Increase in Tuberculosis Diagnostic Delay during First Wave of the COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital

Background: The WHO advised that the impact of COVID-19 pandemic on TB services was estimated to be dramatic due to the disruption of TB services. Methods: A retrospective data collection and evaluation was conducted to include all the patients hospitalized for TB at INMI from 9 March to 31 August 2...

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Vydáno v:Antibiotics (Basel) Ročník 10; číslo 3; s. 272
Hlavní autoři: Di Gennaro, Francesco, Gualano, Gina, Timelli, Laura, Vittozzi, Pietro, Di Bari, Virginia, Libertone, Raffaella, Cerva, Carlotta, Pinnarelli, Luigi, Nisii, Carla, Ianniello, Stefania, Mosti, Silvia, Bevilacqua, Nazario, Iacomi, Fabio, Mondi, Annalisa, Topino, Simone, Goletti, Delia, Vaia, Francesco, Ippolito, Giuseppe, Girardi, Enrico, Palmieri, Fabrizio
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 08.03.2021
MDPI
Témata:
Coronaviruses
COVID 19
Data collection
Delay
diagnostic delay
Diagnostic systems
Health facilities
Health services
Hospitalization
Hospitals
Infectious diseases
pandemic
Pandemics
Patients
Public health
Reduction
SARS CoV2
Severe acute respiratory syndrome coronavirus 2
Tuberculosis
Weight loss
SARS CoV2
diagnostic delay
COVID 19
pandemic
tuberculosis
ISSN:2079-6382, 2079-6382
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Shrnutí:Background: The WHO advised that the impact of COVID-19 pandemic on TB services was estimated to be dramatic due to the disruption of TB services. Methods: A retrospective data collection and evaluation was conducted to include all the patients hospitalized for TB at INMI from 9 March to 31 August 2020 (lockdown period and three months thereafter). For the purpose of the study, data from patients hospitalized in the same period of 2019 were also collected. Results: In the period of March–August 2019, 201 patients were hospitalized with a diagnosis of TB, while in the same period of 2020, only 115 patients, with a case reduction of 43%. Patients with weight loss, acute respiratory failure, concurrent extrapulmonary TB, and higher Timika radiographic scores were significantly more frequently hospitalized during 2020 vs. 2019. The median patient delay was 75 days (IQR: 40–100) in 2020 compared to 30 days (IQR: 10–60) in 2019 (p < 0.01). Diagnostic delays in 2020 remain significant in the multiple logistic model (AOR = 6.93, 95%CI: 3.9–12.3). Conclusions: Our experience suggests that COVID-19 pandemic had an impact on TB patient care in terms of higher diagnostic delay, reduction in hospitalization, and a greater severity of clinical presentations.
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TB-INMI Working Group: Fabrizio Palmieri, Gina Gualano, Andrea Antinori, Nazario Bevilacqua, Maria Capobianchi, Carmine Ciaralli, Gilda Cuzzi, Alessia De Angelis, Antonino Di Caro, Franca Del Nonno, Gianpiero D’Offizi, Emanuela Ercoli, Delia Goletti, Fabio Iacomi, Stefania Ianniello, Giuseppe Ippolito, Luisa Marchioni, Annelisa Mastrobattista, Maria Musso, Paola Mencarini, Annalisa Mondi, Silvia Mosti, Silvia Murachelli, Emanuele Nicastri, Carla Nisii, Carlo Pareo, Antonella Petrecchia, Nicola Petrosillo, Vincenza Puro, Silvia Rosati, Vincenzo Schininà, Paola Scognamiglio, Tommaso Speranza, Simone Topino, Francesco Vaia.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics10030272