Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways

[Display omitted] •Berberine represses human gastric cancer cell growth in vitro and in vivo without toxicity to Human peripheral blood mononuclear cells and nude mice.•Berberine induces cytostatic autophagy in BGC-823 cells via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways.•Autophagy ex...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 128; p. 110245
Main Authors:	Zhang, Qiang, Wang, Xiaobing, Cao, Shijie, Sun, Yujie, He, Xinya, Jiang, Benke, Yu, Yaqin, Duan, Jingshi, Qiu, Feng, Kang, Ning
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01.08.2020
Subjects:	Animals Antineoplastic Agents - pharmacology Autophagy - drug effects Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Berberine Berberine - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cytostatic Agents - pharmacology Cytostatic autophagy Female Gastric cancer Humans Mice, Inbred BALB C Mice, Nude Mitogen-Activated Protein Kinases - metabolism Negative feedback Proto-Oncogene Proteins c-akt - metabolism Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal Transduction Signaling pathway Stomach Neoplasms - drug therapy Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - pathology TOR Serine-Threonine Kinases - metabolism Xenograft Model Antitumor Assays Cytostatic autophagy Berberine Negative feedback Signaling pathway Gastric cancer
ISSN:	0753-3322, 1950-6007, 1950-6007
Online Access:	Get full text
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