Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology

•A new diagnostic tool to distinguish vaccinated from infected immune response for HAV.•Clinical validation of HAV multiplex serology.•High sensitivity, specificity and accuracy to measure HAV infection and vaccination.•Using Luminex® technology to facilitate sero-epidemiological studies. Worldwide...

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Bibliographic Details
Published in:	Vaccine Vol. 35; no. 43; pp. 5883 - 5889
Main Authors:	Bohm, Katrin, Filomena, Angela, Schneiderhan-Marra, Nicole, Krause, Gérard, Sievers, Claudia
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 13.10.2017 Elsevier Limited
Subjects:	Adolescent Adult Antigens Assaying Beads Biomarkers Biomarkers - blood capsid Capsid Proteins - blood Capsid Proteins - immunology Child Child, Preschool childhood Children Cysteine Endopeptidases - blood Cysteine Endopeptidases - immunology Diagnostic systems Differentiation E coli Enzyme-linked immunosorbent assay Fluorescence Foot & mouth disease Genomes Glutathione Glutathione transferase Hepatitis Hepatitis A Hepatitis A - blood Hepatitis A - diagnosis Hepatitis A - immunology Hepatitis A - virology Hepatitis A Antibodies - blood Hepatitis A Antibodies - immunology Hepatitis A Virus Hepatitis A virus - immunology Hepatovirus A Humans Immune status Immunization Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - blood Immunoglobulin M - immunology Immunoglobulins Immunology Infant Infant, Newborn Infections Luminex assay magnetism Medical diagnosis Multiplexing outbreak investigation Outbreaks Population studies Proteins Public health Risk assessment Serology Vaccination Vaccination - methods Vaccines Vaccinology viral nonstructural proteins Viral Proteins - blood Viral Proteins - immunology Viruses Greece Argentina Vaccinology Serology Immunology Luminex assay Hepatitis A Virus
ISSN:	0264-410X, 1873-2518, 1873-2518
Online Access:	Get full text
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