Comprehensive effects of left ventricular assist device speed changes on alveolar gas exchange, sleep ventilatory pattern, and exercise performance

Increasing left ventricular assist device (LVAD) pump speed according to the patient's activity is a fascinating hypothesis. This study analyzed the short-term effects of LVAD speed increase on cardiopulmonary exercise test (CPET) performance, muscle oxygenation (near-infrared spectroscopy), di...

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Vydáno v:The Journal of heart and lung transplantation Ročník 37; číslo 11; s. 1361
Hlavní autoři: Apostolo, Anna, Paolillo, Stefania, Contini, Mauro, Vignati, Carlo, Tarzia, Vincenzo, Campodonico, Jeness, Mapelli, Massimo, Massetti, Massimo, Bejko, Jonida, Righini, Francesca, Bottio, Tomaso, Bonini, Niccolò, Salvioni, Elisabetta, Gugliandolo, Paola, Parati, Gianfranco, Lombardi, Carolina, Gerosa, Gino, Salvi, Luca, Alamanni, Francesco, Agostoni, Piergiuseppe
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.11.2018
Témata:
Aged
Carbon Monoxide - blood
Equipment Design
Exercise - physiology
Female
Heart Failure - physiopathology
Heart Failure - therapy
Heart-Assist Devices
Humans
Male
Middle Aged
Muscle, Skeletal - blood supply
Nitric Oxide - blood
Oxygen Consumption - physiology
Pulmonary Diffusing Capacity - physiology
Pulmonary Gas Exchange - physiology
Sleep - physiology
cardiac output
muscle oxygenation
exercise
CPET
lung diffusion
LVAD
ISSN:1557-3117, 1557-3117
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Shrnutí:Increasing left ventricular assist device (LVAD) pump speed according to the patient's activity is a fascinating hypothesis. This study analyzed the short-term effects of LVAD speed increase on cardiopulmonary exercise test (CPET) performance, muscle oxygenation (near-infrared spectroscopy), diffusion capacity of the lung for carbon monoxide (Dlco) and nitric oxide (Dlno), and sleep quality. We analyzed CPET, Dlco and Dlno, and sleep in 33 patients supported with the Jarvik 2000 (Jarvik Heart Inc., New York, NY). After a maximal CPET (n = 28), patients underwent 2 maximal CPETs with LVAD speed randomly set at 3 or increased from 3 to 5 during effort (n = 15). Then, at LVAD speed randomly set at 2 or 4, we performed (1) constant workload CPETs assessing O kinetics, cardiac output (CO), and muscle oxygenation (n = 15); (2) resting Dlco and Dlno (n = 18); and (3) nocturnal cardiorespiratory monitoring (n = 29). The progressive pump speed increase raised peak volume of oxygen consumption (12.5 ± 2.5 ml/min/kg vs 11.7 ± 2.8 ml/min/kg at speed 3; p = 0.001). During constant workload, from speed 2 to 4, CO increased (at rest: 3.18 ± 0.76 liters/min vs 3.69 ± 0.75 liters/min, p = 0.015; during exercise: 5.91 ± 1.31 liters/min vs 6.69 ± 0.99 liters/min, p = 0.014), and system efficiency (τ = 65.8 ± 15.1 seconds vs 49.9 ± 14.8 seconds, p = 0.002) and muscle oxygenation improved. At speed 4, Dlco decreased, and obstructive apneas increased despite a significant apnea/hypopnea index and a reduction of central apneas. Short-term LVAD speed increase improves exercise performance, CO, O kinetics, and muscle oxygenation. However, it deteriorates lung diffusion and increases obstructive apneas, likely due to an increase of intrathoracic fluids. Self-adjusting LVAD speed is a fascinating but possibly unsafe option, probably requiring a monitoring of intrathoracic fluids.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1557-3117
1557-3117
DOI:10.1016/j.healun.2018.07.005