Transdifferentiation: a cell and molecular reprogramming process

Evidence has emerged recently indicating that differentiation is not entirely a one-way process, and that it is possible to convert one cell type to another, both in vitro and in vivo. This phenomenon is called transdifferentiation, and is generally defined as the stable switch of one cell type to a...

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Veröffentlicht in:Cell and tissue research Jg. 348; H. 3; S. 379 - 396
Hauptverfasser: Sisakhtnezhad, Sajjad, Matin, Maryam M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer-Verlag 01.06.2012
Springer
Springer Nature B.V
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Transdifferentiation
Cell Transdifferentiation - genetics
Cells
Cellular Reprogramming
Cellular Reprogramming - genetics
Chromatin
Chromatin Assembly and Disassembly
Chromatin Assembly and Disassembly - genetics
genes
Genes, Regulator
Genes, Regulator - genetics
genetics
Human Genetics
Humans
medicine
Models, Biological
Molecular Medicine
Morphology
phenotype
physiology
Proteomics
Regeneration
Regeneration - physiology
Review
therapeutics
Tissue engineering
Heterochromatin
Reprogramming
Master switch genes
Regenerative medicine
Transdifferentiation
ISSN:0302-766X, 1432-0878, 1432-0878
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Evidence has emerged recently indicating that differentiation is not entirely a one-way process, and that it is possible to convert one cell type to another, both in vitro and in vivo. This phenomenon is called transdifferentiation, and is generally defined as the stable switch of one cell type to another. Transdifferentiation plays critical roles during development and in regeneration pathways in nature. Although this phenomenon occurs rarely in nature, recent studies have been focused on transdifferentiation and the reprogramming ability of cells to produce specific cells with new phenotypes for use in cell therapy and regenerative medicine. Thus, understanding the principles and the mechanism of this process is important for producing desired cell types. Here some well-documented examples of transdifferentiation, and their significance in development and regeneration are reviewed. In addition, transdifferentiation pathways are considered and their potential molecular mechanisms, especially the role of master switch genes, are considered. Finally, the significance of transdifferentiation in regenerative medicine is discussed.
Bibliographie:http://dx.doi.org/10.1007/s00441-012-1403-y
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ISSN:0302-766X
1432-0878
1432-0878
DOI:10.1007/s00441-012-1403-y