Silencing of LAMC2 Reverses Epithelial-Mesenchymal Transition and Inhibits Angiogenesis in Cholangiocarcinoma via Inactivation of the Epidermal Growth Factor Receptor Signaling Pathway

Cholangiocarcinoma (CCA) is a malignant cancer that is associated with high mortality rates. The relationship between laminin γ 2 chain gene (LAMC2) and epidermal growth factor receptor (EGFR) has been previously documented in gastric cancer and oral squamous cell carcinoma. This study investigates...

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Veröffentlicht in:	The American journal of pathology Jg. 189; H. 8; S. 1637
Hauptverfasser:	Pei, Yao-Fei, Liu, Jie, Cheng, Jian, Wu, Wei-Ding, Liu, Xi-Qiang
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2019
Schlagworte:	Adult Aged Animals Bile Duct Neoplasms - blood supply Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Cell Line, Tumor Cholangiocarcinoma - blood supply Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Epithelial-Mesenchymal Transition ErbB Receptors - metabolism Female Gene Silencing Humans Laminin - metabolism Male Mice Mice, Inbred BALB C Mice, Nude Middle Aged Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Signal Transduction Tumor Suppressor Proteins - metabolism
ISSN:	1525-2191, 1525-2191
Online-Zugang:	Weitere Angaben
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