Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti-oxidative and conductivity promoting wound healing process will be highly desired in wound healing application and its design is still a challenge. We developed a series of injectable conductive...

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Vydáno v:Biomaterials Ročník 122; s. 34 - 47
Hlavní autoři: Zhao, Xin, Wu, Hao, Guo, Baolin, Dong, Ruonan, Qiu, Yusheng, Ma, Peter X.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier Ltd 01.04.2017
Témata:
adhesion
Adhesiveness
Advanced Basic Science
Animals
Anti-Bacterial Agents - administration & dosage
Antibacterial
antibacterial properties
Antioxidants - administration & dosage
Bandages, Hydrocolloid
benzaldehyde
biocompatibility
blood coagulation
collagen
Conductive hydrogel dressing
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - chemistry
Dentistry
Electric Conductivity
Electroactivity
ethylene glycol
free radical scavengers
Full thickness skin defect model
gene expression
glycerol
granulation tissue
hemostasis
Hemostasis - drug effects
hydrocolloids
Hydrogels - administration & dosage
Injections, Subcutaneous
Lacerations - pathology
Lacerations - physiopathology
Lacerations - therapy
longevity
Mice
polyethylene glycol
Self-healing
tissue repair
transforming growth factor beta
Treatment Outcome
vascular endothelial growth factors
Wound healing
Wound Healing - drug effects
Wound Healing - physiology
Full thickness skin defect model
Self-healing
Wound healing
Antibacterial
Conductive hydrogel dressing
Electroactivity
ISSN:0142-9612, 1878-5905, 1878-5905
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Shrnutí:Injectable self-healing hydrogel dressing with multifunctional properties including anti-infection, anti-oxidative and conductivity promoting wound healing process will be highly desired in wound healing application and its design is still a challenge. We developed a series of injectable conductive self-healed hydrogels based on quaternized chitosan-g-polyaniline (QCSP) and benzaldehyde group functionalized poly(ethylene glycol)-co-poly(glycerol sebacate) (PEGS-FA) as antibacterial, anti-oxidant and electroactive dressing for cutaneous wound healing. These hydrogels presented good self-healing, electroactivity, free radical scavenging capacity, antibacterial activity, adhesiveness, conductivity, swelling ratio, and biocompatibility. Interestingly, the hydrogel with an optimal crosslinker concentration of 1.5 wt% PEGS-FA showed excellent in vivo blood clotting capacity, and it significantly enhanced in vivo wound healing process in a full-thickness skin defect model than quaternized chitosan/PEGS-FA hydrogel and commercial dressing (Tegaderm™ film) by upregulating the gene expression of growth factors including VEGF, EGF and TGF-β and then promoting granulation tissue thickness and collagen deposition. Taken together, the antibacterial electroactive injectable hydrogel dressing prolonged the lifespan of dressing relying on self-healing ability and significantly promoted the in vivo wound healing process attributed to its multifunctional properties, meaning that they are excellent candidates for full-thickness skin wound healing.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2017.01.011