37), older age ( P  < 0.001; beta: 0.22), higher level of education ( P  < 0.001; beta: 0.09), more myopic change in refractive error ( P  < 0.001; beta: −0.09) and lower cognitive function score ( P  = 0.02; beta: −0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 ( P  < 0.001; beta: −0.35), older age ( P  < 0.001; beta: 0.20), worse best corrected visual acuity ( P  = 0.001; beta: 0.07), more myopic change in refractive error ( P  < 0.001; beta: −0.07) and higher prevalence of ever smoking ( P  = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with lower cognitive function, after adjusting for choroidal thickness, age, educational level and change in refractive error. The findings point to the clinical value of the assessment of fundus tessellation and suggest potential associations between cognitive function and fundus tessellation/choroidal thickness.
AbstractList To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 (P < 0.001; standardized regression coefficient beta: -0.37), older age (P < 0.001; beta: 0.22), higher level of education (P < 0.001; beta: 0.09), more myopic change in refractive error (P < 0.001; beta: -0.09) and lower cognitive function score (P = 0.02; beta: -0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 (P < 0.001; beta: -0.35), older age (P < 0.001; beta: 0.20), worse best corrected visual acuity (P = 0.001; beta: 0.07), more myopic change in refractive error (P < 0.001; beta: -0.07) and higher prevalence of ever smoking (P = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with lower cognitive function, after adjusting for choroidal thickness, age, educational level and change in refractive error. The findings point to the clinical value of the assessment of fundus tessellation and suggest potential associations between cognitive function and fundus tessellation/choroidal thickness.To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 (P < 0.001; standardized regression coefficient beta: -0.37), older age (P < 0.001; beta: 0.22), higher level of education (P < 0.001; beta: 0.09), more myopic change in refractive error (P < 0.001; beta: -0.09) and lower cognitive function score (P = 0.02; beta: -0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 (P < 0.001; beta: -0.35), older age (P < 0.001; beta: 0.20), worse best corrected visual acuity (P = 0.001; beta: 0.07), more myopic change in refractive error (P < 0.001; beta: -0.07) and higher prevalence of ever smoking (P = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with lower cognitive function, after adjusting for choroidal thickness, age, educational level and change in refractive error. The findings point to the clinical value of the assessment of fundus tessellation and suggest potential associations between cognitive function and fundus tessellation/choroidal thickness.
To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 ( P  < 0.001; standardized regression coefficient beta: −0.37), older age ( P  < 0.001; beta: 0.22), higher level of education ( P  < 0.001; beta: 0.09), more myopic change in refractive error ( P  < 0.001; beta: −0.09) and lower cognitive function score ( P  = 0.02; beta: −0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 ( P  < 0.001; beta: −0.35), older age ( P  < 0.001; beta: 0.20), worse best corrected visual acuity ( P  = 0.001; beta: 0.07), more myopic change in refractive error ( P  < 0.001; beta: −0.07) and higher prevalence of ever smoking ( P  = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with lower cognitive function, after adjusting for choroidal thickness, age, educational level and change in refractive error. The findings point to the clinical value of the assessment of fundus tessellation and suggest potential associations between cognitive function and fundus tessellation/choroidal thickness.
To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 ( P < 0.001; standardized regression coefficient beta: −0.37), older age ( P < 0.001; beta: 0.22), higher level of education ( P < 0.001; beta: 0.09), more myopic change in refractive error ( P < 0.001; beta: −0.09) and lower cognitive function score ( P = 0.02; beta: −0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 ( P < 0.001; beta: −0.35), older age ( P < 0.001; beta: 0.20), worse best corrected visual acuity ( P = 0.001; beta: 0.07), more myopic change in refractive error ( P < 0.001; beta: −0.07) and higher prevalence of ever smoking ( P = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with lower cognitive function, after adjusting for choroidal thickness, age, educational level and change in refractive error. The findings point to the clinical value of the assessment of fundus tessellation and suggest potential associations between cognitive function and fundus tessellation/choroidal thickness.
To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 (P < 0.001; standardized regression coefficient beta: -0.37), older age (P < 0.001; beta: 0.22), higher level of education (P < 0.001; beta: 0.09), more myopic change in refractive error (P < 0.001; beta: -0.09) and lower cognitive function score (P = 0.02; beta: -0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 (P < 0.001; beta: -0.35), older age (P < 0.001; beta: 0.20), worse best corrected visual acuity (P = 0.001; beta: 0.07), more myopic change in refractive error (P < 0.001; beta: -0.07) and higher prevalence of ever smoking (P = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with lower cognitive function, after adjusting for choroidal thickness, age, educational level and change in refractive error. The findings point to the clinical value of the assessment of fundus tessellation and suggest potential associations between cognitive function and fundus tessellation/choroidal thickness.
ArticleNumber 10625
Author Xu, Liang
Xu, Jie
Yang, Xuan
Wang, Ya Xing
Jonas, Jost B.
Yang, Yan
Wang, Qian
Zhou, Wen Jia
Yan, Yan Ni
Yang, Jing Yan
Wei, Wen Bin
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Snippet To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were...
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692/699/3161/1626
9/10
Acuity
Beta
Cognitive ability
Correlation coefficient
Humanities and Social Sciences
multidisciplinary
Multivariate analysis
Population studies
Risk factors
Science
Science (multidisciplinary)
Smoking
Title Long-term Progression and Risk Factors of Fundus Tessellation in the Beijing Eye Study
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